scholarly journals Fabrication of Cellulose Nanocrystal/Chitosan Hydrogel for Controlled Drug Release

Nanomaterials ◽  
2019 ◽  
Vol 9 (2) ◽  
pp. 253 ◽  
Author(s):  
Qinghua Xu ◽  
Yunzhong Ji ◽  
Qiucun Sun ◽  
Yingjuan Fu ◽  
Yongjian Xu ◽  
...  
Keyword(s):  
Drug Release ◽  
Free Amino ◽  
Controlled Drug Release ◽  
Crosslinking Density ◽  
Cellulose Nanocrystal ◽  
Swelling Ratio ◽  
Amino Groups ◽  
Potential Measurement ◽  
Ft Ir ◽  
Aldehyde Groups

In this work, a novel nanocomposite hydrogel based on cellulose nanocrystal (CNC) and chitosan (CS) was fabricated and applied as a carrier for the controlled delivery of theophylline. CNC was firstly periodate-oxidized to obtain dialdehyde nanocellulose (DACNC). Then, chitosan was crosslinked using DACNC as both the matrix and crosslinker in different weight ratios, to fabricate CNC/CS composites. The prepared composites were characterized using Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction pattern (XRD), scanning electron microscopy (SEM), zeta potential measurement and swelling ratio tests. FT-IR results confirmed the successful reaction between the free amino groups on chitosan and the aldehyde groups on DACNC. With the increase of chitosan percentage in the hydrogel, the isoelectric point was shifted towards an alkaline pH, which was probably caused by the higher content of free amino groups. The swelling ratio of the composite also increased, which may have been due to the decrease of crosslinking density. Because the swelling ratio of the drug-loaded hydrogels differed under varied pH values, the cumulative drug release percentage of the composite hydrogel was achieved to approximately 85% and 23% in the gastric (pH 1.5) and intestinal (pH 7.4) fluids, respectively. Therefore, CNC/CS hydrogel has application potential as a theophylline carrier.

Formulation and Evaluation of Gastroretentive Nanoparticles of Repaglinide

2014 ◽  
Vol 7 (1) ◽  
pp. 2363-2370
Author(s):  
P M Jamkar ◽  
K N Gujar ◽  
S B Nemmaniwar ◽  
N B Kulkarni
Keyword(s):  
Particle Size ◽  
Drug Release ◽  
Sodium Alginate ◽  
Encapsulation Efficiency ◽  
Research Work ◽  
Crosslinking Agent ◽  
Controlled Drug Release ◽  
Dsc Studies ◽  
Ft Ir ◽  
Novel Drug

Controlled drug release system is one of the most favourable technique of novel drug delivery system owing to its reproducibility and ease of formulation. Nanotechnology is very useful for controlling the drug release and thus improving the pharmacokinetic and pharmacodynamic properties of the drug. The technique improves patient compliance by reducing both dose and the frequency of administration and thus minimizing the local as well as systemic toxic effects. The aim of the present research work was to formulate and evaluate gastroretentive nanoparticles of Repaglinide, an anti-diabetic drug by using the ionotropic gelation method. Repaglinide has a very short half-life of 1 hour with bioavailability 56%. Sustained release mucoadhesive nanoparticles of Repaglinide were prepared to increase the drug residence time in gastrointestinal tract and thus improving the bioavailability of drug. The mucoadhesive nanoparticles were prepared by using chitosan and sodium alginate as polymers; calcium chloride as the crosslinking agent. Different formulations were prepared with varying concentrations of chitosan and sodium alginate in order to achieve the optimum particle size and maximum encapsulation efficiency. The particle size of nanoparticles was found to be in the range of 300 nm to 756 nm. Drug encapsulation efficiency ranged between 56% to 80% with controlled drug release upto 88% in phosphate buffer pH 7.4 and 75% drug release in 0.1N HCl in 12 hrs. FT-IR and DSC studies showed that the drug and polymers were compatible. The results of swelling study and bioadhesive strength indicated that optimized formulation exhibited excellent mucoadhesive properties

Bioactive Calcium Silicate Coating of Titania Nanotubes for Controlled Drug Release

2014 ◽  
Vol 1033-1034 ◽  
pp. 1005-1008
Author(s):  
Ping Li ◽  
Zhang Wang ◽  
Fei Luo ◽  
Xiu Feng Xiao
Keyword(s):  
Drug Release ◽  
Calcium Silicate ◽  
Controlled Drug Release ◽  
Burst Release ◽  
X Ray Diffraction ◽  
Immersion Method ◽  
Silicate Coating ◽  
Titania Nanotube Arrays ◽  
Ft Ir ◽  
Electronic Microscope

A novel and facile process called “alternative loop immersion method” formed bioactive and biocompatible Zn-doped calcium silicate coating over the drug-loaded titania nanotube arrays to improve the properties of drug release. The samples were characterized by scanning electronic microscope (SEM), x-ray diffraction (XRD) and fourier transform infrared (FT-IR). The results show that TNTs modified by Zn-doped calcium silicate coating possess improved drug release characteristics with reduced burst release (from 83% to 66%) and prolonged drug release (from 11 days to over 15 days). This approach provides an alternative to tailor the surface of TNTs and offer considerable propects for diverse biomedical applications.

scholarly journals PEROXIDASE-LABELED ANTIBODY A NEW METHOD OF CONJUGATION

1974 ◽  
Vol 22 (12) ◽  
pp. 1084-1091 ◽  
Author(s):  
PAUL K. NAKANE ◽  
AKIRA KAWAOI
Keyword(s):  
Horseradish Peroxidase ◽  
Free Amino ◽  
Sodium Periodate ◽  
Enzymatic Activities ◽  
Carbohydrate Moiety ◽  
New Method ◽  
Amino Groups ◽  
Aldehyde Groups

A new method of conjugating horseradish peroxidase with proteins was developed. The carbohydrate moiety of fluorodinitrobenzene-blocked peroxidase was oxidized with sodium periodate to form aldehyde groups. The peroxidase-aldehyde was then bound to free amino groups of proteins unidirectionally at high efficiencies. Peroxidase-labeled immunoglobulin retained its immunologic as well as enzymatic activities.

Synthesis, Characterization and Controlled Drug Release of Thermosensitive Poly(NIPAAm-co-HEMA) and IPN(NIPAAm/HEMA) Hydrogels

2006 ◽  
Vol 11-12 ◽  
pp. 737-740 ◽  
Author(s):  
Yuan Xiao Wang ◽  
Xiu Fen Wang ◽  
Shi Wei Song
Keyword(s):  
Drug Release ◽  
Drug Delivery Systems ◽  
Controlled Drug Delivery ◽  
Controlled Drug Release ◽  
Swelling Ratio ◽  
Interpenetrating Network ◽  
Different Temperatures ◽  
Swelling Characteristics ◽  
Kinetics Of

A series of thermo-sensitive copolymers and interpenetrating network hydrogels were prepared using PNIPAAm and HEMA.The effects of the PNIPAAm/HEMA ratio on the swelling ratio ,and deswelling and reswelling kinetics of gels at different temperatures and drug release characteristics in vitro were discussed. The results showed that the copolymer and IPN hydrogels exhibited thermo-sensitive swelling characteristics. Therefore, the hydrogels may be useful in the controlled drug delivery systems.

scholarly journals Enhancing Removal of Cr(VI), Pb2+, and Cu2+ from Aqueous Solutions Using Amino-Functionalized Cellulose Nanocrystal

Molecules ◽  
2021 ◽  
Vol 26 (23) ◽  
pp. 7315
Author(s):  
Qinghua Xu ◽  
Xiaodi Huang ◽  
Lukuan Guo ◽  
Yu Wang ◽  
Liqiang Jin
Keyword(s):  
Aqueous Solutions ◽  
Cellulose Nanocrystal ◽  
X Ray Diffraction ◽  
Potential Measurement ◽  
Force Microscopy ◽  
Atomic Force ◽  
Adsorption Capacities ◽  
Green Route ◽  
Pseudo Second Order ◽  
Ft Ir

In this work, the amino-functionalized cellulose nanocrystal (ACNC) was prepared using a green route and applied as a biosorbent for adsorption of Cr(VI), Pb2+, and Cu2+ from aqueous solutions. CNC was firstly oxidized by sodium periodate to yield the dialdehyde nanocellulose (DACNC). Then, DACNC reacted with diethylenetriamine (DETA) to obtain amino-functionalized nanocellulose (ACNC) through a Schiff base reaction. The properties of DACNC and ACNC were characterized by using elemental analysis, Fourier transform infrared spectroscopy (FT-IR), Kaiser test, atomic force microscopy (AFM), X-ray diffraction (XRD), and zeta potential measurement. The presence of free amino groups was evidenced by the FT-IR results and Kaiser test. ACNCs exhibited an amphoteric nature with isoelectric points between pH 8 and 9. After the chemical modification, the cellulose I polymorph of nanocellulose remained, while the crystallinity decreased. The adsorption behavior of ACNC was investigated for the removal of Cr(VI), Pb2+, and Cu2+ in aqueous solutions. The maximum adsorption capacities were obtained at pH 2 for Cr(VI) and pH 6 for Cu2+ and Pb2+, respectively. The adsorption all followed pseudo second-order kinetics and Sips adsorption isotherms. The estimated adsorption capacities for Cr(VI), Pb2+, and Cu2+ were 70.503, 54.115, and 49.600 mg/g, respectively.

scholarly journals pH-Sensitive Polyampholyte Microgels of Poly(Acrylic Acid-co-Vinylamine) as Injectable Hydrogel for Controlled Drug Release

Polymers ◽  
2019 ◽  
Vol 11 (2) ◽  
pp. 285 ◽  
Author(s):  
Yanmin Chen ◽  
Peijian Sun
Keyword(s):  
Drug Release ◽  
Acrylic Acid ◽  
Zeta Potential ◽  
Suspension Polymerization ◽  
Controlled Drug Release ◽  
Ph Sensitive ◽  
Swelling Ratio ◽  
Sustained Drug Release ◽  
Injectable Hydrogel ◽  
Poly Acrylic Acid

pH-sensitive polyampholyte microgels of poly(acrylic acid-co-vinylamine) (P(AA-co-VAm)) were developed as an injectable hydrogel for controlled drug release. The microgels of P(AA-co-VAm) were prepared via inverse suspension polymerization of acrylic acid and N-vinylformamide followed by hydrolysis of poly(N-vinylformamide) (PNVF) chains of the resultant microgels under basic condition. The pH-sensitivity of the P(AA-co-VAm) microgels in zeta potential and swelling ratio were investigated using a zeta potential analyzer and optical microscope. The results showed that both the zeta potential and the swelling ratio of the microgels were highly affected by the solution pH. By changing the pH of P(AA-co-VAm) microgel dispersion, the interparticle interaction and the swelling ratio of the microgels could be well adjusted and a colloidal hydrogel could be fabricated at moderate pH, showing a pH-triggered reversible fluid-gel transition. Using the polyampholyte P(AA-co-VAm) microgels as an injectable hydrogel drug release system, a sustained drug release could be achieved, indicating the great potentials of the pH-sensitive P(AA-co-VAm) microgels for controlled drug delivery.

scholarly journals Preparation and Characterization of New Carrier Drug Polymers Based Maleimide and Its Drug Release Behaviour

2019 ◽  
Vol 31 (3) ◽  
pp. 569-574 ◽  
Author(s):  
Fatimah Abdul Razzak Mageed ◽  
Mohanad Musa Kareem ◽  
Mohammad N. Al-Baiati
Keyword(s):  
Free Radicals ◽  
Drug Release ◽  
Methyl Ethyl Ketone ◽  
Controlled Drug Release ◽  
Polymerization Reaction ◽  
Methyl Ethyl Ketone Peroxide ◽  
Methyl Ethyl ◽  
Ft Ir ◽  
Heterogeneous Polymers

In this work, two new drug substituted monomers and new homogenous and heterogeneous polymers were synthesized loaded with medicinal properties to extend the controlled drug. The first step includes preparation of compound (F1) via reaction of maleic anhydride with 4-aminobenzoic acid. Then compound (F1) was converted to its corresponding acyl chloride derivative which reacted with amino drugs (sulfadiazine, chlordiazepoxide) afforded (F2 and F3) monomers. Homogeneous polymers (F8 and F9) prepared through polymerization reaction of free radicals of the monomers (F2 and F3) under nitrogen using methyl ethyl ketone peroxide (MEKP) as initiator. Heterogeneous polymers (F14 and F15) prepared through polymerization reaction of free radicals of the monomers (F2 and F3) separately with acrylic acid under nitrogen using methyl ethyl ketone peroxide (MEKP) as initiator. All these prepared monomers and polymers were characterized by FT-IR and 1H NMR, 13C NMR spectroscopies. Controlled drug release and swelling % was studied in different pH values at 37 ºC. Intrinsic viscosities were measured at 25 ºC with Ostwald viscometer and applied the characteristic of solubility for these polymers.

Poly(p -phenylene) with Poly(ethylene glycol) Chains and Amino Groups as a Functional Platform for Controlled Drug Release and Radiotherapy

2016 ◽  
Vol 16 (5) ◽  
pp. 730-737 ◽  
Author(s):  
Bahar Guler ◽  
Huseyin Akbulut ◽  
Firat Baris Barlas ◽  
Caner Geyik ◽  
Dilek Odaci Demirkol ◽  
...  
Keyword(s):  
Drug Release ◽  
Ethylene Glycol ◽  
Controlled Drug Release ◽  
Poly Ethylene Glycol ◽  
Amino Groups ◽  
Poly Ethylene

scholarly journals Preparation and Characterization of Zein and Zein-Chitosan Microspheres with Great Prospective of Application in Controlled Drug Release

2011 ◽  
Vol 2011 ◽  
pp. 1-6 ◽  
Author(s):  
Vinícius Müller ◽  
Juliana Francis Piai ◽  
André Ricardo Fajardo ◽  
Silvia Luciana Fávaro ◽  
Adley Forti Rubira ◽  
...  
Keyword(s):  
Drug Release ◽  
Morphological Analysis ◽  
Treatment Effectiveness ◽  
Controlled Drug Release ◽  
Natural Polymer ◽  
Sem Images ◽  
Ft Ir ◽  
Conventional Systems ◽  
Ft Ir Spectroscopy

Biomaterials applied as carriers for controlled drug delivery offer many advantages over the conventional systems. Among them, the increase of treatment effectiveness and also a significant reduction of toxicity, due to their biodegradability property, are some special features. In this work, microspheres based on the protein Zein (ZN) and ZN associated to the natural polymer Chitosan (CHI) were prepared and characterized. The microspheres of ZN and ZN/CHI were characterized by FT-IR spectroscopy and thermal analysis, and the morphology was analyzed by SEM images. The results confirmed the incorporation of CHI within the ZN-based microspheres. The morphological analysis showed that the CHI added increased the microspheres porosity when compared to the ZN microspheres. The chemical and physical characterization and the morphological analysis allow inferring that ZN/CHI microspheres are good candidates to act as a carrier for controlled drug release.

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