scholarly journals A Pilot Screening of Agro-Food Waste Products as Sources of Nutraceutical Formulations to Improve Simulated Postprandial Glycaemia and Insulinaemia in Healthy Subjects

Nutrients ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 1292
Author(s):  
Gian Carlo Tenore ◽  
Domenico Caruso ◽  
Maria D’Avino ◽  
Giuseppe Buonomo ◽  
Giuseppe Caruso ◽  
...  
Keyword(s):  
Glycaemic Control ◽  
Healthy Subjects ◽  
Glucose Solution ◽  
Waste Products ◽  
Polyphenolic Extract ◽  
Plasma Peak ◽  
Glucose Plasma ◽  
The Individual ◽  
By Products ◽  
Nutraceutical Products

The control of glucose homeostasis is the main goal for both the prevention and management of diabetes and pre-diabetes. Numerous drugs are available, despite their side effects. This is constantly leading people to be inclined to natural alternative treatments. Evidence indicates antioxidant-based nutraceuticals as an optimal tool for the glycaemic control. Currently, a great interest has been focused on the valorisation of agro-food by-products as sources of bioactive compounds including polyphenols. In this sense, we tested the efficacy of novel nutraceutical products based on polyphenolic extract from nectarines (NecP), tomato peels (TP), and olive leaves (EOL) on glycaemic and insulinemic responses. The three formulations contained, respectively, 0.007 mg abscisic acid (ABA)/g, 0.5 mg carotenoids/g, and 150 mg oleuropein/g. Twenty healthy subjects consumed a regular glucose solution (RG) or a treatment beverage (TB) obtained by mixing RG with the individual formulations (TB NecP, TB EOL, and TB TP), separately, and on different days. All three formulations significantly lowered the 30 min glucose plasma peak (p < 0.05 for all); similarly, NecP and TP also significantly lowered the 30 min insulin plasma peak (p < 0.05 for all). These results may lead to the hypothesis of a formulation of a multi-component nutraceutical with a synergistic efficacy for the glycaemic control.

scholarly journals Effects of food and sucralfate on a single oral dose of 500 milligrams of levofloxacin in healthy subjects.

1997 ◽  
Vol 41 (10) ◽  
pp. 2196-2200 ◽  
Author(s):  
L J Lee ◽  
B Hafkin ◽  
I D Lee ◽  
J Hoh ◽  
R Dix
Keyword(s):  
Oral Dose ◽  
Healthy Subjects ◽  
High Fat ◽  
Time Curve ◽  
Mean Values ◽  
Treatment Groups ◽  
The Mean ◽  
The Individual ◽  
Individual Profiles ◽  
Fat Meal

The effects of food and sucralfate on the pharmacokinetics of levofloxacin following the administration of a single 500-mg oral dose were investigated in a randomized, three-way crossover study with young healthy subjects (12 males and 12 females). Levofloxacin was administered under three conditions: fasting, fed (immediately after a standardized high-fat breakfast), and fasting with sucralfate given 2 h following the administration of levofloxacin. The concentrations of levofloxacin in plasma and urine were determined by high-pressure liquid chromatography. By noncompartmental methods, the maximum concentration of drug in serum (Cmax), the time to Cmax (Tmax), the area under the concentration-time curve (AUC), half-life (t1/2), clearance (CL/F), renal clearance (CLR), and cumulative amount of levofloxacin in urine (Ae) were estimated. The individual profiles of the drug concentration in plasma showed little difference among the three treatments. The only consistent effect of the coadministration of levofloxacin with a high-fat meal for most subjects was that levofloxacin absorption was delayed and Cmax was slightly reduced (Tmax, 1.0 and 2.0 h for fasting and fed conditions, respectively [P = 0.002]; Cmax, 5.9 +/- 1.3 and 5.1 +/- 0.9 microg/ml [90% confidence interval = 0.79 to 0.94] for fasting and fed conditions, respectively). Sucralfate, which was administered 2 h after the administration of levofloxacin, appeared to have no effect on levofloxacin's disposition compared with that under the fasting condition. Mean values of Cmax and AUC from time zero to infinity were 6.7 +/- 3.2 microg/ml and 47.9 +/- 8.4 microg x h/ml, respectively, following the administration of sucralfate compared to values of 5.9 +/- 1.3 microg/ml and 50.5 +/- 8.1 microg x h/ml, respectively, under fasting conditions. The mean t1/2, CL/F, CLR, and Ae values were similar among all three treatment groups. In conclusion, the absorption of levofloxacin was slightly delayed by food, although the overall bioavailability of levofloxacin following a high-fat meal was not altered. Finally, sucralfate did not alter the disposition of levofloxacin when sucralfate was given 2 h after the administration of the antibacterial agent, thus preventing a potential drug-drug interaction.

scholarly journals Current Status and Future of Nitrile Catalysis using Key Nitrilases Enzymes and their Biotechnological Impact

2021 ◽  
Vol 15 (1) ◽  
pp. 71-81
Author(s):  
Ashish Bhatt ◽  
Darshankumar Prajapati ◽  
Akshaya Gupte
Keyword(s):  
Organic Synthesis ◽  
Current Status ◽  
Fine Chemicals ◽  
Converting Enzyme ◽  
Waste Products ◽  
Current Review ◽  
Agricultural Industries ◽  
Widespread Interest ◽  
By Products ◽  
Classification Structure

Nitriles are organic compounds consisting of −C≡N group. They are frequently known to occur in nature and as intermediate by-products and waste products of various chemical, pharmaceutical, and agricultural industries. They are also found in fruit pits, cabbage, cauliflower, and sprouts, which are released upon hydrolysis. Nitrile converting enzymes like nitrilases have been extracted from microorganisms and plants. Nitrilase-mediated biocatalysis reactions have continuously aroused widespread interest to scientists and entrepreneurs in organic synthesis. Nitrile converting biocatalysts (Nitrilases) are now of substantial industrial interest from the perspective of treating toxic nitrile and cyanide-containing compounds. Nitrile degrading enzymes generally consist of nitrilases and amidases. The aim of the current review is to summarize the recent advancements on regioselective nitrilases concerning their fundamental researches and their application in the synthesis of series of high-value fine chemicals and pharmaceuticals. The present review also focuses on the utility of nitrile converting enzyme, sources, properties, classification, structure, and applications as well.

scholarly journals Palm Creases Analysis in Students and Staff of a Teaching Hospital in Kathmandu

2019 ◽  
Vol 18 (1) ◽  
pp. 51-58
Author(s):  
Nirju Ranjit ◽  
Bidur Adhikari ◽  
Rajani Shrestha ◽  
Anusuya Shrestha ◽  
Rosha Bhandari ◽  
...  
Keyword(s):  
Healthy Subjects ◽  
Age Groups ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Closed Type ◽  
Long Time ◽  
Left And Right ◽  
Palm Print ◽  
The Individual

Introduction: Palm creases have been studied for a long time and have been recently found to be helpful in tracking underlying medical and genetic conditions. Scientific study and typing of palm prints have been found to be lacking in the Nepalese population Methods: A cross sectional study was done on 252 subjects, 153 male and 99 females, from Kathmandu, Nepal. Subjects were selected by purposive sampling from different age groups. Demographic profile including age, sex, and handedness was collected. Palm print pattern was recorded by digital photography. Each photograph was analysed visually by single observer and pattern of palm crease was noted. Variation of each crease was also noted. Results: On the basis of relation between radial longitudinal crease and proximal transverse crease, 17.3% subjects had open type of palm crease which was significantly more in females while 76.6% subjects had closed type crease which was significantly more in males. Meeting type of palm crease was found in 5.7% of subjects. On the basis of relation between proximal and distal transverse crease, normal crease type was found in 90.1% of subjects, Simian type was found in 7.7% subjects and Sydney type was found in 1.4% of subjects. The concordance of this pattern in left and right palms was found statistically significant. Conclusions: This study presented data from 252 seemingly normal healthy subjects and found that most of them had the normal with no branching, that is normal 1 and closed crease types. Most of the individual major creases were seen to be branched type.  

Dairy Waste Treatment and Utilization

2020 ◽  
pp. 160-182
Author(s):  
Anum Ishaq ◽  
Ubaid ur Rahman ◽  
Muhammad Haseeb Ahmad ◽  
Amna Sahar ◽  
Qamar Abbas Syed ◽  
...  
Keyword(s):  
Suspended Solids ◽  
Waste Treatment ◽  
Dairy Industry ◽  
Waste Materials ◽  
Organic Substances ◽  
Proper Treatment ◽  
Aquatic Resources ◽  
Waste Products ◽  
Dairy Waste ◽  
By Products

The dairy industry produces waste materials and by-products including soluble and suspended organic substances, wastewater, suspended solids, and whey. These substances contain significant amounts of organic and inorganic toxins that can cause serious health threats if not treated properly. Additionally, toxins produced by dairy waste would negatively affect the environment as well as quality and availability of aquatic resources. However, these waste materials and by-products can be utilized in different ways after proper treatment and processing. This chapter will provide an overview of waste products of dairy industries and highlight different treatments and utilization of these by-products in other industries.

Soft Palate Reflex: Technical Requirements and First Results

1992 ◽  
Vol 29 (4) ◽  
pp. 340-345 ◽  
Author(s):  
Godber S. Godbersen ◽  
Johannes Schneider-Littfeld ◽  
Jochen A. Werner ◽  
Sönke Wolters ◽  
Axel Pellner
Keyword(s):  
Soft Palate ◽  
Healthy Subjects ◽  
Processing System ◽  
Data Processing System ◽  
Response Latencies ◽  
Technical Requirements ◽  
First Results ◽  
The Individual ◽  
Electromyographic Signals ◽  
Stimulation Of

The present study describes technical prerequisites for soft palate reflex measurements and first results. Reflex measurements can be done using standard electromyographic methods. The data-processing system that records and processes the electromyographic signals was activated when the soft palate was stimulated by a newly developed device. The first results of objective soft palate reflex measurements in 15 healthy subjects show that the musculus levator veli palatini reacts to a mechanical stimulation of the soft palate with a contraction that can be measured electromyographicslly. The response latencies were constant in the individual subjects. In 12 subjects a minimum of 30 ms and a maximum of 61 ms was recorded. In one healthy subject, the reflex was activated only after 167 ms. No reflex could be evoked in two subjects. The stimulus was always supraliminal. Reaction time was longer following surface anesthesia of the oral mucosa.

scholarly journals Correction: Marhuenda, J., et al. A Randomized, Double-Blind, Placebo Controlled Trial to Determine the Effectiveness a Polyphenolic Extract (Hibiscus sabdariffa and Lippia citriodora) in the Reduction of Body Fat Mass in Healthy Subjects. Foods 2020, 9(1), 55

Foods ◽  
2020 ◽  
Vol 9 (3) ◽  
pp. 279
Author(s):  
Javier Marhuenda ◽  
Silvia Perez-Piñero ◽  
Desirée Victoria-Montesinos ◽  
María Salud Abellán-Ruiz ◽  
Nuria Caturla ◽  
...  
Keyword(s):  
Body Fat ◽  
Fat Mass ◽  
Healthy Subjects ◽  
Controlled Trial ◽  
Body Fat Mass ◽  
Hibiscus Sabdariffa ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Lippia Citriodora ◽  
Polyphenolic Extract

The authors wish to make the following correction to this paper [...]

Health hazards in the paleontology laboratory

1989 ◽  
Vol 4 ◽  
pp. 30-36
Author(s):  
Katherine M. Thomas
Keyword(s):  
Ionizing Radiation ◽  
Direct Contact ◽  
Medical Literature ◽  
Safety Information ◽  
Health Hazards ◽  
Industrial Wastes ◽  
Toxic Chemicals ◽  
The Common ◽  
The Individual ◽  
By Products

Recent medical literature has pointed out the health hazards associated with industrial wastes and by-products; however, little emphasis has been placed on the dangers inherent in scientific laboratories. These hazards range from direct contact with toxic chemicals and vapors to exposure to ionizing radiation. The damage may be acute or chronic; the effects temporary or residual. What follows is a summary of the common hazards, the basic management of laboratory trauma, and guidelines to prevent injury. The individual preceding chapters also contain safety information relative to the specific lab techniques discussed.

scholarly journals Chromium VI and Fluoride Competitive Adsorption on Different Soils and By-Products

Processes ◽  
2019 ◽  
Vol 7 (10) ◽  
pp. 748
Author(s):  
Ana Quintáns-Fondo ◽  
Gustavo Ferreira-Coelho ◽  
Manuel Arias-Estévez ◽  
Juan Carlos Nóvoa-Muñoz ◽  
David Fernández-Calviño ◽  
...  
Keyword(s):  
Pine Bark ◽  
Competitive System ◽  
Chromium Vi ◽  
Batch Type ◽  
System A ◽  
The Individual ◽  
Polluted Waters ◽  
By Products ◽  
Different Soils ◽  
Oak Ash

Chromium (as Cr(VI)) and fluoride (F−) are frequently found in effluents from different industrial activities. In cases where these effluents reach soil, it can play an important role in retaining those pollutants. Similarly, different byproducts could act as bio-adsorbents to directly treat polluted waters or to enhance the purging potential of soil. In this work, we used batch-type experiments to study competitive Cr(VI) and F− adsorption in two different soils and several kinds of byproducts. Both soils, as well as mussel shell, oak ash, and hemp waste showed higher adsorption for F−, while pyritic material, pine bark, and sawdust had a higher affinity for Cr(VI). Considering the binary competitive system, a clear competition between both elements in anionic form is shown, with decreases in adsorption of up to 90% for Cr(VI), and of up to 30% for F−. Adsorption results showed better fitting to Freundlich’s than to Langmuir’s model. None of the individual soils or byproducts were able to adsorbing high percentages of both pollutants simultaneously, but it could be highly improved by adding pine bark to increase Cr(VI) adsorption in soils, thus drastically reducing the risks of pollution and deleterious effects on the environment and on public health.

Glycemic and Insulinemic Response to Preexercise Carbohydrate Feedings

1994 ◽  
Vol 4 (1) ◽  
pp. 46-53 ◽  
Author(s):  
John G. Seifert ◽  
Greg L. Paul ◽  
Dennis E. Eddy ◽  
Robert Murray
Keyword(s):  
Plasma Glucose ◽  
Plasma Insulin ◽  
Glucose Solution ◽  
Physiological Responses ◽  
Metabolic Responses ◽  
Moderate Intensity ◽  
Baseline Values ◽  
Glucose Plasma ◽  
Insulinemic Response

The effects of preexercise hyperinsulinemia on exercising plasma glucose, plasma insulin, and metabolic responses were assessed during 50 min cycling at 62%. Subjects were fed a 6% sucrose/glucose solution (LCHO) or a 20% maltodextrin/glucose solution (HCHO) to induce changes in plasma insulin. During exercise, subjects assessed perceived nauseousness and lightheadedness. By the start of exercise, plasma glucose and plasma insulin had increased. In the LCHO trial, plasma glucose values significantly decreased below the baseline value at 30 min of exercise. However, by 40 min, exercise plasma glucose and insulin values were similar to the baseline value. Exercise plasma glucose and insulin did not differ from baseline values in the HCHO trial. Ingestion of LCHO or HCHO was not associated with nausea or lightheadedness. It was concluded that the hyperinsulinemia induced by preexercise feediigs of CHO did not result in frank hypoglycemia or adversely affect sensory or physiological responses during 50 min of moderate-intensity cycling.

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