scholarly journals Association between Maternal and Foetal Erythrocyte Fatty Acid Profiles and Birth Weight

Nutrients ◽  
2018 ◽  
Vol 10 (4) ◽  
pp. 402 ◽  
Author(s):  
Giulia Cinelli ◽  
Marta Fabrizi ◽  
Lucilla Ravà ◽  
Fabrizio Signore ◽  
Pamela Vernocchi ◽  
...  
1990 ◽  
Vol 18 (3) ◽  
pp. 207-208 ◽  
Author(s):  
W. Heard ◽  
A. Kohler ◽  
A. D. Postle

2019 ◽  
Vol 60 (6) ◽  
pp. 1154-1163 ◽  
Author(s):  
Lara T. Meital ◽  
Mark T. Windsor ◽  
Rebecca M. L. Ramirez Jewell ◽  
Peter Young ◽  
Karl Schulze ◽  
...  

Abdominal aortic aneurysm (AAA) is an important cause of death in older adults, which has no current drug therapy. Inflammation and abnormal redox status are believed to be key pathogenic mechanisms for AAA. In light of evidence correlating inflammation with aberrant fatty acid profiles, this study compared erythrocyte fatty acid content in 43 AAA patients (diameter 3.0–4.5 cm) and 52 healthy controls. In addition, the effect of omega-3 PUFA (n-3 PUFA) supplementation on erythrocyte fatty acid content was examined in a cohort of 30 AAA patients as part of a 12 week randomized placebo-controlled clinical trial. Blood analyses identified associations between AAA and decreased linoleic acid (LA), and AAA and increased Δ6-desaturase activity and biosynthesis of arachidonic acid (AA) from LA. Omega-3 PUFA supplementation (1.5 g DHA + 0.3 g EPA/day) decreased red blood cell distribution width (14.8 ± 0.4% to 13.8 ± 0.2%; P = 0.003) and levels of pro-inflammatory n-6 PUFAs (AA, 12.46 ± 0.23% to 10.14 ± 0.3%, P < 0.001; adrenic acid, 2.12 ± 0.13% to 1.23 ± 0.09%; P < 0.001). In addition, Δ-4 desaturase activity increased (DHA/docosapentaenoic acid ratio, 1.85 ± 0.14 to 3.93 ± 0.17; P < 0.001) and elongase 2/5 activity decreased (adrenic acid/AA ratio, 0.17 ± 0.01 to 0.12 ± 0.01; P < 0.01) following supplementation. The findings suggest that n-3 PUFAs improve fatty acid profiles and ameliorate factors associated with inflammation in AAA patients.


Author(s):  
A Taylor ◽  
A Manche ◽  
I Wilson ◽  
D Watson ◽  
H Pandov ◽  
...  

The use of the erythrocyte stearic:oleic acid ratio in the diagnosis and prognosis of bronchogenic carcinoma has been assessed. Although there was a significant difference ( P<0·02) in the erythrocyte stearic:oleic acid ratio between bronchogenic carcinoma patients and healthy adults, the large overlap observed in the two groups rendered the test unsuitable for the diagnosis of malignancy. Furthermore, there was no consistent rise in this ratio after surgical resection, indicating the test to be of little prognostic use. A new explanation for the lower stearic:oleic acid ratios in certain patients has been postulated.


2019 ◽  
Vol 632 ◽  
pp. 159-174 ◽  
Author(s):  
SL Bierwagen ◽  
H Pethybridge ◽  
MR Heupel ◽  
A Chin ◽  
CA Simpfendorfer

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