scholarly journals Cardioprotective Effects of Nutraceuticals: Focus on Omega-3 Polyunsaturated Fatty Acids

Nutrients ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 3184
Author(s):  
Grazyna Sypniewska ◽  
Stefan Kruszewski
Keyword(s):  
Fatty Acids ◽  
Cardiovascular Diseases ◽  
Polyunsaturated Fatty Acids ◽  
Omega 3 ◽  
Cardioprotective Effects

Cardiovascular diseases are the leading cause of mortality worldwide [...]

scholarly journals The Role of Omega-3 Polyunsaturated Fatty Acids in Stroke

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Jiyuan Bu ◽  
Yang Dou ◽  
Xiaodi Tian ◽  
Zhong Wang ◽  
Gang Chen
Keyword(s):  
Oxidative Stress ◽  
Fatty Acids ◽  
Cardiovascular Diseases ◽  
Polyunsaturated Fatty Acids ◽  
Fish Oil ◽  
Metabolic Diseases ◽  
Cerebral Injury ◽  
Omega 3 ◽  
Stroke Treatment ◽  
Beneficial Effects

Stroke is the third commonest cause of death following cardiovascular diseases and cancer. In particular, in recent years, the morbidity and mortality of stroke keep remarkable growing. However, stroke still captures people attention far less than cardiovascular diseases and cancer. Past studies have shown that oxidative stress and inflammation play crucial roles in the progress of cerebral injury induced by stroke. Evidence is accumulating that the dietary supplementation of fish oil exhibits beneficial effects on several diseases, such as cardiovascular diseases, metabolic diseases, and cancer. Omega-3 polyunsaturated fatty acids (n-3 PUFAs), the major component of fish oil, have been found against oxidative stress and inflammation in cardiovascular diseases. And the potential of n-3 PUFAs in stroke treatment is attracting more and more attention. In this review, we will review the effects of n-3 PUFAs on stroke and mainly focus on the antioxidant and anti-inflammatory effects of n-3 PUFAs.

scholarly journals Microbiota, a New Playground for the Omega-3 Polyunsaturated Fatty Acids in Cardiovascular Diseases

Marine Drugs ◽  
2021 ◽  
Vol 19 (2) ◽  
pp. 54
Author(s):  
Guy Rousseau
Keyword(s):  
Fatty Acids ◽  
Cardiovascular Diseases ◽  
Polyunsaturated Fatty Acids ◽  
Intestinal Barrier ◽  
Omega 3 ◽  
Cardiac Health ◽  
Potential Impact ◽  
Harmful Effects ◽  
Pro Inflammatory Cytokines

Several cardioprotective mechanisms attributed to Omega-3 polyunsaturated fatty acids (PUFAs) have been studied and widely documented. However, in recent years, studies have supported the concept that the intestinal microbiota can play a much larger role than we had anticipated. Microbiota could contribute to several pathologies, including cardiovascular diseases. Indeed, an imbalance in the microbiota has often been reported in patients with cardiovascular disease and produces low-level inflammation. This inflammation contributes to, more or less, long-term development of cardiovascular diseases. It can also worsen the symptoms and the consequences of these pathologies. According to some studies, omega-3 PUFAs in the diet could restore this imbalance and mitigate its harmful effects on cardiovascular diseases. Many mechanisms are involved and included: (1) a reduction of bacteria producing trimethylamine (TMA); (2) an increase in bacteria producing butyrate, which has anti-inflammatory properties; and (3) a decrease in the production of pro-inflammatory cytokines. Additionally, omega-3 PUFAs would help maintain better integrity in the intestinal barrier, thereby preventing the translocation of intestinal contents into circulation. This review will summarize the effects of omega-3 PUFAs on gut micro-biota and the potential impact on cardiac health.

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