scholarly journals Divergent Changes in Plasma AGEs and sRAGE Isoforms Following an Overnight Fast in T1DM

Nutrients ◽  
2019 ◽  
Vol 11 (2) ◽  
pp. 386 ◽  
Author(s):  
Edwin Miranda ◽  
Kelly Fuller ◽  
Ryan Perkins ◽  
Paul Beisswenger ◽  
Sarah Farabi ◽  
...  
Keyword(s):  
Diabetic Complications ◽  
Energy Restriction ◽  
Short Term ◽  
Metabolic Substrates ◽  
Soluble Rage ◽  
Glycation End Products ◽  
Before And After ◽  
Term Energy ◽  
Endogenous Secretory Rage

Advanced glycation end products (AGEs) promote the development of diabetic complications through activation of their receptor (RAGE). Isoforms of soluble RAGE (sRAGE) sequester AGEs and protect against RAGE-mediated diabetic complications. We investigated the effect of an overnight fast on circulating metabolic substrates, hormones, AGEs, and sRAGE isoforms in 26 individuals with type 1 diabetes (T1DM). Blood was collected from 26 young (18–30 years) T1DM patients on insulin pumps before and after an overnight fast. Circulating AGEs were measured via LC-MS/MS and sRAGE isoforms were analyzed via ELISA. Glucose, insulin, glucagon, and eGFRcystatin-c decreased while cortisol increased following the overnight fast (p < 0.05). AGEs (CML, CEL, 3DG-H, MG-H1, and G-H1) decreased (21–58%, p < 0.0001) while total sRAGE, cleaved RAGE (cRAGE), and endogenous secretory RAGE (esRAGE) increased (22–24%, p < 0.0001) following the overnight fast. The changes in sRAGE isoforms were inversely related to MG-H1 (rho = −0.493 to −0.589, p < 0.05) and the change in esRAGE was inversely related to the change in G-H1 (rho = −0.474, p < 0.05). Multiple regression analyses revealed a 1 pg/mL increase in total sRAGE, cRAGE, or esRAGE independently predicted a 0.42–0.52 nmol/L decrease in MG-H1. Short-term energy restriction via an overnight fast resulted in increased sRAGE isoforms and may be protective against AGE accumulation.

Abstract #1004271: The Effect of Short-term Energy Restriction on Appetite

2021 ◽  
Vol 27 (6) ◽  
pp. S82-S83
Author(s):  
Chinelo C. Okigbo ◽  
Joselyne Tessa Tonleu ◽  
Skand Shekhar ◽  
Helen F. Leka ◽  
Anne E. Kim ◽  
...  
Keyword(s):  
Energy Restriction ◽  
Short Term ◽  
Term Energy

Short-term energy restriction during late gestation of beef cows decreases postweaning calf humoral immune response to vaccination1

2016 ◽  
Vol 94 (6) ◽  
pp. 2542-2552 ◽  
Author(s):  
P. Moriel ◽  
M. B. Piccolo ◽  
L. F. A. Artioli ◽  
R. S. Marques ◽  
M. H. Poore ◽  
...  
Keyword(s):  
Immune Response ◽  
Humoral Immune Response ◽  
Beef Cows ◽  
Energy Restriction ◽  
Late Gestation ◽  
Short Term ◽  
Humoral Immune ◽  
Term Energy

scholarly journals Endogenous secretory RAGE but not soluble RAGE is associated with carotid atherosclerosis in type 1 diabetes patients

2008 ◽  
Vol 5 (3) ◽  
pp. 190-197 ◽  
Author(s):  
Naoto Katakami ◽  
Munehide Matsuhisa ◽  
Hideaki Kaneto ◽  
Taka-Aki Matsuoka ◽  
Ken'Ya Sakamoto ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Carotid Atherosclerosis ◽  
Soluble Rage ◽  
Endogenous Secretory Rage ◽  
Diabetes Patients

Short-term energy restriction reduces resting energy expenditure in patients with HIV lipodystrophy and hypermetabolism

Metabolism ◽  
2007 ◽  
Vol 56 (2) ◽  
pp. 289-295 ◽  
Author(s):  
Lisa A. Kosmiski ◽  
Daniel H. Bessesen ◽  
Sarah A. Stotz ◽  
John R. Koeppe ◽  
Tracy J. Horton
Keyword(s):  
Energy Expenditure ◽  
Resting Energy Expenditure ◽  
Energy Restriction ◽  
Short Term ◽  
Term Energy ◽  
Hiv Lipodystrophy ◽  
Resting Energy

scholarly journals Expansion of Functional Regulatory T Cells Using Soluble RAGE Prevents Type 1 Diabetes

2020 ◽  
Author(s):  
Sherman S. Leung ◽  
Danielle J. Borg ◽  
Domenica A. McCarthy ◽  
Tamar E. Boursalian ◽  
Justen Cracraft ◽  
...  
Keyword(s):  
T Cells ◽  
Type 1 Diabetes ◽  
Regulatory T Cells ◽  
Soluble Rage ◽  
Human T Cells ◽  
Glycation End Products ◽  
Term Administration ◽  
Pancreatic Lymph Nodes ◽  
And Function

AbstractType 1 diabetes (T1D) is an autoimmune disease with no cure. Therapeutic translation has been hampered by preclinical reproducibility. Here, short-term administration of an antagonist to the receptor for advanced glycation end products (sRAGE) protected against murine diabetes at two independent centers. Treatment with sRAGE increased regulatory T cells (Tregs) within islets, pancreatic lymph nodes and spleen, increasing islet insulin expression and function. Diabetes protection was abrogated by Treg depletion and shown to be dependent on antagonizing RAGE using knockout mice. Human Tregs treated with a RAGE ligand downregulated genes for suppression, migration and Treg homeostasis (FOXP3, IL7R, TIGIT, JAK1, STAT3, STAT5b, CCR4). Loss of suppressive function was reversed by sRAGE, where Tregs increased proliferation and suppressed conventional T cell division, confirming that sRAGE expands functional human Tregs. These results highlight sRAGE as an attractive treatment to prevent diabetes, showing efficacy at multiple research centers and in human T cells.

scholarly journals Specific features of pregnancy in patients with type 1 diabetes in the prepubertal period. Results of a 15-year long clinical observation

2009 ◽  
Vol 12 (4) ◽  
pp. 28-31
Author(s):  
Lyubov' Leonidovna Bolotskaya ◽  
Natalya Vladimirovna Efremova ◽  
Yury Ivanovich Suntsov
Keyword(s):  
Type 1 Diabetes ◽  
Diabetic Complications ◽  
Insulin Dose ◽  
Research Centre ◽  
Nocturnal Hypoglycemia ◽  
Significant Difference ◽  
Before And After ◽  
Pregnancy And Delivery ◽  
The Difference

Aim. To evaluate effect of different factors on pregnancy course in patients with type 1 diabetes mellitus developing in the prepubertal period. Materials and methods. The study based at Endocrinological Research Centre included 77 women with prepubertal diabetes 18 of whom developedpregnancy that ended in delivery. Results. As per 2009, the age of the patients is 26,6?4,6 years. They became pregnant at 23,2?3,3 years and had had diabetes since the age of9,6?4,8 years. Their HbA1c level before and after pregnancy was 8,6?1,4 and 6,8?1,6% respectively, the difference being insignificant (p=0,3).Significant difference was documented between these HbA1c levels and that during pregnancy (p=0,0004 and 0.003 respectively). Nine (56,2%) patientsused ultrashort-acting insulin analogs and the remaining 7 (43,7%) recombinant human insulins. The mean insulin dose was 43,7?11 U/din the 1st trimester, 51,8?13,7 U/d in the 2bd trimester, and 45,3?10,8 U/d after delivery. 16 (88%) of the patients reported frequent hypoglycemia,five (27,8%) of them had episodes of severe daytime and nocturnal hypoglycemia. 11 (61%) developed microvascular diabetic complications beforepregnancy, with 9 (50%) having DR and 4 (22,2%) DN (microalbuminuria). The delivery occurred on weeks 36-37 in 7 (38,9%) women. Naturaland cesarean section deliveries took place in one and 17 (94,4%) patients respectively. Conclusion. Long-term follow-up of patients wit DM1 in accordance with algorithms of specialized medical aid to DM1 patients in Russia at a multidisciplinaryendocrinological centre decreases the risk of pregnancy and delivery complications and that of microvascular diabetic complications

Chewing gum increases energy expenditure before and after controlled breakfasts

2015 ◽  
Vol 40 (4) ◽  
pp. 401-406 ◽  
Author(s):  
Daniel L. Kresge ◽  
Kathleen Melanson
Keyword(s):  
Blood Glucose ◽  
Energy Expenditure ◽  
Respiratory Exchange Ratio ◽  
Short Term ◽  
Gum Chewing ◽  
Energy Needs ◽  
Increase Energy Expenditure ◽  
Before And After ◽  
Term Energy ◽  
Randomized Crossover Study

Chewing has been associated with improved satiation and satiety, but little is known about the metabolic impact of gum chewing. We tested the hypothesis that gum chewing would increase energy expenditure (EE) and reduce respiratory exchange ratio (RER) before and after a controlled test meal. Seventeen males and 13 females (age 21.5 ± 6.6 years, body mass index 23.9 ± 2.8 kg/m2) participated in a randomized crossover study in which subjects chewed sugar-free gum for a total of 1 h (3 sessions of 20 min) on the test day (GC) and did not chew gum on a control day (NG). EE and RER were measured by indirect calorimetry after an overnight fast. Subjects consumed a breakfast shake containing 30% of their measured energy needs, and then postprandial EE and RER were measured for 3 h. Blood glucose (GLC) was measured in the fasting and postprandial states at regular intervals. Fasting EE was higher during GC (1.23 ± 0.04 kcal/min; 1 kcal = 4.2 kJ) than during NG (1.17 ± 0.04 kcal/min; p = 0.016). Postprandial EE was also higher during GC (1.46 ± 0.05 kcal/min) than during NG (1.42 ± 0.05 kcal/min; p = 0.037). Fasting and postprandial RER and GLC did not differ between GC and NG. The findings demonstrate that GC is associated with higher fasting and postprandial EE without altering blood glucose or substrate oxidation as measured by RER. These data suggest that gum chewing potentially could influence short-term energy balance in this population; however, longer-term research is needed.

Sign in / Sign up

Export Citation Format

Share Document