scholarly journals Preconception Micronutrient Supplementation Reduced Circulating Branched Chain Amino Acids at 12 Weeks Gestation in an Open Trial of Guatemalan Women Who Are Overweight or Obese

Nutrients ◽  
2018 ◽  
Vol 10 (9) ◽  
pp. 1282 ◽  
Author(s):  
Sarah Borengasser ◽  
Peter Baker ◽  
Mattie Kerns ◽  
Leland Miller ◽  
Alexandra Palacios ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Amino Acids ◽  
Body Mass ◽  
Early Pregnancy ◽  
Controlled Trial ◽  
Branched Chain Amino Acids ◽  
Serum Samples ◽  
Double Burden ◽  
Cross Sectional ◽  
Branched Chain

Elevated branched chain amino acids (BCAAs: valine, leucine, and isoleucine) are well-established biomarkers of obesity-associated insulin resistance (IR). Mounting evidence suggests that low- and middle-income countries are suffering from a “double burden” of both undernutrition (growth stunting) and overnutrition (obesity) as these countries undergo a “nutrition transition”. The purpose of this study was to examine if pre-pregnancy body mass index (BMI, kg/m2) and a daily lipid-based micronutrient supplement (LNS, Nutriset) would lead to cross-sectional differences in circulating levels of branched chain amino acids (BCAAs) in Guatemalan women experiencing short stature during early pregnancy. Using data from an ongoing randomized controlled trial, Women First, we studied women who were normal weight (NW, BMI range for this cohort = 20.1–24.1 kg/m2) or overweight/obese (OW/OB, BMI range for this cohort = 25.6–31.9 kg/m2), and divided into two groups: those who received daily LNS ≥ 3 months prior to conception through 12 weeks gestation (+LNS), or no LNS (−LNS) (n = 9–10/group). BCAAs levels were obtained from dried blood spot card samples (DBS) assessed at 12 weeks gestation. DBS cards provide a stable, efficient, and reliable means of collecting, transporting, and storing blood samples in low resource or field settings. Circulating maternal leptin, adiponectin, and insulin were determined by immunoassays from serum samples collected at 12 weeks gestation. We found maternal pre-pregnancy body mass index (ppBMI) was associated with higher circulating BCAAs (r2 = 0.433, p = 0.002) and higher leptin/adiponectin ratio (r = 0.466, p = 0.044) in −LNS mothers at 12 weeks gestation. +LNS mothers demonstrated no correlations between BCAAs or leptin/adiponectin ratio across ppBMI suggesting LNS may be effective at improving metabolic status in OW/OB mothers during early pregnancy.

The Weight Loss Effects of Branched Chain Amino Acids and Vitamin B6: A Randomized Controlled Trial on Obese and Overweight Women

2018 ◽  
Vol 88 (1-2) ◽  
pp. 80-89 ◽  
Author(s):  
Zahra Shakibay Novin ◽  
Saeed Ghavamzadeh ◽  
Alireza Mehdizadeh
Keyword(s):  
Amino Acids ◽  
Weight Loss ◽  
Body Composition ◽  
Vitamin B6 ◽  
Controlled Trial ◽  
Density Lipoprotein ◽  
Branched Chain Amino Acids ◽  
Model Assessment ◽  
Waist To Hip Ratio ◽  
Branched Chain

Abstract. Branched chain amino acids (BCAA), with vitamin B6 have been reported to improve fat metabolism and muscle synthesis. We hypothesized that supplementation with BCAA and vitamin B6 would result in more weight loss and improve body composition and blood markers related to cardiovascular diseases. Our aim was to determine whether the mentioned supplementation would affect weight loss, body composition, and cardiovascular risk factors during weight loss intervention. To this end, we performed a placebo-controlled randomized clinical trial in 42 overweight and obese women (BMI = 25–34.9 kg/m2). Taking a four-week moderate deficit calorie diet (–500 kcal/day), participants were randomized to receive BCAA (6 g/day) with vitamin B6 (40 mg/day) or placebo. Body composition variables measured with the use of bioelectrical impedance analysis, homeostatic model assessment, and plasma insulin, Low density lipoprotein, High density lipoprotein, Total Cholesterol, Triglyceride, and fasting blood sugar were measured. The result indicated that, weight loss was not significantly affected by BCAA and vitamin B6 supplementation (–2.43 ± 1.02 kg) or placebo (–1.64 ± 1.48 kg). However, significant time × treatment interactions in waist to hip ratio (P = 0.005), left leg lean (P = 0.004) and right leg lean (P = 0.023) were observed. Overall, supplementation with BCAA and vitamin B6 could preserve legs lean and also attenuated waist to hip ratio.

Vegan diet reduces neutrophils, monocytes and platelets related to branched-chain amino acids – A randomized, controlled trial

2020 ◽  
Vol 39 (11) ◽  
pp. 3241-3250 ◽  
Author(s):  
Ann-Kathrin Lederer ◽  
Andrea Maul-Pavicic ◽  
Luciana Hannibal ◽  
Manuel Hettich ◽  
Carmen Steinborn ◽  
...  
Keyword(s):  
Amino Acids ◽  
Randomized Controlled Trial ◽  
Controlled Trial ◽  
Branched Chain Amino Acids ◽  
Vegan Diet ◽  
Randomized Controlled ◽  
Branched Chain

Branched-Chain Amino Acids Depletion during Hemodialysis Is Associated with Fatigue

2020 ◽  
Vol 51 (7) ◽  
pp. 565-571 ◽  
Author(s):  
Subrata Debnath ◽  
Carlos Lorenzo ◽  
Shweta Bansal ◽  
Juan Morales ◽  
Rain O. Rueda ◽  
...  
Keyword(s):  
Amino Acids ◽  
Plasma Levels ◽  
Significant Negative Correlation ◽  
Essential Amino Acids ◽  
Branched Chain Amino Acids ◽  
Maintenance Hemodialysis ◽  
Dialysis Session ◽  
Cross Sectional ◽  
Fatigue Score ◽  
Branched Chain

Background: Fatigue is one of the most debilitating symptoms reported by maintenance hemodialysis (MHD) patients. Hemodialysis causes marked depletion in plasma essential amino acids. We studied the cross-sectional relationship of pre- and post-hemodialysis branched-chain amino acids (BCAAs) concentrations with fatigue in MHD patients. Methods: MHD patients self-reported fatigue during a dialysis session using the Brief Fatigue Inventory. Pre- and post-dialysis plasma levels of BCAAs (valine, leucine, and isoleucine) were measured using HPLC-mass spectrometry. Results: The mean age of study participants (n = 114) was 54.8 ± 12.8 years. Plasma levels of BCAAs decreased significantly post-dialysis compared to pre-dialysis (303.8 ± 9.4 vs. 392.1 ± 9.4 μM/L, p < 0.0001). Fatigue score increased as a function of age (p = 0.015). There was no association between pre-dialysis plasma levels of BCAAs and fatigue. A significant negative correlation was found between post-dialysis plasma levels of BCAAs and fatigue (p < 0.05). Conclusions: These preliminary findings suggest that disruption in BCAAs homeostasis may play a role in precipitating fatigue.

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