scholarly journals Vitamin D and Abdominal Aortic Calcification in Older African American Women, the PODA Clinical Trial

Nutrients ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 861 ◽  
Author(s):  
Saloni Brahmbhatt ◽  
Mageda Mikhail ◽  
Shahidul Islam ◽  
John F. Aloia
Keyword(s):  
Clinical Trial ◽  
Vitamin D ◽  
African American ◽  
Placebo Group ◽  
African American Women ◽  
Aortic Calcification ◽  
Vertebral Fracture Assessment ◽  
Abdominal Aortic Calcification ◽  
American Women ◽  
Abdominal Aortic

Abdominal aortic calcification (AAC) detected on lateral vertebral fracture assessment is associated with increased cardiovascular risk. Vitamin D deficiency and toxicity have been linked with vascular calcification. The objective of this study was to determine the effect of high-dose vitamin D on the progression of AAC. The Physical Performance, Osteoporosis and vitamin D in African American Women (PODA) is a randomized, clinical trial examining the effect of vitamin D. There were 14.7% subjects with AAC in the vitamin D group, compared to 12.1% in the placebo group at baseline. The prevalence of extended AAC at baseline was 6.4% in the vitamin D group and 3.5% in the placebo group. The extended calcification scores over time were not different between groups. There was no association between AAC and serum 25(OH)D. However, PTH was associated with an increase in AAC in the placebo group.

Vitamin D and Falls in Older African American Women: The PODA Randomized Clinical Trial

2019 ◽  
Vol 67 (5) ◽  
pp. 1043-1049 ◽  
Author(s):  
John F. Aloia ◽  
Rakhil Rubinova ◽  
Melissa Fazzari ◽  
Shahidul Islam ◽  
Mageda Mikhail ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Vitamin D ◽  
African American ◽  
African American Women ◽  
Randomized Clinical Trial ◽  
American Women ◽  
Older African American Women

scholarly journals Vitamin D and Acute Respiratory Infections—The PODA Trial

2019 ◽  
Vol 6 (9) ◽  
Author(s):  
John F Aloia ◽  
Shahidul Islam ◽  
Mageda Mikhail
Keyword(s):  
Vitamin D ◽  
African American ◽  
Placebo Group ◽  
African American Women ◽  
Physical Performance ◽  
Respiratory Infections ◽  
Vitamin D Supplementation ◽  
Acute Respiratory Infections ◽  
American Women ◽  
Older African American Women

Abstract Background There is considerable heterogeneity in clinical trials examining the role of vitamin D in the prevention of acute respiratory infections (ARIs). Methods The primary aim of the Physical Performance, Osteoporosis, and Vitamin D in Older African-American Women (PODA) trial was the prevention of bone loss and decline in physical performance. A questionnaire about ARIs was administered every 3 months for 3 years to 260 black American women in a double-blind randomized clinical trial that had a placebo group and a vitamin D supplementation group. The serum 25(OH)D level was maintained >30 ng/mL in the vitamin D group. Results Serum 25(OH)D was maintained >30 ng/mL in 90% of the active group, whereas levels approximated those associated with the recommended dietary allowance (20 ng/mL) in the placebo group. There was no difference in occurrence of ARIs in the treatment group vs the placebo group. ARIs were not related to total or free 25(OH)D, which were measured at baseline and annually for 36 months. Conclusions Vitamin D supplementation sufficient to maintain serum 25(OH)D >30 ng/mL does not prevent ARIs in older African American women. ClinicalTrials.gov Registration Number NCT01153568.

Factors Affecting Older African American Women's Decisions to Join the PLCO Cancer Screening Trial

2005 ◽  
Vol 23 (34) ◽  
pp. 8730-8738 ◽  
Author(s):  
Jeanette M. Trauth ◽  
Jan C. Jernigan ◽  
Laura A. Siminoff ◽  
Donald Musa ◽  
Derietra Neal-Ferguson ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Clinical Trials ◽  
African American ◽  
Cancer Screening ◽  
African American Women ◽  
Trial Participation ◽  
American Women ◽  
Older African American Women ◽  
Cancer Screening Trial ◽  
Screening Trial

Purpose The purpose of this study is to describe the factors associated with the decisions of older African American women to join the PLCO (Prostate, Lung, Colorectal and Ovarian) Cancer Screening Trial when recruited. Methods African American women between ages 55 and 74 years who were never diagnosed with a PLCO cancer were eligible for our study. Two methods of recruitment were used. First, mailings were sent to a random sample of women describing the PLCO followed by a telephone call to determine interest in the PLCO. If women were not interested in PLCO but consented to participate in our study, they were interviewed immediately. Second, we followed up with African American women who responded to mass mailings sent out before the start of our study by the Pittsburgh PLCO office. Women completed an interview about their cancer and clinical trial knowledge, attitudes, beliefs, and behaviors. The responses of women who joined the PLCO Trial are contrasted with the responses of women who did not join. Results Numerous factors were associated with the decision of older African American women to join the PLCO, including perceptions of cancer prevention and detection, the experience of having a loved one with cancer, knowledge of and experience with clinical trials, and beliefs regarding the benefits and risks of clinical trial participation. Conclusion Minority recruitment to cancer clinical trials could be increased by designing interventions focused on individual, organizational, and community needs.

Vitamin D Nutritional Status and Antenatal Depressive Symptoms in African American Women

2012 ◽  
Vol 21 (11) ◽  
pp. 1189-1195 ◽  
Author(s):  
Andrea E. Cassidy-Bushrow ◽  
Rosalind M. Peters ◽  
Dayna A. Johnson ◽  
Jia Li ◽  
D. Sudhaker Rao
Keyword(s):  
Vitamin D ◽  
African American ◽  
Depressive Symptoms ◽  
Nutritional Status ◽  
African American Women ◽  
American Women ◽  
Antenatal Depressive Symptoms
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