scholarly journals Effect of Phaseolus Vulgaris on Urinary Biochemical Parameters among Patients with Kidney Stones in Saudi Arabia

Nutrients ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 3346
Author(s):  
Sahbanathul Missiriya Jalal ◽  
Abdulrahman Abdulhadi Alsultan ◽  
Hala Hazam Alotaibi ◽  
Ester Mary ◽  
Abeer Abbas Ibrahim Alabdullatif
Keyword(s):  
Uric Acid ◽  
Phaseolus Vulgaris ◽  
Kidney Stones ◽  
Biochemical Parameters ◽  
Urine Volume ◽  
Controlled Study ◽  
Urinary Volume ◽  
Potassium Oxalate ◽  
Before And After ◽  
Post Test

The study purpose was to investigate the effect of Phaseolus Vulgaris (PV) on urinary biochemical parameters among patients with kidney stones. We conducted a randomized controlled study among 60 patients with kidney stones (size < 10 mm) in the nephrology unit of both government and private hospitals, Al-Ahsa. Urinary volume, calcium, magnesium, potassium, oxalate, uric acid, and power of hydrogen (pH) were assessed before and after the intervention of giving 250 g of PV consumption as an extract thrice weekly (2.2 L to 2.5 L per week) for 6 weeks, which was compared with control. A ‘t’ test was used with the significance at 5%. Mean score of age was 44.5 ± 10.16 in PV group and 43.73 ± 9.79 in control. Four (13.3%) and two (6.7%) had family history of kidney stones. Body mass Index (BMI) mean was 26.44 ± 2.7 and 26.36 ± 2.65 in pre and post-test, respectively, which were significant (p = 0.01017). There were significant changes (p = 0.000) in urine volume from 1962 ± 152.8 to 2005 ± 148.8, calcium 205.4 ± 11.99 to 198.4 ± 12.52, potassium 44.07 ± 3.66 to 52.15 ± 4.37, oxalate 37.12 ± 5.38 to 33.02 ± 5.71, and uric acid 6.88 ± 0.7 to 6.31 ± 0.58. In conclusion, PV is effective management for the patients with kidney stones as it increases the urinary volume and enhances the elimination of small kidney stones.

scholarly journals Saxifraga ligulata sebagai Alternatif Pengobatan Batu Ginjal

2019 ◽  
Author(s):  
Stefany Marcellia
Keyword(s):  
Clinical Trials ◽  
Uric Acid ◽  
Side Effects ◽  
Kidney Stones ◽  
Open Surgery ◽  
Potassium Oxalate ◽  
Complex Process ◽  
Other Substances

Kidney stones are a condition where there are stones or crystals in urinary tract (ureter, bladder, kidneys). It’s because of the results of a complex process from several photochemical processes. This situation occurs, because of the accumulation of compounds such as calcium, uric acid, potassium oxalate, or other substances in the form of crystals. Urine that contains these substances will be difficult to filter by the kidneys, which will then settle and potentially become kidney stones. Medications and treatments that have been applied for kidney stones so far such as ESWL, PNL, open surgery and chemical drugs. These treatments need a lot of money and also have side effects. Continuous consumption of chemical drugs can cause other complications and using shock waves will cause damage to the kidneys. Data from in vitro, in vivo, and clinical trials reveal that the use of herbs such as Saxifraga ligulata as an alternative treatment can be useful and have smaller side effects.

scholarly journals Evaluation of Certain Biochemical Parameters of Wrestlers before and after the 20 m Shuttle Run Test

2017 ◽  
Vol 5 (9) ◽  
pp. 187
Author(s):  
Mehmet Türkmen
Keyword(s):  
Biochemical Parameters ◽  
Hdl Cholesterol ◽  
Cholesterol Concentration ◽  
Serum Samples ◽  
Heart Rates ◽  
Before And After ◽  
Post Test ◽  
Acute Changes ◽  
Run Test ◽  
Shuttle Run

This study was conducted to determine the acute changes after the 20 m shuttle run test in the biochemical parameters and heart rates of wrestlers competing in international competitions on a study population of 21 wrestlers. The mean age of participants was 24.14±2.01years, mean heights 176±0.06 cm, body weight 76.48±14.76 kg, MaxVO2 52.78±3.20 ml/kg/min, and mean BMI 24.44±2.63 kg/m2.20-meter run and sit-up test was applied to measure the MaxVO2 scores of included subjects. Heart rates were monitored using a Polar heart rate monitor before and after the tests. The blood samples that collected at the same time intervals from the vena cephalica were stored in tubes without anticoagulants. The samples were then centrifuged for 10 minutes at 5000 rpm to obtain serum samples, and analyzed. The data obtained were treated using SPSS 15.0 software.This study showed that there was a significant increase (p<0.05) in post-test glucose, HDL-cholesterol and urea concentrations compared to pre-test levels. While the post-test LDL cholesterol concentration was significantly reduced (p<0.05), acute changes in other biochemical parameters were found to be statistically insignificant (p>0.05).It can be concluded that mean glucose, HDL and urea were increased while LDL was reduced after the 20 m shuttle run test in wrestlers.

scholarly journals Comparison of Two Dietary Supplements for Treatment of Uric Acid Renal Lithiasis: Citrate vs. Citrate + Theobromine

Nutrients ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 2012
Author(s):  
Yumaira Hernandez ◽  
Antonia Costa-Bauza ◽  
Paula Calvó ◽  
Joan Benejam ◽  
Pilar Sanchis ◽  
...  
Keyword(s):  
Uric Acid ◽  
Dietary Supplements ◽  
Kidney Stones ◽  
Potent Inhibitor ◽  
Urine Volume ◽  
High Rate ◽  
Intervention Period ◽  
Renal Lithiasis ◽  
Urinary Ph ◽  
Promising Strategy

Background. Uric acid (UA) renal lithiasis has a high rate of recurrence and a prevalence ranging from 10% and 15%, depending on the population. The most important etiological factor is persistence of urinary pH below 5.5 and one of the most common treatments is alkalization with citrate. Recent studies demonstrated that theobromine, which is abundant in chocolate and cocoa, is a potent inhibitor of UA crystallization. Aim. The aim was to compare the efficacy of citrate versus citrate + theobromine as treatment for UA lithiasis. Methods. This randomized cross-over trial investigated the efficacy of two treatments in 47 patients with UA renal lithiasis. Urine volume, pH, UA excretion, theobromine excretion, and risk of UA crystallization (RUAC) at baseline and at the end of each intervention period were measured. Results. Each treatment significantly reduced the risk of UA crystallization compared to basal values. The RUAC after citrate + theobromine was lower than the RUAC after citrate, although this difference was not statistically significant. Conclusion. The combined consumption of citrate and theobromine may be a promising strategy for the prevention of UA kidney stones.

scholarly journals EFEKTIVITAS KOMPRES JAHE TERHADAP PENURUNAN SKALA NYERI SENDI PENDERITA ASAM URAT DI DESA TEMPUREJO DAN JURUG JUMAPOLO KARANGANYAR

2018 ◽  
Vol 6 (1) ◽  
Author(s):  
Lilik Sriwiyati ◽  
Dwi Noviyanti
Keyword(s):  
Uric Acid ◽  
Standard Deviation ◽  
Sampling Method ◽  
Data Use ◽  
Pain Scale ◽  
P Value ◽  
Test Design ◽  
Menstrual Cycles ◽  
Before And After ◽  
Post Test

Background : The uric acid disease continues to increase in prevalence, with the mainsymptom being severe pain in the joints. One of the non-pharmacological painmanagement is to use warm compresses, one of which the ingredients can use gingerbecause ginger contains some substances that can reduce pain. The purpose of thisstudy was to analyze the effectiveness of ginger compress on decreasing the scale ofjoint pain in people with uric acid in Tempurejo dan Jurug JumapoloSubjects of this research : were Tempurejo and Jurug villagers. The samples were 22respondents selected by using total sampling method. Method of the research is aqueasy experiment with pre-post test design. This research has two variables, theindependent variable is compressed ginger and the dependent variable is pain scale.Collecting data use observation paper. Data analysis using paired t-test with p=0.05The result of this research : is the average scale of the pain before giving the gingercompress is 4.18 with standard deviation ± 1.053. While the average scale of pain afterthe ginger compression is done 2.73 with standard deviation + 1.162. The meandifference of pain scale before and after giving ginger compress is 1.455 with standarddeviation + 0.671. The p-value is 0.000.The Conclusion of this research : is a ginger compress effective against the decrease inpain scale of uric acid sufferers on villagers of Tempurejo and Jurug Jumapolo.Keywords: stress level, menstrual cycles

scholarly journals Saxifraga ligulata sebagai Alternatif Pengobatan Batu Ginjal

2019 ◽  
Author(s):  
Stefany Marcellia
Keyword(s):  
Clinical Trials ◽  
Uric Acid ◽  
Side Effects ◽  
Kidney Stones ◽  
Open Surgery ◽  
Potassium Oxalate ◽  
Complex Process ◽  
Other Substances

Kidney stones are a condition where there are stones or crystals in urinary tract (ureter, bladder, kidneys). It’s because of the results of a complex process from several photochemical processes. This situation occurs, because of the accumulation of compounds such as calcium, uric acid, potassium oxalate, or other substances in the form of crystals. Urine that contains these substances will be difficult to filter by the kidneys, which will then settle and potentially become kidney stones. Medications and treatments that have been applied for kidney stones so far such as ESWL, PNL, open surgery and chemical drugs. These treatments need a lot of money and also have side effects. Continuous consumption of chemical drugs can cause other complications and using shock waves will cause damage to the kidneys. Data from in vitro, in vivo, and clinical trials reveal that the use of herbs such as Saxifraga ligulata as an alternative treatment can be useful and have smaller side effects.

scholarly journals Pengaruh Pemberian Jus Sirsak (Annona Muricata Linn) Terhadap Kadar Asam Urat Pada Lansia Dengan Gout

2019 ◽  
Vol 10 (2) ◽  
pp. 634-645
Author(s):  
Fakhrudin Nasrul Sani ◽  
Annisa Cindy Nurul Afni
Keyword(s):  
Uric Acid ◽  
Gouty Arthritis ◽  
The Elderly ◽  
The Body ◽  
Adult Women ◽  
Annona Muricata ◽  
Test Analysis ◽  
Metabolism Disorder ◽  
Before And After ◽  
Post Test

Latar belakang: gout (pirai) merupakan kelainan metabolisme purin bawaan yang ditandai dengan penimbunan kristal asam urat di sendi. Hal ini menimbulkan arthritis gout akut.Penatalaksanaan secara non farmakologi salah satunya dengan pengobatan tradisional yaitu dengan pemberian jus sirsak. Asamuratsekitar80-85 %diproduksiolehtubuh, sedangkan sisanyaberasaldarimakanan.Kadarasamuratnormalwanitadewasa2,5-5,7 mg.dlpria dewasa 3,4-7,0 mg/ dl dan anak - anak 2,8-4,0 mg/dl.Tujuan: menganalisis pengaruh pemberian jus sirsak terhadap kadar asam urat pada lansia dengan gout. Manfaat Penelitian: meningkatkan ilmu pengetahuan tentang manfaat pemberian jus sirsak (Annona muricata linn.)untuk mengurangi kadar asam urat pada lansia dengan asam urat.Metode penelitian:penelitian ini menggunakan desain penelitian pre eksperimen dengan pre and post test without control yaitu pengaruh pemberian jus sirsak terhadap penurunan  kadar asam urat pada lansia yang menderita gout. Pengambilan data dilakukan dua kali pada saat sebelum perlakuan dan sesudah perlakuan. Pemberian jus sirsak sehari sekali selama 7 hari.Hasil: hasil analisis uji statistik wilcoxon menunjukkan bahwa ada pengaruh pemberian jus sirsak (Annona muricata linn.)terhadap kadar asam urat sebelum dan sesudah pemberian jus sirsak (Annona muricata linn.)dengan nilai p = 0,000 (p 0,05).Kesimpulan: Berdasarkan hasil tersebut, jus sirsak (Annona muricata linn.) berpengaruhterhadap penurunan kadar asam urat pada lansia.Kata Kunci: Gout, jus sirsak, penurunan kadar asam urat Background: gout (gout) is an inherited purine metabolism disorder characterized by accumulation of uric acid crystals in the joints. This causes acute gouty arthritis. One of the non-pharmacological treatments is traditional medicine, which is soursop juice. About 80-85% of the acid is produced by the body, while the remaining is derived from food. Normal normal adult women 2.5-5.7 mg. Adult men 3.4-7.0 mg / dl and children 2.8-4.0 mg / dl.Objective: to analyze the effect of soursop juice on uric acid levels in the elderly with gout.Benefits of research: increasing knowledge about the benefits of soursop juice (Annona muricata linn.) To reduce levels of uric acid in the elderly with gout.Research methods: this study used a pre-experimental research design with pre and post test without control, namely the effect of giving soursop juice on decreasing uric acid levels in the elderly suffering from gout. Data was collected twice before and after treatment. Giving soursop juice once a day for 7 days.Results: the results of the Wilcoxon statistical test analysis showed that there was an effect of soursop juice (Annona muricata linn.) On uric acid levels before and after administration of soursop juice (Annona muricata linn.) With a value of p = 0,000 (p 0.05).Conclusion: Based on these results, soursop juice (Annona muricata linn.) Affects the decrease in uric acid levels in the elderly.Keywords: Gout, soursop juice, decreased uric acid levels

scholarly journals Responses of Uric Acid, Glucose, Thyroid Hormones and Liver Enzymes to Aerobic and Combined Exercises in University Students

2020 ◽  
Vol 10 (1) ◽  
pp. 109
Author(s):  
Taner Akbulut
Keyword(s):  
Uric Acid ◽  
Biochemical Parameters ◽  
Liver Enzymes ◽  
Exercise Program ◽  
Exercise Group ◽  
Control Group ◽  
Blood Samples ◽  
Glucose Levels ◽  
Combined Exercise ◽  
Post Test

Physiological effects of aerobic and anaerobic exercises are frequently investigated. However, it is considered that combined exercises may be more effective. The aim of this study was to investigate the effect of aerobic and combined exercise program on some biochemical parameters. The study group consisted of 45 male volunteers with sedentary life. The participants were divided into three groups as control (n: 15), aerobic exercise (n: 15) and combined exercise (n: 15). The control group did not perform any exercise. Aerobic and combined exercise groups participated in the exercise program 4 days a week for 10 weeks. Blood samples were taken from the participants twice. TSH, T3, T4, AST, ALT, Uric acid and glucose levels were determined in blood samples. SPSS software was used for the analysis of the data and the significance level was accepted as p &lt;0.05. As a result of analysis; no difference was observed in the control group (p&gt; 0.05). In the aerobic exercise group, T3, AST, Uric acid levels of post test were found to be different according to baseline, while in the combined exercise group, there were significant differences in T3, AST, Uric acid and glucose levels between pre and post test values (p &lt;0.05). As a result, it was determined that both aerobic and combined exercises had effects on biochemical parameters (thyroid hormones, liver enzymes, Uric acid and glucose). According to this study it can be said that combined exercises may be more effective than aerobic exercises.

Renal blood flow distribution measured by microspheres during isovolemic hematocrit alteration in rats

1980 ◽  
Vol 58 (4) ◽  
pp. 368-372 ◽  
Author(s):  
U. Ackermann ◽  
A. T. Veress ◽  
H. Sonnenberg
Keyword(s):  
Blood Flow ◽  
Renal Blood Flow ◽  
Rat Kidney ◽  
Urine Volume ◽  
Flow Distribution ◽  
Urinary Volume ◽  
Outer Cortex ◽  
Before And After ◽  
Renal Blood Flow Distribution ◽  
Sodium And Potassium

The distribution of 15-μm microspheres was measured in rat kidneys before and after the animals had undergone either isovolemic hematocrit increase or isovolemic hematocrit decrease. Raising the systemic arterial hematocrit from 46 ± 1% (mean ± SEM) to 59 ± 1% caused a significant decrease in the rates of urinary sodium and potassium excretion [Formula: see text], but no significant changes in total renal blood flow (RBF), filtration fraction (FF), outer cortical flow, inner cortical flow, or rate of urinary volume excretion [Formula: see text]. Fractional sodium excretion was also unchanged suggesting that the decreased [Formula: see text] was the result of a decreased glomerular filtration rate (GFR). The measured decrease in GFR was not statistically significant. Lowering the systemic hematocrit from 45 ± 1% to 33 ± 1% caused a significant fall in FF as well as significant increases in the rate of urine volume excretion [Formula: see text], [Formula: see text], and GFR. There was a significant increase in RBF but again no change in the flow distribution between inner and outer cortex. The findings show that hematocrit alterations alone do not immediately lead to a redistribution of blood flow between inner and outer cortex of the rat kidney.

Perbedaan Kadar Asam Urat Darah Sebelum dan Sesudah Pemberian Minuman Asam Jawa

2020 ◽  
Vol 2 (1) ◽  
pp. 55-64
Author(s):  
Shania Ocha Sativa ◽  
Annisa Dwi Anggreni Kusuma
Keyword(s):  
Uric Acid ◽  
Quantitative Research ◽  
Venous Blood ◽  
Purine Metabolism ◽  
T Test ◽  
Group Design ◽  
Blood Uric Acid ◽  
Before And After ◽  
Post Test ◽  
Paired T Test

Asam urat merupakan hasil akhir metabolisme purin yang dapat berasal dari makanan. Prevalensi hiperurisemia (asam urat berlebih) secara stabil meningkat selama beberapa dekade terakhir. Asam jawa merupakan salah satu tanaman obat tradisional di Indonesia yang mengandung flavonoid. Flavonoid dapat menghambat kerja enzim xantin oksidase dalam proses metabolisme purin sehingga dapat menurunkan kadar asam urat darah. Jenis penelitian kuantitatif dengan desain penelitian pre-experimental design yaitu pre-test post-test one group design. Penelitian dilaksanakan pada bulan Oktober-Desember 2019 di Fakultas Kedokteran Universitas Lampung dan UPTD Balai Laboratorium Kesehatan Provinsi Lampung. Sampel berjumlah 10 orang mahasiswa. Darah vena sampel akan diambil sebelum dan sesudah penelitian lalu diukur kadar asam uratnya dengan spektrofotmeter. Pemberian minuman asam jawa dilakukan setiap 2 kali sehari sebanyak 401 cc selama 7 hari. Data diuji normalitasnya dengan uji Shapiro-Wilk kemudian dianalisis dengan uji Paired T-Test. Hasil uji normalitas dengan uji Shapiro-Wilk menunjukan data terdistribusi normal. Kemudian hasil uji Paired T-Test menunjukan nilai  p=0,008 (<0,05). Terdapat perbedaan kadar asam urat sebelum dan sesudah pemberian minuman asam jawa.   Kata kunci: asam urat, flavonoid, minuman asam jawa  AVERAGE DIFFERENCE OF BLOOD URIC ACID LEVEL BEFORE AND AFTER CONSUMPTION OF TAMARIND DRINKS                                                                                        ABSTRACT Uric acid is the final result of purine metabolism that can come from the food. The prevalence of hyperuricemia (excessive uric acid) has steadily increased over the past few decades. Tamarind is one of the traditional medicinal plants in Indonesia which contains flavonoids. Flavonoids can inhibit the work of xanthine oxidase enzyme in the purine metabolism process so that it can reduce blood uric acid levels. This type of quantitative research with pre-experimental research design is pre-test post-test one group design. The study is conducted in October-December 2019 at Medical Faculty of Lampung University and Lampung Provincial Health Laboratory. The samples are 10 students. Venous blood samples are taken before and after the intervention and uric acid levels is measured by spectrophotometer. Tamarind drinks are given every 2 times a day as much as 401 cc for 7 days. Data are tested for normality by the Shapiro-Wilk test and analyzed by Paired T-Test. The results of the normality test with the Shapiro-Wilk test shows that the data are normally distributed. Then the results of Paired T-Test shows the value of p=0.008 (<0,05). Conclusion is there is a difference of blood uric acid levels before and after the consumption of tamarind drinks.  Keyword : uric acid, flavonoids, tamarind drinks

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