scholarly journals The serum 25-hydroxyvitamin D levels and hip fracture risk: a meta-analysis of prospective cohort studies

Oncotarget ◽  
2017 ◽  
Vol 8 (24) ◽  
pp. 39849-39858 ◽  
Author(s):  
Qing-Bo Lv ◽  
Xiang Gao ◽  
Xiang Liu ◽  
Zhen-Xuan Shao ◽  
Qian-Hui Xu ◽  
...  
2007 ◽  
Vol 86 (6) ◽  
pp. 1780-1790 ◽  
Author(s):  
Heike A Bischoff-Ferrari ◽  
Bess Dawson-Hughes ◽  
John A Baron ◽  
Peter Burckhardt ◽  
Ruifeng Li ◽  
...  

Nutrients ◽  
2019 ◽  
Vol 11 (10) ◽  
pp. 2295 ◽  
Author(s):  
Jianmin Han ◽  
Xiaofei Guo ◽  
Xiao Yu ◽  
Shuang Liu ◽  
Xinyue Cui ◽  
...  

Epidemiological studies have suggested inconclusive associations between 25-hydroxyvitamin D and total cancer incidence and mortality. The aim of this study was to quantitatively assess these associations by combining results from prospective cohort studies. A systematic literature search was implemented in PubMed and Scopus databases in April 2019. Comparing the highest with the lowest categories, the multivariate-adjusted relative risks (RRs) and the corresponding 95% confidence intervals (CIs) were pooled using a random-effects model. A trend estimation was performed using a two-stage, dose-response, meta-analysis method. Twenty-three independent prospective studies were included for data synthesis. Eight studies investigated the association between 25-hydroxyvitamin D and the risk of cancer incidence (7511 events and 70,018 participants), and the summary estimate showed that 25-hydroxyvitamin D is marginally associated with cancer risk (Summary RR = 0.86; 95% CI: 0.73, 1.02; I2 = 70.8%; p = 0.001). Sixteen studies investigated the association between 25-hydroxyvitamin D and the risk of cancer mortality (8729 events and 101,794 participants), and a higher 25-hydroxyvitamin D concentration was inversely associated with the risk of cancer mortality (Summary RR = 0.81; 95% CI: 0.71, 0.93; I2 = 48.8%, p = 0.012). Dose-response analysis indicated that the risk of cancer incidence was reduced by 7% (RRs = 0.93; 95% CI: 0.91, 0.96), and the risk of cancer mortality was reduced by 2% (RRs = 0.98; 95% CI: 0.97, 0.99), with each 20 nmol/L increment of 25-hydroxyvitamin D concentration. This meta-analysis provides evidence that a higher 25-hydroxyvitamin D concentration is associated with a lower cancer incidence and cancer mortality.


Injury ◽  
2015 ◽  
Vol 46 (7) ◽  
pp. 1333-1340 ◽  
Author(s):  
Guang Si Shen ◽  
Yong Li ◽  
GuoYang Zhao ◽  
Hai Bin Zhou ◽  
Zong Gang Xie ◽  
...  

PLoS ONE ◽  
2013 ◽  
Vol 8 (4) ◽  
pp. e55077 ◽  
Author(s):  
Xianye Tang ◽  
Gang Liu ◽  
Jian Kang ◽  
Yang Hou ◽  
Fungui Jiang ◽  
...  

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