The chemopreventive effect of 5-demethylnobiletin, a unique citrus flavonoid, on colitis-driven colorectal carcinogenesis in mice is associated with its colonic metabolites

2020 ◽  
Vol 11 (6) ◽  
pp. 4940-4952 ◽  
Author(s):  
Mingyue Song ◽  
Yaqi Lan ◽  
Xian Wu ◽  
Yanhui Han ◽  
Minqi Wang ◽  
...  
Keyword(s):  
Inhibitory Effect ◽  
Colorectal Carcinogenesis ◽  
Chemopreventive Effect

The inhibitory effect of dietary 5-demethylnobiletin on colitis-driven colorectal carcinogenesis and the potential roles of its colonic metabolites were reported.

scholarly journals Chemopreventive Effect of Aster glehni on Inflammation-Induced Colorectal Carcinogenesis in Mice

Nutrients ◽  
2018 ◽  
Vol 10 (2) ◽  
pp. 202 ◽  
Author(s):  
Kyung-Sook Chung ◽  
Se-Yun Cheon ◽  
Seong-Soo Roh ◽  
Minho Lee ◽  
Hyo-Jin An
Keyword(s):  
Colorectal Carcinogenesis ◽  
Chemopreventive Effect

Cancer chemopreventive effect of quassinoid derivatives. Introduction of side chain to shinjulactone C for enhancement of inhibitory effect on Epstein–Barr virus activation

2002 ◽  
Vol 185 (1) ◽  
pp. 47-51 ◽  
Author(s):  
Sadaaki Tamura ◽  
Narihiko Fukamiya ◽  
Masayoshi Okano ◽  
Harukuni Tokuda ◽  
Wataru Aoi ◽  
...  
Keyword(s):  
Epstein Barr Virus ◽  
Inhibitory Effect ◽  
Side Chain ◽  
Barr Virus ◽  
Chemopreventive Effect ◽  
Epstein Barr

Chemopreventive effect of a vitamin D3 analog, alfacalcidol, on colorectal carcinogenesis in mice with ulcerative colitis

2007 ◽  
Vol 18 (10) ◽  
pp. 1183-1187 ◽  
Author(s):  
Hiroyuki Kikuchi ◽  
Saburou Murakami ◽  
Satoe Suzuki ◽  
Hideki Kudo ◽  
Shuji Sassa ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Vitamin D3 ◽  
Colorectal Carcinogenesis ◽  
Chemopreventive Effect

The inhibitory effect of Filipendula ulmaria (L.) Maxim. on colorectal carcinogenesis induced in rats by methylnitrosourea

2018 ◽  
Vol 227 ◽  
pp. 1-7 ◽  
Author(s):  
Vladimir G. Bespalov ◽  
Valerij A. Alexandrov ◽  
Alexander L. Semenov ◽  
Galina I. Vysochina ◽  
Vera A. Kostikova ◽  
...  
Keyword(s):  
Inhibitory Effect ◽  
Colorectal Carcinogenesis ◽  
Filipendula Ulmaria

scholarly journals Chemical Constituent of β-Glucuronidase Inhibitors from the Root of Neolitsea acuminatissima

Molecules ◽  
2020 ◽  
Vol 25 (21) ◽  
pp. 5170
Author(s):  
Chu-Hung Lin ◽  
Hsiao-Jung Chou ◽  
Chih-Chi Chang ◽  
Ih-Sheng Chen ◽  
Hsun-Shuo Chang ◽  
...  
Keyword(s):  
Enzyme Activity ◽  
Spectroscopic Analysis ◽  
Methanolic Extract ◽  
Chemical Constituent ◽  
Inhibitory Effect ◽  
Mechanisms Of Action ◽  
Colorectal Carcinogenesis ◽  
Endemic Plant ◽  
Inhibition Ratio

Neolitsea acuminatissima (Lauraceae) is an endemic plant in Taiwan. One new carboline alkaloid, demethoxydaibucarboline A (1), two new eudesmanolide-type sesquiterpenes, methyl-neolitacumone A (2), neolitacumone E (3), and twelve known compounds (4–15) were isolated from the root of Neolitsea acuminatissima. Their structures were elucidated by spectroscopic analysis. Glucuronidation represents a major metabolism process of detoxification for carcinogens in the liver. However, intestinal bacterial β-Glucuronidase (βG) has been considered pivotal to colorectal carcinogenesis. To develop specific bacterial-βG inhibitors with no effect on human βG, methanolic extract of roots of N. acuminatissima was selected to evaluate their anti-βG activity. Among the isolates, demethoxydaibucarboline A (1) and quercetin (8) showed a strong bacterial βG inhibitory effect with an inhibition ratio of about 80%. Methylneolitacumone A (2) and epicatechin (10) exhibited a moderate or weak inhibitory effect and the enzyme activity was less than 45% and 74%, respectively. These four compounds specifically inhibit bacterial βG but not human βG. Thus, they are expected to be used for the purpose of reducing chemotherapy-induced diarrhea (CID). The results suggest that the constituents of N. acuminatissima have the potential to be used as CID relief candidates. However, further investigation is required to determine their mechanisms of action.

scholarly journals β-Catenin Regulation in Sporadic Colorectal Carcinogenesis: Not as Simple as APC

2018 ◽  
Vol 2018 ◽  
pp. 1-10 ◽  
Author(s):  
Ernst Fredericks ◽  
Gill Dealtry ◽  
Saartjie Roux
Keyword(s):  
Colorectal Cancer ◽  
Protein Expression ◽  
Statistical Significance ◽  
Inhibitory Effect ◽  
Colorectal Carcinogenesis ◽  
Sporadic Colorectal Cancer ◽  
Peroxisome Proliferator ◽  
Mrna Levels ◽  
Peroxisome Proliferator Activated Receptor ◽  
Cox 2

Background. The wnt/APC/β-catenin pathway is a critical initiator in colorectal carcinogenesis in both hereditary and sporadic colorectal cancer (CRC). The progression of this process remains incompletely understood, although inflammation is pivotal. Drivers of inflammation are elevated in malignant tissue and have been shown to regulate β-catenin expression. Interleukin-17A (IL-17A) is protumorigenic at elevated levels via COX-2 stimulation. Elevated peroxisome proliferator-activated receptor γ (PPARγ) expression has reduced risk of carcinogenesis and good overall prognosis in established CRC. Activation of PPARγ has inhibitory effect on β-catenin. Methods. Using qPCR and IHC, we compared β-catenin, PPARγ, COX-2, and IL-17A in the colonic mucosa of patients with sporadic CRC, inflammatory bowel disease (IBD), and irritable bowel syndrome (IBS), against a normal control population. Results. β-catenin mRNA and protein expression progressively increased from the Normal group, through IBS and IBD reaching statistical significance in CRC. COX-2 mRNA levels increased similarly with statistical significance in IBD and CRC. However, COX-2 protein expression was inverted with significant expression in the Normal and IBS groups and reduced levels in IBD and CRC. PPARγ mRNA expression was unchanged in IBD and CRC but was significantly elevated in the IBS. IL-17A mRNA was significantly reduced in IBS and CRC but unchanged in IBD. There were no differences in all parameters tested in the Normal and IBS groups. Conclusion. β-catenin is confirmed as a major driver of colorectal carcinogenesis but is controlled by many more players other than APC. Elevated levels of PPARγ may have an anticarcinogenic effect. The role of COX-2 expression, especially its posttranscriptional regulation in colorectal cancer, needs further elucidation.

scholarly journals Thymoquinone subdues tumor growth and potentiates the chemopreventive effect of 5-fluorouracil on the early stages of colorectal carcinogenesis in rats

2016 ◽  
Vol Volume 10 ◽  
pp. 2239-2253 ◽  
Author(s):  
Adel El-Shemi ◽  
Osama Kensara ◽  
Amr Mohamed ◽  
Bassem Refaat ◽  
Shakir Idris ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Colorectal Carcinogenesis ◽  
Early Stages ◽  
Chemopreventive Effect
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