scholarly journals Sialylated Oligosaccharides and Glycoconjugates of Human Milk. The Impact on Infant and Newborn Protection, Development and Well-Being

Nutrients ◽  
2019 ◽  
Vol 11 (2) ◽  
pp. 306 ◽  
Author(s):  
Jolanta Lis-Kuberka ◽  
Magdalena Orczyk-Pawiłowicz
Keyword(s):  
Human Milk ◽  
Well Being ◽  
Cellular Level ◽  
Biologically Active ◽  
Current State ◽  
Wide Range ◽  
The Impact ◽  
Active Effects ◽  
Immunological System ◽  
Immature Immune System

Human milk not only has nutritional value, but also provides a wide range of biologically active molecules, which are adapted to meet the needs of newborns and infants. Mother’s milk is a source of sialylated oligosaccharides and glycans that are attached to proteins and lipids, whose concentrations and composition are unique. Sialylated human milk glycoconjugates and oligosaccharides enrich the newborn immature immune system and are crucial for their proper development and well-being. Some of the milk sialylated oligosaccharide structures can locally exert biologically active effects in the newborn’s and infant’s gut. Sialylated molecules of human milk can be recognized and bound by sialic acid-dependent pathogens and inhibit their adhesion to the epithelial cells of newborns and infants. A small amount of intact sialylated oligosaccharides can be absorbed from the intestine and remain in the newborn’s circulation in concentrations high enough to modulate the immunological system at the cellular level and facilitate proper brain development during infancy. Conclusion: The review summarizes the current state of knowledge on sialylated human milk oligosaccharides and glycoconjugates, discusses the significance of sialylated structures of human milk in newborn protection and development, and presents the advantages of human milk over infant formula.

scholarly journals The Impact of Dietary Fucosylated Oligosaccharides and Glycoproteins of Human Milk on Infant Well-Being

Nutrients ◽  
2020 ◽  
Vol 12 (4) ◽  
pp. 1105 ◽  
Author(s):  
Magdalena Orczyk-Pawiłowicz ◽  
Jolanta Lis-Kuberka
Keyword(s):  
Human Milk ◽  
Infant Nutrition ◽  
Feeding Strategy ◽  
Well Being ◽  
Human Milk Oligosaccharides ◽  
Adhesive Properties ◽  
Milk Oligosaccharides ◽  
Wide Range ◽  
Carbohydrate Components ◽  
The Impact

Apart from optimal nutritional value, human milk is the feeding strategy to support the immature immunological system of developing newborns and infants. The most beneficial dietary carbohydrate components of breast milk are human milk oligosaccharides (HMOs) and glycoproteins (HMGs), involved in both specific and nonspecific immunity. Fucosylated oligosaccharides represent the largest fraction of human milk oligosaccharides, with the simplest and the most abundant being 2′-fucosyllactose (2′-FL). Fucosylated oligosaccharides, as well as glycans of glycoproteins, as beneficial dietary sugars, elicit anti-adhesive properties against fucose-dependent pathogens, and on the other hand are crucial for growth and metabolism of beneficial bacteria, and in this aspect participate in shaping a healthy microbiome. Well-documented secretor status related differences in the fucosylation profile of HMOs and HMGs may play a key but underestimated role in assessment of susceptibility to fucose-dependent pathogen infections, with a potential impact on applied clinical procedures. Nevertheless, due to genetic factors, about 20% of mothers do not provide their infants with beneficial dietary carbohydrates such as 2′-FL and other α1,2-fucosylated oligosaccharides and glycans of glycoproteins, despite breastfeeding them. The lack of such structures may have important implications for a wide range of aspects of infant well-being and healthcare. In light of the above, some artificial mixtures used in infant nutrition are supplemented with 2′-FL to more closely approximate the unique composition of maternal milk, including dietary-derived fucosylated oligosaccharides and glycoproteins.

Religion and Medicine

2020 ◽  
Author(s):  
Jeff Levin ◽  
Stephen G. Post
Keyword(s):  
Clinical Decision Making ◽  
Well Being ◽  
Clinical Decision ◽  
Religion And Medicine ◽  
Physical And Mental Health ◽  
Faith Based ◽  
Baylor University ◽  
Wide Range ◽  
History Of ◽  
The Impact

In Religion and Medicine, Dr. Jeff Levin, distinguished Baylor University epidemiologist, outlines the longstanding history of multifaceted interconnections between the institutions of religion and medicine. He traces the history of the encounter between these two institutions from antiquity through to the present day, highlighting a myriad of contemporary alliances between the faith-based and medical sectors. Religion and Medicine tells the story of: religious healers and religiously branded hospitals and healthcare institutions; pastoral professionals involved in medical missions, healthcare chaplaincy, and psychological counseling; congregational health promotion and disease prevention programs and global health initiatives; research studies on the impact of religious and spiritual beliefs and practices on physical and mental health, well-being, and healing; programs and centers for medical research and education within major universities and academic institutions; religiously informed bioethics and clinical decision-making; and faith-based health policy initiatives and advocacy for healthcare reform. Religion and Medicine is the first book to cover the full breadth of this subject. It documents religion-medicine alliances across religious traditions, throughout the world, and over the course of history. It summarizes a wide range of material of relevance to historians, medical professionals, pastors and theologians, bioethicists, scientists, public health educators, and policymakers. The product of decades of rigorous and focused research, Dr. Levin has produced the most comprehensive history of these developments and the finest introduction to this emerging field of scholarship.

scholarly journals Climate-dependent propagation of precipitation uncertainty into the water cycle

2020 ◽  
Author(s):  
Ali Fallah ◽  
Sungmin O ◽  
Rene Orth
Keyword(s):  
Hydrological Model ◽  
Water Cycle ◽  
State Of The Art ◽  
Rain Gauge ◽  
Multiple Sources ◽  
Current State ◽  
Wide Range ◽  
The Impact ◽  
Conceptual Hydrological Model

Abstract. Precipitation is a crucial variable for hydro-meteorological applications. Unfortunately, rain gauge measurements are sparse and unevenly distributed, which substantially hampers the use of in-situ precipitation data in many regions of the world. The increasing availability of high-resolution gridded precipitation products presents a valuable alternative, especially over gauge-sparse regions. Nevertheless, uncertainties and corresponding differences across products can limit the applicability of these data. This study examines the usefulness of current state-of-the-art precipitation datasets in hydrological modelling. For this purpose, we force a conceptual hydrological model with multiple precipitation datasets in > 200 European catchments. We consider a wide range of precipitation products, which are generated via (1) interpolation of gauge measurements (E-OBS and GPCC V.2018), (2) combination of multiple sources (MSWEP V2) and (3) data assimilation into reanalysis models (ERA-Interim, ERA5, and CFSR). For each catchment, runoff and evapotranspiration simulations are obtained by forcing the model with the various precipitation products. Evaluation is done at the monthly time scale during the period of 1984–2007. We find that simulated runoff values are highly dependent on the accuracy of precipitation inputs, and thus show significant differences between the simulations. By contrast, simulated evapotranspiration is generally much less influenced. The results are further analysed with respect to different hydro-climatic regimes. We find that the impact of precipitation uncertainty on simulated runoff increases towards wetter regions, while the opposite is observed in the case of evapotranspiration. Finally, we perform an indirect performance evaluation of the precipitation datasets by comparing the runoff simulations with streamflow observations. Thereby, E-OBS yields the best agreement, while furthermore ERA5, GPCC V.2018 and MSWEP V2 show good performance. In summary, our findings highlight a climate-dependent propagation of precipitation uncertainty through the water cycle; while runoff is strongly impacted in comparatively wet regions such as Central Europe, there are increasing implications on evapotranspiration towards drier regions.

scholarly journals Impact of family social support on psychological wellbeing of infertile women attending Yusuf Dantsoho Memorial Hospital, Kaduna, Nigeria

2020 ◽  
Vol 3 (1) ◽  
Author(s):  
Abubakar R ◽  
Zubairu HD ◽  
Yohanna S
Keyword(s):  
Social Support ◽  
Psychological Distress ◽  
Well Being ◽  
Social Consequences ◽  
Psychological Wellbeing ◽  
Memorial Hospital ◽  
Infertile Women ◽  
Family Social Support ◽  
Wide Range ◽  
The Impact

Infertility could be a life crisis with a wide range of socio-cultural and emotional problems. These social consequences are usually not voluntarily disclosed by the affected women and consequently do not receive adequate attention so the women continue to suffer in silence. The study aimed to determine the impact of family social support on psychological well-being of infertile women attending Yusuf Dantsoho Memorial Hospital (YDMH), Kaduna. The study was a cross sectional study conducted at the YDMH, T/Wada, Kaduna. Two hundred and fifty-four women who presented to the gynecology clinic during the study period and consented to participate in the study were recruited consecutively. Data on socio-demographics and family social support were determined using a self-structured questionnaire. Psychological wellbeing was assessed using a General Health Questioner. Data was analyzed using EPI-INFO statistical package. Majority of the participants were Northerners (70.1%), Muslims (91.7%), and Unemployed (52.8%) with an average monthly income of less than N 20,000 (73.6%). Most were within the age group of 25–30 years (40.2%) and from monogamous families (70.1%) with most families having 0–5 children (89.4%). 67.7% of the participants had adequate social support from their husbands as against 32.3% who had inadequate support (such as availability of financial, support encouragement, concern and sense of social belonging). Only 33.5% had adequate social support from their in-laws while majority of them (66.5%) had inadequate social support. A total of 203 (79.9%) of the participants had psychological distress (self-administered questioner) while 51 (20.1%) had no psychological distress. Husbands and in-laws support were significantly related to psychological wellbeing of the infertile women. Adequate social support provided by family members reduces stress, improves psychological wellbeing and quality of life of infertile women.

8. Behaviour in the macroeconomy

2017 ◽  
pp. 100-115
Author(s):  
Michelle Baddeley
Keyword(s):  
Psychological Factors ◽  
Well Being ◽  
Personality Types ◽  
Behavioural Economics ◽  
Macroeconomic Fluctuations ◽  
Wide Range ◽  
The Impact

Behavioural macroeconomics has significant constraints, reflecting the difficulty of bringing together the choices of different people with widely different personality types, moods, and emotions, making decisions in complex ways using a wide range of heuristics that generate an even wider range of biases. ‘Behaviour in the macroeconomy’ explores how behavioural economists can overcome these difficulties, contributing to the development of innovative macroeconomic theories and collection of new types of behavioural macroeconomic data. It focuses on how social and psychological factors, including optimism and pessimism, help us to understand macroeconomic fluctuations; the impact of confidence and social mood on macroeconomic outcomes; and another theme in behavioural economics—happiness and well-being.

scholarly journals The Potential Therapeutic Value of Medicinal Plants in the Management of Metabolic Disorders

Molecules ◽  
2020 ◽  
Vol 25 (11) ◽  
pp. 2669 ◽  
Author(s):  
Trevor T. Nyakudya ◽  
Thulani Tshabalala ◽  
Rachael Dangarembizi ◽  
Kennedy H. Erlwanger ◽  
Ashwell R. Ndhlala
Keyword(s):  
Risk Factors ◽  
Medicinal Plants ◽  
South African ◽  
Health Benefits ◽  
Well Being ◽  
High Energy ◽  
Biologically Active ◽  
Potential Health ◽  
Increased Risk ◽  
The Impact

Metabolic syndrome (MetS) is a prevalent, multifactorial and complex disease that is associated with an increased risk of developing diabetes and other major cardiovascular complications. The rise in the global prevalence of MetS has been attributed to genetic, epigenetic, and environmental factors. The adoption of sedentary lifestyles that are characterized by low physical activity and the consumption of high-energy diets contributes to MetS development. Current management criteria for MetS risk factors involve changes in lifestyle and the use of pharmacological agents that target specific biochemical pathways involved in the metabolism of nutrients. Pharmaceutical drugs are usually expensive and are associated with several undesirable side effects. Alternative management strategies of MetS risk factors involve the use of medicinal plants that are considered to have multiple therapeutic targets and are easily accessible. Medicinal plants contain several different biologically active compounds that provide health benefits. The impact of phytochemicals present in local medicinal plants on sustainable health and well-being of individuals has been studied for many years and found to involve a plethora of complex biochemical, metabolic, and physiological mechanisms. While some of these phytochemicals are the basis of mainstream prescribed drugs (e.g., metformin, reserpine, quinine, and salicin), there is a need to identify more medicinal plants that can be used for the management of components of MetS and to describe their possible mechanisms of action. In this review, we assess the potential health benefits of South African ethnomedicinal plants in protecting against the development of health outcomes associated with MetS. We aim to provide the state of the current knowledge on the use of medicinal plants and their therapeutically important phytochemicals by discussing the current trends, with critical examples from recent primary references of how medicinal plants are being used in South African rural and urban communities.

Interactions between human behaviour and the built environment in terms of facility management

Facilities ◽  
2018 ◽  
Vol 36 (1/2) ◽  
pp. 2-12 ◽  
Author(s):  
Darja Kobal Grum
Keyword(s):  
Built Environment ◽  
Low Income ◽  
Well Being ◽  
Human Behaviour ◽  
Natural Environments ◽  
Psychological Well Being ◽  
Content Type ◽  
Sustainable Solutions ◽  
Wide Range ◽  
The Impact

Purpose In comparison with the relations between the human and natural environments that have been the central focus of environmental psychology for many years, the interactions between the psychological processes underlying human behaviour and the built environment have only recently regained the interest of researchers. In this paper, the author first discusses the reasons for the slower development of human – built environment relations. Afterwards, the author systematically examines the impact that the research of environmental stress, namely, poor housing and poor neighbourhood quality, had on the contemporary understanding of human – built environment relations. Design/methodology/approach The author focuses on social, biophilic and evidence-based design. The author proposes deeper psychological engagement in correlation with human behaviour, psychological well-being and society. The author highlights the inclusion of psychologists in interdisciplinary research teams addressing the development of sustainable solutions to the issues of residential environments. Findings It has been shown that substandard house quality, high noise, lack of natural light in houses, poorer physical quality of urban neighbourhoods, living in a low-income neighbourhood, etc. are linked to elevated physiological and psychological stress. Despite this evidence, there is still a gap between building designers and building users in modern industrialised societies, which could deepen tenants’ dissatisfaction due to specific behavioural needs and consequently lower their psychological well-being and health risk behaviour. Research limitations/implications These are potential risks of error arising from the use of assumptions, limited samples size and data from the secondary resources. Originality/value The major contributions of this paper are as follows. If the environment is understood as a dynamic, constantly changing and complex system of a wide range of players, the author can discern in this environment a dynamic that is otherwise characteristic of emotional dynamics. Expressed participants’ high satisfaction with residential status does not necessarily generate high expectations regarding real estate factors.

scholarly journals Speech synthesis systems: disadvantages and limitations

2018 ◽  
Vol 7 (2.28) ◽  
pp. 234 ◽  
Author(s):  
Karolina Kuligowska ◽  
Paweł Kisielewicz ◽  
Aleksandra Włodarz
Keyword(s):  
Text Analysis ◽  
Speech Synthesis ◽  
Analysis Problem ◽  
Current State ◽  
Wide Range ◽  
Current Classification ◽  
Weak Points ◽  
The Impact ◽  
Further Development ◽  
Insight Into

The present speech synthesis systems can be successfully used for a wide range of diverse purposes. However, there are serious and important limitations in using various synthesizers. Many of these problems can be identified and resolved. The aim of this paper is to present the current state of development of speech synthesis systems and to examine their drawbacks and limitations. The paper dis-cusses the current classification, construction and functioning of speech synthesis systems, which gives an insight into synthesizers implemented so far. The analysis of disadvantages and limitations of speech synthesis systems focuses on identification of weak points of these systems, namely: the impact of emotions and prosody, spontaneous speech in terms of naturalness and intelligibility, preprocessing and text analysis, problem of ambiguity, natural sounding, adaptation to the situation, variety of systems, sparsely spoken languages, speech synthesis for older people, and some other minor limitations. Solving these problems stimulates further development of speech synthesis domain. 

Yes, But

2016 ◽  
Vol 40 (4) ◽  
pp. 504-517 ◽  
Author(s):  
Laina Y. Bay-Cheng ◽  
Anne E. Bruns
Keyword(s):  
Young Women ◽  
Low Income ◽  
Well Being ◽  
Gender Inequalities ◽  
Sexual Experiences ◽  
Unwanted Sex ◽  
Unwanted Sexual Experiences ◽  
Wide Range ◽  
Almost All ◽  
The Impact

Reflecting the wide range of consensual unwanted sexual experiences, researchers often have contrasting views of the impact of these incidents on young women. Some scholars support a normalizing view of these as fairly harmless and ordinary aspects of relationships, akin to other forms of willing compromises between partners. Other researchers problematize unwanted sexual experiences, framing them in terms of gender inequalities and detrimental effects. In the current study, we were interested in how young women themselves characterized their unwanted sexual experiences and whether these accounts varied according to a woman’s social location. We interviewed 41 young women (18–22 years old) from three groups: affluent undergraduates, low-income undergraduates, and low-income nonstudents. Almost all of the affluent undergraduates framed their unwanted sexual experiences in normalizing terms, representing such events as relatively harmless incidents and outgrowths of developmental experimentation. In contrast, the low-income students and nonstudents both articulated more ambivalent positions and were more inclined to link their experience to sources of vulnerability, including personal adversity (e.g., trauma, social, and material insecurity) and social norms and stigma. Participants’ sexual histories, life circumstances, and standpoints at the intersection of gender and class were reflected in their experiences of unwanted sex, reinforcing that contextualized analyses and interventions are essential to advancing women’s sexual rights and well-being. Online slides for instructors who want to use this article for teaching are available on PWQ 's website at http://pwq.sagepub.com/supplemental

scholarly journals A Modified Version of the Transactional Stress Concept According to Lazarus and Folkman Was Confirmed in a Psychosomatic Inpatient Sample

2021 ◽  
Vol 12 ◽  
Author(s):  
Nina Obbarius ◽  
Felix Fischer ◽  
Gregor Liegl ◽  
Alexander Obbarius ◽  
Matthias Rose
Keyword(s):  
Health Status ◽  
Stress Response ◽  
Well Being ◽  
Personal Resources ◽  
Stress Model ◽  
Psychological Well Being ◽  
Wide Range ◽  
Reported Health ◽  
Self Reported Health Status ◽  
The Impact

BackgroundStress is a major risk factor for the impairment of psychological well-being. The present study aimed to evaluate the empirical evidence of the Transactional Stress Model proposed by Lazarus and Folkman in patients with psychosomatic health conditions.MethodsA structural equation model was applied in two separate subsamples of inpatients from the Department of Psychosomatic Medicine (total n = 2,216) for consecutive model building (sample 1, n = 1,129) and confirmatory analyses (sample 2, n = 1,087) using self-reported health status information about perceived stress, personal resources, coping mechanisms, stress response, and psychological well-being.ResultsThe initial model was created to reflect the theoretical assumptions by Lazarus and Folkman about their transactional stress concept. This model was modified until a sufficient model fit was reached (sample 1: CFI = 0.904, TLI = 0.898, RMSEA = 0.072 [0.071–0.074], SRMR = 0.061). The modified model was confirmed in a second sample (sample 2: CFI = 0.932, TLI = 0.928, RMSEA = 0.066 [0.065–0.068], SRMR = 0.052). Perceived external stressors and personal resources explained 91% of the variance of the stress response, which was closely related to symptoms of depression (63% variance explained). The attenuating effect of resources on stress response was higher (standardized β = -0.73, p < 0.001) than the impact of perceived stressors on stress response (standardized β = 0.34, p < 0.001).ConclusionThe empirical data largely confirmed the theoretical assumption of the Transactional Stress Model, which was first presented by Lazarus and Folkman, in patients with a wide range of psychosomatic conditions. However, data analyses were solely based on self-reported health status. Thus, proposed inner psychological mechanisms such as the appraisal process could not be included in this empirical validation. The operationalization and understanding of coping processes should be further improved.

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