scholarly journals Diet and Skin Aging—From the Perspective of Food Nutrition

Nutrients ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 870 ◽  
Author(s):  
Changwei Cao ◽  
Zhichao Xiao ◽  
Yinglong Wu ◽  
Changrong Ge
Keyword(s):  
Human Life ◽  
Skin Aging ◽  
The Body ◽  
Research Progress ◽  
Healthy Skin ◽  
Internal Factors ◽  
Chronological Aging ◽  
Complex Biological Process ◽  
Food And Nutrition

We regularly face primary challenges in deciding what to eat to maintain young and healthy skin, defining a healthy diet and the role of diet in aging. The topic that currently attracts maximum attention is ways to maintain healthy skin and delay skin aging. Skin is the primary barrier that protects the body from external aggressions. Skin aging is a complex biological process, categorized as chronological aging and photo-aging, and is affected by internal factors and external factors. With the rapid breakthrough of medicine in prolonging human life and the rapid deterioration of environmental conditions, it has become urgent to find safe and effective methods to treat skin aging. For diet, as the main way for the body to obtain energy and nutrients, people have gradually realized its importance to the skin. Therefore, in this review, we discuss the skin structure, aging manifestations, and possible mechanisms, summarize the research progress, challenges, possible directions of diet management, and effects of foodborne antioxidants on skin aging from the perspective of food and nutrition.

scholarly journals Polyphenols as Natural Antioxidants in Skin Aging

2020 ◽  
Vol 3 (3) ◽  
Author(s):  
Satya Wydya Yenny ◽  
Yulia Eka Suryani
Keyword(s):  
Human Life ◽  
Radical Scavenging ◽  
Natural Antioxidants ◽  
Skin Aging ◽  
The Body ◽  
Extrinsic Factors ◽  
Naturally Occurring ◽  
Complex Biological Process ◽  
Scavenging Capacity ◽  
High Antioxidant Activity

Skin aging is a complex biological process influenced by a combination of intrinsic and extrinsic factors, leading to cumulative alterations of skin struture, function and appearance. Polyphenols represent a superfamily of diverse naturally occurring phytochemicals. Current research reveals that phenolic compounds in plants possess high antioxidant activity and free radical scavenging capacity and can prevent the body from oxidative damage over human life span. This review focuses on present understanding of skin aging and the effects of polyphenols in the context of anti-agieng activity.  

scholarly journals COVID-19: Nutrition to Boost Immune System to Fight Infection

2020 ◽  
pp. 1-4
Author(s):  
Syed M. Shahid ◽  
◽  
Muhammad Jawed ◽  
Keyword(s):  
Immune System ◽  
Fruits And Vegetables ◽  
Daily Intake ◽  
The Body ◽  
Food And Nutrition ◽  
Working Together ◽  
Scientific Significance ◽  
Global Population

The immunity and immune system functions to fight against infections are significantly impacted by inappropriate food and nutrition. Long term malnutrition is universally considered as the leading cause of immune system deficiency. A substantial proportion of the global population does not meet the recommended daily intake of nutrients. The COVID-19 pandemic has focused attention on the role of the immune system, with health scientists and nutritionists urging people to take supplements and/or eat particular foods (nutrients) to super-charge their immune systems.The immune system is the most complex system of human body. This system is made up of a complex network of structural and functional units like cells, molecules, tissues and organs all working together to safeguard the body as a whole.This precise review provides a chance to go through the efficacy, efficiency and scientific significance of nutritional components and relevant food (especially fruits and vegetables). This will help you keep appropriate food items in your daily meals so that you can get a progressive increment in your body’s defence mechanisms and immunity to fight appropriately against COVID-19. This will also help to decrease your risk for catching the viral infection and/or reducing the chances of having complications from COVID-19.

scholarly journals Microbiocenosis Of Open Cavities Of The Body

2021 ◽  
Vol 03 (07) ◽  
pp. 1-45
Author(s):  
Ziyaeva E.R. ◽  
Keyword(s):  
Environmental Pollution ◽  
Human Body ◽  
Human Life ◽  
The Body ◽  
Chemotherapeutic Drugs ◽  
Topical Problem ◽  
Normal Microflora ◽  
Open Cavities

The article is devoted to a review of the topical problem of our time “Microbiocenosis of open cavities of the body and its role in the occurrence of many diseases of the human body ”. It has now been proven that the normal microflora of the human body plays a huge role in the normal course of life processes. The slightest violation of the composition of microorganisms leads to various irreversible defects in the normal course of human life, which are associated with the functions of the microbiocenosis and which no medicine can replace. The concept of microbiocenosis appeared in the 70s of the last century, although the first stone in this direction was put by Louis Pasteur, who proved the role of a microorganism in the process of fermentation and digestion. Many scientists contributed to the leap forward development of this science, which was forced due to errors in the use of antibiotics and chemotherapeutic drugs. Yes, indeed, the path of development of the science of biocenoses is closely related to the misuse of drugs, which often leads to dysbiosis. In addition, environmental pollution due to the uncontrollable development of urbanization plays a huge role in the development of dysbiotic processes.Therefore, with the aim of acquainting readers with the concept of biocenoses, certain pathways of pathogenetic links in the development of various diseases in violation of the composition of the normal microflora of the human body, we set ourselves the task of conducting a partial review of the achievement of the science of biocenoses of open cavities of the body.

Furor Liturgicus: The Religious Concerns of Russian Poetry

2020 ◽  
pp. 395-411
Author(s):  
Martha M. F. Kelly
Keyword(s):  
Eighteenth Century ◽  
Human Life ◽  
Literary Tradition ◽  
Russian Literature ◽  
The Body ◽  
Poetic Tradition ◽  
The World ◽  
Russian Poetry ◽  
Modern Russian

In a now classic 1994 article Victor Zhivov counters the idea that the eighteenth-century quest to create a modern Russian literature represented a wholesale rejection of Russia’s previous literary tradition. He shows instead how poets appropriated elements of Orthodox liturgical tradition in a bid to adapt the classical notion of ‘furor poeticus’, marking it by the eruption of Church Slavonic norms into modern poetics. This chapter demonstrates how, as Zhivov contends, elements of Orthodox liturgical culture have continued to shape the modern Russian poetic tradition from the eighteenth century into the present. In particular, Russian poets have long presented poetry as uniquely able to transform the world by drawing on Orthodox imagery of theosis or divinization—the transfiguration of human life and thus the world, by the divine light and being. The liturgically inflected religious concerns of Russian poetry that sections address include prophecy, human co-creation with God, the problem of the body, and the role of silence.

Anthropomorphic Clay Figurines of the Jomon Period of Japan

2017 ◽  
Author(s):  
Koji Mizoguchi
Keyword(s):  
Female Body ◽  
Human Life ◽  
Visual Representation ◽  
Well Being ◽  
The Body ◽  
Japanese Archipelago ◽  
Bodily Experiences ◽  
The Subject ◽  
The Japanese Archipelago

This chapter charts the trajectory of change of Jomon period clay anthropomorphic figurines in the Japanese archipelago. The earliest specimens embodied the perception of the body and female bodily experiences rather than accurately representing the body itself. Emphasis gradually shifted from the material embodiment of unmediated bodily perception and experiences to the visual representation of the body. Through this process, the subject of the representation expanded from the female body to the bodies of various categories of being, including animals and fantastic/supernatural beings, and the figurines came to embody the mutual transformability. These beings were networked to form an ‘animistic’ cosmology whose successful reproduction was metaphorically linked to that of human life and community. The decline of the symbolic role of the female reproductive faculty as the universal referent in the prayer for communal well-being led to the end of the Jomon clay anthropomorphic figurines.

scholarly journals Koebner phenomenon leading to the formation of new psoriatic lesions: evidences and mechanisms

2019 ◽  
Vol 39 (12) ◽  
Author(s):  
Yong-Zhi Ji ◽  
Shi-Rui Liu
Keyword(s):  
Growth Factor ◽  
Viral Infections ◽  
Critical Role ◽  
Skin Incision ◽  
The Body ◽  
Healthy Skin ◽  
Koebner Phenomenon ◽  
Body Regions ◽  
Psoriatic Lesions

Abstract Koebner phenomenon refers to the emergence of new psoriatic lesions in the healthy skin regions following an injury/trauma to psoriatic patients. The occurrence of psoriatic lesions at unusual areas of the body regions such as on penis, around eyes and on keloids suggest that the Koebner phenomenon may be responsible for these lesions. A number of agents/triggers have been reported to induce the development of new psoriatic lesions in healthy skin areas and these include, tattooing skin, radiations, skin incision, viral infections and striae etc. The different mechanisms that contribute in inducing the development of new psoriatic lesions as Koebernization include the involvement of mast cell-derived inflammatory mediators such as tryptase, IL-6, IL-8, IL-17, and IL-36γ. Moreover, an increased expression of nerve growth factor (NGF) and vascular endothelial growth factor (VEGF) also contribute in Koebernization. Apart from these, there is a critical role of α 2 β1 integrins, S100A7 (psoriasin) and S100A15 (koebnerisin), change in the ratio of CD4+/CD8+ T cells, down-regulation of mechanosensitive polycystin 1 protein, decrease in inflammation controlling atypical chemokine receptor 2 (ACKR2), reduced expression of N-methyl-d-aspartate (NMDA) receptors (NMDARs) on the keratinocytes and increase in levels of chemokines (CXCL8 and CCL20) in inducing formation of new psoriatic lesions. The present review discusses the role of Koebner phenomenon in the development of new psoriatic lesions. Moreover, it also describes the mechanisms involved in Koebernization in the form of discussion of different key targets that may be potentially modulated pharmacologically to attenuate/halt the development of new psoriatic lesions.

scholarly journals Role of PGE-2 and Other Inflammatory Mediators in Skin Aging and Their Inhibition by Topical Natural Anti-Inflammatories

Cosmetics ◽  
2019 ◽  
Vol 6 (1) ◽  
pp. 6 ◽  
Author(s):  
Bryan Fuller
Keyword(s):  
Skin Cancer ◽  
Inflammatory Mediators ◽  
Normal Skin ◽  
Sun Exposure ◽  
Skin Aging ◽  
Tnf Alpha ◽  
Dermal Matrix ◽  
Chronological Aging ◽  
And Function

Human skin aging is due to two types of aging processes, “intrinsic” (chronological) aging and “extrinsic” (external factor mediated) aging. While inflammatory events, triggered mainly by sun exposure, but also by pollutants, smoking and stress, are the principle cause of rapid extrinsic aging, inflammation also plays a key role in intrinsic aging. Inflammatory events in the skin lead to a reduction in collagen gene activity but an increase in activity of the genes for matrix metalloproteinases. Inflammation also alters proliferation rates of cells in all skin layers, causes thinning of the epidermis, a flattening of the dermo-epidermal junction, an increase in irregular pigment production, and, finally, an increased incidence of skin cancer. While a large number of inflammatory mediators, including IL-1, TNF-alpha and PGE-2, are responsible for many of these damaging effects, this review will focus primarily on the role of PGE-2 in aging. Levels of this hormone-like mediator increase quickly when skin is exposed to ultraviolet radiation (UVR), causing changes in genes needed for normal skin structure and function. Further, PGE-2 levels in the skin gradually increase with age, regardless of whether or not the skin is protected from UVR, and this smoldering inflammation causes continuous damage to the dermal matrix. Finally, and perhaps most importantly, PGE-2 is strongly linked to skin cancer. This review will focus on: (1) the role of inflammation, and particularly the role of PGE-2, in accelerating skin aging, and (2) current research on natural compounds that inhibit PGE-2 production and how these can be developed into topical products to retard or even reverse the aging process, and to prevent skin cancer.

scholarly journals Ultraviolet Radiation-Induced Skin Aging: The Role of DNA Damage and Oxidative Stress in Epidermal Stem Cell Damage Mediated Skin Aging

2016 ◽  
Vol 2016 ◽  
pp. 1-14 ◽  
Author(s):  
Uraiwan Panich ◽  
Gunya Sittithumcharee ◽  
Natwarath Rathviboon ◽  
Siwanon Jirawatnotai
Keyword(s):  
Oxidative Stress ◽  
Stem Cells ◽  
Dna Damage ◽  
Mesenchymal Stem Cells ◽  
Stem Cell ◽  
Ultraviolet Radiation ◽  
Skin Aging ◽  
The Body ◽  
And Oxidative Stress

Skin is the largest human organ. Skin continually reconstructs itself to ensure its viability, integrity, and ability to provide protection for the body. Some areas of skin are continuously exposed to a variety of environmental stressors that can inflict direct and indirect damage to skin cell DNA. Skin homeostasis is maintained by mesenchymal stem cells in inner layer dermis and epidermal stem cells (ESCs) in the outer layer epidermis. Reduction of skin stem cell number and function has been linked to impaired skin homeostasis (e.g., skin premature aging and skin cancers). Skin stem cells, with self-renewal capability and multipotency, are frequently affected by environment. Ultraviolet radiation (UVR), a major cause of stem cell DNA damage, can contribute to depletion of stem cells (ESCs and mesenchymal stem cells) and damage of stem cell niche, eventually leading to photoinduced skin aging. In this review, we discuss the role of UV-induced DNA damage and oxidative stress in the skin stem cell aging in order to gain insights into the pathogenesis and develop a way to reduce photoaging of skin cells.

scholarly journals Glyoxalase System in the Progression of Skin Aging and Skin Malignancies

2020 ◽  
Vol 22 (1) ◽  
pp. 310
Author(s):  
Silvia Yumnam ◽  
Lalita Subedi ◽  
Sun Yeou Kim
Keyword(s):  
Glucose Metabolism ◽  
Skin Aging ◽  
The Body ◽  
Glyoxalase I ◽  
Health Issues ◽  
Future Prospects ◽  
Glyoxalase System ◽  
Skin Abnormalities ◽  
Anticancer Drug Development

Dicarbonyl compounds, including methylglyoxal (MGO) and glyoxal (GO), are mainly formed as byproducts of glucose metabolism. The main glyoxalase system consists of glyoxalase I and II (Glo1 and Glo2) and is the main enzyme involved in the detoxification of dicarbonyl stress, which occurs as an accumulation of MGO or GO due to decreased activity or expression of Glo1. Dicarbonyl stress is a major cause of cellular and tissue dysfunction that causes various health issues, including diabetes, aging, and cancer. The skin is the largest organ in the body. In this review, we discuss the role of the glyoxalase system in the progression of skin aging, and more importantly, skin malignancies. We also discuss the future prospects of the glyoxalase system in other skin abnormalities such as psoriasis and vitiligo, including hyperpigmentation. Finally, in the present review, we suggest the role of glyoxalase in the progression of skin aging and glyoxalase system as a potential target for anticancer drug development for skin cancer.

scholarly journals Role of long non-coding RNA H19 in the development of osteoporosis

2021 ◽  
Vol 27 (1) ◽  
Author(s):  
Senxiang Chen ◽  
Da Liu ◽  
Zimo Zhou ◽  
Sen Qin
Keyword(s):  
Molecular Mechanisms ◽  
The Body ◽  
Research Progress ◽  
Effective Prevention ◽  
Treatment Of Osteoporosis ◽  
Non Coding Rna ◽  
Metabolic Bone ◽  
Different Types ◽  
Long Non Coding Rna

Abstract Background Osteoporosis is a widespread and serious metabolic bone disease. At present, revealing the molecular mechanisms of osteoporosis and developing effective prevention and treatment methods are of great significance to health worldwide. LncRNA is a non-coding RNA peptide chain with more than 200 nucleotides. Researchers have identified many lncRNAs implicated in the development of diseases and lncRNA H19 is an example. Results A large amount of evidence supports the fact that long non-coding RNA (lncRNA) genes, such as H19, have multiple, far-reaching effects on various biological functions. It has been found that lncRNA H19 has a role in the regulation of different types of cells in the body including the osteoblasts, osteocytes, and osteoclasts found in bones. Therefore, it can be postulated that lncRNA H19 affects the incidence and development of osteoporosis. Conclusion The prospect of targeting lncRNA H19 in the treatment of osteoporosis is promising because of the effects that lncRNA H19 has on the process of osteogenic differentiation. In this review, we summarize the molecular pathways and mechanisms of lncRNA H19 in the pathogenesis of osteoporosis and summarize the research progress of targeting H19 as a treatment option. Research is emerging that explores more effective treatment possibilities for bone metabolism diseases using molecular targets.

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