scholarly journals Vitamin D Status in Japanese Adults: Relationship of Serum 25-Hydroxyvitamin D with Simultaneously Measured Dietary Vitamin D Intake and Ultraviolet Ray Exposure

Nutrients ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 743 ◽  
Author(s):  
Keiko Asakura ◽  
Norihito Etoh ◽  
Haruhiko Imamura ◽  
Takehiro Michikawa ◽  
Takahiro Nakamura ◽  
...  
Keyword(s):  
Vitamin D ◽  
Exposure Time ◽  
Serum Vitamin ◽  
Vitamin D Insufficiency ◽  
Uv Exposure ◽  
Dietary Vitamin ◽  
Hydroxyvitamin D ◽  
Vitamin D Intake ◽  
25 Hydroxyvitamin D ◽  
Ultraviolet Ray

Vitamin D insufficiency/deficiency is prevalent worldwide. We investigated the effect of vitamin D intake and ultraviolet ray (UV) exposure on serum vitamin D concentration in Japan. A total of 107 healthy adult participants were recruited from Hokkaido (43° N) and Kumamoto (33° N) prefectures. All participants undertook surveys in both summer and winter. Serum 25-hydroxyvitamin D (25(OH)D3) was examined, and vitamin D intake was assessed with a diet history questionnaire. UV exposure was measured with a wearable UV dosimeter. Regression analysis was performed to investigate the relationship between these factors, with covariates such as sun avoidance behavior. The prevalence of vitamin D insufficiency (serum 25(OH)D3; 12 ng/mL (30 nmol/L) ≤ and <20 ng/mL (50 nmol/L))/deficiency (<12 ng/mL) was 47.7% in summer and 82.2% in winter. UV exposure time was short in Kumamoto (the urban area), at 11.6 min in summer and 14.9 min in winter. In Hokkaido (the rural area), UV exposure time was 58.3 min in summer and 22.5 min in winter. Vitamin D intake was significantly associated with serum 25(OH)D3, and a 1 μg/1000kcal increase in intake was necessary to increase 25(OH)D3 by 0.88 ng/mL in summer and by 1.7 ng/mL in winter. UV exposure time was significantly associated with serum 25(OH)D3 in summer, and a 10 min increase in UV exposure time was necessary to increase 25(OH)D3 by 0.47 ng/mL. Although consideration of personal occupation and lifestyle is necessary, most Japanese may need to increase both vitamin D intake and UV exposure.

scholarly journals A 250 μg/week dose of vitamin D was as effective as a 50 μg/d dose in healthy adults, but a regimen of four weekly followed by monthly doses of 1250 μg raised the risk of hypercalciuria

2013 ◽  
Vol 110 (10) ◽  
pp. 1866-1872 ◽  
Author(s):  
Sara R. Zwart ◽  
Howard Parsons ◽  
Michael Kimlin ◽  
Sheila M. Innis ◽  
James P. Locke ◽  
...  
Keyword(s):  
Vitamin D ◽  
Side Effects ◽  
Vitamin D Insufficiency ◽  
Vitamin D Supplementation ◽  
Healthy Adults ◽  
Dietary Vitamin ◽  
Steady Increase ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
Dietary Vitamin D

The risk of vitamin D insufficiency is increased in persons having limited sunlight exposure and dietary vitamin D. Supplementation compliance might be improved with larger doses taken less often, but this may increase the potential for side effects. The objective of the present study was to determine whether a weekly or weekly/monthly regimen of vitamin D supplementation is as effective as daily supplementation without increasing the risk of side effects. Participants were forty-eight healthy adults who were randomly assigned for 3 months to placebo or one of three supplementation regimens: 50 μg/d (2000 IU/d, analysed dose 70 μg/d), 250 μg/week (10 000 IU/week, analysed dose 331 μg/week) or 1250 μg/week (50 000 IU/week, analysed dose 1544 μg/week) for 4 weeks and then 1250 μg/month for 2 months. Daily and weekly doses were equally effective at increasing serum 25-hydroxyvitamin D, which was significantly greater than baseline in all the supplemented groups after 30 d of treatment. Subjects in the 1250 μg treatment group, who had a BMI >26 kg/m2, had a steady increase in urinary Ca in the first 3 weeks of supplementation, and, overall, the relative risk of hypercalciuria was higher in the 1250 μg group than in the placebo group (P= 0·01). Although vitamin D supplementation remains a controversial issue, these data document that supplementing with ≤ 250 μg/week ( ≤ 10 000 IU/week) can improve or maintain vitamin D status in healthy populations without the risk of hypercalciuria, but 24 h urinary Ca excretion should be evaluated in healthy persons receiving vitamin D3 supplementation in weekly single doses of 1250 μg (50 000 IU).

scholarly journals Vitamin D Insufficiency and Hyperparathyroidism in a Low Income, Multiracial, Elderly Population1

2000 ◽  
Vol 85 (11) ◽  
pp. 4125-4130 ◽  
Author(s):  
Susan S. Harris ◽  
Elpidoforos Soteriades ◽  
Jo Anna Stina Coolidge ◽  
Sharmilla Mudgal ◽  
Bess Dawson-Hughes
Keyword(s):  
Vitamin D ◽  
Low Income ◽  
Positive Association ◽  
Vitamin D Insufficiency ◽  
Inverse Association ◽  
Hydroxyvitamin D ◽  
Vitamin D Intake ◽  
Northern Areas ◽  
25 Hydroxyvitamin D ◽  
Pth Level

This report examines the wintertime vitamin D and PTH status of 308 participants in the Boston Low Income Elderly Osteoporosis Study of noninstitutionalized low income elderly men and women (age, 64–100 yr) living in subsidized housing in Boston, MA. Twenty-one percent of the 136 black subjects and 11% of the 110 whites had very low plasma 25-hydroxyvitamin D (25OHD) concentrations (&lt;25 nmol/L), and 73% of the blacks and 35% of the whites had 25OHD concentrations less than 50 nmol/L. The mean 25OHD levels of the smaller Hispanic and Asian subsets were generally similar to those of the white subjects. In addition to race, significant predictors of 25OHD included vitamin D intake (positive association) and smoking (inverse association), but not sex or age. Low 25OHD concentrations were associated with increased PTH and reduced serum calcium. The PTH level in the black subjects was substantially higher than that in the white subjects, and this difference was only partially explained by the racial difference in 25OHD. Elderly individuals who live in northern areas, particularly African-Americans, should be strongly encouraged to increase their vitamin D intake, especially in winter.

scholarly journals Low serum vitamin D concentrations in Spring-born dairy calves are associated with elevated peripheral leukocytes

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Susana Flores-Villalva ◽  
Megan B. O’Brien ◽  
Cian Reid ◽  
Seán Lacey ◽  
Stephen V. Gordon ◽  
...  
Keyword(s):  
Vitamin D ◽  
Immune Cell ◽  
Serum Vitamin ◽  
Vitamin D Insufficiency ◽  
Hydroxyvitamin D ◽  
Serum Vitamin D ◽  
Holstein Friesian ◽  
Vitamin D Levels ◽  
25 Hydroxyvitamin D ◽  
Peripheral Leukocytes

AbstractA role for vitamin D in the immune system is emerging from human research but data in the bovine is limited. In the current study, 48 Holstein–Friesian calves were randomly assigned to one of 4 groups designed to expose calves to divergent vitamin D levels for a 7 month period and to determine its effects on circulating immunity in young calves. Concentrations of circulating 25-hydroxyvitamin D (25OHD) was measured in serum using a commercial ELISA with validated bovine standards. Results showed that mean circulating concentrations of 25OHD at birth was 7.64 ± 3.21 ng/ml indicating vitamin D deficiency. Neither the injection of Vit D3 at birth nor the elevated levels in milk replacer yield discernible changes to pre-weaning circulating concentration of 25OHD. No calf reached the recommended level of vitamin D immune sufficiencyof 30 ng/ml of 25OHD until at least 3 months of age (T4). Increasing dietary Vit D3 via ration in the post-weaning period significantly elevated 25OHD concentrations in serum in VitD-In calves. Maximal levels of circulating 25OHD were achieved in VitD-Out calves, reaching 60.86 ± 7.32 ng/ml at 5 months of age (T7). Greatest divergence in haematology profile was observed between Ctl-In vs VitD-In groups with Ctl-In calves showing an elevated count of neutrophils, eosinophils, and basophils associated with reduced 25OHD concentrations. Neither IL-8 expression nor ROS production in serum were significantly different between calves with high and low 25OHD, indicating that other vitamin D-dependent mechanisms may contribute to the divergent circulating cellular profiles observed. This novel data on the vitamin D status of neonatal calves identifies a significant window of vitamin D insufficiency which is associated with significant differences in circulating immune cell profiles. Vitamin D insufficiency may therefore exacerbate pre-weaning disease susceptibility, and further work in now warranted.

scholarly journals Prospective study on food fortification with vitamin D among adolescent females in Finland: minor effects

2008 ◽  
Vol 100 (2) ◽  
pp. 418-423 ◽  
Author(s):  
Marjo Lehtonen-Veromaa ◽  
Timo Möttönen ◽  
Aila Leino ◽  
Olli J. Heinonen ◽  
Essi Rautava ◽  
...  
Keyword(s):  
Vitamin D ◽  
Adolescent Girls ◽  
Vitamin D Insufficiency ◽  
Adolescent Females ◽  
Dietary Vitamin ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
One Year ◽  
The Impact ◽  
Dietary Vitamin D

Vitamin D insufficiency is common particularly during wintertime. After the recommendation by the Ministry of Social Affairs and Health, Finnish fluid milks and margarines have been fortified with vitamin D since February 2003. The aims of the present study were to examine the impact of vitamin D fortification of food supplies on serum 25-hydroxyvitamin D (S-25(OH)D) concentrations and on daily dietary vitamin D intake among adolescent females. One hundred and forty-two girls of Caucasian ethnicity aged 12–18 years completed semi-quantitative FFQ from which the dietary vitamin D and Ca intakes were calculated. S-25(OH)D was measured by radioimmunoassay. The study was performed from February–March 2000 to February–March 2004, one year after the initiation of fortification. The mean dietary intake of vitamin D was < 7·5 μg in 91·5 % of the adolescent girls in 2000 and 83·8 % in 2004. The midwinter mean S-25(OH)D concentration did not change significantly during the follow-up period (48·3 v. 48·1 nmol/l, NS). The proportion of participants who had S-25(OH)D concentration < 50 nmol/l was 60·6 % in 2000 and 65·5 % in 2004. Only 7·0 % of the participants had an adequate S-25(OH)D ( ≥ 75 nmol/l) level in 2000 or 4 years later. The vitamin D fortification of fluid milks and margarines was inadequate to prevent vitamin D insufficiency. There are numerous adolescent girls and women who are not reached by the current fortification policy. Therefore new innovative and feasible ways of improving vitamin D nutrition are urged.

scholarly journals Prevalence and determinants of vitamin D deficiency and insufficiency among three immigrant groups in Finland: evidence from a population-based study using standardised 25-hydroxyvitamin D data

2020 ◽  
Vol 23 (7) ◽  
pp. 1254-1265
Author(s):  
Folasade A Adebayo ◽  
Suvi T Itkonen ◽  
Eero Lilja ◽  
Tuija Jääskeläinen ◽  
Annamari Lundqvist ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Migrant Health ◽  
Population Based ◽  
Vitamin D Insufficiency ◽  
Dietary Vitamin ◽  
Cross Sectional ◽  
Hydroxyvitamin D ◽  
Dairy Consumption ◽  
25 Hydroxyvitamin D

AbstractObjective:We investigated the determinants of serum 25-hydroxyvitamin D [S-25(OH)D] and dietary vitamin D sources among three immigrant groups in Finland and compared their S-25(OH)D to the general Finnish population.Design:Cross-sectional population-based Migrant Health and Wellbeing Study and the nationally representative Finnish Health 2011 Survey. S-25(OH)D was standardised according to the Vitamin D Standardisation Program. Vitamin D sources were assessed by interview.Setting:Six different municipalities in Finland (60°–63°N).Participants:Immigrants aged 18–64 years (446 Russians, 346 Somalis, 500 Kurds), 798 Finns aged 30–64 years.Results:The mean of S-25(OH)D was 64 (95 % CI 62, 66), 44 (95 % CI 41, 46), 35 (95 % CI 34, 37) and 64 (95 % CI 62, 66) nmol/l for Russians, Somalis, Kurds and Finns, respectively. S-25(OH)D among Somalis and Kurds was lower compared with Finns (P < 0·001). The prevalence of vitamin D deficiency (S-25(OH)D <30 nmol/l) and insufficiency (S-25(OH)D <50 nmol/l) was higher among immigrants than Finns (P < 0·001). Vitamin D-rich foods differed between the groups; vitamin D-fortified fat spread consumption was higher among Somalis (91 %) than among Russians (73 %) and Kurds (60 %); fish was less consumed among Kurds (17 %) than among Russians (43 %) and Somalis (38 %); and 57 % Russians, 56 % Kurds and 36 % Somalis consumed vitamin D-fortified dairy daily (P < 0·001 for all). Daily smoking, alcohol consumption and winter blood sampling were determinants of vitamin D insufficiency (P ≤ 0·03). Older age, physical activity, fish and vitamin D-fortified dairy consumption were associated with lower odds of insufficiency (P ≤ 0·04).Conclusions:Vitamin D status differed among immigrant groups and the determinants are, to some degree, associated with learned or existing cultural behaviours.

scholarly journals Changes in Serum 25 Hydroxyvitamin D Concentrations in Male University Long-Distance Runners Following Vitamin D3 Supplementation During Winter: A Randomized Controlled Trial

2021 ◽  
Author(s):  
Toraishi Mami ◽  
Kasai Mayumi ◽  
Nakano Takayuki ◽  
Sasahara Jun
Keyword(s):  
Vitamin D ◽  
Placebo Group ◽  
Dietary Vitamin ◽  
Intervention Period ◽  
Distance Runners ◽  
Post Intervention ◽  
Long Distance ◽  
Hydroxyvitamin D ◽  
Vitamin D Intake ◽  
25 Hydroxyvitamin D

Abstract BackgroundVitamin D insufficiency and deficiency remain a global problem, even among athletes. In this study, we evaluated the serum 25 hydroxyvitamin D [25 (OH) D] concentrations of male long-distance runners during winter and the effect of short-term vitamin D3 supplementation to elucidate their dietary vitamin D requirements. MethodsUsing double-blind randomization, 34 athletes on the “Ekiden” (long-distance road race) team at University A were divided into a vitamin D group (n = 17, 25 μg/day of vitamin D3 intake) and a placebo group (n = 17, placebo tablet intake). Both groups ate normal meals with either the supplement or placebo included, and all subjects underwent a 31-day dietary survey. The pre- and post-intervention body composition and blood test were measured and compared.ResultsPrior to intervention, the vitamin D intake amount was 16.7 ± 7.2 μg/day, but the serum 25 (OH) D concentration was 28.9 ± 5.7 ng/mL, and 22 (65%) of the 34 subjects had insufficient vitamin D (<30 ng/mL). During the intervention period, the mean amount of vitamin D intake was 40.0 ± 5.5 μg/day in the vitamin D group and 13.4 ± 7.7 μg/day in the placebo group. Serum 25 (OH) D concentrations increased from 30.7 ± 6.7 ng/mL to 35.4 ± 6.6 ng/mL in the vitamin D group and from 27.1 ± 3.9 ng/mL to 28.5 ± 4.4 ng/mL in the placebo group, respectively (p < 0.001, p < 0.01). After intervention, the serum 25 (OH) D concentration in the vitamin D group was significantly higher (p < 0.001). Additionally, the rate of vitamin D sufficiency was 82% in the vitamin D group and 43% in the placebo group, indicating a significant difference (p < 0.01). ConclusionsOur results demonstrate that post-intervention serum 25 (OH) D concentration was related to both mean vitamin D intake amount during the intervention period and pre-intervention serum 25 (OH) D concentration. However, to better quantify the required amount of vitamin D, further study of the effect of vitamin D supplementation on bone health is needed.

scholarly journals Genetic and environmental predictors of serum 25-hydroxyvitamin D concentrations among middle-aged and elderly Chinese in Singapore

2012 ◽  
Vol 109 (3) ◽  
pp. 493-502 ◽  
Author(s):  
Kim Robien ◽  
Lesley M. Butler ◽  
Renwei Wang ◽  
Kenneth B. Beckman ◽  
Dinesha Walek ◽  
...  
Keyword(s):  
Vitamin D ◽  
Bone Structure ◽  
Health Study ◽  
Dietary Vitamin ◽  
Middle Aged ◽  
Hydroxyvitamin D ◽  
Vitamin D Intake ◽  
Singapore Chinese ◽  
25 Hydroxyvitamin D ◽  
Dietary Vitamin D

Vitamin D is known for maintaining Ca homeostasis and bone structure, and may also decrease susceptibility to chronic and infectious diseases. However, data on vitamin D status and its predictors among Southeast Asian populations are limited. We evaluated the distribution and determinants (genetic and environmental) of serum 25-hydroxyvitamin D (25(OH)D) concentrations among 504 middle-aged and elderly participants (aged 45–74 years) in the Singapore Chinese Health Study. Data on dietary and other lifestyle factors were collected by trained interviewers. Serum 25(OH)D concentrations and genetic polymorphisms in vitamin D metabolism pathway enzymes (cytochrome P450 (CYP)2R1,3A4,27B1,24A1; vitamin D binding protein (also known as group-specific component,GC); and vitamin D receptor) were measured using stored biospecimens. Mean 25(OH)D concentration was 68·8 nmol/l. Serum 25(OH)D concentrations were positively associated with dietary vitamin D intake, and inversely associated with hours spent sitting at work. BMI was not associated with 25(OH)D concentrations.CYP2R1rs10741657, rs12794714, rs1993116;CYP3A4rs2242480; andGCrs4588, rs7041, rs16847015, rs2298849 were statistically significantly associated with 25(OH)D concentrations. Individuals with theGc2-2haplotype (rs4588AA/rs7041TT) had statistically significantly lower 25(OH)D concentrations compared to all otherGchaplotypes (P-trend < 0·001). The majority of participants (86 %) had 25(OH)D concentrations ≥ 50 nmol/l, which is consistent with the 2011 Institute of Medicine (US) recommendation for bone health, and 32 % had concentrations of ≥ 75 nmol/l that are thought to be required for broader health effects. Dietary vitamin D intake, hours spent indoors at work and genetic variation inCYP2R1,CYP3A4andGCare significant predictors of 25(OH)D concentrations among Singapore Chinese.

Sign in / Sign up

Export Citation Format

Share Document