A ROS-scavenging multifunctional nanoparticle for combinational therapy of diabetic nephropathy

Nanoscale ◽  
2020 ◽  
Vol 12 (46) ◽  
pp. 23607-23619
Author(s):  
Yuna Tong ◽  
Lijuan Zhang ◽  
Rong Gong ◽  
Jianyou Shi ◽  
Lei Zhong ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Mesoporous Silica ◽  
Drug Loading ◽  
Loading Capacity ◽  
Ros Scavenging ◽  
High Drug ◽  
Combinational Therapy ◽  
Multifunctional Nanoparticle ◽  
Hollow Mesoporous Silica ◽  
High Drug Loading

A renoprotective activity hollow mesoporous silica nanocomposite (HMSN) particle doped with trace cerium oxide has been constructed, which not only has the ability to prevent ROS-associated DN pathogenesis but also has high drug loading capacity.

scholarly journals Synthesis and compatibility evaluation of versatile mesoporous silica nanoparticles with red blood cells: an overview

RSC Advances ◽  
2019 ◽  
Vol 9 (61) ◽  
pp. 35566-35578 ◽  
Author(s):  
Subhankar Mukhopadhyay ◽  
Hanitrarimalala Veroniaina ◽  
Tadious Chimombe ◽  
Lidong Han ◽  
Wu Zhenghong ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Blood Cells ◽  
Drug Delivery Systems ◽  
Mesoporous Silica Nanoparticles ◽  
Drug Loading ◽  
Loading Capacity ◽  
High Drug ◽  
High Drug Loading

Protean mesoporous silica nanoparticles are propitious candidates over decades for nanoscale drug delivery systems due to their unique characteristics, including changeable pore size, mesoporosity, high drug loading capacity and biodegradability.

Hollow mesoporous silica as a high drug loading carrier for regulation insoluble drug release

2016 ◽  
Vol 510 (1) ◽  
pp. 184-194 ◽  
Author(s):  
Hongjian Geng ◽  
Yating Zhao ◽  
Jia Liu ◽  
Yu Cui ◽  
Ying Wang ◽  
...  
Keyword(s):  
Drug Release ◽  
Mesoporous Silica ◽  
Drug Loading ◽  
High Drug ◽  
Hollow Mesoporous Silica ◽  
High Drug Loading

Design of dual-responsive nanocarries with high drug loading capacity based on hollow mesoporous organosilica nanoparticles

2019 ◽  
Vol 233 ◽  
pp. 230-235 ◽  
Author(s):  
Li-li Lu ◽  
Wen-ya Xiong ◽  
Jun-bin Ma ◽  
Tian-fang Gao ◽  
Si-yuan Peng ◽  
...  
Keyword(s):  
Drug Loading ◽  
Loading Capacity ◽  
High Drug ◽  
Dual Responsive ◽  
Mesoporous Organosilica ◽  
High Drug Loading

scholarly journals Cancer Nanomedicines Stabilized by π-π Stacking between Heterodimeric Prodrugs Enable Exceptionally High Drug Loading Capacity and Safer Delivery of Drug Combinations

Theranostics ◽  
2017 ◽  
Vol 7 (15) ◽  
pp. 3638-3652 ◽  
Author(s):  
Hangxiang Wang ◽  
Jianmei Chen ◽  
Chang Xu ◽  
Linlin Shi ◽  
Munire Tayier ◽  
...  
Keyword(s):  
Drug Loading ◽  
Drug Combinations ◽  
Loading Capacity ◽  
High Drug ◽  
Π Stacking ◽  
High Drug Loading

scholarly journals Core-Shell Structure Design of Hollow Mesoporous Silica Nanospheres Based on Thermo-Sensitive PNIPAM and pH-Responsive Catechol-Fe3+ Complex

Polymers ◽  
2019 ◽  
Vol 11 (11) ◽  
pp. 1832 ◽  
Author(s):  
Weili Peng ◽  
Zeping Zhang ◽  
Minzhi Rong ◽  
Mingqiu Zhang
Keyword(s):  
Mesoporous Silica ◽  
Mesoporous Silica Nanoparticles ◽  
Drug Loading ◽  
Structure Design ◽  
Raw 264.7 Cells ◽  
Core Shell ◽  
Loading Capacity ◽  
Ph Responsive ◽  
Hierarchical Porous ◽  
Hollow Mesoporous Silica

A kind of core-shell hybrid nanoparticle comprised of a hollow mesoporous silica nanoparticles (HMS) core and a copolymer shell bearing N-(3,4-dihydroxyphenethyl) methacrylamide (DMA) and N-isopropylacrylamide (NIPAM) as responsive moieties was prepared. Moreover, the factors that could impact the surface morphology and hierarchical porous structure were discussed. In the presence of Fe3+, catechol-Fe3+ complexes were formed to achieve pH-responsive polymer shell, combining with thermal-sensitiveness of poly(N-isopropylacrylamide). Doxorubicin (DOX) was applied as a model drug and the behaviors of its loading/release behaviors were investigated to prove the idea. The results exhibited a significant drug loading capacity of 8.6% and embed efficiency of 94.6% under 1 mg ml–1 DOX/PBS solution. In fact, the loading capacity of drug can be easily improved to as high as 28.0% by increasing the DOX concentration. The vitro cytotoxicity assay also indicated that the as-prepared nanoparticles have no significant cytotoxicity on RAW 264.7 cells. The in vitro experiment showed that the cumulative release of DOX was obviously dependent on the temperature and pH values. This pH/temperature-sensitive hollow mesoporous silica nanosphere is expected to have potential applications in controlled drug release.

Magnetic carbon nanotubes with particle-free surfaces and high drug loading capacity

2011 ◽  
Vol 22 (35) ◽  
pp. 355602 ◽  
Author(s):  
Eleni C Vermisoglou ◽  
George Pilatos ◽  
George E Romanos ◽  
Eamon Devlin ◽  
Nick K Kanellopoulos ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Drug Loading ◽  
Loading Capacity ◽  
Free Surfaces ◽  
High Drug ◽  
Magnetic Carbon ◽  
High Drug Loading ◽  
Magnetic Carbon Nanotubes
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