scholarly journals Dietary vitamin D intake and serum 25-hydroxyvitamin D level in relation to disease outcomes in head and neck cancer patients

2010 ◽  
Vol 128 (7) ◽  
pp. 1741-1746 ◽  
Author(s):  
François Meyer ◽  
Geoffrey Liu ◽  
Pierre Douville ◽  
Élodie Samson ◽  
Wei Xu ◽  
...  
Keyword(s):  
Vitamin D ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Patients ◽  
Dietary Vitamin ◽  
Hydroxyvitamin D ◽  
Vitamin D Intake ◽  
Disease Outcomes ◽  
25 Hydroxyvitamin D ◽  
Dietary Vitamin D

scholarly journals Association Between Vitamin D Exposure and Head and Neck Cancer: A Systematic Review With Meta-Analysis

2021 ◽  
Vol 12 ◽  
Author(s):  
Yuting Pu ◽  
Gangcai Zhu ◽  
Yimin Xu ◽  
Siyuan Zheng ◽  
Bin Tang ◽  
...  
Keyword(s):  
Systematic Review ◽  
Vitamin D ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Meta Analysis ◽  
Hydroxyvitamin D ◽  
Vitamin D Intake ◽  
25 Hydroxyvitamin D ◽  
High Concentrations

BackgroundVitamin D deficiency is a well-described preventable cause of many cancers; the association of vitamin D use with the development of head and neck cancer (HNC) is not clear. We aim to conduct a systematic review of the studies assessing the relation between vitamin D exposure and the prevention and prognosis of the HNC using meta-analysis.MethodsPubMed, EMBASE, Cochrane Library, Web of Science up to 1 January 2021, and reference lists of related studies were searched. We extracted observational studies reporting the association between vitamin D (vitamin D receptor gene polymorphisms, 25-hydroxyvitamin D concentrations, and vitamin D intake) and the outcomes of interest (HNC incidence and HNC mortality) in HNC patients aged 18 or older. Fixed effects models were used to calculate pooled effect sizes and 95% confidence intervals (CIs) by RevMan (version 5.3).ResultsSixteen studies with a total of 81,908 participants were enrolled in our meta-analysis. Based on the pooled genomic analysis, comparing with participants with the genotypes of Ff + FF or FF, the pooled odds ratio (OR) of participants with the genotype of ff was 0.77 (95% CI: 0.61 to 0.97) and 0.75 (0.58 to 0.97), respectively. A similar trend was noted when comparing tt with Tt + TT or TT, in which OR (95% CI) was 0.70 (0.55 to 0.90) and 0.72 (0.55 to 0.95). No significant association was identified between BsmI polymorphism and HNC. Furthermore, the OR of HNC incidence was 0.77 (0.65 to 0.92) for participants with vitamin D intake over the ones with a regular diet. High concentrations of circulated 25-hydroxyvitamin D (25-OHD) significantly decreased by 32% of HNC incidence (OR (95% CI): 0.68 (0.59 to 0.78)) and increased HNC survival (pooled hazard ratio 1.13, 1.05 to 1.22) during a 4–5 years follow-up. High concentrations of circulating 25-OHD in patients with HNC led to a decreased risk of mortality to 0.75 (0.60 to 0.94) as the follow-up extends to 8–12 years.ConclusionsElevated activities of vitamin D by diet intake, genomic polymorphisms, or circulated 25-OHD may protect people from HNC and improve the prognosis of patients with HNC.Systematic Review RegistrationPROSPERO, identifier CRD42020176002 (https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=176002).

scholarly journals Genetic and environmental predictors of serum 25-hydroxyvitamin D concentrations among middle-aged and elderly Chinese in Singapore

2012 ◽  
Vol 109 (3) ◽  
pp. 493-502 ◽  
Author(s):  
Kim Robien ◽  
Lesley M. Butler ◽  
Renwei Wang ◽  
Kenneth B. Beckman ◽  
Dinesha Walek ◽  
...  
Keyword(s):  
Vitamin D ◽  
Bone Structure ◽  
Health Study ◽  
Dietary Vitamin ◽  
Middle Aged ◽  
Hydroxyvitamin D ◽  
Vitamin D Intake ◽  
Singapore Chinese ◽  
25 Hydroxyvitamin D ◽  
Dietary Vitamin D

Vitamin D is known for maintaining Ca homeostasis and bone structure, and may also decrease susceptibility to chronic and infectious diseases. However, data on vitamin D status and its predictors among Southeast Asian populations are limited. We evaluated the distribution and determinants (genetic and environmental) of serum 25-hydroxyvitamin D (25(OH)D) concentrations among 504 middle-aged and elderly participants (aged 45–74 years) in the Singapore Chinese Health Study. Data on dietary and other lifestyle factors were collected by trained interviewers. Serum 25(OH)D concentrations and genetic polymorphisms in vitamin D metabolism pathway enzymes (cytochrome P450 (CYP)2R1,3A4,27B1,24A1; vitamin D binding protein (also known as group-specific component,GC); and vitamin D receptor) were measured using stored biospecimens. Mean 25(OH)D concentration was 68·8 nmol/l. Serum 25(OH)D concentrations were positively associated with dietary vitamin D intake, and inversely associated with hours spent sitting at work. BMI was not associated with 25(OH)D concentrations.CYP2R1rs10741657, rs12794714, rs1993116;CYP3A4rs2242480; andGCrs4588, rs7041, rs16847015, rs2298849 were statistically significantly associated with 25(OH)D concentrations. Individuals with theGc2-2haplotype (rs4588AA/rs7041TT) had statistically significantly lower 25(OH)D concentrations compared to all otherGchaplotypes (P-trend < 0·001). The majority of participants (86 %) had 25(OH)D concentrations ≥ 50 nmol/l, which is consistent with the 2011 Institute of Medicine (US) recommendation for bone health, and 32 % had concentrations of ≥ 75 nmol/l that are thought to be required for broader health effects. Dietary vitamin D intake, hours spent indoors at work and genetic variation inCYP2R1,CYP3A4andGCare significant predictors of 25(OH)D concentrations among Singapore Chinese.

scholarly journals Dietary Calcium Intake and Hypertension: Importance of Serum Concentrations of 25-Hydroxyvitamin D

Nutrients ◽  
2019 ◽  
Vol 11 (4) ◽  
pp. 911 ◽  
Author(s):  
Nakamura ◽  
Tsujiguchi ◽  
Hara ◽  
Kambayashi ◽  
Miyagi ◽  
...  
Keyword(s):  
Vitamin D ◽  
Calcium Intake ◽  
Dietary Calcium ◽  
Dietary Vitamin ◽  
Dietary Calcium Intake ◽  
Serum Concentrations ◽  
Hydroxyvitamin D ◽  
Vitamin D Intake ◽  
25 Hydroxyvitamin D ◽  
Dietary Vitamin D

The relationship among dietary calcium, hypertension and vitamin D status currently remains unclear. This population-based cross-sectional study examined the association between dietary calcium intake and hypertension and the influence of serum concentrations of 25-hydroxyvitamin D [25(OH)D] in Japanese subjects. A total of 619 subjects aged from 40 years were recruited. Dietary intake was measured using a validated brief self-administered diet history questionnaire. Hypertension was defined as the use of antihypertensive medication or a blood pressure of 140/90 mmHg. Serum concentrations of 25(OH)D were used as the biomarker of vitamin D status. The prevalence of hypertension and low serum 25(OH)D levels (<20 ng/mL) were 55 and 32%, respectively. Dietary calcium intake inversely correlated with hypertension in subjects with serum 25(OH)D levels higher than 20 ng/mL (OR: 0.995; 95% CI: 0.991, 0.999) but it was not significant in those with serum 25(OH)D levels of 20 ng/mL or lower. Furthermore, dietary vitamin D intake correlated with serum concentrations of 25(OH)D after adjustments for various confounding factors. The present results demonstrate that the regular consumption of calcium may contribute to the prevention and treatment of hypertension in subjects with a non-vitamin D deficiency and also that dietary vitamin D intake may effectively prevents this deficiency.

scholarly journals Associations of the risk of lung cancer with serum 25-hydroxyvitamin D level and dietary vitamin D intake

Medicine ◽  
2018 ◽  
Vol 97 (37) ◽  
pp. e12282 ◽  
Author(s):  
Hu Wei ◽  
Hu Jing ◽  
Qian Wei ◽  
Guo Wei ◽  
Zhou Heng
Keyword(s):  
Lung Cancer ◽  
Vitamin D ◽  
Dietary Vitamin ◽  
Hydroxyvitamin D ◽  
Vitamin D Intake ◽  
25 Hydroxyvitamin D ◽  
Dietary Vitamin D

scholarly journals Relationship between dietary vitamin D and serum 25-hydroxyvitamin D levels in Portuguese adolescents

2017 ◽  
Vol 21 (2) ◽  
pp. 325-332
Author(s):  
Maria Cabral ◽  
Joana Araújo ◽  
Carla Lopes ◽  
Henrique Barros ◽  
João Tiago Guimarães ◽  
...  
Keyword(s):  
Vitamin D ◽  
Food Sources ◽  
Dietary Vitamin ◽  
Cross Sectional ◽  
Hydroxyvitamin D ◽  
Vitamin D Intake ◽  
Significant Difference ◽  
25 Hydroxyvitamin D ◽  
Dietary Vitamin D ◽  
Portuguese Adolescents

AbstractObjectiveTo understand the relationship between vitamin D intake and serum 25-hydroxyvitamin D (25(OH)D) levels in a sample of Portuguese adolescents.DesignCross-sectional evaluation carried out in the 2003/2004 school year. Vitamin D intake was assessed by an FFQ and 25(OH)D was measured in a fasting blood sample.SettingPublic and private schools in Porto, Portugal.SubjectsAdolescents aged 13 years (n 521) enrolled at school (EPITeen cohort).ResultsBoth mean (sd) intake and serum 25(OH)D level were far below the recommended, 4·47 (2·49) µg/d and 16·5 (5·7) ng/ml, respectively. A significant difference in serum level was found according to season, with lower values in winter than summer (14·8 (4·6) v. 17·3 (5·9) ng/ml, P<0·001). Vitamin D intake was weakly correlated with serum 25(OH)D (r=0·056, P=0·203).ConclusionsDietary vitamin D and serum 25(OH)D levels were positively but weakly correlated and the error was higher among those with higher serum 25(OH)D concentration. Our results support the need for strategies that promote increase of the most important food sources of vitamin D to reduce the high prevalence of low vitamin D status.

scholarly journals Vitamin D Status in Japanese Adults: Relationship of Serum 25-Hydroxyvitamin D with Simultaneously Measured Dietary Vitamin D Intake and Ultraviolet Ray Exposure

Nutrients ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 743 ◽  
Author(s):  
Keiko Asakura ◽  
Norihito Etoh ◽  
Haruhiko Imamura ◽  
Takehiro Michikawa ◽  
Takahiro Nakamura ◽  
...  
Keyword(s):  
Vitamin D ◽  
Exposure Time ◽  
Serum Vitamin ◽  
Vitamin D Insufficiency ◽  
Uv Exposure ◽  
Dietary Vitamin ◽  
Hydroxyvitamin D ◽  
Vitamin D Intake ◽  
25 Hydroxyvitamin D ◽  
Ultraviolet Ray

Vitamin D insufficiency/deficiency is prevalent worldwide. We investigated the effect of vitamin D intake and ultraviolet ray (UV) exposure on serum vitamin D concentration in Japan. A total of 107 healthy adult participants were recruited from Hokkaido (43° N) and Kumamoto (33° N) prefectures. All participants undertook surveys in both summer and winter. Serum 25-hydroxyvitamin D (25(OH)D3) was examined, and vitamin D intake was assessed with a diet history questionnaire. UV exposure was measured with a wearable UV dosimeter. Regression analysis was performed to investigate the relationship between these factors, with covariates such as sun avoidance behavior. The prevalence of vitamin D insufficiency (serum 25(OH)D3; 12 ng/mL (30 nmol/L) ≤ and <20 ng/mL (50 nmol/L))/deficiency (<12 ng/mL) was 47.7% in summer and 82.2% in winter. UV exposure time was short in Kumamoto (the urban area), at 11.6 min in summer and 14.9 min in winter. In Hokkaido (the rural area), UV exposure time was 58.3 min in summer and 22.5 min in winter. Vitamin D intake was significantly associated with serum 25(OH)D3, and a 1 μg/1000kcal increase in intake was necessary to increase 25(OH)D3 by 0.88 ng/mL in summer and by 1.7 ng/mL in winter. UV exposure time was significantly associated with serum 25(OH)D3 in summer, and a 10 min increase in UV exposure time was necessary to increase 25(OH)D3 by 0.47 ng/mL. Although consideration of personal occupation and lifestyle is necessary, most Japanese may need to increase both vitamin D intake and UV exposure.

Sign in / Sign up

Export Citation Format

Share Document