scholarly journals Role of PGE-2 and Other Inflammatory Mediators in Skin Aging and Their Inhibition by Topical Natural Anti-Inflammatories

Cosmetics ◽  
2019 ◽  
Vol 6 (1) ◽  
pp. 6 ◽  
Author(s):  
Bryan Fuller
Keyword(s):  
Skin Cancer ◽  
Inflammatory Mediators ◽  
Normal Skin ◽  
Sun Exposure ◽  
Skin Aging ◽  
Tnf Alpha ◽  
Dermal Matrix ◽  
Chronological Aging ◽  
And Function

Human skin aging is due to two types of aging processes, “intrinsic” (chronological) aging and “extrinsic” (external factor mediated) aging. While inflammatory events, triggered mainly by sun exposure, but also by pollutants, smoking and stress, are the principle cause of rapid extrinsic aging, inflammation also plays a key role in intrinsic aging. Inflammatory events in the skin lead to a reduction in collagen gene activity but an increase in activity of the genes for matrix metalloproteinases. Inflammation also alters proliferation rates of cells in all skin layers, causes thinning of the epidermis, a flattening of the dermo-epidermal junction, an increase in irregular pigment production, and, finally, an increased incidence of skin cancer. While a large number of inflammatory mediators, including IL-1, TNF-alpha and PGE-2, are responsible for many of these damaging effects, this review will focus primarily on the role of PGE-2 in aging. Levels of this hormone-like mediator increase quickly when skin is exposed to ultraviolet radiation (UVR), causing changes in genes needed for normal skin structure and function. Further, PGE-2 levels in the skin gradually increase with age, regardless of whether or not the skin is protected from UVR, and this smoldering inflammation causes continuous damage to the dermal matrix. Finally, and perhaps most importantly, PGE-2 is strongly linked to skin cancer. This review will focus on: (1) the role of inflammation, and particularly the role of PGE-2, in accelerating skin aging, and (2) current research on natural compounds that inhibit PGE-2 production and how these can be developed into topical products to retard or even reverse the aging process, and to prevent skin cancer.

scholarly journals The control of inflammation via the phosphorylation and dephosphorylation of tristetraprolin: a tale of two phosphatases

2016 ◽  
Vol 44 (5) ◽  
pp. 1321-1337 ◽  
Author(s):  
Andrew R. Clark ◽  
Jonathan L.E. Dean
Keyword(s):  
Inflammatory Mediators ◽  
Knockout Mouse ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Human Orthologue ◽  
And Function ◽  
Detailed Picture ◽  
Lines Of Evidence

Twenty years ago, the first description of a tristetraprolin (TTP) knockout mouse highlighted the fundamental role of TTP in the restraint of inflammation. Since then, work from several groups has generated a detailed picture of the expression and function of TTP. It is a sequence-specific RNA-binding protein that orchestrates the deadenylation and degradation of several mRNAs encoding inflammatory mediators. It is very extensively post-translationally modified, with more than 30 phosphorylations that are supported by at least two independent lines of evidence. The phosphorylation of two particular residues, serines 52 and 178 of mouse TTP (serines 60 and 186 of the human orthologue), has profound effects on the expression, function and localisation of TTP. Here, we discuss the control of TTP biology via its phosphorylation and dephosphorylation, with a particular focus on recent advances and on questions that remain unanswered.

Sun safety advice for families

2021 ◽  
Vol 9 (5) ◽  
pp. 202-204
Author(s):  
Amy Noakes
Keyword(s):  
Skin Cancer ◽  
Sun Exposure ◽  
Vital Role ◽  
Sun Safety

Sun exposure is the primary cause of skin cancer, and it has been suggested that most cases of melanoma could be prevented with greater understanding of sun damage and protection. Amy Noakes explains the vital role of sunscreen

Skin cancer on Instagram: implications for adolescents and young adults

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Corey H. Basch ◽  
Grace C. Hillyer
Keyword(s):  
Young Adults ◽  
Skin Cancer ◽  
Preventive Measures ◽  
Sun Exposure ◽  
Adolescents And Young Adults ◽  
Skin Cancer Prevention ◽  
Age Group ◽  
Protective Gear ◽  
Considerable Portion

AbstractGiven the popularity and reach of Instagram among American adolescents and young adults (AYA), the well-known influence of social media on the behaviors of youth, and the rising rates of melanoma in this age group, this study sought to examine and describe the content of a sample of Instagram posts related to skin cancer. At three different times, a search of Instagram was conducted using #skincancer as the hashtag. Descriptive analyses of Instagram characteristics and content was performed. Overall, content focused on prevention (33.3%), skin cancer treatment (29.3%) and preventive measures such as using sunscreen and protective gear (29.3%). Nearly one-quarter discussed the ABCDEs (Asymmetrical; Borders are irregular; Color is not even; Diameter is large; Evolving) of screening and detection. Instagram postings that covered skin cancer prevention (n = 50, 33.3%) more often discussed the role of sun exposure in the development of skin cancer (28.0% vs. 10.0%, p = 0.005) and use of sunscreen and protective gear (62.0% vs. 13.0%, p < 0.001). The findings of this study indicate that a considerable portion of the Instagram posts included in this study focused on prevention. Thus, indicating that Instagram could be used to promote health, particularly among AYA.

Geographic Pathology of Skin Cancer

1999 ◽  
Vol 3 (3) ◽  
pp. 120-122
Author(s):  
Robert Jackson
Keyword(s):  
Squamous Cell Carcinoma ◽  
Skin Cancer ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Basal Cell ◽  
Sun Exposure

Background: The development of knowledge concerning the role of sun exposure in causing skin cancer has been a gradual one. Objective: This article reviews the article by Urbach who used manikin coated with an ultraviolet dosimeter to see exactly where on the head and neck the exposure was greatest. Conclusion: Urbach showed that the areas of greatest sun exposure on his manikins corresponded with the location of 95% of squamous cell carcinoma and 66% of basal cell carcinoma. He also clearly showed the importance of scattered sky and reflected radiation.

scholarly journals 12 Weeks of Combined Endurance and Resistance Training Reduces Innate Markers of Inflammation in a Randomized Controlled Clinical Trial in Patients with Multiple Sclerosis

2016 ◽  
Vol 2016 ◽  
pp. 1-13 ◽  
Author(s):  
Nathalie Deckx ◽  
Inez Wens ◽  
Amber H. Nuyts ◽  
Niel Hens ◽  
Benedicte Y. De Winter ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Inflammatory Mediators ◽  
Exercise Program ◽  
Underlying Disease ◽  
Peripheral Tolerance ◽  
Controlled Clinical Trial ◽  
Tissue Mass ◽  
Markers Of Inflammation ◽  
And Function

Previously, we reported that patients with multiple sclerosis (MS) demonstrate improved muscle strength, exercise tolerance, and lean tissue mass following a combined endurance and resistance exercise program. However, the effect of exercise on the underlying disease pathogenesis remains elusive. Since recent evidence supports a crucial role of dendritic cells (DC) in the pathogenesis of MS, we investigated the effect of a 12-week combined exercise program in MS patients on the number and function of DC. We demonstrate an increased number of plasmacytoid DC (pDC) following the exercise program. These pDC display an activated phenotype, as evidenced by increased numbers of circulating CD62L+and CD80+pDC. Interestingly, the number of CD80+pDC positively correlates with the presence of IL-10-producing regulatory type 1 cells (Tr1), an important cell type for maintaining peripheral tolerance to self-antigens. In addition, decreased production of the inflammatory mediators, TNF-αand MMP-9, upon Toll-like receptor (TLR) stimulation was found at the end of the exercise program. Overall, our findings suggest that the 12-week exercise program reduces the secretion of inflammatory mediators upon TLR stimulation and promotes the immunoregulatory function of circulating pDC, suggestive for a favorable impact of exercise on the underlying immunopathogenesis of MS.

scholarly journals Diet and Skin Aging—From the Perspective of Food Nutrition

Nutrients ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 870 ◽  
Author(s):  
Changwei Cao ◽  
Zhichao Xiao ◽  
Yinglong Wu ◽  
Changrong Ge
Keyword(s):  
Human Life ◽  
Skin Aging ◽  
The Body ◽  
Research Progress ◽  
Healthy Skin ◽  
Internal Factors ◽  
Chronological Aging ◽  
Complex Biological Process ◽  
Food And Nutrition

We regularly face primary challenges in deciding what to eat to maintain young and healthy skin, defining a healthy diet and the role of diet in aging. The topic that currently attracts maximum attention is ways to maintain healthy skin and delay skin aging. Skin is the primary barrier that protects the body from external aggressions. Skin aging is a complex biological process, categorized as chronological aging and photo-aging, and is affected by internal factors and external factors. With the rapid breakthrough of medicine in prolonging human life and the rapid deterioration of environmental conditions, it has become urgent to find safe and effective methods to treat skin aging. For diet, as the main way for the body to obtain energy and nutrients, people have gradually realized its importance to the skin. Therefore, in this review, we discuss the skin structure, aging manifestations, and possible mechanisms, summarize the research progress, challenges, possible directions of diet management, and effects of foodborne antioxidants on skin aging from the perspective of food and nutrition.

scholarly journals Ultradeep sequencing differentiates patterns of skin clonal mutations associated with sun-exposure status and skin cancer burden

2021 ◽  
Vol 7 (1) ◽  
pp. eabd7703
Author(s):  
Lei Wei ◽  
Sean R. Christensen ◽  
Megan E. Fitzgerald ◽  
James Graham ◽  
Nicholas D. Hutson ◽  
...  
Keyword(s):  
Skin Cancer ◽  
Cancer Risk ◽  
Normal Skin ◽  
Sun Exposure ◽  
Uv Exposure ◽  
Induced Mutations ◽  
Carcinogenic Effect ◽  
Normal Human Skin ◽  
Cancer Burden ◽  
Skin Cancer Risk

In ultraviolet (UV) radiation–exposed skin, mutations fuel clonal cell growth. The relationship between UV exposure and the accumulation of clonal mutations (CMs) and the correlation between CMs and skin cancer risk are largely unexplored. We characterized 450 individual-matched sun-exposed (SE) and non-SE (NE) normal human skin samples. The number and relative contribution of CMs were significantly different between SE and NE areas. Furthermore, we identified hotspots in TP53, NOTCH1, and GRM3 where mutations were significantly associated with UV exposure. In the normal skin from patients with cutaneous squamous cell carcinoma, we found that the cancer burden was associated with the UV-induced mutations, with the difference mostly conferred by the low-frequency CMs. These findings provide previously unknown information on UV’s carcinogenic effect and pave the road for future development of quantitative assessment of subclinical UV damage and skin cancer risk.

Sun Exposure, Sunscreens, and Skin Cancer Prevention: A Year-Round Concern

1996 ◽  
Vol 30 (6) ◽  
pp. 662-673 ◽  
Author(s):  
Kevin C Farmer ◽  
Mark F Naylor ◽  
Juan Roca-Acén ◽  
Marie Larouche
Keyword(s):  
Skin Cancer ◽  
Uv Radiation ◽  
Animal Studies ◽  
Sun Exposure ◽  
Short Wave ◽  
Skin Aging ◽  
Skin Cancer Prevention ◽  
Original Research ◽  
Medline Search ◽  
Sunscreen Use

Objective To review the role of sunlight in skin aging and skin cancer formation, and to provide guidelines on the use of sunscreens to minimize the adverse effects of sun damage. Data Sources A MEDLINE search of applicable articles on ultraviolet (UV) radiation, melanoma, sunscreens, and skin cancer, evaluating both human and animal studies. Published and unpublished original research as well as clinical experience were also used. Data Synthesis The interaction of UV radiation and skin type plays a central role in melanoma formation. Mortality from melanoma is highest in geographic locations near the equator, where UV intensity is greatest. The incidence of melanomas in light-complected individuals (skin types I-III) is several times higher than those with darker skin types (types IV-VI), even in similar geographic regions. The UVB portion of the spectrum appears to be primarily responsible for skin cancer formation and photoaging, while short wave UVA rays play a significant contributing role. Regular sunscreen use has been shown to reduce the formation of precancerous actinic keratoses (AK) lesions by 36%. A dose-response relationship has also been found between the amount of sunscreen used and AK formation. Conclusions Sunscreens have now been shown to reduce the carcinogenic effects of sunlight in humans. Patients should be advised of the long-term consequences of sun exposure and the benefits of regular sunscreen use.

Sun safety advice: Protecting against skin cancer

2021 ◽  
Vol 31 (5) ◽  
pp. 24-26
Author(s):  
Amy Noakes
Keyword(s):  
Skin Cancer ◽  
Sun Exposure ◽  
Vital Role ◽  
Sun Safety

Sun exposure is the primary cause of skin cancer, and it has been suggested that most cases of melanoma could be prevented with greater understanding of sun damage and protection. Amy Noakes explains the vital role of sunscreen

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