Ginseng (Panax ginseng Meyer) oligopeptides regulate innate and adaptive immune responses in mice via increased macrophage phagocytosis capacity, NK cell activity and Th cells secretion

2017 ◽  
Vol 8 (10) ◽  
pp. 3523-3532 ◽  
Author(s):  
Li-Xia He ◽  
Jin-Wei Ren ◽  
Rui Liu ◽  
Qi-He Chen ◽  
Jian Zhao ◽  
...  
Keyword(s):  
Immune Responses ◽  
Panax Ginseng ◽  
Nk Cell ◽  
Cell Activity ◽  
Nk Cell Activity ◽  
Adaptive Immune Responses ◽  
Th Cells ◽  
Adaptive Immune ◽  
Macrophage Phagocytosis

Traditionally used as a restorative medicine, ginseng (Panax ginseng Meyer) has been widely used and acclaimed herb in Chinese communities for thousands of years.

Solannm lyratum extract affected immune response in normal and leukemia murine animal in vivo

2010 ◽  
Vol 29 (5) ◽  
pp. 359-367 ◽  
Author(s):  
Jai-Sing Yang ◽  
Chia-Chun Wu ◽  
Chao-Lin Kuo ◽  
Chin-Chung Yeh ◽  
Fu-Shin Chueh ◽  
...  
Keyword(s):  
Immune Responses ◽  
Mononuclear Cells ◽  
Nk Cell ◽  
Folk Medicine ◽  
Cell Activity ◽  
Colon Adenocarcinoma ◽  
Target Cells ◽  
Peripheral Blood Mononuclear ◽  
Macrophage Phagocytosis

Solanum lyratum Thunberg (Solanaceae) has been used as a folk medicine for treating liver, lung and esophagus in the Chinese population. Our previous studies have shown that the crude extract of S. lyratum Thunberg (SLE) induced apoptosis in colo 205 human colon adenocarcinoma cells; however, there is no report to show SLE affect immune responses in vivo. In this study, the in vivo effects of SLE on leukemia WEHI-3 cells and immune responses such as phagocytosis and natural killer (NK) cell activity in normal and leukemia mice were investigated. The SLE treatment decreases surface markers of CD3 and Mac-3 in normal and leukemia mice but promoted the cell markers of CD19 and CD11b in normal mice and CD11b in leukemia mice indicating that the precursors of T cells was inhibited and B cells and macrophage were promoted. The SLE treatment promoted the activity of macrophage phagocytosis in the peripheral blood mononuclear cells (PBMC) and peritoneal cells from normal and leukemia mice. The results also showed that NK cells from the normal and leukemia mice after treatment with SLE can kill the YAC-1 target cells. Therefore, the SLE treatment increased macrophage and NK cell activities. These consistent results indicate SLE could be a potent immune responses agent.

Effect of Jin Jiang Granules on Immune Function in Normal Mice

2013 ◽  
Vol 850-851 ◽  
pp. 1259-1262
Author(s):  
Ming San Miao ◽  
Rui Qi Li ◽  
Xue Xia Zhang
Keyword(s):  
Immune Function ◽  
Peripheral Blood ◽  
Blood Lymphocyte ◽  
Nk Cell ◽  
Early Stage ◽  
Cell Activity ◽  
Lymphocyte Transformation ◽  
Transformation Rate ◽  
Nk Cell Activity ◽  
Macrophage Phagocytosis

Objective: Explore the effect of functional food Jin Jiang granules on immune function in normal mice, to provide basis for Jin Jiang granules which are applied in early stage of cold. Methods: After normal mice were given to different doses of Jin Jiang granules, levels of peritoneal macrophage phagocytosis rate and indexes, thymus and spleen indexes, haemolysin, hemolytic plaque, peripheral blood lymphocyte transformation rate, NK cell activity were determined. Results: Compared with blank group, Jin Jiang granules can improve levels of peritoneal macrophage phagocytosis, organ indexes, haemolysin, hemolytic plaque, peripheral blood lymphocyte transformation rate, NK cell activity. Conclusion: Jin Jiang granules can improve the organisms immunity, relieve symptoms and promote recovery when applied in early stage of cold.

scholarly journals Activating receptors promote NK cell expansion for maintenance, IL-10 production, and CD8 T cell regulation during viral infection

2009 ◽  
Vol 206 (10) ◽  
pp. 2235-2251 ◽  
Author(s):  
Seung-Hwan Lee ◽  
Kwang-Sin Kim ◽  
Nassima Fodil-Cornu ◽  
Silvia M. Vidal ◽  
Christine A. Biron
Keyword(s):  
T Cell ◽  
Immune Responses ◽  
Viral Infection ◽  
Nk Cells ◽  
Cell Expansion ◽  
Nk Cell ◽  
Cd8 T Cell ◽  
Adaptive Immune Responses ◽  
Adaptive Immune ◽  
Activating Receptors

Natural killer (NK) cells have the potential to deliver both direct antimicrobial effects and regulate adaptive immune responses, but NK cell yields have been reported to vary greatly during different viral infections. Activating receptors, including the Ly49H molecule recognizing mouse cytomegalovirus (MCMV), can stimulate NK cell expansion. To define Ly49H's role in supporting NK cell proliferation and maintenance under conditions of uncontrolled viral infection, experiments were performed in Ly49h−/−, perforin 1 (Prf1)−/−, and wild-type (wt) B6 mice. NK cell numbers were similar in uninfected mice, but relative to responses in MCMV-infected wt mice, NK cell yields declined in the absence of Ly49h and increased in the absence of Prf1, with high rates of proliferation and Ly49H expression on nearly all cells. The expansion was abolished in mice deficient for both Ly49h and Prf1 (Ly49h−/−Prf1−/−), and negative consequences for survival were revealed. The Ly49H-dependent protection mechanism delivered in the absence of Prf1 was a result of interleukin 10 production, by the sustained NK cells, to regulate the magnitude of CD8 T cell responses. Thus, the studies demonstrate a previously unappreciated critical role for activating receptors in keeping NK cells present during viral infection to regulate adaptive immune responses.

scholarly journals Herpesvirus Evasion of Natural Killer Cells

2018 ◽  
Vol 92 (11) ◽  
Author(s):  
Steffi De Pelsmaeker ◽  
Nicolas Romero ◽  
Massimo Vitale ◽  
Herman W. Favoreel
Keyword(s):  
Nk Cells ◽  
Natural Killer ◽  
Viral Infections ◽  
Nk Cell ◽  
Cell Activity ◽  
Adaptive Immune Response ◽  
Nk Cell Activity ◽  
Disease Symptoms ◽  
Adaptive Immune ◽  
Life Threatening

ABSTRACTNatural killer (NK) cells play an important role in the host response against viral infections and cancer development. They are able to kill virus-infected and tumor cells, and they produce different important cytokines that stimulate the antiviral and antitumor adaptive immune response, particularly interferon gamma. NK cells are of particular importance in herpesvirus infections, which is illustrated by systemic and life-threatening herpesvirus disease symptoms in patients with deficiencies in NK cell activity and by the myriad of reports describing herpesvirus NK cell evasion strategies. The latter is particularly obvious for cytomegaloviruses, but increasing evidence indicates that most, if not all, members of the herpesvirus family suppress NK cell activity to some extent. This review discusses the different NK cell evasion strategies described for herpesviruses and how this knowledge may translate to clinical applications.

Standardized extract of Tinospora crispa stimulates innate and adaptive immune responses in Balb/c mice

2016 ◽  
Vol 7 (3) ◽  
pp. 1380-1389 ◽  
Author(s):  
Waqas Ahmad ◽  
Ibrahim Jantan ◽  
Endang Kumolosasi ◽  
Syed Nasir Abbas Bukhari
Keyword(s):  
Nitric Oxide ◽  
Immune Responses ◽  
Peritoneal Macrophage ◽  
Delayed Type Hypersensitivity ◽  
Nitric Oxide Production ◽  
Adaptive Immune Responses ◽  
Adaptive Immune ◽  
Oxide Production ◽  
Macrophage Phagocytosis ◽  
Serum Lysozyme

Tinospora crispa extract exhibited immunostimulatory effects by promoting nitric oxide production ability, peritoneal macrophage phagocytosis, delayed type hypersensitivity, and enhancing serum immunoglobulins and serum lysozyme levels.

scholarly journals SARS-CoV-2 mRNA Vaccines: Immunological Mechanism and Beyond

Vaccines ◽  
2021 ◽  
Vol 9 (2) ◽  
pp. 147
Author(s):  
Emily Bettini ◽  
Michela Locci
Keyword(s):  
Immune Responses ◽  
B Cell ◽  
Clinical Studies ◽  
Rapid Development ◽  
Cell Activity ◽  
Effective Vaccine ◽  
Adaptive Immune Responses ◽  
Immunological Mechanism ◽  
Cell Responses ◽  
Adaptive Immune

To successfully protect against pathogen infection, a vaccine must elicit efficient adaptive immunity, including B and T cell responses. While B cell responses are key, as they can mediate antibody-dependent protection, T cells can modulate B cell activity and directly contribute to the elimination of pathogen-infected cells. In the unprecedented race to develop an effective vaccine for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of the respiratory disease coronavirus disease 2019 (COVID-19), messenger RNA (mRNA) vaccines have emerged as front runners thanks to their capacity for rapid development and ability to drive potent adaptive immune responses. In this review article, we provide an overview of the results from pre-clinical studies in animal models as well as clinical studies in humans that assessed the efficacy of SARS-CoV-2 mRNA vaccines, with a primary focus on adaptive immune responses post vaccination.

Lymphocytes and NK cell activity during repeated bouts of maximal exercise

1996 ◽  
Vol 271 (1) ◽  
pp. R222-R227 ◽  
Author(s):  
H. B. Nielsen ◽  
N. H. Secher ◽  
N. J. Christensen ◽  
B. K. Pedersen
Keyword(s):  
Immune Responses ◽  
Maximal Exercise ◽  
Nk Cell ◽  
Cell Activity ◽  
Neutrophilic Granulocytes ◽  
Nk Cell Activity ◽  
Blood Samples ◽  
Ergometer Rowing ◽  
Muscle Groups ◽  
Large Muscle

Effects on the immune system of 6-min “all-out” ergometer rowing were investigated over 2 days (2 x 3 bouts) in eight male oarsmen with a maximal oxygen uptake of 5.5 +/- 0.1 l/min (mean +/- SE). Blood samples were obtained before, during, and 2 h after each bout and on the day after the last bout. Compared with levels at rest, the first bout of exercise increased the concentration of leukocytes (2-fold); neutrophilic granulocytes (2-fold); lymphocytes (2-fold); monocytes (2-fold); the blood mononuclear cell (BMNC) subsets CD3+ (2-fold), CD4+ (2-fold), CD8+ (3-fold), CD16+ (8-fold), CD19+ (2-fold), and CD14+ (2-fold); the NK cell activity (2-fold); and plasma interleukin-6 (3-fold) (P < 0.05). During the last bout even higher levels were noted for leukocytes (3-fold); neutrophilic granulocytes (3-fold); lymphocytes (4-fold); the BMNC subsets CD4+ (3-fold), CD8+ (5-fold), CD16+ (13-fold), CD19+ (5-fold), and CD14+ (3-fold); and for the NK cell activity (4-fold) (P < 0.05). During the recovery periods all values were at or above the level at rest, and elevated concentrations of leukocytes (38%), neutrophilic granulocytes (48%), and lymphocytes (46%) reflected in the BMNC subsets and increased NK cell activity (119%) were also noted on the day after the last bout (P < 0.05). The results show that maximal exercise with large muscle groups provokes higher immune responses during repetitive bouts.

scholarly journals Chemokine Receptor Expression on Normal Blood CD56+NK-Cells Elucidates Cell Partners That Comigrate during the Innate and Adaptive Immune Responses and Identifies a Transitional NK-Cell Population

2015 ◽  
Vol 2015 ◽  
pp. 1-18 ◽  
Author(s):  
Margarida Lima ◽  
Magdalena Leander ◽  
Marlene Santos ◽  
Ana Helena Santos ◽  
Catarina Lau ◽  
...  
Keyword(s):  
Immune Responses ◽  
Nk Cells ◽  
Chemokine Receptors ◽  
Nk Cell ◽  
Cxcr4 Expression ◽  
Receptor Expression ◽  
Normal Blood ◽  
Adaptive Immune Responses ◽  
Adaptive Immune ◽  
Cd56 Expression

Studies of chemokine receptors (CKR) in natural killer- (NK-) cells have already been published, but only a few gave detailed information on its differential expression on blood NK-cell subsets. We report on the expression of the inflammatory and homeostatic CKR on normal bloodCD56+lowCD16+andCD56+high  CD16-/+lowNK-cells. ConventionalCD56+lowandCD56+highNK-cells present in the normal PB do express CKR for inflammatory cytokines, although with different patternsCD56+lowNK-cells are mainly CXCR1/CXCR2+and CXCR3/CCR5−/+, whereas mostlyCD56+highNK-cells are CXCR1/CXCR2−and CXCR3/CCR5+. Both NK-cell subsets have variable CXCR4 expression and are CCR4−and CCR6−. The CKR repertoire of theCD56+lowNK-cells approaches to that of neutrophils, whereas the CKR repertoire of theCD56+highNK-cells mimics that of Th1+T cells, suggesting that these cells are prepared to migrate into inflamed tissues at different phases of the immune response. In addition, we describe a subpopulation of NK-cells with intermediate levels of CD56 expression, which we namedCD56+intNK-cells. These NK-cells are CXCR3/CCR5+, they have intermediate levels of expression of CD16, CD62L, CD94, and CD122, and they are CD57−and CD158a−. In view of their phenotypic features, we hypothesize that they correspond to a transitional stage, between the well-knownCD56+highandCD56+lowNK-cells populations.

scholarly journals Naked Oat (Avena nuda L.) Oligopeptides: Immunomodulatory Effects on Innate and Adaptive Immunity in Mice via Cytokine Secretion, Antibody Production, and Th Cells Stimulation

Nutrients ◽  
2019 ◽  
Vol 11 (4) ◽  
pp. 927 ◽  
Author(s):  
Mao ◽  
Wu ◽  
Zhu ◽  
Liu ◽  
Liu ◽  
...  
Keyword(s):  
Nk Cell ◽  
Cell Activity ◽  
Immunomodulatory Activity ◽  
Intragastric Administration ◽  
Nk Cell Activity ◽  
Water Control ◽  
Naked Oat ◽  
Macrophage Phagocytosis ◽  
Th Cell ◽  
Avena Nuda

The study aimed to investigate the immunomodulatory activity of oligopeptides derivedfrom oat (Avena Nuda L.) (OOPs). Healthy female BALB/c mice were randomly assigned to fivegroups, given deionized water (control) and 0.25, 0.5, 1.0, and 2.0 g/kg body weight (BW) of OOPsdaily by intragastric administration. Seven assays were performed to determine theimmunomodulatory effects of OOPs on immune organ ratios, cellular and humoral immuneresponses, macrophage phagocytosis, and natural killer (NK) cell activity. Spleen T lymphocytesubpopulations (by flow cytometry), serum cytokine and immunoglobulin levels (by multiplexsandwich immunoassays) were determined to evaluate how OOPs affected the immune system.Our results showed that OOPs could significantly improve innate and adaptive immune responsesin mice through the enhancement of cell-mediated and humoral immunity, macrophagephagocytosis capacity, and NK cell activity. We concluded that the immunomodulatory effectsmight be attributed to increased T and Th cell percentages, serum interferon (IFN)-γ, interleukin(IL)-1 α, IL-2, IL-6, IL-10, IL-12, tumor necrosis factor (TNF)- α, and granulocyte-macrophagecolony-stimulating factor (GM-CSF) secretions as well as immunoglobulin (Ig) A, IgG, and IgMproductions. These results indicate that dietary OOPs could be considered as promisingimmunomodulators with dosages ranging from 0.25 to 2.0 g/kg BW.

scholarly journals T and NK Cell-Based Immunotherapy in Chronic Viral Hepatitis and Hepatocellular Carcinoma

Cells ◽  
2022 ◽  
Vol 11 (2) ◽  
pp. 180
Author(s):  
Paola Fisicaro ◽  
Carolina Boni
Keyword(s):  
Hepatocellular Carcinoma ◽  
T Cells ◽  
Immune Responses ◽  
Viral Hepatitis ◽  
Nk Cell ◽  
Chronic Viral Hepatitis ◽  
Regulatory Activity ◽  
Adaptive Immune Responses ◽  
Pathogenetic Role ◽  
Adaptive Immune

In chronic viral hepatitis and in hepatocarcinoma (HCC), antigen-specific T cells are deeply exhausted, and evidence of dysfunction has also been observed for NK cells, which can play a pathogenetic role, exerting a regulatory activity on adaptive immune responses [...]

Sign in / Sign up

Export Citation Format

Share Document