Open‐label pilot study of ethosuximide as adjunctive therapy for relieving abdominal pain related to Irritable Bowel Syndrome

2021 ◽  
Author(s):  
Sahar M. El‑Haggar ◽  
Sahar K. Hegazy ◽  
Sherief M. Abd‐Elsalam ◽  
Mostafa M Bahaa
Keyword(s):  
Irritable Bowel Syndrome ◽  
Abdominal Pain ◽  
Pilot Study ◽  
Adjunctive Therapy ◽  
Open Label ◽  
Irritable Bowel

Duloxetine in the treatment of irritable bowel syndrome: an open-label pilot study

2009 ◽  
Vol 24 (5) ◽  
pp. 423-428 ◽  
Author(s):  
Brian P. Brennan ◽  
Kate V. Fogarty ◽  
Jacqueline L. Roberts ◽  
Karina A. Reynolds ◽  
Harrison G. Pope ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Pilot Study ◽  
Open Label ◽  
Irritable Bowel

The Efficacy of an Herbal Medicine, Carmint, on the Relief of Abdominal Pain and Bloating in Patients with Irritable Bowel Syndrome: A Pilot Study

2006 ◽  
Vol 51 (8) ◽  
pp. 1501-1507 ◽  
Author(s):  
Reyhaneh Vejdani ◽  
Hamid Reza Mohaghegh Shalmani ◽  
Mina Mir-Fattahi ◽  
Faranak Sajed-Nia ◽  
Morteza Abdollahi ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Abdominal Pain ◽  
Pilot Study ◽  
Herbal Medicine ◽  
Irritable Bowel

scholarly journals Igg Food Antibody Guided Elimination-Rotation Diet Was More Effective than FODMAP Diet and Control Diet in the Treatment of Women with Mixed IBS—Results from an Open Label Study

2021 ◽  
Vol 10 (19) ◽  
pp. 4317
Author(s):  
Lucyna Ostrowska ◽  
Diana Wasiluk ◽  
Camille F. J. Lieners ◽  
Mirosława Gałęcka ◽  
Anna Bartnicka ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Abdominal Pain ◽  
Control Diet ◽  
Dietary Treatment ◽  
Control Group ◽  
Open Label ◽  
Open Label Study ◽  
Label Study ◽  
Irritable Bowel ◽  
Fodmap Diet

Irritable bowel syndrome (IBS) is a chronic disease with recurrent abdominal pain, disturbed bowel emptying, and changes in stool consistency. We compared the effectiveness of three different dietary treatment plans (G1-FM-low FODMAP diet, G2-IP IgG based elimination-rotation-diet, and as control group, the G3-K control diet recommended by an attending gastroenterologist) in treating patients diagnosed with mixed irritable bowel syndrome. A total of seventy-three female patients diagnosed with a mixed form of irritable bowel syndrome (IBS-M) were enrolled in the study. The diet of each patient in Group 1 (G1-FM) and 2 (G2-IP) was determined individually during a meeting with a dietitian. Patients from Group 3 (G3-K) received nutrition advice from a gastroenterologist. Significant differences in the reduction of IBS symptoms were found between the groups. IBS symptoms as well as comorbid symptoms significantly improved or disappeared completely in the G2-IP group (idiopathic abdominal pain, p < 0.001; abdominal pain after a meal, p < 0.001; abdominal pain during defecation, p = 0.008), while in the G1-FM group, some of the IBS symptoms significantly improved (mucus in stool, p = 0.031; bloating, p < 0.001). In group G3-K no significant improvement was seen. Based on the results of this open-label study, it was concluded that various dietary interventions in the treatment of IBS-M patients do not uniformly affect the course and outcomes of disease management. Rotation diets based on IgG show significantly better results compared to other diets.

A pilot-study of hypnotherapy as complementary treatment for pain in chronic pancreatitis

2018 ◽  
Vol 15 (4) ◽  
Author(s):  
Jacob Juel ◽  
Randi Abrahamsen ◽  
Søren S. Olesen ◽  
Asbjørn M. Drewes
Keyword(s):  
Abdominal Pain ◽  
Chronic Pancreatitis ◽  
Pilot Study ◽  
Pain Relief ◽  
Social Life ◽  
Chronic Abdominal Pain ◽  
Primary Efficacy ◽  
Open Label ◽  
Efficacy Parameter ◽  
Irritable Bowel

Abstract BackgroundChronic pain is the hallmark symptom of chronic pancreatitis (CP). Its treatment is complicated, and often the patients have side-effects notwithstanding that pain is not ameliorated in many cases. Hypnotherapy has been shown to improve symptoms of irritable bowel syndrome including abdominal pain and, as such, may serve as a remedy to relive pain. The aim of this open-label pilot-study was to test the effect of hypnotherapy for pain in patients with CP. MethodsFour patients with CP and chronic abdominal pain were included and followed for four consecutive weeks. The primary efficacy parameter was pain relief. After 1 week of baseline patients received a 1-h session of hypnotherapy. This was repeated at day 15 and day 23 and supplemented by self-administered hypnotherapy. ResultsThree of four participants completed the trial and experienced short lasting pain reduction during the trial. The reported pain relief was in the range of 20%–39% compared to baseline. Hypnotherapy improved self-reported sleep, vitality, and social life. ConclusionsThe results suggest that hypnotherapy may reduce pain related to CP. Furthermore, no adverse effects were reported and the majority of participants completed the trial. Further prospective controlled trials are warranted to examine the potential of hypnotherapy.

scholarly journals Arrowroot as a treatment for diarrhoea in irritable bowel syndrome patients: a pilot study

2000 ◽  
Vol 37 (1) ◽  
pp. 20-24 ◽  
Author(s):  
Caroline COOKE ◽  
Irene CARR ◽  
Keith ABRAMS ◽  
John MAYBERRY
Keyword(s):  
Irritable Bowel Syndrome ◽  
Abdominal Pain ◽  
Pilot Study ◽  
Term Effect ◽  
Treatment Results ◽  
Long Term Effect ◽  
Number Of Patients ◽  
Bowel Action ◽  
Irritable Bowel

Objectives - Arrowroot is an old-fashioned remedy for diarrhoea, but no clinical studies have been done to evaluate its effectiveness. The aim of this pilot study was to assess its efficacy as a treatment for diarrhoea in 11 patients, all of whom had irritable bowel syndrome with diarrhoea as a feature. Methods - The patients were interviewed and a questionnaire completed on entry into the trial. They then took 10 mL arrowroot powder three times a day for one month and discontinued the treatment for the subsequent month. Questionnaires were completed after one month on treatment and at the end of the trial after one month off treatment. Results - Arrowroot reduced diarrhoea and had a long-term effect on constipation. It also eased abdominal pain. Conclusion - Arrowroot is an effective treatment for diarrhoea. Its action could be explained by several theories which relate to an increase in faecal bulk and thus a more efficient bowel action. The number of patients was small, and further studies are needed to substantiate preliminary results.

scholarly journals Irritable Bowel Syndrome-Like Disorders in Endometriosis: Prevalence of Nickel Sensitivity and Effects of a Low-Nickel Diet. An Open-Label Pilot Study

Nutrients ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 341 ◽  
Author(s):  
Raffaele Borghini ◽  
Maria Grazia Porpora ◽  
Rossella Casale ◽  
Mariacatia Marino ◽  
Emilia Palmieri ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Contact Dermatitis ◽  
Pilot Study ◽  
Gastrointestinal Disorders ◽  
Open Label ◽  
High Prevalence ◽  
Intestinal Symptoms ◽  
Irritable Bowel ◽  
Allergic Contact ◽  
Positive Results

Alimentary nickel (Ni) may result in allergic contact mucositis (ACM), whose prevalence is >30% and may present with IBS-like and extra-intestinal symptoms. These symptoms are also frequent in endometriosis, and Ni allergic contact dermatitis has already been observed in endometriosis. Therefore, intestinal and extra-intestinal symptoms in endometriosis may depend on a Ni ACM, and a low-Ni diet could improve symptoms. We studied the prevalence of Ni ACM in endometriosis and focused on the effects of a low-Ni diet on gastrointestinal, extra-intestinal, and gynecological symptoms. We recruited 84 women with endometriosis, symptomatic for gastrointestinal disorders. Thirty-one out of 84 patients completed the study. They underwent Ni oral mucosa patch test (omPT), questionnaire for intestinal/extra-intestinal/gynecological symptoms, and a low-Ni diet. Clinical evaluation was performed at baseline (T0) and after three months (T1). Twenty-eight out 31 (90.3%) patients showed Ni omPT positive results, with Ni ACM diagnosis, whereas three out of 31 (9.7%) patients showed negative Ni omPT. After three months of low-Ni diet, all gastrointestinal, extra-intestinal and gynecological symptoms showed a statistically significant reduction. Ni ACM has a high prevalence in endometriosis and a low-Ni diet may be recommended in this condition to reduce gastrointestinal, extra-intestinal and gynecological symptoms.

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