scholarly journals Magnetic Iron Oxide Nanoparticles: Synthesis, Characterization and Functionalization for Biomedical Applications in the Central Nervous System

Materials ◽  
2019 ◽  
Vol 12 (3) ◽  
pp. 465 ◽  
Author(s):  
Shoeb Ansari ◽  
Eleonora Ficiarà ◽  
Federico Ruffinatti ◽  
Ilaria Stura ◽  
Monica Argenziano ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Magnetic Iron Oxide Nanoparticles ◽  
Close Link ◽  
Wide Range ◽  
Methods Of Synthesis ◽  
The Central Nervous System

Magnetic Nanoparticles (MNPs) are of great interest in biomedicine, due to their wide range of applications. During recent years, one of the most challenging goals is the development of new strategies to finely tune the unique properties of MNPs, in order to improve their effectiveness in the biomedical field. This review provides an up-to-date overview of the methods of synthesis and functionalization of MNPs focusing on Iron Oxide Nanoparticles (IONPs). Firstly, synthesis strategies for fabricating IONPs of different composition, sizes, shapes, and structures are outlined. We describe the close link between physicochemical properties and magnetic characterization, essential to developing innovative and powerful magnetic-driven nanocarriers. In conclusion, we provide a complete background of IONPs functionalization, safety, and applications for the treatment of Central Nervous System disorders.

scholarly journals Superparamagnetic Iron Oxide Nanoparticles: Diagnostic Magnetic Resonance Imaging and Potential Therapeutic Applications in Neurooncology and Central Nervous System Inflammatory Pathologies, a Review

2009 ◽  
Vol 30 (1) ◽  
pp. 15-35 ◽  
Author(s):  
Jason S Weinstein ◽  
Csanad G Varallyay ◽  
Edit Dosa ◽  
Seymur Gahramanov ◽  
Bronwyn Hamilton ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Central Nervous System ◽  
Nervous System ◽  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Superparamagnetic Iron Oxide ◽  
Superparamagnetic Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Resonance Imaging ◽  
Therapeutic Applications

Superparamagnetic iron oxide nanoparticles have diverse diagnostic and potential therapeutic applications in the central nervous system (CNS). They are useful as magnetic resonance imaging (MRI) contrast agents to evaluate: areas of blood–brain barrier (BBB) dysfunction related to tumors and other neuroinflammatory pathologies, the cerebrovasculature using perfusion-weighted MRI sequences, and in vivo cellular tracking in CNS disease or injury. Novel, targeted, nanoparticle synthesis strategies will allow for a rapidly expanding range of applications in patients with brain tumors, cerebral ischemia or stroke, carotid atherosclerosis, multiple sclerosis, traumatic brain injury, and epilepsy. These strategies may ultimately improve disease detection, therapeutic monitoring, and treatment efficacy especially in the context of antiangiogenic chemotherapy and antiinflammatory medications. The purpose of this review is to outline the current status of superparamagnetic iron oxide nanoparticles in the context of biomedical nanotechnology as they apply to diagnostic MRI and potential therapeutic applications in neurooncology and other CNS inflammatory conditions.

Targeted Cell Uptake of a Noninternalizing Antibody Through Conjugation to Iron Oxide Nanoparticles in Primary Central Nervous System Lymphoma

2013 ◽  
Vol 80 (1-2) ◽  
pp. 134-141 ◽  
Author(s):  
Tingzhong Wang ◽  
Forrest M. Kievit ◽  
Omid Veiseh ◽  
Hamed Arami ◽  
Zachary R. Stephen ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Central Nervous System Lymphoma ◽  
Cell Uptake ◽  
Oxide Nanoparticles

scholarly journals Surface Modification of Magnetic Iron Oxide Nanoparticles

Nanomaterials ◽  
2018 ◽  
Vol 8 (10) ◽  
pp. 810 ◽  
Author(s):  
Nan Zhu ◽  
Haining Ji ◽  
Peng Yu ◽  
Jiaqi Niu ◽  
M. Farooq ◽  
...  
Keyword(s):  
Surface Modification ◽  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Inorganic Materials ◽  
Oxide Nanoparticles ◽  
Magnetic Iron Oxide Nanoparticles ◽  
Preparation Methods ◽  
Practical Applications ◽  
Wide Range ◽  
Surface Modified

Functionalized iron oxide nanoparticles (IONPs) are of great interest due to wide range applications, especially in nanomedicine. However, they face challenges preventing their further applications such as rapid agglomeration, oxidation, etc. Appropriate surface modification of IONPs can conquer these barriers with improved physicochemical properties. This review summarizes recent advances in the surface modification of IONPs with small organic molecules, polymers and inorganic materials. The preparation methods, mechanisms and applications of surface-modified IONPs with different materials are discussed. Finally, the technical barriers of IONPs and their limitations in practical applications are pointed out, and the development trends and prospects are discussed.

Sign in / Sign up

Export Citation Format

Share Document