scholarly journals 25-Hydroxyvitamin D and Total Cancer Incidence and Mortality: A Meta-Analysis of Prospective Cohort Studies

Nutrients ◽  
2019 ◽  
Vol 11 (10) ◽  
pp. 2295 ◽  
Author(s):  
Jianmin Han ◽  
Xiaofei Guo ◽  
Xiao Yu ◽  
Shuang Liu ◽  
Xinyue Cui ◽  
...  
Keyword(s):  
Cohort Studies ◽  
Cancer Incidence ◽  
Cancer Mortality ◽  
Meta Analysis ◽  
Hydroxyvitamin D ◽  
Prospective Cohort Studies ◽  
Incidence And Mortality ◽  
Total Cancer ◽  
25 Hydroxyvitamin D ◽  
Risk Of Cancer

Epidemiological studies have suggested inconclusive associations between 25-hydroxyvitamin D and total cancer incidence and mortality. The aim of this study was to quantitatively assess these associations by combining results from prospective cohort studies. A systematic literature search was implemented in PubMed and Scopus databases in April 2019. Comparing the highest with the lowest categories, the multivariate-adjusted relative risks (RRs) and the corresponding 95% confidence intervals (CIs) were pooled using a random-effects model. A trend estimation was performed using a two-stage, dose-response, meta-analysis method. Twenty-three independent prospective studies were included for data synthesis. Eight studies investigated the association between 25-hydroxyvitamin D and the risk of cancer incidence (7511 events and 70,018 participants), and the summary estimate showed that 25-hydroxyvitamin D is marginally associated with cancer risk (Summary RR = 0.86; 95% CI: 0.73, 1.02; I2 = 70.8%; p = 0.001). Sixteen studies investigated the association between 25-hydroxyvitamin D and the risk of cancer mortality (8729 events and 101,794 participants), and a higher 25-hydroxyvitamin D concentration was inversely associated with the risk of cancer mortality (Summary RR = 0.81; 95% CI: 0.71, 0.93; I2 = 48.8%, p = 0.012). Dose-response analysis indicated that the risk of cancer incidence was reduced by 7% (RRs = 0.93; 95% CI: 0.91, 0.96), and the risk of cancer mortality was reduced by 2% (RRs = 0.98; 95% CI: 0.97, 0.99), with each 20 nmol/L increment of 25-hydroxyvitamin D concentration. This meta-analysis provides evidence that a higher 25-hydroxyvitamin D concentration is associated with a lower cancer incidence and cancer mortality.

Circulating 25-hydroxyvitamin D serum concentration and total cancer incidence and mortality: A systematic review and meta-analysis

2013 ◽  
Vol 57 (6) ◽  
pp. 753-764 ◽  
Author(s):  
Lu Yin ◽  
José M. Ordóñez-Mena ◽  
Tianhui Chen ◽  
Ben Schöttker ◽  
Volker Arndt ◽  
...  
Keyword(s):  
Systematic Review ◽  
Serum Concentration ◽  
Cancer Incidence ◽  
Meta Analysis ◽  
Hydroxyvitamin D ◽  
Incidence And Mortality ◽  
Total Cancer ◽  
25 Hydroxyvitamin D

scholarly journals Muscle-strengthening activities and cancer incidence and mortality: a systematic review and meta-analysis of observational studies

2021 ◽  
Vol 18 (1) ◽  
Author(s):  
Wilson Nascimento ◽  
Gerson Ferrari ◽  
Camila Bertini Martins ◽  
Juan Pablo Rey-Lopez ◽  
Mikel Izquierdo ◽  
...  
Keyword(s):  
Kidney Cancer ◽  
Cancer Incidence ◽  
Cancer Mortality ◽  
Meta Analysis ◽  
Random Effects Models ◽  
Muscle Strengthening ◽  
Incidence And Mortality ◽  
Total Cancer ◽  
Low Levels

Abstract Background Physical activity has been associated with reduced risk of seven types of cancer. It remains unclear, however, whether muscle-strengthening activities also reduce cancer incidence and mortality. Methods PubMed, Embase, Web of Science and Scopus were searched from inception to March 2020. Summary hazard ratio (HR) and 95% confidence intervals (CI) were estimated using random-effects models. Results Twelve studies (11 cohorts; 1 case-control), 6 to 25 years of follow-up, including 1,297,620 participants, 32,196 cases and 31,939 deaths, met inclusion criteria. Muscle-strengthening activities were associated with a 26% lower incidence of kidney cancer (HR for high vs low levels of muscle-strengthening activities: 0.74; 95% CI 0.56 to 0.98; I2 0%; 2 studies), but not with incidence of other 12 types of cancer. Muscle-strengthening activities were associated with lower total cancer mortality: HRs for high vs low levels of muscle-strengthening activities was 0.87 (95% CI 0.73 to 1.02; I2 58%; 6 studies); and HR for ≥2 times/week vs < 2 times/week of muscle-strengthening activities was 0.81 (95% CI 0.74 to 0.87; I2 0%; 4 studies). Regarding the weekly duration of muscle-strengthening activities, HR for total cancer mortality were 0.91 (95% CI 0.82 to 1.01; I2 0%; 2 studies) for 1–59 min/week and 0.98 (95% CI 0.89 to 1.07; I2 0%) for ≥60 min/week vs none. Combined muscle-strengthening and aerobic activities (vs none) were associated with a 28% lower total cancer mortality (HR 0.72; 95% CI 0.53 to 0.98; I2 85%; 3 studies). Conclusions Muscle-strengthening activities were associated with reduced incidence of kidney cancer and total cancer mortality. Combined muscle-strengthening and aerobic activities may provide a greater reduction in total cancer mortality.

scholarly journals Dietary intake and biomarkers of alpha linolenic acid and risk of all cause, cardiovascular, and cancer mortality: systematic review and dose-response meta-analysis of cohort studies

BMJ ◽  
2021 ◽  
pp. n2213 ◽  
Author(s):  
Sina Naghshi ◽  
Dagfinn Aune ◽  
Joseph Beyene ◽  
Sara Mobarak ◽  
Masoomeh Asadi ◽  
...  
Keyword(s):  
Systematic Review ◽  
Cohort Studies ◽  
Dose Response ◽  
Cancer Mortality ◽  
Prospective Cohort ◽  
Lower Risk ◽  
Meta Analysis ◽  
Response Analysis ◽  
Prospective Cohort Studies ◽  
Risk Of Cancer

Abstract Objective To examine the associations between dietary intake and tissue biomarkers of alpha linolenic acid (ALA) and risk of mortality from all causes, cardiovascular disease (CVD), and cancer. Design Systematic review and meta-analysis of prospective cohort studies. Data sources PubMed, Scopus, ISI Web of Science, and Google Scholar to 30 April 2021. Study selection Prospective cohort studies that reported the risk estimates for death from all causes, CVD, and cancer. Data synthesis Summary relative risks and 95% confidence intervals were calculated for the highest versus lowest categories of ALA intake using random effects and fixed effects models. Linear and non-linear dose-response analyses were conducted to assess the dose-response associations between ALA intake and mortality. Results 41 articles from prospective cohort studies were included in this systematic review and meta-analysis, totalling 1 197 564 participants. During follow-up ranging from two to 32 years, 198 113 deaths from all causes, 62 773 from CVD, and 65 954 from cancer were recorded. High intake of ALA compared with low intake was significantly associated with a lower risk of deaths from all causes (pooled relative risk 0.90, 95% confidence interval 0.83 to 0.97, I 2 =77.8%, 15 studies), CVD (0.92, 0.86 to 0.99, I 2 =48.2%, n=16), and coronary heart disease (CHD) (0.89, 0.81 to 0.97, I 2 =5.6%, n=9), and a slightly higher risk of cancer mortality (1.06, 1.02 to 1.11, I 2 =3.8%, n=10). In the dose-response analysis, a 1 g/day increase in ALA intake (equivalent to one tablespoon of canola oil or 0.5 ounces of walnut) was associated with a 5% lower risk of all cause (0.95, 0.91 to 0.99, I 2 =76.2%, n=12) and CVD mortality (0.95, 0.91 to 0.98, I 2 =30.7%, n=14). The pooled relative risks for the highest compared with lowest tissue levels of ALA indicated a significant inverse association with all cause mortality (0.95, 0.90 to 0.99, I 2 =8.2%, n=26). Also, based on the dose-response analysis, each 1 standard deviation increment in blood concentrations of ALA was associated with a lower risk of CHD mortality (0.92, 0.86 to 0.98, I 2 =37.1%, n=14). Conclusions The findings show that dietary ALA intake is associated with a reduced risk of mortality from all causes, CVD, and CHD, and a slightly higher risk of cancer mortality, whereas higher blood levels of ALA are associated with a reduced risk of all cause and CHD mortality only. Systematic review registration PROSPERO CRD42021229487.

scholarly journals The serum 25-hydroxyvitamin D levels and hip fracture risk: a meta-analysis of prospective cohort studies

Oncotarget ◽  
2017 ◽  
Vol 8 (24) ◽  
pp. 39849-39858 ◽  
Author(s):  
Qing-Bo Lv ◽  
Xiang Gao ◽  
Xiang Liu ◽  
Zhen-Xuan Shao ◽  
Qian-Hui Xu ◽  
...  
Keyword(s):  
Hip Fracture ◽  
Cohort Studies ◽  
Fracture Risk ◽  
Prospective Cohort ◽  
Meta Analysis ◽  
Hip Fracture Risk ◽  
Hydroxyvitamin D ◽  
Prospective Cohort Studies ◽  
25 Hydroxyvitamin D

scholarly journals Serum Uric Acid Increases Risk of Cancer Incidence and Mortality: A Systematic Review and Meta-Analysis

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Shushan Yan ◽  
Pengjun Zhang ◽  
Wei Xu ◽  
Yuqing Liu ◽  
Bin Wang ◽  
...  
Keyword(s):  
Cancer Incidence ◽  
Meta Analysis ◽  
Positive Association ◽  
Epidemiological Studies ◽  
Protective Role ◽  
Increased Risk ◽  
Incidence And Mortality ◽  
Total Cancer ◽  
Risk Of Cancer

SUA is a potent antioxidant and thus may play a protective role against cancer. Many epidemiological studies have investigated this hypothesis but provided inconsistent and inconclusive findings. We aimed to precisely elucidate the association between SUA levels and cancer by pooling all available publications. Totally, 5 independent studies with 456,053 subjects and 12 with 632,472 subjects were identified after a comprehensive literature screening from PubMed, Embase, and Web of Science. The pooled RRs showed that individuals with high SUA levels were at an increased risk of total cancer incidence (RR=1.03, 95% CI 1.01–1.05,P=0.007). Positive association between high SUA levels and total cancer incidence was observed in males but not females (for men:RR=1.05, 95% CI 1.02–1.08,P=0.002; for women,RR=1.01, 95% CI 0.98–1.04,P=0.512). Besides, high SUA levels were associated with an elevated risk of total cancer mortality (RR=1.17, 95% CI 1.04–1.32,P=0.010), particularly in females (RR=1.25, 95% CI 1.07–1.45,P=0.004). The study suggests that high SUA levels increase the risk of total cancer incidence and mortality. The data do not support the hypothesis of a protective role of SUA in cancer.

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