scholarly journals Surface Modification of Magnetic Iron Oxide Nanoparticles

Nanomaterials ◽  
2018 ◽  
Vol 8 (10) ◽  
pp. 810 ◽  
Author(s):  
Nan Zhu ◽  
Haining Ji ◽  
Peng Yu ◽  
Jiaqi Niu ◽  
M. Farooq ◽  
...  
Keyword(s):  
Surface Modification ◽  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Inorganic Materials ◽  
Oxide Nanoparticles ◽  
Magnetic Iron Oxide Nanoparticles ◽  
Preparation Methods ◽  
Practical Applications ◽  
Wide Range ◽  
Surface Modified

Functionalized iron oxide nanoparticles (IONPs) are of great interest due to wide range applications, especially in nanomedicine. However, they face challenges preventing their further applications such as rapid agglomeration, oxidation, etc. Appropriate surface modification of IONPs can conquer these barriers with improved physicochemical properties. This review summarizes recent advances in the surface modification of IONPs with small organic molecules, polymers and inorganic materials. The preparation methods, mechanisms and applications of surface-modified IONPs with different materials are discussed. Finally, the technical barriers of IONPs and their limitations in practical applications are pointed out, and the development trends and prospects are discussed.

scholarly journals Magnetic Iron Oxide Nanoparticles: Synthesis, Characterization and Functionalization for Biomedical Applications in the Central Nervous System

Materials ◽  
2019 ◽  
Vol 12 (3) ◽  
pp. 465 ◽  
Author(s):  
Shoeb Ansari ◽  
Eleonora Ficiarà ◽  
Federico Ruffinatti ◽  
Ilaria Stura ◽  
Monica Argenziano ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Magnetic Iron Oxide Nanoparticles ◽  
Close Link ◽  
Wide Range ◽  
Methods Of Synthesis ◽  
The Central Nervous System

Magnetic Nanoparticles (MNPs) are of great interest in biomedicine, due to their wide range of applications. During recent years, one of the most challenging goals is the development of new strategies to finely tune the unique properties of MNPs, in order to improve their effectiveness in the biomedical field. This review provides an up-to-date overview of the methods of synthesis and functionalization of MNPs focusing on Iron Oxide Nanoparticles (IONPs). Firstly, synthesis strategies for fabricating IONPs of different composition, sizes, shapes, and structures are outlined. We describe the close link between physicochemical properties and magnetic characterization, essential to developing innovative and powerful magnetic-driven nanocarriers. In conclusion, we provide a complete background of IONPs functionalization, safety, and applications for the treatment of Central Nervous System disorders.

Magnetic Iron Oxide Nanoparticles as Contrast Agents: Hydrothermal Synthesis, Characterization and Properties

2015 ◽  
Vol 232 ◽  
pp. 111-145 ◽  
Author(s):  
Tokeer Ahmad ◽  
Ruby Phul
Keyword(s):  
Magnetic Properties ◽  
Surface Modification ◽  
Iron Oxide ◽  
Hydrothermal Synthesis ◽  
Contrast Agents ◽  
Iron Oxide Nanoparticles ◽  
Surface Coating ◽  
Colloidal Stability ◽  
Oxide Nanoparticles ◽  
Magnetic Iron Oxide Nanoparticles

Superparamagnetic Iron oxide nanoparticles (SPIONs) have fascinated researchers due to their vast applications in biomedical fields such as magnetic resonance imaging, cell sorting, hyperthermia, drug delivery etc. The special properties of SPIONs depend on the method of synthesis and surface modification. Among various synthetic protocols, hydrothermal method has attracted much attention due to simplicity, uniformity and excellent magnetic properties of iron oxide nanoparticles. Magnetic properties of SPIONs could be tuned by controlling the size and shape of the particles as well as by the surface modification. Low colloidal stability and high hydrophobic nature of SPIONs result in aggregation of the particles which could be avoided by surface modification of the SPIONs using various capping agents. The size, shape and surface environment of SPIONs can also be controlled by the surface coating. SPIONs are promising contrast agents due to their non-poisonous nature, biocompatibility and large surface area. The biocompatibility of SPIONs is enhanced by the surface coating/modification. The present review focuses on the hydrothermal synthesis of SPIONs and their characterization using various techniques and the applications of SPIONs in the MRI.Table of Contents

scholarly journals Multifunctional magnetic iron oxide nanoparticles: diverse synthetic approaches, surface modifications, cytotoxicity towards biomedical and industrial applications

BMC Materials ◽  
2019 ◽  
Vol 1 (1) ◽  
Author(s):  
Subramanian Natarajan ◽  
Kannan Harini ◽  
Gnana Prakash Gajula ◽  
Bruno Sarmento ◽  
Maria Teresa Neves-Petersen ◽  
...  
Keyword(s):  
Surface Modification ◽  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Surface Modifications ◽  
Synthetic Methods ◽  
Biomedical Science ◽  
Oxide Nanoparticles ◽  
Magnetic Iron Oxide Nanoparticles ◽  
Cytotoxic Effects ◽  
Magnetic Iron Oxide

AbstractMagnetic iron oxide nanoparticles (MIONPs) play a major role in the emerging fields of nanotechnology to facilitate rapid advancements in biomedical and industrial platforms. The superparamagnetic properties of MIONPs and their environment friendly synthetic methods with well-defined particle size have become indispensable to obtain their full potential in a variety of applications ranging from cellular to diverse areas of biomedical science. Thus, the broadened scope and need for MIONPs in their demanding fields of applications required to be highlighted for a comprehensive understanding of their state-of-the-art. Many synthetic methods, however, do not entirely abolish their undesired cytotoxic effects caused by free radical production and high iron dosage. In addition, the agglomeration of MIONPs has also been a major problem. To alleviate these issues, suitable surface modification strategies adaptive to MIONPs has been suggested not only for the effective cytotoxicity control but also to minimize their agglomeration. The surface modification using inorganic and organic polymeric materials would represent an efficient strategy to utilize the diagnostic and therapeutic potentials of MIONPs in various human diseases including cancer. This review article elaborates the structural and magnetic properties of MIONPs, specifically magnetite, maghemite and hematite, followed by the important synthetic methods that can be exploited for biomedical approaches. The in vivo cytotoxic effects and the possible surface modifications employed to eliminate the cytotoxicity thereby enhancing the nanoparticle efficacy are also critically discussed. The roles and applications of surface modified MIONPs in medical and industrial platforms have been described for the benefits of global well-being.

DOPAMINE SERVES AS A STABLE SURFACE MODIFIER FOR IRON OXIDE NANOPARTICLES

2013 ◽  
Vol 01 (02) ◽  
pp. 1350001 ◽  
Author(s):  
XIAOQIN CHI ◽  
XIAOMIN WANG ◽  
JUAN HU ◽  
LIRONG WANG ◽  
JINHAO GAO ◽  
...  
Keyword(s):  
Surface Modification ◽  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Biomedical Applications ◽  
Ph Value ◽  
Detailed Examination ◽  
Blocking Temperature ◽  
Oxide Nanoparticles ◽  
Long Term Stability ◽  
Surface Modified

Iron oxide nanoparticles are an important class of nanomaterials in a broad range of biomedical applications because of their superparamagnetism and biocompatibility. The success of biomedical applications of iron oxide nanoparticles relies on the particles' surface functionalization, which requires robust and versatile surface anchors. Here, we report on a detailed examination of the dopamine-based surface modification of iron oxide nanoparticles. We used dopamine (2-(3,4-dihydroxyphenyl)ethylamine) and L-dopa (3,4-dihydroxy-L-phenylalanine) as two surface modifiers and chose Fe 2 O 3 hollow nanoparticles and Fe 3 O 4 nanoparticles as two representative substrates. Optical and TEM images showed that iron oxide nanoparticles dispersed very well in water after surface modification. The analysis of the UV-Vis spectra indicated that dopamine and L-dopa are stable after being immobilized on the surface of iron oxide nanoparticles when the pH value of the environment is about 7. The magnetic properties analysis further showed that the blocking temperature of the dopamine- or L-dopa-decorated iron oxide nanoparticles hardly changed over 20 days, confirming long-term stability of these surface modified nanoparticles. Cell assay indicated that these dopamine- or L-dopa-modified iron oxide nanoparticles were biocompatible. These results confirm that dopamine serves as a stable modifier and a robust anchor to functionalize iron oxide nanoparticles in biomedical applications.

Controlled oxidation and surface modification increase heating capacity of magnetic iron oxide nanoparticles

2021 ◽  
Vol 8 (3) ◽  
pp. 031407
Author(s):  
Kaiyi Jiang ◽  
Qingbo Zhang ◽  
Daniel Torres Hinojosa ◽  
Linlin Zhang ◽  
Zhen Xiao ◽  
...  
Keyword(s):  
Surface Modification ◽  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Magnetic Iron Oxide Nanoparticles ◽  
Magnetic Iron Oxide ◽  
Heating Capacity

Synthesis, surface modification, and applications of magnetic iron oxide nanoparticles

2019 ◽  
Vol 34 (11) ◽  
pp. 1828-1844 ◽  
Author(s):  
Wenhui Ling ◽  
Mingyu Wang ◽  
Chunxia Xiong ◽  
Dengfeng Xie ◽  
Qiyu Chen ◽  
...  
Keyword(s):  
Surface Modification ◽  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Magnetic Iron Oxide Nanoparticles ◽  
Magnetic Iron Oxide ◽  
Image Position

Abstract

Evaluation of Surface-modified Superparamagnetic Iron Oxide Nanoparticles to Optimize Bacterial Immobilization for Bio-separation with the Least Inhibitory Effect on Microorganism Activity

2020 ◽  
Vol 10 (2) ◽  
pp. 166-174
Author(s):  
Mehdi Khoshneviszadeh ◽  
Sarah Zargarnezhad ◽  
Younes Ghasemi ◽  
Ahmad Gholami
Keyword(s):  
Iron Oxide ◽  
Amino Acid ◽  
Magnetic Nanoparticles ◽  
Iron Oxide Nanoparticles ◽  
Surface Coating ◽  
Superparamagnetic Iron Oxide ◽  
Superparamagnetic Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Surface Charges ◽  
Surface Modified

Background: Magnetic cell immobilization has been introduced as a novel, facile and highly efficient approach for cell separation. A stable attachment between bacterial cell wall with superparamagnetic iron oxide nanoparticles (SPIONs) would enable the microorganisms to be affected by an outer magnetic field. At high concentrations, SPIONs produce reactive oxygen species in cytoplasm, which induce apoptosis or necrosis in microorganisms. Choosing a proper surface coating could cover the defects and increase the efficiency. Methods: In this study, asparagine, APTES, lipo-amino acid and PEG surface modified SPIONs was synthesized by co-precipitation method and characterized by FTIR, TEM, VSM, XRD, DLS techniques. Then, their protective effects against four Gram-positive and Gram-negative bacterial strains including Enterococcus faecalis, Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa were examined through microdilution broth and compared to naked SPION. Results: The evaluation of characterization results showed that functionalization of magnetic nanoparticles could change their MS value, size and surface charges. Also, the microbial analysis revealed that lipo-amino acid coated magnetic nanoparticles has the least adverse effect on microbial strain among tested SPIONs. Conclusion: This study showed lipo-amino acid could be considered as the most protective and even promotive surface coating, which is explained by its optimizing effect on cell penetration and negligible reductive effects on magnetic properties of SPIONs. lipo-amino acid coated magnetic nanoparticles could be used in microbial biotechnology and industrial microbiology.

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