scholarly journals Potential Cardiovascular and Metabolic Beneficial Effects of ω-3 PUFA in Male Obesity Secondary Hypogonadism Syndrome

Nutrients ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 2519 ◽  
Author(s):  
Annalisa Noce ◽  
Giulia Marrone ◽  
Francesca Di Daniele ◽  
Manuela Di Lauro ◽  
Anna Pietroboni Zaitseva ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Body Composition ◽  
Polyunsaturated Fatty Acids ◽  
Cardiovascular System ◽  
Scientific Literature ◽  
Review Article ◽  
Beneficial Effects ◽  
Metabolic Functions ◽  
Secondary Hypogonadism ◽  
Long Chain

Long-chain ω-3 polyunsaturated fatty acids (PUFAs) are fundamental biocomponents of lipids and cell membranes. They are involved in the maintenance of cellular homeostasis and they are able to exert anti-inflammatory and cardioprotective actions. Thanks to their potential beneficial effects on the cardiovascular system, metabolic axis and body composition, we have examined their action in subjects affected by male obesity secondary hypogonadism (MOSH) syndrome. MOSH syndrome is characterized by the presence of obesity associated with the alteration of sexual and metabolic functions. Therefore, this review article aims to analyze scientific literature regarding the possible benefits of ω-3 PUFA administration in subjects affected by MOSH syndrome. We conclude that there are strong evidences supporting ω-3 PUFA administration and/or supplementation for the treatment and management of MOSH patients.

scholarly journals Fish Hydrolysate Supplementation Containing n-3 Long Chain Polyunsaturated Fatty Acids and Peptides Prevents LPS-Induced Neuroinflammation

Nutrients ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 824
Author(s):  
Mathilde Chataigner ◽  
Marie Martin ◽  
Céline Lucas ◽  
Veronique Pallet ◽  
Sophie Layé ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Microglial Activation ◽  
Neuronal Damage ◽  
Low Grade ◽  
Activation Markers ◽  
Beneficial Effects ◽  
Behavioral Impairments ◽  
Inflammatory Profile ◽  
Long Chain

Neuroinflammation constitutes a normal part of the brain immune response orchestrated by microglial cells. However, a sustained and uncontrolled production of proinflammatory factors together with microglial activation contribute to the onset of a chronic low-grade inflammation, leading to neuronal damage and cognitive as well as behavioral impairments. Hence, limiting brain inflammatory response and improving the resolution of inflammation could be particularly of interest to prevent these alterations. Dietary n-3 long chain polyunsaturated fatty acids (LC-PUFAs) and low molecular weight peptides are good candidates because of their immunomodulatory and proresolutive properties. These compounds are present in a fish hydrolysate derived from marine-derived byproducts. In this study, we compared the effect of an 18-day supplementation with this fish hydrolysate to a supplementation with docosahexaenoic acid (DHA) on lipopolysaccharide (LPS)-induced inflammation in mice. In response to peripherally injected LPS, the fish hydrolysate supplementation decreased the hippocampal mRNA expression of the proinflammatory cytokines IL-6 (p < 0.001), IL-1β (p = 0.0008) and TNF-α (p < 0.0001), whereas the DHA supplementation reduced only the expression of IL-6 (p = 0.004). This decline in proinflammatory cytokine expressions was associated with an increase in the protein expression of IκB (p = 0.014 and p = 0.0054 as compared to the DHA supplementation and control groups, respectively) and to a modulation of microglial activation markers in the hippocampus. The beneficial effects of the fish hydrolysate could be due in part to the switch of the hippocampal oxylipin profile towards a more anti-inflammatory profile as compared to the DHA supplementation. Thus, the valorization of fish byproducts seems very attractive to prevent and counteract neuroinflammation.

scholarly journals Omega-3 fatty acids and blood pressure

2012 ◽  
Vol 107 (S2) ◽  
pp. S195-S200 ◽  
Author(s):  
Jorge Cabo ◽  
Rodrigo Alonso ◽  
Pedro Mata
Keyword(s):  
Blood Pressure ◽  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Mild Hypertension ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Beneficial Effects ◽  
Metabolic Functions ◽  
Blue Fish ◽  
High Doses

Epidemiological and clinical studies suggest that consumption of omega (ω-3) polyunsaturated fatty acids (PUFA) contributes to the reduction of cardiovascular mortality through different mechanisms including modulation of cellular metabolic functions, gene expression and beneficial effects on lipid profile or blood pressure. The aim of the study is to review the effects of ω-3 PUFA supplemented as fish oil or blue fish in blood pressure. The analysis of different studies suggests that high doses ω-3 PUFA ( ≥  3 g/day) produces a small but significant decrease in blood pressure, especially systolic blood pressure, in older and hypertensive subjects; however, the evidence is not consistent among different studies. ω-3 polyunsaturated fatty acids consumption might have a place in the control of patients with mild hypertension before starting drug treatment and of those who prefer changes of lifestyles like diet.

Beneficial effects and oxidative stability of omega-3 long-chain polyunsaturated fatty acids

2012 ◽  
Vol 25 (1) ◽  
pp. 24-33 ◽  
Author(s):  
Elmira Arab-Tehrany ◽  
Muriel Jacquot ◽  
Claire Gaiani ◽  
Muhammad Imran ◽  
Stephane Desobry ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Oxidative Stability ◽  
Omega 3 ◽  
Beneficial Effects ◽  
Long Chain

Fibroblast Growth Factor-21 and the Beneficial Effects of Long-Chain n-3 Polyunsaturated Fatty Acids

Lipids ◽  
2014 ◽  
Vol 49 (11) ◽  
pp. 1081-1089 ◽  
Author(s):  
Joan Villarroya ◽  
Pavel Flachs ◽  
Ibon Redondo-Angulo ◽  
Marta Giralt ◽  
Dasa Medrikova ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Growth Factor ◽  
Polyunsaturated Fatty Acids ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth Factor 21 ◽  
Fibroblast Growth ◽  
Beneficial Effects ◽  
Long Chain

Beneficial effects of the n-3 long-chain polyunsaturated fatty acids in surgical patients: Updating the evidence

2011 ◽  
Vol 85 (5) ◽  
pp. 261-266 ◽  
Author(s):  
M. Bernabe-Garcia ◽  
M. Lopez-Alarcón ◽  
F. Blanco-Favela ◽  
J. Mancilla-Ramírez ◽  
A. Mansilla-Olivares ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Surgical Patients ◽  
Beneficial Effects ◽  
Long Chain
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