scholarly journals Polyunsaturated Fatty Acids and Their Potential Therapeutic Role in Cardiovascular System Disorders—A Review

Nutrients ◽  
2018 ◽  
Vol 10 (10) ◽  
pp. 1561 ◽  
Author(s):  
Ewa Sokoła-Wysoczańska ◽  
Tomasz Wysoczański ◽  
Jolanta Wagner ◽  
Katarzyna Czyż ◽  
Robert Bodkowski ◽  
...  

Cardiovascular diseases are described as the leading cause of morbidity and mortality in modern societies. Therefore, the importance of cardiovascular diseases prevention is widely reflected in the increasing number of reports on the topic among the key scientific research efforts of the recent period. The importance of essential fatty acids (EFAs) has been recognized in the fields of cardiac science and cardiac medicine, with the significant effects of various fatty acids having been confirmed by experimental studies. Polyunsaturated fatty acids are considered to be important versatile mediators for improving and maintaining human health over the entire lifespan, however, only the cardiac effect has been extensively documented. Recently, it has been shown that omega-3 fatty acids may play a beneficial role in several human pathologies, such as obesity and diabetes mellitus type 2, and are also associated with a reduced incidence of stroke and atherosclerosis, and decreased incidence of cardiovascular diseases. A reasonable diet and wise supplementation of omega-3 EFAs are essential in the prevention and treatment of cardiovascular diseases prevention and treatment.

Nutrients ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 3184
Author(s):  
Grazyna Sypniewska ◽  
Stefan Kruszewski

Cardiovascular diseases are the leading cause of mortality worldwide [...]


2020 ◽  
Vol 21 (3) ◽  
pp. 741 ◽  
Author(s):  
Anamaria Balić ◽  
Domagoj Vlašić ◽  
Kristina Žužul ◽  
Branka Marinović ◽  
Zrinka Bukvić Mokos

Omega-3 (ω-3) and omega-6 (ω-6) polyunsaturated fatty acids (PUFAs) are nowadays desirable components of oils with special dietary and functional properties. Their therapeutic and health-promoting effects have already been established in various chronic inflammatory and autoimmune diseases through various mechanisms, including modifications in cell membrane lipid composition, gene expression, cellular metabolism, and signal transduction. The application of ω-3 and ω-6 PUFAs in most common skin diseases has been examined in numerous studies, but their results and conclusions were mostly opposing and inconclusive. It seems that combined ω-6, gamma-linolenic acid (GLA), and ω-3 long-chain PUFAs supplementation exhibits the highest potential in diminishing inflammatory processes, which could be beneficial for the management of inflammatory skin diseases, such as atopic dermatitis, psoriasis, and acne. Due to significant population and individually-based genetic variations that impact PUFAs metabolism and associated metabolites, gene expression, and subsequent inflammatory responses, at this point, we could not recommend strict dietary and supplementation strategies for disease prevention and treatment that will be appropriate for all. Well-balanced nutrition and additional anti-inflammatory PUFA-based supplementation should be encouraged in a targeted manner for individuals in need to provide better management of skin diseases but, most importantly, to maintain and improve overall skin health.


2011 ◽  
Vol 59 (6) ◽  
pp. 369 ◽  
Author(s):  
A. J. Hulbert ◽  
Sarah K. Abbott

There are four types of fatty acids but only two types are essential nutritional requirements for many animals. These are the omega-6 polyunsaturated fatty acids (n-6 PUFA) and the omega-3 polyunsaturated fatty acids (n-3 PUFA) and because they cannot be converted to one another they are separate essential dietary requirements. They are only required in small amounts in the diet and their biological importance stems largely from their role as constituents of membrane lipids. They are synthesised by plants and, as a generalisation, green leaves are the source of n-3 PUFA while seeds are the source of n-6 PUFA in the food chain. While the fatty acid composition of storage fats (triglycerides) is strongly influenced by dietary fatty acid composition, this is not the case for membrane fats. The fatty acid composition of membrane lipids is relatively unresponsive to dietary fatty acid composition, although n-3 PUFA and n-6 PUFA can substitute for each in membrane lipids to some extent. Membrane fatty acid composition appears to be regulated and specific for different species. The role of essential fats in the diet of animals on (1) basal metabolic rate, (2) thermoregulation, (3) maximum longevity, and (4) exercise performance is discussed.


2020 ◽  
Vol 10 (10) ◽  
pp. 419
Author(s):  
Ksenia Varakina-Mitrail ◽  
Yuliya Berezovskaya ◽  
Viktoriya Nechaeva ◽  
Irina Kholodova

Today, hundreds of millions of children under the age of 5 fall short of their development potential. Advances in neuroscience have confirmed that adult health and well-being are based on the developmental conditions and opportunities they had in early childhood, from conception to 24 months (first 1000 days) and then to the age of 5 (second 1000 days). Young children, who eat a healthy balanced diet, who are treated with care and attention, and who have more opportunities to learn, have a better chance to thrive. Data from a survey of adopted children, as well as experimental and quasi-experimental studies, showed that prevention of stunting is most effective during the first 1000 days and developmental delays in both the first and second 1000 days. External factors affect cognitive development significantly less after this period, and the older a person becomes, the less effective educational programs are, and the longer it takes to learn a new skill. In this regard, it is necessary to identify the degree of influence of nutrient components, such as polyunsaturated fatty acids and lutein, on the cognitive development of the child in the first year of life, as it determines the intellectual potential of the person throughout life. The goal of this review is to review the existing literature to find out how certain food components (polyunsaturated fatty acids and lutein) affect infant and toddler brain development.Keywords: omega-3, omega-6, polyunsaturated fatty acids, lutein, cognitive development


Fisheries ◽  
2020 ◽  
Vol 2020 (5) ◽  
pp. 101-106
Author(s):  
Elena Chupikova ◽  
Konstantin Pavel ◽  
Svetlana Tkachenko

The article analyzes the fatty acid composition of the frozen iwashi lipids of different shelf lives. It is established that the total amount of essential fatty acids omega-3 and omega-6 in iwashi’s fat reaches almost 90% of all polyunsaturated fatty acids and remains practically unchanged for 12 months of fish cold storage. It is shown that products from iwashi contain a significant amount of essential fatty acids, indispensable for the human body, which can be used to optimize the population nutrition and satisfy the physiological needs in eicosopentaenoic and docosahexaenoic fatty acids.


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