Beneficial Long-Term Effects of Combined Oral/Topical Antioxidant Treatment with the Carotenoids Lutein and Zeaxanthin on Human Skin: A Double-Blind, Placebo-Controlled Study

2007 ◽  
Vol 20 (4) ◽  
pp. 199-210 ◽  
Author(s):  
P. Palombo ◽  
G. Fabrizi ◽  
V. Ruocco ◽  
E. Ruocco ◽  
J. Fluhr ◽  
...  
Keyword(s):  
Human Skin ◽  
Controlled Study ◽  
Long Term Effects ◽  
Antioxidant Treatment ◽  
Double Blind ◽  
Double Blind Placebo

scholarly journals Oral Intake of Hydrangea serrata (Thunb.) Ser. Leaves Extract Improves Wrinkles, Hydration, Elasticity, Texture, and Roughness in Human Skin: A Randomized, Double-Blind, Placebo-Controlled Study

Nutrients ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 1588
Author(s):  
Da-Bin Myung ◽  
Jeong-Hun Lee ◽  
Hee-Soo Han ◽  
Kwang-Young Lee ◽  
Hye Shin Ahn ◽  
...  
Keyword(s):  
Human Skin ◽  
Elastic Recovery ◽  
Controlled Trial ◽  
Water Extract ◽  
Hot Water ◽  
Controlled Study ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Skin Wrinkles

Previously, we reported that the hot water extract of Hydrangea serrata leaves (WHS) and its active component, hydrangenol, possess in vitro and in vivo effects on skin wrinkles and moisturization. We conducted a randomized, double-blind, placebo-controlled trial to clinically evaluate the effect of WHS on human skin. Participants (n = 151) were randomly assigned to receive either WHS 300 mg, WHS 600 mg, or placebo, once daily for 12 weeks. Skin wrinkle, hydration, elasticity, texture, and roughness parameters were assessed at baseline and after 4, 8, and 12 weeks. Compared to the placebo, skin wrinkles were significantly reduced in both WHS groups after 8 and 12 weeks. In both WHS groups, five parameters (R1–R5) of skin wrinkles significantly improved and skin hydration was significantly enhanced when compared to the placebo group after 12 weeks. Compared with the placebo, three parameters of skin elasticity, including overall elasticity (R2), net elasticity (R5), and ratio of elastic recovery to total deformation (R7), improved after 12 weeks of oral WHS (600 mg) administration. Changes in skin texture and roughness were significantly reduced in both WHS groups. No WHS-related adverse reactions were reported. Hence, WHS could be used as a health supplement for skin anti-aging.

Long-Term Antibiotic Treatment of Children with Secretory Otitis Media: A Double-Blind Placebo-Controlled Study

1988 ◽  
Vol 105 (sup449) ◽  
pp. 49-50 ◽  
Author(s):  
J. Thomsen ◽  
J. Sederberg-Olsen ◽  
S. E. Stangerup ◽  
V. Balle ◽  
R. Vejlsgaard
Keyword(s):  
Otitis Media ◽  
Antibiotic Treatment ◽  
Controlled Study ◽  
Secretory Otitis Media ◽  
Double Blind ◽  
Double Blind Placebo

scholarly journals Double blind, placebo-controlled study of long-term intermittent dobutamine infusion with concomitant oral amiodarone for end stage heart failure

2003 ◽  
Vol 41 (6) ◽  
pp. 162-163
Author(s):  
Eleftheria Tsagalou ◽  
Maria Anastasiou-Nana ◽  
George Alexopoulos ◽  
John Terrovitis ◽  
Konstantinos Chalkias ◽  
...  
Keyword(s):  
Heart Failure ◽  
Dobutamine Infusion ◽  
Controlled Study ◽  
Double Blind ◽  
Double Blind Placebo ◽  
End Stage Heart Failure ◽  
End Stage
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