scholarly journals Naked Oat (Avena nuda L.) Oligopeptides: Immunomodulatory Effects on Innate and Adaptive Immunity in Mice via Cytokine Secretion, Antibody Production, and Th Cells Stimulation

Nutrients ◽  
2019 ◽  
Vol 11 (4) ◽  
pp. 927 ◽  
Author(s):  
Mao ◽  
Wu ◽  
Zhu ◽  
Liu ◽  
Liu ◽  
...  
Keyword(s):  
Nk Cell ◽  
Cell Activity ◽  
Immunomodulatory Activity ◽  
Intragastric Administration ◽  
Nk Cell Activity ◽  
Water Control ◽  
Naked Oat ◽  
Macrophage Phagocytosis ◽  
Th Cell ◽  
Avena Nuda

The study aimed to investigate the immunomodulatory activity of oligopeptides derivedfrom oat (Avena Nuda L.) (OOPs). Healthy female BALB/c mice were randomly assigned to fivegroups, given deionized water (control) and 0.25, 0.5, 1.0, and 2.0 g/kg body weight (BW) of OOPsdaily by intragastric administration. Seven assays were performed to determine theimmunomodulatory effects of OOPs on immune organ ratios, cellular and humoral immuneresponses, macrophage phagocytosis, and natural killer (NK) cell activity. Spleen T lymphocytesubpopulations (by flow cytometry), serum cytokine and immunoglobulin levels (by multiplexsandwich immunoassays) were determined to evaluate how OOPs affected the immune system.Our results showed that OOPs could significantly improve innate and adaptive immune responsesin mice through the enhancement of cell-mediated and humoral immunity, macrophagephagocytosis capacity, and NK cell activity. We concluded that the immunomodulatory effectsmight be attributed to increased T and Th cell percentages, serum interferon (IFN)-γ, interleukin(IL)-1 α, IL-2, IL-6, IL-10, IL-12, tumor necrosis factor (TNF)- α, and granulocyte-macrophagecolony-stimulating factor (GM-CSF) secretions as well as immunoglobulin (Ig) A, IgG, and IgMproductions. These results indicate that dietary OOPs could be considered as promisingimmunomodulators with dosages ranging from 0.25 to 2.0 g/kg BW.

Ginseng (Panax ginseng Meyer) oligopeptides regulate innate and adaptive immune responses in mice via increased macrophage phagocytosis capacity, NK cell activity and Th cells secretion

2017 ◽  
Vol 8 (10) ◽  
pp. 3523-3532 ◽  
Author(s):  
Li-Xia He ◽  
Jin-Wei Ren ◽  
Rui Liu ◽  
Qi-He Chen ◽  
Jian Zhao ◽  
...  
Keyword(s):  
Immune Responses ◽  
Panax Ginseng ◽  
Nk Cell ◽  
Cell Activity ◽  
Nk Cell Activity ◽  
Adaptive Immune Responses ◽  
Th Cells ◽  
Adaptive Immune ◽  
Macrophage Phagocytosis

Traditionally used as a restorative medicine, ginseng (Panax ginseng Meyer) has been widely used and acclaimed herb in Chinese communities for thousands of years.

Effect of Jin Jiang Granules on Immune Function in Normal Mice

2013 ◽  
Vol 850-851 ◽  
pp. 1259-1262
Author(s):  
Ming San Miao ◽  
Rui Qi Li ◽  
Xue Xia Zhang
Keyword(s):  
Immune Function ◽  
Peripheral Blood ◽  
Blood Lymphocyte ◽  
Nk Cell ◽  
Early Stage ◽  
Cell Activity ◽  
Lymphocyte Transformation ◽  
Transformation Rate ◽  
Nk Cell Activity ◽  
Macrophage Phagocytosis

Objective: Explore the effect of functional food Jin Jiang granules on immune function in normal mice, to provide basis for Jin Jiang granules which are applied in early stage of cold. Methods: After normal mice were given to different doses of Jin Jiang granules, levels of peritoneal macrophage phagocytosis rate and indexes, thymus and spleen indexes, haemolysin, hemolytic plaque, peripheral blood lymphocyte transformation rate, NK cell activity were determined. Results: Compared with blank group, Jin Jiang granules can improve levels of peritoneal macrophage phagocytosis, organ indexes, haemolysin, hemolytic plaque, peripheral blood lymphocyte transformation rate, NK cell activity. Conclusion: Jin Jiang granules can improve the organisms immunity, relieve symptoms and promote recovery when applied in early stage of cold.

scholarly journals Varicella-Zoster Virus and Herpes Simplex Virus 1 Differentially Modulate NKG2D Ligand Expression during Productive Infection

2015 ◽  
Vol 89 (15) ◽  
pp. 7932-7943 ◽  
Author(s):  
Tessa M. Campbell ◽  
Brian P. McSharry ◽  
Megan Steain ◽  
Barry Slobedman ◽  
Allison Abendroth
Keyword(s):  
Nk Cells ◽  
Nk Cell ◽  
Cell Activity ◽  
Nkg2d Ligand ◽  
Nk Cell Activity ◽  
Herpes Simplex Virus 1 ◽  
Varicella Zoster ◽  
Ligand Expression ◽  
Simplex Virus ◽  
Hsv 1

ABSTRACTNatural killer (NK) cell-deficient patients are particularly susceptible to severe infection with herpesviruses, especially varicella-zoster virus (VZV) and herpes simplex virus 1 (HSV-1). The critical role that NK cells play in controlling these infections denotes an intricate struggle for dominance between virus and NK cell antiviral immunity; however, research in this area has remained surprisingly limited. Our study addressed this absence of knowledge and found that infection with VZV was not associated with enhanced NK cell activation, suggesting that the virus uses specific mechanisms to limit NK cell activity. Analysis of viral regulation of ligands for NKG2D, a potent activating receptor ubiquitously expressed on NK cells, revealed that VZV differentially modulates expression of the NKG2D ligands MICA, ULBP2, and ULBP3 by upregulating MICA expression while reducing ULBP2 and ULBP3 expression on the surface of infected cells. Despite being closely related to VZV, infection with HSV-1 produced a remarkably different effect on NKG2D ligand expression. A significant decrease in MICA, ULBP2, and ULBP3 was observed with HSV-1 infection at a total cellular protein level, as well as on the cell surface. We also demonstrate that HSV-1 differentially regulates expression of an additional NKG2D ligand, ULBP1, by reducing cell surface expression while total protein levels are unchanged. Our findings illustrate both a striking point of difference between two closely related alphaherpesviruses, as well as suggest a powerful capacity for VZV and HSV-1 to evade antiviral NK cell activity through novel modulation of NKG2D ligand expression.IMPORTANCEPatients with deficiencies in NK cell function experience an extreme susceptibility to infection with herpesviruses, in particular, VZV and HSV-1. Despite this striking correlation, research into understanding how these two alphaherpesviruses interact with NK cells is surprisingly limited. Through examination of viral regulation of ligands to the activating NK cell receptor NKG2D, we reveal patterns of modulation by VZV, which were unexpectedly varied in response to regulation by HSV-1 infection. Our study begins to unravel the undoubtedly complex interactions that occur between NK cells and alphaherpesvirus infection by providing novel insights into how VZV and HSV-1 manipulate NKG2D ligand expression to modulate NK cell activity, while also illuminating a distinct variation between two closely related alphaherpesviruses.

scholarly journals Normalized natural killer (NK) cell activity in long-term remission of acute leukaemia

1983 ◽  
Vol 55 (2) ◽  
pp. 305-309 ◽  
Author(s):  
Yasuhiro Yoda ◽  
Tsukasa Abe ◽  
Akio Tashiro ◽  
Shinsaku Hirosawa ◽  
Kenichi Kawada ◽  
...  
Keyword(s):  
Natural Killer ◽  
Acute Leukaemia ◽  
Nk Cell ◽  
Cell Activity ◽  
Nk Cell Activity

scholarly journals Immunosurveillance of Cancer and Viral Infections with Regard to Alterations of Human NK Cells Originating from Lifestyle and Aging

Biomedicines ◽  
2021 ◽  
Vol 9 (5) ◽  
pp. 557
Author(s):  
Xuewen Deng ◽  
Hiroshi Terunuma ◽  
Mie Nieda
Keyword(s):  
Nk Cells ◽  
Viral Infections ◽  
Nk Cell ◽  
Healthy Lifestyle ◽  
Cell Activity ◽  
Nk Cell Activity ◽  
Effector Cells ◽  
Cell Dysfunction ◽  
Forest Bathing ◽  
Infected Cells

Natural killer (NK) cells are cytotoxic immune cells with an innate capacity for eliminating cancer cells and virus- infected cells. NK cells are critical effector cells in the immunosurveillance of cancer and viral infections. Patients with low NK cell activity or NK cell deficiencies are predisposed to increased risks of cancer and severe viral infections. However, functional alterations of human NK cells are associated with lifestyles and aging. Personal lifestyles, such as cigarette smoking, alcohol consumption, stress, obesity, and aging are correlated with NK cell dysfunction, whereas adequate sleep, moderate exercise, forest bathing, and listening to music are associated with functional healthy NK cells. Therefore, adherence to a healthy lifestyle is essential and will be favorable for immunosurveillance of cancer and viral infections with healthy NK cells.

scholarly journals Selective and Potent CDK8/19 Inhibitors Enhance NK-Cell Activity and Promote Tumor Surveillance

2020 ◽  
Vol 19 (4) ◽  
pp. 1018-1030 ◽  
Author(s):  
Marco H. Hofmann ◽  
Rajeswaran Mani ◽  
Harald Engelhardt ◽  
Maria A. Impagnatiello ◽  
Sebastian Carotta ◽  
...  
Keyword(s):  
Nk Cell ◽  
Cell Activity ◽  
Nk Cell Activity ◽  
Tumor Surveillance

scholarly journals Potentiating NK cell activity by combination of Rosuvastatin and Difluoromethylornithine for effective chemopreventive efficacy against Colon Cancer

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Naveena B. Janakiram ◽  
Altaf Mohammed ◽  
Taylor Bryant ◽  
Yuting Zhang ◽  
Misty Brewer ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Nk Cell ◽  
Cell Activity ◽  
Nk Cell Activity
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