scholarly journals Quantifying Sweet Taste Liker Phenotypes: Time for Some Consistency in the Classification Criteria

Nutrients ◽  
2019 ◽  
Vol 11 (1) ◽  
pp. 129 ◽  
Author(s):  
Vasiliki Iatridi ◽  
John Hayes ◽  
Martin Yeomans
Keyword(s):  
Cluster Analysis ◽  
Young Adults ◽  
Hierarchical Cluster ◽  
Sweet Taste ◽  
Classification Criteria ◽  
Ingestive Behavior ◽  
Response Patterns ◽  
Sucrose Solutions ◽  
Liking Rating

Taste hedonics is a well-documented driver of food consumption. The role of sweetness in directing ingestive behavior is largely rooted in biology. One can then intuit that individual differences in sweet-liking may constitute an indicator of variations in the susceptibility to diet-related health outcomes. Despite half a century of research on sweet-liking, the best method to identify the distinct responses to sweet taste is still debated. To help resolve this issue, liking and intensity ratings for eight sucrose solutions ranging from 0 to 1 M were collected from 148 young adults (29% men). Hierarchical cluster analysis (HCA) revealed three response patterns: a sweet-liker (SL) phenotype characterized by a rise in liking as concentration increased, an inverted U-shaped phenotype with maximum liking at 0.25 M, and a sweet-disliker (SD) phenotype characterized by a decline in liking as a function of concentration. Based on sensitivity and specificity analyses, present data suggest the clearest discrimination between phenotypes is seen with 1.0 M sucrose, where a liking rating between −15 and +15 on a −50/+50 scale reliably distinguished individuals with an inverted U-shaped response from the SLs and the SDs. If the efficacy of this approach is confirmed in other populations, the discrimination criteria identified here can serve as the basis for a standard method for classifying sweet taste liker phenotypes in adults.

scholarly journals A Tournament Approach to Price Discovery in the U.S. Cattle Market

2020 ◽  
pp. 1-16
Author(s):  
Jeffrey Wright ◽  
Man-Keun Kim ◽  
Hernan A. Tejeda ◽  
Hwa-Neyon Kim
Keyword(s):  
Cluster Analysis ◽  
Futures Markets ◽  
Hierarchical Cluster ◽  
Correction Model ◽  
Cattle Markets ◽  
Price Leader ◽  
Dynamic Relationships ◽  
Cattle Market ◽  
The U.S

Abstract The dominant market where information is discovered plays the role of price leader providing substantial market information to other markets. This study investigates the dynamic relationships of 30 cattle markets across regions, cattle types, and cash/futures markets. The comparison of many markets, using an error correction model, is accomplished with the introduction of a tournament with a hierarchical cluster analysis, which allows us to conclude that the leading price for the U.S. cattle markets is discovered in the futures markets for both feeder and fed cattle.

Differential Gurmarin Suppression of Sweet Taste Responses in Rat Solitary Nucleus Neurons

2003 ◽  
Vol 90 (2) ◽  
pp. 911-923 ◽  
Author(s):  
Christian H. Lemon ◽  
Toshiaki Imoto ◽  
David V. Smith
Keyword(s):  
Cluster Analysis ◽  
Sucrose Concentration ◽  
Hierarchical Cluster ◽  
Initial Response ◽  
Sweet Taste ◽  
Induced Response ◽  
Response Suppression ◽  
Response Profiles ◽  
Neuronal Type ◽  
Concentration Series

We examined the effect of the sweet transduction blocker gurmarin on taste responses recorded from neurons in the rat solitary nucleus (NST) to determine how gurmarin sensitivity is distributed across neuronal type. Initially, responses evoked by washing the anterior tongue and palate with 0.5 M sucrose, 0.1 M NaCl, 0.01 M HCl, and 0.01 M quinine-HCl were recorded from 35 neurons. For some cells, responses to a sucrose concentration series (0.01–1.0 M) or an array of sweet-tasting compounds were also measured. Gurmarin (10 μg/ml, 2–4 ml) was then applied to the tongue and palate. Stimuli were reapplied after 10–15 min. Neurons were segregated into groups based on similarities among their initial response profiles using hierarchical cluster analysis (HCA). Results indicated that sucrose responses recorded from neurons representative of each HCA-defined class were suppressed by gurmarin. However, a disproportionate percentage of cells in each group displayed sucrose responses that were substantially attenuated after gurmarin treatment. Postgurmarin sucrose responses recorded from neurons that composed 57% of class S, 40% of class N, and 33% of class H were suppressed by ≥50% relative to control. On average, attenuation was statistically significant only in class S and N neurons. Although the magnitude of gurmarin-induced response suppression did not differ across sucrose concentration, responses to different sweet-tasting compounds were differentially affected. Responses to NaCl, HCl, or quinine were not suppressed by gurmarin. Results suggest that information from gurmarin-sensitive and -insensitive receptor processes converges onto single NST neurons.

scholarly journals Neuropsychological Method in the Differential Diagnosis of Cognitive Impairment in Children and Adolescents with Mental Disorders

2017 ◽  
Vol 6 (2) ◽  
pp. 141-157
Author(s):  
A. Sergienko
Keyword(s):  
Cluster Analysis ◽  
Children And Adolescents ◽  
Cognitive Deficits ◽  
Hierarchical Cluster ◽  
Schizophrenia Spectrum Disorders ◽  
Qualitative And Quantitative ◽  
Schizophrenia Spectrum ◽  
Neuropsychological Diagnostics ◽  
Spectrum Disorders

The article describes the neuropsychological techniques which are applied in the clinical practice in child psychiatry. It describes a system of qualitative and quantitative neuropsychological diagnostics. The role of neuropsychological analysis of the cognitive deficits associated with schizophrenia spectrum disorders in children and adolescents is reflected. Hierarchical cluster analysis according to neuropsychological diagnosis helps in the establishing the psychiatric diagnosis.

scholarly journals T1R3 taste receptor is critical for sucrose but not Polycose taste

2009 ◽  
Vol 296 (4) ◽  
pp. R866-R876 ◽  
Author(s):  
Steven Zukerman ◽  
John I. Glendinning ◽  
Robert F. Margolskee ◽  
Anthony Sclafani
Keyword(s):  
Critical Role ◽  
Taste Receptor ◽  
Sweet Taste ◽  
Sucrose Preference ◽  
Chorda Tympani ◽  
Chorda Tympani Nerve ◽  
Sweet Taste Receptor ◽  
Sucrose Solutions ◽  
Nerve Recordings

In addition to their well-known preference for sugars, mice and rats avidly consume starch-derived glucose polymers (e.g., Polycose). T1R3 is a component of the mammalian sweet taste receptor that mediates the preference for sugars and artificial sweeteners in mammals. We examined the role of the T1R3 receptor in the ingestive response of mice to Polycose and sucrose. In 60-s two-bottle tests, knockout (KO) mice preferred Polycose solutions (4–32%) to water, although their overall preference was lower than WT mice (82% vs. 94%). KO mice also preferred Polycose (0.5–32%) in 24-h two-bottle tests, although less so than WT mice at dilute concentrations (0.5–4%). In contrast, KO mice failed to prefer sucrose to water in 60-s tests. In 24-h tests, KO mice were indifferent to 0.5–8% sucrose, but preferred 16–32% sucrose; this latter result may reflect the post-oral effects of sucrose. Overall sucrose preference and intake were substantially less in KO mice than WT mice. However, when retested with 0.5–32% sucrose solutions, the KO mice preferred all sucrose concentrations, although they drank less sugar than WT mice. The experience-induced sucrose preference is attributed to a post-oral conditioned preference for the T1R3-independent orosensory features of the sugar solutions (odor, texture, T1R2-mediated taste). Chorda tympani nerve recordings revealed virtually no response to sucrose in KO mice, but a near-normal response to Polycose. These results indicate that the T1R3 receptor plays a critical role in the taste-mediated response to sucrose but not Polycose.

scholarly journals The Effect of Sleep Curtailment on Hedonic Responses to Liquid and Solid Food

Foods ◽  
2019 ◽  
Vol 8 (10) ◽  
pp. 465 ◽  
Author(s):  
Edward J. Szczygiel ◽  
Sungeun Cho ◽  
Robin M. Tucker
Keyword(s):  
Cluster Analysis ◽  
Energy Intake ◽  
Hierarchical Cluster Analysis ◽  
Single Channel ◽  
Hierarchical Cluster ◽  
Sweet Taste ◽  
Primary Objective ◽  
Taste Perception ◽  
Model Systems ◽  
Food Matrices

It is currently unclear whether changes in sweet taste perception of model systems after sleep curtailment extend to complex food matrices. Therefore, the primary objective of this study was to use a novel solid oat-based food (crisps) and oat-based beverage stimulus sweetened with sucralose to assess changes in taste perception after sleep curtailment. Forty-one participants recorded a habitual and curtailed night of sleep using a single-channel electroencephalograph. The next morning, overall sweetness, flavor, and texture liking responses to energy- and nutrient-matched oat products across five concentrations of sweetness were measured. Overall (p = 0.047) and flavor (p = 0.017) liking slopes across measured concentrations were steeper after curtailment, suggesting that sweeter versions of the oat products were liked more after sleep curtailment. Additionally, a hierarchical cluster analysis was used to classify sweet likers and non-likers. While the effect of sleep curtailment on sweet liking did not differ between sweet liking classification categories, sleep curtailment resulted in decreased texture liking in the solid oat crisps for sweet non-likers (p < 0.001), but not in the oat beverage. These findings illustrate the varied effects of sleep on hedonic response in complex food matrices and possible mechanisms by which insufficient sleep can lead to sensory-moderated increases in energy intake.

scholarly journals Acute Sleep Curtailment Increases Sweet Taste Preference, Appetite and Food Intake in Healthy Young Adults: A Randomized Crossover Trial

2020 ◽  
Vol 10 (2) ◽  
pp. 47 ◽  
Author(s):  
Eri Tajiri ◽  
Eiichi Yoshimura ◽  
Yoichi Hatamoto ◽  
Hideki Shiratsuchi ◽  
Shigeho Tanaka ◽  
...  
Keyword(s):  
Young Adults ◽  
Food Intake ◽  
Energy Intake ◽  
Crossover Trial ◽  
Taste Preference ◽  
Sweet Taste ◽  
Blood Tests ◽  
Randomized Crossover Trial ◽  
Sucrose Solutions ◽  
Ad Libitum Intake

This study aimed to examine the effect of acute sleep curtailment on sweet taste preference, appetite and food intake, and the correlation between food intake and sweet taste preference or active ghrelin using a randomized crossover design (5 h sleep curtailment vs. 8 h control). Twenty-four participants (11 men) aged 21.4 ± 1.0 years, with BMI 19.8 ± 1.7 kg/m2, who habitually slept 5 h/night or more experienced interventions lasting three consecutive nights. Participants came into the laboratory for testing on day 4. Fasting blood tests were conducted at 8:00 a.m. to measure active ghrelin and leptin levels. Sweet taste preference was assessed by presenting five different concentration sucrose solutions at 9:00 a.m. Ad libitum intake at breakfast was assessed for 30 min from 9:30 a.m. Sweet taste preference was higher following sleep curtailment than control. Active ghrelin was likewise higher following sleep curtailment than control. Leptin did not differ between conditions. Energy intake was higher following sleep curtailment than control, being derived primarily from carbohydrates. However, sweet taste preference and active ghrelin did not correlate with energy intake. These results suggest that acute consecutive sleep curtailment increases sweet taste preference, active ghrelin, and energy intake in healthy young adults.

Particularities of tinnitus in children and adolescents

ORL ro ◽  
2016 ◽  
Vol 4 (1) ◽  
pp. 40-42
Author(s):  
Alexandra Boloș ◽  
Sebastian Cozma ◽  
Andreea Silvana Szalontay
Keyword(s):  
Quality Of Life ◽  
Young Adults ◽  
Children And Adolescents ◽  
Psychological Factors ◽  
Ambient Noise ◽  
Psychological Consequences ◽  
Therapeutic Approaches

Tinnitus is a common otologic symptom and probably the most troublesome. Tinnitus causes a number of physical and psychological consequences, that interfere with the quality of life of the patient. Many authors believe that the presence of tinnitus in children is a matter of lesser importance than in adults because it is met less frequently and would be a fleeting symptom, inoffensive for them (Graham, 1981). In addition, the prevalence of tinnitus during adolescence and even in young adults is increasing, possibly as a consequence of the increased ambient noise (Bulbul SF, Shargorodsky J). Various therapeutic approaches have generated different results, which led us to consider the role of psychological factors, hence the need to underline the particularities of this symptom in childhood.  

DRSA: a non-hierarchical clustering algorithm using k-NN graph and its application in vegetation classification

2015 ◽  
pp. 125-138 ◽  
Author(s):  
I. V. Goncharenko
Keyword(s):  
Cluster Analysis ◽  
Clustering Algorithm ◽  
Nearest Neighbor ◽  
Clustering Algorithms ◽  
Protein Structures ◽  
Hierarchical Cluster ◽  
Vegetation Classification ◽  
K Nearest Neighbor ◽  
Neighbor Graph ◽  
Nearest Neighbor Graph

In this article we proposed a new method of non-hierarchical cluster analysis using k-nearest-neighbor graph and discussed it with respect to vegetation classification. The method of k-nearest neighbor (k-NN) classification was originally developed in 1951 (Fix, Hodges, 1951). Later a term “k-NN graph” and a few algorithms of k-NN clustering appeared (Cover, Hart, 1967; Brito et al., 1997). In biology k-NN is used in analysis of protein structures and genome sequences. Most of k-NN clustering algorithms build «excessive» graph firstly, so called hypergraph, and then truncate it to subgraphs, just partitioning and coarsening hypergraph. We developed other strategy, the “upward” clustering in forming (assembling consequentially) one cluster after the other. Until today graph-based cluster analysis has not been considered concerning classification of vegetation datasets.

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