scholarly journals Three-Dimensional Printed Polylactic Acid (PLA) Surgical Retractors with Sonochemically Immobilized Silver Nanoparticles: The Next Generation of Low-Cost Antimicrobial Surgery Equipment

Nanomaterials ◽  
2020 ◽  
Vol 10 (5) ◽  
pp. 985 ◽  
Author(s):  
Lazaros Tzounis ◽  
Petros I. Bangeas ◽  
Aristomenis Exadaktylos ◽  
Markos Petousis ◽  
Nectarios Vidakis
Keyword(s):  
Electron Microscopy ◽  
3D Printing ◽  
Polylactic Acid ◽  
Low Cost ◽  
Three Dimensional ◽  
Film Deposition ◽  
Average Particle ◽  
Ag Nps ◽  
Fused Deposition ◽  
Vis Spectroscopy

A versatile method is reported for the manufacturing of antimicrobial (AM) surgery equipment utilising fused deposition modelling (FDM), three-dimensional (3D) printing and sonochemistry thin-film deposition technology. A surgical retractor was replicated from a commercial polylactic acid (PLA) thermoplastic filament, while a thin layer of silver (Ag) nanoparticles (NPs) was developed via a simple and scalable sonochemical deposition method. The PLA retractor covered with Ag NPs (PLA@Ag) exhibited vigorous AM properties examined by a reduction in Staphylococcus aureus (S. aureus), Pseudomonas aeruginosa (P. aeruginosa) and Escherichia coli (E. coli) bacteria viability (%) experiments at 30, 60 and 120 min duration of contact (p < 0.05). Scanning electron microscopy (SEM) showed the surface morphology of bare PLA and PLA@Ag retractor, revealing a homogeneous and full surface coverage of Ag NPs. X-Ray diffraction (XRD) analysis indicated the crystallinity of Ag nanocoating. Ultraviolent-visible (UV-vis) spectroscopy and transmission electron microscopy (TEM) highlighted the AgNP plasmonic optical responses and average particle size of 31.08 ± 6.68 nm. TEM images of the PLA@Ag crossection demonstrated the thickness of the deposited Ag nanolayer, as well as an observed tendency of AgNPs to penetrate though the outer surface of PLA. The combination of 3D printing and sonochemistry technology could open new avenues in the manufacturing of low-cost and on-demand antimicrobial surgery equipment.

scholarly journals An overview on 3D Printed Medicine

2021 ◽  
Vol 18 (1) ◽  
pp. 07-13
Author(s):  
Neha Thakur ◽  
Hari Murthy
Keyword(s):  
3D Printing ◽  
Fused Deposition Modeling ◽  
Low Cost ◽  
Selective Laser Sintering ◽  
Three Dimensional ◽  
Herbal Medicines ◽  
Fused Deposition ◽  
Digitally Controlled ◽  
3D Printed ◽  
Semi Solid

Three-dimensional printing (3DP) is a digitally-controlled additive manufacturing technique used for fast prototyping. This paper reviews various 3D printing techniques like Selective Laser Sintering (SLS), Fused Deposition Modeling, (FDM), Semi-solid extrusion (SSE), Stereolithography (SLA), Thermal Inkjet (TIJ) Printing, and Binder jetting 3D Printing along with their application in the field of medicine. Normal medicines are based on the principle of “one-size-fits-all”. This is not true always, it is possible medicine used for curing one patient is giving some side effects to another. To overcome this drawback “3D Printed medicines” are developed. In this paper, 3D printed medicines forming different Active Pharmaceutical Ingredients (API) are reviewed. Printed medicines are capable of only curing the diseases, not for the diagnosis. Nanomedicines have “theranostic” ability which combines therapeutic and diagnostic. Nanoparticles are used as the drug delivery system (DDS) to damaged cells’ specific locations. By the use of nanomedicine, the fast recovery of the disease is possible. The plant-based nanoparticles are used with herbal medicines which give low-cost and less toxic medication called nanobiomedicine. 4D and 5D printing technology for the medical field are also enlightened in this paper.

scholarly journals Analysis of Mechanical Properties of Polylactic Acid Using a New 3D Printer Nozzle

2018 ◽  
Vol 15 (2) ◽  
pp. 666-675
Author(s):  
Nor Aiman Sukindar ◽  
Mohd Khairol Anuar Mohd Ariffin ◽  
B. T. Hang Tuah Baharudin ◽  
Che Nor Aiza Jaafar ◽  
Mohd Idris Shah Ismail
Keyword(s):  
Mechanical Properties ◽  
3D Printing ◽  
Polylactic Acid ◽  
Low Cost ◽  
Three Dimensional ◽  
Extrusion Process ◽  
3D Printer ◽  
Layer By Layer ◽  
The Stability ◽  
Stability And Accuracy

Additive manufacturing, also known as three-dimensional (3D) printing, is the process of developing 3D products in a layer-by-layer manner using filament as a material feedstock to create a solid structure. Owing to its unique properties and advantages, which include biodegradability and printing speed, polylactic acid is one of the most common 3D printing extrusion materials. While a considerable attention has been paid to the manipulation of process parameters in order to achieve desired finished product quality, to date less research has been performed on improving the hardware systems of low-cost 3D printers. This study focuses on fabricating the 3D printer nozzle parts, with an emphasis on die angle, nozzle diameter, liquefier design, and insulator composition. Modifying the properties of these components from the conventional nozzle, it is possible to optimize the stability and accuracy of the extrusion process, leading to better-quality printed products. To demonstrate the capability of the new nozzle, its tensile and compressive strengths were compared to those of a conventional nozzle. The obtained results proved that the proposed augmentations to the nozzle system lead to finished products with improved mechanical properties.

scholarly journals Green Method Synthesised Graphene-Silver Electrochemical Nanobiosensors for Ethambutol and Pyrazinamide

Processes ◽  
2020 ◽  
Vol 8 (7) ◽  
pp. 879
Author(s):  
Rachel Fanelwa AjayI ◽  
Siphokazi Tshoko ◽  
Yonela Mgwili ◽  
Siphamandla Nqunqa ◽  
Takalani Mulaudzi ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
High Resolution ◽  
Limit Of Detection ◽  
Low Cost ◽  
Ag Nps ◽  
Green Method ◽  
Tb Treatment ◽  
Transmission Electron ◽  
Vis Spectroscopy ◽  
P450 2D6

A novel nanobiosensor was constructed with graphene oxide (GO) sheets coupled to pear extract-based green-synthesised silver nanoparticles (Ag-NPs) to which cytochrome P450-2D6 (CYP2D6) enzyme was attached. The biosensor was applied in the electrochemical detection of the tuberculosis (TB) treatment drugs, ethambutol (EMB) and pyrazinamide (PZA). The surface morphology of the green-synthesised nanocomposites was studied by performing High-Resolution Transmission Electron Microscopy (HR-TEM) and High-Resolution Scanning Electron Microscopy (HR-SEM). Fourier Transform Infrared Spectroscopy (FTIR) and Raman Spectroscopy were used for structural analysis, while Ultraviolet Visible (UV-Vis) Spectroscopy was used in the optical characterisation of the nanocomposite material. Electrochemical studies on glassy carbon electrode (GCE), which were done by Cyclic Voltammetry (CV), showed that the GO|Ag-NPs||GCE electrode was highly conductive, and thereby indicating its suitability as a platform for nanobiosensor development. The non-toxic and low-cost green GO|Ag-NPs|CYP2D6||GCE nanobiosensor was used to determine EMB and PZA. The very low limit of detection (LOD) values of the biosensor for EMB (0.2962 × 10−2 nM, S/N = 3) and PZA (0.897 × 10−2 nM, S/N = 3) demonstrate that the green nanobiosensor is more sensitive than other biosensors reported for EMB and PZA.

scholarly journals Three-dimensional printing versus conventional machining in the creation of a meatal urethral dilator: a cost and mechanical strength analysis

2020 ◽  
Author(s):  
Michael Yue-Cheng Chen ◽  
Jacob Skewes ◽  
Ryan Daley ◽  
Maria Ann Woodruff ◽  
Nicholas John Rukin
Keyword(s):  
3D Printing ◽  
Low Cost ◽  
Three Dimensional ◽  
Patient Specific ◽  
Strength Analysis ◽  
3D Printer ◽  
Fused Deposition ◽  
3D Printed ◽  
The Cost ◽  
Conventional Machining

Abstract Background Three-dimensional (3D) printing is a promising technology in medicine. Low-cost 3D printing options are accessible but the limitations are often poorly understood. We aim to compare fused deposition modelling (FDM), the most common and low cost 3D printing technique, with selective laser sintering (SLS) and conventional machining techniques in manufacturing meatal urethral dilators which were recently removed from the Australian market.Methods A meatal urethral dilator was designed using computer-aided design (CAD). The dilator was 3D printed vertically orientated on a low cost FDM 3D printer in polylactic acid (PLA) and acrylonitrile butadiene styrene (ABS). It was also 3D printed horizontally orientated in ABS on a high-end FDM 3D printer with soluble support material, as well as on a SLS 3D printer in medical nylon. The dilator was also machined in medical stainless steel using a lathe. All dilators were tested mechanically in a custom rig by hanging calibrated weights from the handle until the dilator snapped.Results The horizontally printed ABS dilator experienced failure at a greater load than the vertically printed PLA and ABS dilators respectively (503g vs 283g vs 163g, p < 0.001). The SLS nylon dilator did not fail but began to bend and deformed at around 5,000g of pressure. The steel dilator did not bend even at 10,000g of pressure. The cost per dilator is highest for the steel dilator if assuming a low quantity of five at 98 USD, but this decreases to 30 USD for a quantity of 1000. In contrast, the cost for the SLS dilator is 33 USD for a quantity of five but relatively unchanged at 27 for a quantity of 1000.Conclusions SLS and conventional machining created clinically functional meatal dilators but low-cost FDM printing could not. We suggest that at the current time 3D printing is not a replacement for conventional manufacturing techniques which are still the most reliable way to produce large quantities of parts with a simple geometry such as the meatal dilator. 3D printing is best used for patient-specific parts, prototyping or manufacturing complex parts that have additional functionality that cannot be achieved with conventional machining methods.

Application of Fused Deposition Modelling (FDM) Method of 3D Printing in Drug Delivery

2017 ◽  
Vol 23 (3) ◽  
pp. 433-439 ◽  
Author(s):  
Jingjunjiao Long ◽  
Hamideh Gholizadeh ◽  
Jun Lu ◽  
Craig Bunt ◽  
Ali Seyfoddin
Keyword(s):  
Drug Delivery ◽  
3D Printing ◽  
Low Cost ◽  
Three Dimensional ◽  
Fused Deposition Modelling ◽  
Layer By Layer ◽  
Fused Deposition ◽  
Accurate Dose ◽  
Drug Delivery Devices ◽  
3D Printing Technique

Three-dimensional (3D) printing is an emerging manufacturing technology for biomedical and pharmaceutical applications. Fused deposition modelling (FDM) is a low cost extrusion-based 3D printing technique that can deposit materials layer-by-layer to create solid geometries. This review article aims to provide an overview of FDM based 3D printing application in developing new drug delivery systems. The principle methodology, suitable polymers and important parameters in FDM technology and its applications in fabrication of personalised tablets and drug delivery devices are discussed in this review. FDM based 3D printing is a novel and versatile manufacturing technique for creating customised drug delivery devices that contain accurate dose of medicine( s) and provide controlled drug released profiles.

scholarly journals Research of TPU Materials for 3D Printing Aiming at Non-Pneumatic Tires by FDM Method

Polymers ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 2492
Author(s):  
Jun Wang ◽  
Bin Yang ◽  
Xiang Lin ◽  
Lei Gao ◽  
Tao Liu ◽  
...  
Keyword(s):  
3D Printing ◽  
Fused Deposition Modeling ◽  
Low Cost ◽  
Three Dimensional ◽  
Printing Technology ◽  
Performance Simulation ◽  
3D Printing Technology ◽  
Fused Deposition ◽  
3D Printed ◽  
Pneumatic Tires

3D printing technology has been widely used in various fields, such as biomedicine, clothing design, and aerospace, due to its personalized customization, rapid prototyping of complex structures, and low cost. However, the application of 3D printing technology in the field of non-pneumatic tires has not been systematically studied. In this study, we evaluated the application of potential thermoplastic polyurethanes (TPU) materials based on FDM technology in the field of non-pneumatic tires. First, the printing process of TPU material based on fused deposition modeling (FDM) technology was studied through tensile testing and SEM observation. The results show that the optimal 3D printing temperature of the selected TPU material is 210 °C. FDM technology was successfully applied to 3D printed non-pneumatic tires based on TPU material. The study showed that the three-dimensional stiffness of 3D printed non-pneumatic tires is basically 50% of that obtained by simulation. To guarantee the prediction of the performance of 3D printed non-pneumatic tires, we suggest that the performance of these materials should be moderately reduced during the structural design for performance simulation.

scholarly journals An Overview of Natural Polymers as Reinforcing Agents for 3D Printing

2021 ◽  
Vol 5 (4) ◽  
pp. 78
Author(s):  
Beatrice Sabbatini ◽  
Alessandra Cambriani ◽  
Marco Cespi ◽  
Giovanni Filippo Palmieri ◽  
Diego Romano Perinelli ◽  
...  
Keyword(s):  
3D Printing ◽  
Low Cost ◽  
Selective Laser Sintering ◽  
Three Dimensional ◽  
Polymeric Materials ◽  
Industrial Wastes ◽  
Fused Deposition Modelling ◽  
Natural Polymers ◽  
Fused Deposition ◽  
Glass Carbon

Three-dimensional (3D) printing, or additive manufacturing, is a group of innovative technologies that are increasingly employed for the production of 3D objects in different fields, including pharmaceutics, engineering, agri-food and medicines. The most processed materials by 3D printing techniques (e.g., fused deposition modelling, FDM; selective laser sintering, SLS; stereolithography, SLA) are polymeric materials since they offer chemical resistance, are low cost and have easy processability. However, one main drawback of using these materials alone (e.g., polylactic acid, PLA) in the manufacturing process is related to the poor mechanical and tensile properties of the final product. To overcome these limitations, fillers can be added to the polymeric matrix during the manufacturing to act as reinforcing agents. These include inorganic or organic materials such as glass, carbon fibers, silicon, ceramic or metals. One emerging approach is the employment of natural polymers (polysaccharides and proteins) as reinforcing agents, which are extracted from plants or obtained from biomasses or agricultural/industrial wastes. The advantages of using these natural materials as fillers for 3D printing are related to their availability together with the possibility of producing printed specimens with a smaller environmental impact and higher biodegradability. Therefore, they represent a “green option” for 3D printing processing, and many studies have been published in the last year to evaluate their ability to improve the mechanical properties of 3D printed objects. The present review provides an overview of the recent literature regarding natural polymers as reinforcing agents for 3D printing.

scholarly journals Fabrication of Polylactic Acid/β-Tricalcium Phosphate FDM 3D Printing Fiber to Enhance Osteoblastic-Like Cell Performance

2021 ◽  
Vol 8 ◽  
Author(s):  
Eisner Salamanca ◽  
Ting-Chia Tsao ◽  
Hao-Wen Hseuh ◽  
Yi-Fan Wu ◽  
Cheuk-Sing Choy ◽  
...  
Keyword(s):  
3D Printing ◽  
Polylactic Acid ◽  
Tricalcium Phosphate ◽  
Fused Deposition Modeling ◽  
Three Dimensional ◽  
Fused Deposition ◽  
Base Materials ◽  
Effective Combination ◽  
Collagen Type 1

Guided-bone regeneration (GBR) is increasingly using three-dimensional (3D) printing by fused deposition modeling (FDM) to build the filaments used for treatment. Polylactic acid (PLA) and beta-tricalcium phosphate (β-TCP) are widely used as base materials in 3D printing, necessitating that they are studied together in the context of GBR treatment. This study sought to test and compare the properties and efficacy of different ratios of β-TCP and PLA used to make the 3D-printed filament material to find the most effective combination of materials for GBR treatment. Several ratios of PLA to β-TCP were tested, including PLA/β-TCP ratios of 95%/5% (PLA-5), 90%/10% (PLA-10), 85%/15% (PLA-15), and 80%/20% (PLA-20), and quantitative real-time polymerase chain reaction (qPCR) in vitro testing was done to characterize the material. After adding β-TCP to PLA, mechanical testing indicated that tensile and elongation strengths decreased, hardness was retained, and cell proliferation was promoted. The effect of PLA and β-TCP on increasing alkaline phosphatase (ALP) activity was significantly greater in a ratio of 10% β-TCP/90% PLA at 5 days (p &lt; 0.05) than in any other ratios tested. This is supported by results from qPCR testing, which showed early osteoblast-like differentiation of DLX5, RUNX2, OPG, OC, and collagen type 1 (COL-1) expression levels similar to cells cultured on PLA-10. Our results demonstrated that 3D printing of filaments produced in a ratio of 90% PLA to 10% β-TCP was more effective for GBR than that of filaments produced only using PLA.

scholarly journals Supercritical Impregnation of PLA Filaments with Mango Leaf Extract to Manufacture Functionalized Biomedical Devices by 3D Printing

Polymers ◽  
2021 ◽  
Vol 13 (13) ◽  
pp. 2125
Author(s):  
José María Rosales ◽  
Cristina Cejudo ◽  
Lidia Verano ◽  
Lourdes Casas ◽  
Casimiro Mantell ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
3D Printing ◽  
Polylactic Acid ◽  
Leaf Extract ◽  
Three Dimensional ◽  
3D Printer ◽  
Pharmacological Properties ◽  
Bioactive Properties ◽  
Supercritical Impregnation ◽  
Mango Leaves

Polylactic Acid (PLA) filaments impregnated with ethanolic mango leaves extract (MLE) with pharmacological properties were obtained by supercritical impregnation. The effects of pressure, temperature and amount of extract on the response variables, i.e., swelling, extract loading and bioactivity of the PLA filaments, were determined. The analysis of the filaments biocapacities revealed that impregnated PLA filaments showed 11.07% antidenaturant capacity and 88.13% antioxidant activity, which after a 9-day incubation shifted to 30.10% and 9.90%, respectively. Subsequently, the same tests were conducted on printed samples. Before their incubation, the printed samples showed 79.09% antioxidant activity and no antidenaturant capacity was detected. However, after their incubation, the antioxidant activity went down to only 2.50%, while the antidenaturant capacity raised up to 23.50%. The persistence of the bioactive properties after printing opens the possibility of using the functionalized PLA filaments as the feed for a three-dimensional (3D) printer.

scholarly journals Mesh-Type Three-Dimensional (3D) Printing of Human Organs and Tumors: Fast, Cost-Effective, and Personalized Anatomic Modeling of Patient-Oriented Visual Aids

2021 ◽  
Vol 11 (3) ◽  
pp. 1047
Author(s):  
Jungirl Seok ◽  
Sungmin Yoon ◽  
Chang Hwan Ryu ◽  
Junsun Ryu ◽  
Seok-ki Kim ◽  
...  
Keyword(s):  
3D Printing ◽  
3D Modeling ◽  
Fused Deposition Modeling ◽  
Three Dimensional ◽  
Tumor Location ◽  
Visual Aids ◽  
Surgical Specimen ◽  
Personalized Care ◽  
Fused Deposition ◽  
Mesh Work

Although three-dimensional (3D)-printed anatomic models are not new to medicine, the high costs and lengthy production times entailed have limited their application. Our goal was developing a new and less costly 3D modeling method to depict organ-tumor relations at faster printing speeds. We have devised a method of 3D modeling using tomographic images. Coordinates are extracted at a specified interval, connecting them to create mesh-work replicas. Adjacent constructs are depicted by density variations, showing anatomic targets (i.e., tumors) in contrasting colors. An array of organ solid-tumor models was printed via a Fused Deposition Modeling 3D printer at significantly less cost ($0.05/cm3) and time expenditure (1.73 min/cm3; both, p < 0.001). Printed models helped promote visual appreciation of organ-tumor anatomy and adjacent tissues. Our mesh-work 3D thyroidal prototype reproduced glandular size/contour and tumor location, readily approximating the surgical specimen. This newly devised mesh-type 3D printing method may facilitate anatomic modeling for personalized care and improve patient awareness during informed surgical consent.

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