scholarly journals Food Consumption as a Modifier of the Association between LEPR Gene Variants and Excess Body Weight in Children and Adolescents: A Study of the SCAALA Cohort

Nutrients ◽  
2018 ◽  
Vol 10 (8) ◽  
pp. 1117 ◽  
Author(s):  
Aline dos Santos Rocha ◽  
Rita de Cássia Ribeiro-Silva ◽  
Gustavo Nunes de Oliveira Costa ◽  
Camila Alexandrina Figueiredo ◽  
Laura Cunha Rodrigues ◽  
...  

No studies showing that food consumption is a modifier of the association of variants of the leptin receptor gene (LEPR) with body weight have involved a Brazilian population. The aim of this study was to evaluate the modifying effect of dietary intake on the association between the LEPR gene and excess weight. In this study, 1211 children and adolescents aged 4–11 years were assessed. Participants were genotyped for 112 single-nucleotide variants of the LEPR gene. Anthropometric measurements were performed, and dietary data were obtained. Logistic regressions were used to study the associations of interest. Of the participants, 13.4% were overweight/obese. The risk allele (G) of the rs1137100 variant was associated with excess weight in individuals with fat consumption below the median (odds ratio OR = 1.92; 95% confidence interval CI = 1.18–3.14), with daily frequency of consumption of drink/artificial juice (OR = 2.15; 95% CI = 1.26–3.68) and refined cereals (OR = 2.17; 95% CI = 1.31–3.62) above the median. The risk allele (G) of variant rs1177681 was also associated with excess weight (OR = 2.74; 95% CI = 1.65–4.57) in subjects with a daily frequency of refined cereal consumption above the median. The association between LEPR and excess weight can be modulated by the type and distribution of dietary fatty acids, sugary drinks, and refined cereals.

Obesity ◽  
2021 ◽  
Vol 29 (3) ◽  
pp. 601-609
Author(s):  
Giulia Pestoni ◽  
Linda Habib ◽  
Emilie Reber ◽  
Sabine Rohrmann ◽  
Kaspar Staub ◽  
...  

2016 ◽  
Vol 30 (6) ◽  
pp. 457-463 ◽  
Author(s):  
Teresa Arechavala ◽  
Xavier Continente ◽  
Anna Pérez-Giménez ◽  
Xavier Bartoll ◽  
Francesca Sànchez-Martínez ◽  
...  

Author(s):  
Magdalena Żegleń ◽  
Łukasz Kryst ◽  
Małgorzata Kowal ◽  
Agnieszka Woronkowicz

Abstract Background Human development is strongly influenced by environmental factors, including the socioeconomic status (SES) of the family. The aim of this study is to analyze the prevalence of excess body weight among Polish children and adolescents from families of varying SES examined in 1983 and 2020. Methods The study group included 3–15-year olds from two cross-sectional surveys (1983 and 2020) conducted in kindergartens and schools. The 1983 cohort consisted of 3394 individuals and the one from 2020—of 1253 children and adolescents. Body height and weight were measured and body mass index was calculated. Inclusion into underweight, normal weight and overweight/obese categories was based on Cole’s cutoff points. SES was established based on the place of the parents’ birth, parents’, education status and the number of children in the family, which were self-reported in a questionary by the parents of the examined individuals. Results The mean overall SES was higher in the 2020 cohort, in comparison to the one examined in 1983. This change was also reflected by the changing prevalence of excess body weight, which, in 1983 was the greatest in the high socioeconomic category. On the other hand, in 2020 overweight/obesity was the most prevalent among individuals from families of low SES. Conclusions The present results confirm the findings obtained in other countries, which suggest that changing the level of socioeconomic development modifies the changes regarding the prevalence of excess body weight. It is an important observation because a study of this type has not yet been conducted in the Polish population.


2011 ◽  
Vol 43 (3) ◽  
pp. 369-378 ◽  
Author(s):  
FABIANA SILVA COSTA ◽  
DAISY LOPES DEL PINO ◽  
ROGÉRIO FRIEDMAN

SummaryChildhood excess weight is probably associated with, or reflected in, parental attitudes. The objective of this study was to study the relationships between childhood excess weight and parental attitudes. The study subjects were 53 boys and 56 girls, aged 6–10, regularly attending schools in Porto Alegre, south Brazil, and one of their parents or caregivers. Attitudes of the parents or caregivers were assessed by the Child Feeding Questionnaire (CFD). Weight and height of the children were measured, parents self-reported their weight and height and body mass indexes were calculated for both. The WHO criteria for overweight and obesity were used for the adults. The CDC criteria for overweight and risk for overweight were used for the corresponding children. Boys presented excess weight more often than girls. The parents of children with excess weight showed higher scores for perceived child weight, concern about child weight, restriction and monitoring. In logistic regression, excess weight in children was associated with perceived child weight, restriction and male sex; pressure to eat was negatively associated with excess BMI. In Porto Alegre, south Brazil, excess body weight in children aged 6–10 is associated with parental perceived child weight and concern about it, monitoring and restriction; being a boy increases the odds of being overweight.


2014 ◽  
Vol 14 (1) ◽  
Author(s):  
Jucemar Benedet ◽  
Adair da Silva Lopes ◽  
Fernando Adami ◽  
Patrícia de Fragas Hinnig ◽  
Francisco de Assis Guedes de Vasconcelos

2003 ◽  
Vol 6 (5) ◽  
pp. 471-477 ◽  
Author(s):  
Laidon Shapo ◽  
Joceline Pomerleau ◽  
Martin McKee ◽  
Richard Coker ◽  
Agron Ylli

AbstractObjective:This paper reports the distribution and determinants of body mass index (BMI) and obesity in Tirana City (Albania).Design:Cross-sectional survey conducted in mid-2001.Setting:Tirana City.Subjects:One thousand one hundred and twenty adults aged 25 years and over (response rate 72.7%), selected using multi-stage cluster sampling.Results:Over three-quarters of male and female respondents had an excess body weight. The overall population prevalence of obesity in Tirana was estimated to be 22.0% in men and 30.9% in women. Obesity affected both genders (age-standardised prevalence in males 22.0%, females 30.9%; age-adjusted odds ratio (OR) 1.89; 99% confidence interval (CI) 1.33–2.67) and all age groups, but most particularly middle-aged women. The age-standardised overall prevalence of central obesity was 21.6% in men and 29.4% in women (age-adjusted OR 1.58; 99% CI 1.11–2.25), increasing with age (P<0.01). In women, the likelihood of being obese was inversely related to educational achievement (trendP= 0.001) and alcohol consumption (trendP= 0.009). Income, smoking and leisure-time physical activity were not associated with obesity.Conclusions:Excess weight and obesity are major public health problems in the adult population of Tirana, but most particularly in middle-aged women. The high obesity prevalence observed along with the recent decrease in physical activity, dietary changes and increase in smoking prevalence make it probable that there will be substantial increases in many non-communicable diseases in Albania in the coming decades. Health promotion strategies are needed that prevent excess weight gain in the Albanian population.


2010 ◽  
Vol 42 (5) ◽  
pp. 601-618 ◽  
Author(s):  
HUGUES PLOURDE ◽  
BERTRAND NOLIN ◽  
OLIVIER RECEVEUR ◽  
MARIELLE LEDOUX

SummaryThe objective of the present analysis was to study the associations between body weight psychosocial correlates and body mass index (BMI) among four groups of adults in the Quebec population. Data were taken from the Social Lifestyles and Health 1998 Survey performed by the Institut de la Statistique du Québec (ISQ). The suggested guidelines of the ISQ were used to estimate the population's proportions and for statistical analysis. The groups studied were 25- to 44- and the 45- to 64-year-old men and women. In all groups, currently trying to lose weight increased the odds of reporting an excess weight. Better perceived eating habits was associated with lower BMI in most groups except in the 25- to 44-year-old women, where the trend was not significant. Higher number of physical activities related to transport and cigarette smoking were associated with lower BMI in both men groups. In both women groups, more frequent consumption of alcoholic beverages decreased significantly the odds of reporting excess body weight. A university degree was associated with a lower BMI only in the 25- to 44-year-old men. Regular practise of leisure time physical activity was associated with a lower BMI only in 45- to 64-year-old women. Opposite associations were observed between perceived health and BMI. In the 45- to 64-year-old men, better perceived health increased the odds of reporting an excess weight. Conversely, the odds of reporting excess weight decreased with better health in 25- to 44-year-old women. Many correlates differ between age group and sex. The identification of these factors illustrates the need to adapt obesity-related programmes toward specific sub-groups within the general population.


2018 ◽  
Vol 31 (2) ◽  
pp. 159-173
Author(s):  
Ricardo Paulino NAKANO ◽  
Tainá Cardoso da Silva CAMINHA ◽  
Renata Elyonara de Sousa CARVALHO ◽  
Antônio Fernando Silva XAVIER JÚNIOR ◽  
Monica Lopes de ASSUNÇÃO ◽  
...  

ABSTRACT Objective This study aims to evaluate the prevalence, temporal trends and associated factors with excess weight in mothers of children under five years of age. Methods This is a time-series study using data from two household surveys conducted in 2005 and 2015. A total of 1,436 mothers were evaluated in 2005, and 690 were evaluated in 2015. The dependent variables were excess body weight (Body Mass Index [BMI] ≥25.0kg/m2), high percentage of Body Fat (%BF ≥33%) and abdominal obesity (waist circumference >80cm). The independent variables were the socioeconomic and demographic factors. The changes that occurred between the two surveys were expressed in percentages, and the measure of association was the Prevalence Ratio, calculated by Poisson regression, in both the crude and multivariate analyses. Results There were increases of 33.2%, 59.2% and 31.0%, respectively, for the prevalence of excess weight (PR=1.33, 95% Confidence Interval [CI]:1.21-1.46), abdominal obesity (PR=1.59, 95% CI:1.43-1.77) and high %BF (PR=1.31, 95% CI:1.07-1.60). The factors independently associated with excess weight and abdominal obesity were the highest age group (>30 years), menarche ≤12 years and higher parity (>2 children). The same was observed for high %BF, except for the loss of significance in the adjusted analysis for the variable menarche ≤12 years. Conclusion The prevalence of high body adiposity is a problem of relevant importance in the studied population and has presented an upward trend in the last 10 years. Women over 30 years and with more than two children should be given priority in prevention and control.


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