scholarly journals Oral Intake of Low-Molecular-Weight Collagen Peptide Improves Hydration, Elasticity, and Wrinkling in Human Skin: A Randomized, Double-Blind, Placebo-Controlled Study

Nutrients ◽  
2018 ◽  
Vol 10 (7) ◽  
pp. 826 ◽  
Author(s):  
Do-Un Kim ◽  
Hee-Chul Chung ◽  
Jia Choi ◽  
Yasuo Sakai ◽  
Boo-Yong Lee
Keyword(s):  
Molecular Weight ◽  
Human Skin ◽  
Oral Intake ◽  
Controlled Study ◽  
Low Molecular Weight ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Collagen Peptide

Randomized Double-Blind, Placebo Controlled Safety Study of a Low Molecular Weight Heparinoid in Patients Undergoing Transurethral Resection of the Prostate

1987 ◽  
Vol 57 (01) ◽  
pp. 092-096 ◽  
Author(s):  
Hugo ten Cate ◽  
Ch Pieter Henny ◽  
Jan W ten Cate ◽  
Harry R Büller ◽  
Nosjir F Dabhoiwala
Keyword(s):  
Molecular Weight ◽  
Blood Loss ◽  
Transurethral Resection ◽  
Postoperative Blood Loss ◽  
Controlled Study ◽  
Low Molecular Weight ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Dose Dependent Increase ◽  
Dose Dependent

SummaryIn preparation for an efficacy study, the effect of the low molecular weight heparinoid Org 10172 on postoperative blood loss was assessed in a randomized double-blind, placebo controlled study in patients undergoing transurethral resection of the prostate (TURP). Org 10172 and placebo were given twice daily as i.v. injection for three postoperative days starting one hour preoperatively. Three doses of Org 10172 (800, 1600, and 2400 anti-Xa units b.d.) were evaluated against placebo in three consecutive patient blocks respectively. Each block consisted of 20 patients, 15 receiving Org 10172 and 5 patients placebo. The study was discontinued after 9 patients of the third block had completed the protocol because of excessive urinary blood loss. Data analysis showed a dose-dependent increase in postoperative haemoglobin loss, this was not significant for the 800 anti-Xa units b. d. dosage but was significant in those patients treated with 1600 (p <0.05) and 2400 anti-Xa units b.d. (p <0.01).It was concluded that the heparinoid Org 10172 caused a dose dependent increase in urinary blood loss following TURP.

scholarly journals Oral Intake of Hydrangea serrata (Thunb.) Ser. Leaves Extract Improves Wrinkles, Hydration, Elasticity, Texture, and Roughness in Human Skin: A Randomized, Double-Blind, Placebo-Controlled Study

Nutrients ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 1588
Author(s):  
Da-Bin Myung ◽  
Jeong-Hun Lee ◽  
Hee-Soo Han ◽  
Kwang-Young Lee ◽  
Hye Shin Ahn ◽  
...  
Keyword(s):  
Human Skin ◽  
Elastic Recovery ◽  
Controlled Trial ◽  
Water Extract ◽  
Hot Water ◽  
Controlled Study ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Skin Wrinkles

Previously, we reported that the hot water extract of Hydrangea serrata leaves (WHS) and its active component, hydrangenol, possess in vitro and in vivo effects on skin wrinkles and moisturization. We conducted a randomized, double-blind, placebo-controlled trial to clinically evaluate the effect of WHS on human skin. Participants (n = 151) were randomly assigned to receive either WHS 300 mg, WHS 600 mg, or placebo, once daily for 12 weeks. Skin wrinkle, hydration, elasticity, texture, and roughness parameters were assessed at baseline and after 4, 8, and 12 weeks. Compared to the placebo, skin wrinkles were significantly reduced in both WHS groups after 8 and 12 weeks. In both WHS groups, five parameters (R1–R5) of skin wrinkles significantly improved and skin hydration was significantly enhanced when compared to the placebo group after 12 weeks. Compared with the placebo, three parameters of skin elasticity, including overall elasticity (R2), net elasticity (R5), and ratio of elastic recovery to total deformation (R7), improved after 12 weeks of oral WHS (600 mg) administration. Changes in skin texture and roughness were significantly reduced in both WHS groups. No WHS-related adverse reactions were reported. Hence, WHS could be used as a health supplement for skin anti-aging.

scholarly journals Effects of oral intake of heat-killed Lactobacillus brevis SBC8803 (SBL88™) on dry skin conditions: A randomized, double-blind, placebo-controlled study

2016 ◽  
Vol 12 (6) ◽  
pp. 3863-3872 ◽  
Author(s):  
Masahiro Ogawa ◽  
Asako Saiki ◽  
Yuuta Matsui ◽  
Norihiko Tsuchimoto ◽  
Yasukazu Nakakita ◽  
...  
Keyword(s):  
Oral Intake ◽  
Lactobacillus Brevis ◽  
Controlled Study ◽  
Dry Skin ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Skin Conditions
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