scholarly journals Chemopreventive Effect of Aster glehni on Inflammation-Induced Colorectal Carcinogenesis in Mice

Nutrients ◽  
2018 ◽  
Vol 10 (2) ◽  
pp. 202 ◽  
Author(s):  
Kyung-Sook Chung ◽  
Se-Yun Cheon ◽  
Seong-Soo Roh ◽  
Minho Lee ◽  
Hyo-Jin An
Keyword(s):  
Colorectal Carcinogenesis ◽  
Chemopreventive Effect

The chemopreventive effect of 5-demethylnobiletin, a unique citrus flavonoid, on colitis-driven colorectal carcinogenesis in mice is associated with its colonic metabolites

2020 ◽  
Vol 11 (6) ◽  
pp. 4940-4952 ◽  
Author(s):  
Mingyue Song ◽  
Yaqi Lan ◽  
Xian Wu ◽  
Yanhui Han ◽  
Minqi Wang ◽  
...  
Keyword(s):  
Inhibitory Effect ◽  
Colorectal Carcinogenesis ◽  
Chemopreventive Effect

The inhibitory effect of dietary 5-demethylnobiletin on colitis-driven colorectal carcinogenesis and the potential roles of its colonic metabolites were reported.

Chemopreventive effect of a vitamin D3 analog, alfacalcidol, on colorectal carcinogenesis in mice with ulcerative colitis

2007 ◽  
Vol 18 (10) ◽  
pp. 1183-1187 ◽  
Author(s):  
Hiroyuki Kikuchi ◽  
Saburou Murakami ◽  
Satoe Suzuki ◽  
Hideki Kudo ◽  
Shuji Sassa ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Vitamin D3 ◽  
Colorectal Carcinogenesis ◽  
Chemopreventive Effect

scholarly journals Thymoquinone subdues tumor growth and potentiates the chemopreventive effect of 5-fluorouracil on the early stages of colorectal carcinogenesis in rats

2016 ◽  
Vol Volume 10 ◽  
pp. 2239-2253 ◽  
Author(s):  
Adel El-Shemi ◽  
Osama Kensara ◽  
Amr Mohamed ◽  
Bassem Refaat ◽  
Shakir Idris ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Colorectal Carcinogenesis ◽  
Early Stages ◽  
Chemopreventive Effect

Chemopreventive effect of dietary curcumin on inflammation-induced colorectal carcinogenesis in mice

2010 ◽  
Vol 55 (2) ◽  
pp. 259-267 ◽  
Author(s):  
Isabel Villegas ◽  
Susana Sánchez-Fidalgo ◽  
Catalina Alarcón de la Lastra
Keyword(s):  
Colorectal Carcinogenesis ◽  
Chemopreventive Effect

A Tale of Two Colons and Two Cancers

Swiss Surgery ◽  
2003 ◽  
Vol 9 (1) ◽  
pp. 3-7 ◽  
Author(s):  
Gervaz ◽  
Bühler ◽  
Scheiwiller ◽  
Morel
Keyword(s):  
Colorectal Cancer ◽  
Colon Cancer ◽  
Adjuvant Chemotherapy ◽  
Splenic Flexure ◽  
Chromosomal Instability ◽  
Proximal Colon ◽  
Colorectal Carcinogenesis ◽  
Physiological Data ◽  
Central Hypothesis ◽  
Group Stratification

The central hypothesis explored in this paper is that colorectal cancer (CRC) is a heterogeneous disease. The initial clue to this heterogeneity was provided by genetic findings; however, embryological and physiological data had previously been gathered, showing that proximal (in relation to the splenic flexure) and distal parts of the colon represent distinct entities. Molecular biologists have identified two distinct pathways, microsatellite instability (MSI) and chromosomal instability (CIN), which are involved in CRC progression. In summary, there may be not one, but two colons and two types of colorectal carcinogenesis, with distinct clinical outcome. The implications for the clinicians are two-folds; 1) tumors originating from the proximal colon have a better prognosis due to a high percentage of MSI-positive lesions; and 2) location of the neoplasm in reference to the splenic flexure should be documented before group stratification in future trials of adjuvant chemotherapy in patients with stage II and III colon cancer.

4'-Geranyloxyferulic Acid-L-name prodrug inhibits inflammation-related colorectal carcinogenesis in mice

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
T Tanaka ◽  
S Genovese ◽  
T Kochi ◽  
F Epifano ◽  
L Scauri ◽  
...  
Keyword(s):  
Colorectal Carcinogenesis
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