scholarly journals Serum Vitamin Levels and Their Relationships with Other Biomarkers in Korean Breast Cancer Patients

Nutrients ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 2831
Author(s):  
Jee Ah Kim ◽  
Rihwa Choi ◽  
Hojeong Won ◽  
Seonwoo Kim ◽  
Hee Jun Choi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Vitamin D ◽  
Liquid Chromatography ◽  
Cancer Patients ◽  
Benign Breast Disease ◽  
Serum Vitamin ◽  
Breast Disease ◽  
Healthy Controls ◽  
Breast Cancer Patients ◽  
Tumor Stages

Numerous studies have shown that vitamins reduce the risk of cancers, but the relationship between serum vitamin levels and breast cancer is still controversial. In this study, we evaluated serum levels of vitamins in Korean patients with benign breast disease or breast cancer and investigated their associations with clinical and laboratory parameters. Concentrations of vitamin A, D, and E, together with homocysteine and methylmalonic acid as biomarkers of vitamin B12 deficiency, were measured by high-performance liquid chromatography (HPLC) or liquid chromatography with tandem mass spectrometry (LC-MS/MS) in the serum of 104 breast cancer patients, 62 benign breast disease patients, and 75 healthy Korean females. We further assessed possible associations between vitamin levels and breast cancer subtypes, the presence of lymph node metastasis, and tumor stages. Serum concentrations of vitamins A and E were significantly lower in breast cancer patients and in benign breast disease patients than in healthy controls. Severe vitamin D deficiency was more prevalent in breast cancer patients than in healthy controls. Vitamin D level was significantly lower in breast cancer patients with estrogen receptor-negative or triple-negative subtypes than in those with other subtypes. Further research with a larger study population is required to elucidate the role of vitamins in breast cancer.

scholarly journals Serum levels of oxidative stress marker malondialdehyde in breast cancer patients in relation to pathohistological factors, estrogen receptors, menopausal status, and age

2018 ◽  
Vol 8 (3) ◽  
pp. 154-161
Author(s):  
Jasmina Gubaljevic ◽  
Nahida Srabović ◽  
Adlija Jevrić-Čaušević ◽  
Adaleta Softić ◽  
Adi Rifatbegović ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Lymph Nodes ◽  
Cancer Patients ◽  
Benign Breast Disease ◽  
Menopausal Status ◽  
Serum Levels ◽  
Breast Disease ◽  
Breast Cancer Patients ◽  
Node Metastases

Introduction: The aim of this study was to determine the serum levels of malondialdehyde (MDA) in patients with invasive breast cancer in relation to its serum levels in patients with benign breast disease, and to investigate correlation between MDA serum levels with pathohistological prognostic factors (tumor size, lymph node involvement, and histologic grade [HG]), estrogen receptor (ER) status, and with breast cancer patient’s age and menopausal status. Methods: A total of 43 with well-documented invasive breast cancer were included in this study: 27 with positive axillary’s lymph nodes, and 16 with negative axillary’s lymph nodes, and 39 patients with findings of benign breast diseases. MDA determination in serum of breast cancer and benign breast disease patients was performed by the fluorimetric method, immunohistochemical staining was performed for ER, and routine pathohistological examination was conducted for pathohistological factors. Results: MDA serum levels in breast cancer patients were significantly higher than MDA serum levels in benign breast disease patients (p = 0.042). No statistically significant difference between MDA serum levels in breast cancer patients with and without lymph node metastases was found (p = 0.238). No statistically significant correlations between MDA serum levels and tumor size (p = 0.256), HG (p = 0.124), or number of positive lymph nodes (0.113) were found. A statistically significant correlation between serum MDA levels and ages of breast cancer patients with lymph node metastases was found (p = 0.006). Conclusion: Obtained results support the importance of MDA in the carcinogenesis of breast cancer. According to our findings, serum level of MDA could not be a useful prognostic factor in breast cancer.

Prognostic characteristics of 492 newly diagnosed breast cancer patients by serum vitamin D levels.

2015 ◽  
Vol 33 (15_suppl) ◽  
pp. e12619-e12619 ◽  
Author(s):  
Luke Joseph Peppone ◽  
Mohamedtaki Abdulaziz Tejani ◽  
Karen Michelle Mustian ◽  
Michelle Christine Janelsins ◽  
Charles Stewart Kamen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Vitamin D ◽  
Cancer Patients ◽  
Serum Vitamin ◽  
Newly Diagnosed ◽  
Breast Cancer Patients ◽  
Serum Vitamin D ◽  
Vitamin D Levels

The Clinical Utility of Circulating Tumor Cells in Breast Cancer Patients: Detection by a Quantitative Assay of h-MAM Gene Expression

2014 ◽  
Vol 29 (3) ◽  
pp. 268-278 ◽  
Author(s):  
Min Cheng ◽  
Yongyan Chen ◽  
Dehong Zou ◽  
Guodong Shen ◽  
Geng Bian ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Detection Rate ◽  
Benign Breast Disease ◽  
Breast Disease ◽  
Expression Level ◽  
Breast Cancer Patients ◽  
Healthy Individuals ◽  
Epithelial Cancers ◽  
Erbb2 Mrna

The aim of this study was to evaluate tumor markers of molecular abnormalities that display tissue specificity, as to detect circulating tumor cells (CTCs) in breast cancer patients. Quantitative real-time RT-PCR was used to determine h-MAM, BCSG1, CK19, and c-erbB2 mRNA levels in peripheral blood (PB) of breast cancer patients. Results were compared with other epithelial cancers (lung or esophagus cancer), benign breast disease, and healthy individuals. We found that h-MAM mRNA was only detectable in the PB of patients with breast cancer (49 of 65, 75.4%), but not in patients with other epithelial cancers, benign breast disease, or healthy individuals. No significant differences in the expression level and positive detection rate of BCSG1, CK19, and c-erbB2 mRNA were observed between breast cancer and other epithelial cancers. Furthermore, the expression level and positive detection rate of h-MAM mRNA in PB were significantly correlated to the breast cancer pathologic stage (p=0.012 and p=0.015, respectively). Chemotherapy, radiotherapy, or total tumor resection (after 7 days of treatment) resulted in a significant decrease in the expression level of h-MAM mRNA in PB compared to the levels prior to the treatment (p<0.001). Importantly, an increase in h-MAM mRNA expression was detected in patients immediately after surgery, as well as 3 days post-surgery. These results indicate that the quantitative analysis of h-MAM mRNA is a useful tool for detecting CTCs in breast cancer patients, and can have a potential diagnostic utility in early micrometastasis, clinical evaluation of cancer treatment efficacy, and post-treatment monitoring of breast cancer patients.

scholarly journals Impact of serum vitamin D on the response and prognosis in breast cancer patients treated with neoadjuvant chemotherapy

Breast Cancer ◽  
2021 ◽  
Author(s):  
Eriko Tokunaga ◽  
Takanobu Masuda ◽  
Hideki Ijichi ◽  
Wakako Tajiri ◽  
Chinami Koga ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Vitamin D ◽  
Neoadjuvant Chemotherapy ◽  
Cancer Patients ◽  
Clinical Stage ◽  
Univariate Analysis ◽  
Serum Vitamin ◽  
Breast Cancer Patients ◽  
Serum Vitamin D ◽  
Low Serum

Abstract Background Several studies have recently reported that the relationships between serum vitamin D and the prognosis or the pathological response to neoadjuvant chemotherapy (NAC) in breast cancer. However, there are no data regarding the clinical impacts of the vitamin D in Japanese breast cancer patients so far. Patients and methods In the present study, a total of 250 patients with clinical Stage I–III primary breast cancer who were treated with NAC and subsequently underwent definitive surgery were included. Serum 25-hydroxvitamin D (25(OH)D) levels were evaluated using blood samples obtained before NAC. Results The serum 25(OH)D was positively associated with age, and the serum 25(OH)D was significantly higher in postmenopausal women than that in pre/peri-menopausal women. Serum 25(OH)D level was not associated with the achievement of pathological complete response (pCR) in this cohort. The low 25(OH)D levels were significantly associated with shorter time to distant recurrence (TTDR). According to the univariate analysis, high clinical stage before NAC (cStage III) and low serum 25(OH)D level were significantly associated with the shorter TTDR, and pCR was significantly associated with the longer TTDR. According to a multivariate analysis, low serum 25(OH)D level were independent poor prognostic factors for TTDR. Conclusions The low 25(OH)D levels were significantly associated with poorer prognosis in Japanese women with operable breast cancer patients treated with NAC.

scholarly journals Preoperative Peripheral Blood Count in Breast Carcinoma: Predictor of Prognosis or a Routine Test

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Amrit Pal Singh Rana ◽  
Manjit Kaur ◽  
B. Zonunsanga ◽  
Arun Puri ◽  
Amarjit Singh Kuka
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Blood Count ◽  
Benign Breast Disease ◽  
Case Control Study ◽  
Breast Disease ◽  
Case Control ◽  
Breast Cancer Patients ◽  
Peripheral Blood Count ◽  
Control Study

Background.Peripheral blood count is the first investigation to be done in every patient before surgery. As strong relationship exists between cancer and immune response of the body, clinical stage at presentation and altered hematological parameters can influence the progression of cancer and vice versa.Settings and Design.It is a case control study of total 50 cases (35 cases of carcinoma breast and 15 cases of benign breast disease).Methods.A case control study was carried out; 35 cases of breast cancer patients were taken prior to surgery and chemotherapy with 15 cases of benign breast disease as control. Clinical staging according to the tumor, node, and metastasis classification (TNMc) was done and was correlated with complete blood count (CBC).Results.All the cancer patients were females with overall mean age of47.96±13.84years. Amongst all altered blood parameters, correlation of absolute lymphocytic count (pvalue 0.001) with TNMc staging was found significant. Particularly, decrease in absolute leucocytic count was observed with increase in stage of breast carcinoma.Conclusions. The stage-specific mean values of absolute lymphocytic counts of preoperative breast cancer patients can be used as an economical tool to know the evolution of disease.

scholarly journals The association between fat mass and obesity‐associated ( FTO ) genotype and serum vitamin D level in breast cancer patients

2021 ◽  
Vol 25 (20) ◽  
pp. 9627-9633
Author(s):  
Maryam Gholamalizadeh ◽  
Zohreh Mokhtari ◽  
Saeid Doaei ◽  
Vahideh Jalili ◽  
Sayed Hossein Davoodi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Vitamin D ◽  
Cancer Patients ◽  
Fat Mass ◽  
Serum Vitamin ◽  
Breast Cancer Patients ◽  
Serum Vitamin D

scholarly journals Using an Untargeted Metabolomics Approach to Identify Salivary Metabolites in Women with Breast Cancer

Metabolites ◽  
2020 ◽  
Vol 10 (12) ◽  
pp. 506
Author(s):  
Daniele Xavier Assad ◽  
Ana Carolina Acevedo ◽  
Elisa Cançado Porto Mascarenhas ◽  
Ana Gabriela Costa Normando ◽  
Valérie Pichon ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Liquid Chromatography ◽  
Cancer Patients ◽  
Area Under The Curve ◽  
Untargeted Metabolomics ◽  
Healthy Controls ◽  
Breast Cancer Patients ◽  
Flight Mass Spectrometry ◽  
Cancer Group ◽  
Pre Treatment

Metabolic alterations are a hallmark of the malignant transformation in cancer cells, which is characterized by multiple changes in metabolic pathways that are linked to macromolecule synthesis. This study aimed to explore whether salivary metabolites could help discriminate between breast cancer patients and healthy controls. Saliva samples from 23 breast cancer patients and 35 healthy controls were subjected to untargeted metabolomics using liquid chromatography-quadrupole time-of-flight mass spectrometry and a bioinformatics tool (XCMS Online), which revealed 534 compounds, characterized by their retention time in reverse-phase liquid chromatography and by the m/z ratio detected, that were shared by the two groups. Using the METLIN database, 31 compounds that were upregulated in the breast cancer group (p < 0.05) were identified, including seven oligopeptides and six glycerophospholipids (PG14:2, PA32:1, PS28:0, PS40:6, PI31:1, and PI38:7). In addition, pre-treatment and post-treatment saliva samples were analyzed for 10 patients who experienced at least a partial response to their treatment. In these patients, three peptides and PG14:2 were upregulated before but not after treatment. The area under the curve, sensitivity, and specificity for PG14:2 was 0.7329, 65.22%, and 77.14%, respectively. These results provide new information regarding the salivary metabolite profiles of breast cancer patients, which may be useful biomarkers.

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