scholarly journals Irritable Bowel Syndrome-Like Disorders in Endometriosis: Prevalence of Nickel Sensitivity and Effects of a Low-Nickel Diet. An Open-Label Pilot Study

Nutrients ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 341 ◽  
Author(s):  
Raffaele Borghini ◽  
Maria Grazia Porpora ◽  
Rossella Casale ◽  
Mariacatia Marino ◽  
Emilia Palmieri ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Contact Dermatitis ◽  
Pilot Study ◽  
Gastrointestinal Disorders ◽  
Open Label ◽  
High Prevalence ◽  
Intestinal Symptoms ◽  
Irritable Bowel ◽  
Allergic Contact ◽  
Positive Results

Alimentary nickel (Ni) may result in allergic contact mucositis (ACM), whose prevalence is >30% and may present with IBS-like and extra-intestinal symptoms. These symptoms are also frequent in endometriosis, and Ni allergic contact dermatitis has already been observed in endometriosis. Therefore, intestinal and extra-intestinal symptoms in endometriosis may depend on a Ni ACM, and a low-Ni diet could improve symptoms. We studied the prevalence of Ni ACM in endometriosis and focused on the effects of a low-Ni diet on gastrointestinal, extra-intestinal, and gynecological symptoms. We recruited 84 women with endometriosis, symptomatic for gastrointestinal disorders. Thirty-one out of 84 patients completed the study. They underwent Ni oral mucosa patch test (omPT), questionnaire for intestinal/extra-intestinal/gynecological symptoms, and a low-Ni diet. Clinical evaluation was performed at baseline (T0) and after three months (T1). Twenty-eight out 31 (90.3%) patients showed Ni omPT positive results, with Ni ACM diagnosis, whereas three out of 31 (9.7%) patients showed negative Ni omPT. After three months of low-Ni diet, all gastrointestinal, extra-intestinal and gynecological symptoms showed a statistically significant reduction. Ni ACM has a high prevalence in endometriosis and a low-Ni diet may be recommended in this condition to reduce gastrointestinal, extra-intestinal and gynecological symptoms.

Duloxetine in the treatment of irritable bowel syndrome: an open-label pilot study

2009 ◽  
Vol 24 (5) ◽  
pp. 423-428 ◽  
Author(s):  
Brian P. Brennan ◽  
Kate V. Fogarty ◽  
Jacqueline L. Roberts ◽  
Karina A. Reynolds ◽  
Harrison G. Pope ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Pilot Study ◽  
Open Label ◽  
Irritable Bowel

Gut Feelings: Irritable Bowel Syndrome and Psychiatric Disorders

CNS Spectrums ◽  
2005 ◽  
Vol 10 (11) ◽  
pp. 876-876 ◽  
Author(s):  
R. Bruce Lydiard
Keyword(s):  
Irritable Bowel Syndrome ◽  
Psychiatric Disorders ◽  
Pain Perception ◽  
Functional Gastrointestinal Disorders ◽  
Clinical Samples ◽  
Gastrointestinal Disorders ◽  
Community Studies ◽  
Visceral Hyperalgesia ◽  
High Prevalence ◽  
Irritable Bowel

Irritable bowel syndrome (IBS) is one of over 20 functional gastrointestinal disorders. There is considerable overlap of IBS with panic disorder as well as other anxiety disorders and depression. It has been proposed that the high prevalence of psychiatric disorders in clinical samples of IBS patients is a result of self-selection of individuals with anxiety and depression, which drives treatment-seeking behavior. Over the past several years, data from some community studies have shown that there is a high prevalence of psychiatric disorders in individuals with IBS who never sought treatment. This suggests that there may be a more fundamental linnk between IBS, anxiety and mood disorders, such as shared pathophysiology.This month's issue of CNS Spectrums brings together reviews on the brain-gut axis, each of which provides a unique perspective, which is complementary to the other reviews.Kirsten Tillisch, MD, and Emeran A. Mayer, MD, review the neurobiology of visceral sensation, focusing on visceral hyperalgesia in IBS. In their paper, the importance of expectancy, comorbidity, gender, and other issues on pain perception is discussed. One of the most fascinating points the authors make is that extra-intestinal functional disorders, such as fibromyalgia, which often coexists with IBS, may affect somatic perception and pain thresholds. The observation that these disorders not only co-exist, but can affect each other raises an important and often overlooked issue for researchers. Comorbid disorders should be assessed and taken into account when conducting studies in patients with IBS. The authors highlight advances in methodology and new conceptual frameworks for understanding the functional gastrointestinal disorders (FGIDs) as well as remaining gaps in our knowledge about visceral hyperalgesia.

An Open-Label Pilot Study of Duloxetine in Patients With Irritable Bowel Syndrome and Comorbid Major Depressive Disorder

2016 ◽  
Vol 36 (6) ◽  
pp. 710-715 ◽  
Author(s):  
Roberto Lewis-Fernández ◽  
Peter Lam ◽  
Susan Lucak ◽  
Hanga Galfalvy ◽  
Elizabeth Jackson ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Major Depressive Disorder ◽  
Pilot Study ◽  
Depressive Disorder ◽  
Open Label ◽  
Major Depressive ◽  
Irritable Bowel

scholarly journals Efficacy of Solifenacin on Irritable Bowel Syndrome With Diarrhea: Open-label Prospective Pilot Trial

2012 ◽  
Vol 18 (3) ◽  
pp. 317-323 ◽  
Author(s):  
Yasushi Fukushima ◽  
Hidekazu Suzuki ◽  
Juntaro Matsuzaki ◽  
Arihiro Kiyosue ◽  
Toshifumi Hibi
Keyword(s):  
Irritable Bowel Syndrome ◽  
Pilot Trial ◽  
Open Label ◽  
Irritable Bowel

scholarly journals PSYCHOLOGICAL FEATURES OF CHILDREN WITH IRRITABLE BOWEL SYNDROME

2020 ◽  
Vol 20 (1) ◽  
pp. 91-95
Author(s):  
A.V. Zubarenko ◽  
V.V. Luzan ◽  
T.Yu. Kravchenko ◽  
G.K. Kopiyka ◽  
V.I. Martyuk
Keyword(s):  
Irritable Bowel Syndrome ◽  
Emotional Disorders ◽  
Functional Gastrointestinal Disorders ◽  
Psychological Disorders ◽  
Gastrointestinal Disorders ◽  
Depressed Type ◽  
Clinical Variant ◽  
Irritable Bowel ◽  
Psychological Features ◽  
The Brain

Functional gastrointestinal disorders are considered as a clinical variant of the interaction between psychosocial factors and gastrointestinal tract physiology implemented through the "brain - intestine" axis. The purpose of the study was to investigate psychological peculiarities of children with irritable bowel syndrome. The study included 68 children aged from 14 to 18 years with the confirmed diagnosis of irritable bowel syndrome. To determine the type of character accentuation, the Schmishek -Leonhard test questionnaire (child version) was used. The SCL-90-R test questionnaire (by L. Derogatis method) was applied to determine psycho-emotional disorders. The study has found out the majority of patients have certain psycho-emotional disorders. The group of children with irritable bowel syndrome, who were experiencing constipation, more frequently demonstrated an emotional type of character accentuation and a somatized and depressed type of psychological disorders. The patients with irritable bowel syndrome and diarrhoea had cycloid and demonstrative types of character accentuation and demonstrated an anxious type according to the questionnaire. The patients with mixed bowel rhythms exhibited features of a cycloid, emotional, and pedantic type of character accentuation. Depression, anxiety, somatised types were reported as manifestations of psychological disorders.

Sign in / Sign up

Export Citation Format

Share Document