scholarly journals Strategies to Improve Nanofibrous Scaffolds for Vascular Tissue Engineering

Nanomaterials ◽  
2020 ◽  
Vol 10 (5) ◽  
pp. 887 ◽  
Author(s):  
Tianyu Yao ◽  
Matthew B. Baker ◽  
Lorenzo Moroni
Keyword(s):  
Tissue Engineering ◽  
Self Assembly ◽  
Vascular Tissue ◽  
Vascular Tissue Engineering ◽  
In Vivo Evaluation ◽  
Thermally Induced ◽  
Vascular Regeneration ◽  
Nanofibrous Scaffolds ◽  
Biomimetic Scaffolds

The biofabrication of biomimetic scaffolds for tissue engineering applications is a field in continuous expansion. Of particular interest, nanofibrous scaffolds can mimic the mechanical and structural properties (e.g., collagen fibers) of the natural extracellular matrix (ECM) and have shown high potential in tissue engineering and regenerative medicine. This review presents a general overview on nanofiber fabrication, with a specific focus on the design and application of electrospun nanofibrous scaffolds for vascular regeneration. The main nanofiber fabrication approaches, including self-assembly, thermally induced phase separation, and electrospinning are described. We also address nanofibrous scaffold design, including nanofiber structuring and surface functionalization, to improve scaffolds’ properties. Scaffolds for vascular regeneration with enhanced functional properties, given by providing cells with structural or bioactive cues, are discussed. Finally, current in vivo evaluation strategies of these nanofibrous scaffolds are introduced as the final step, before their potential application in clinical vascular tissue engineering can be further assessed.

Surface Modification by Nanobiomaterials for Vascular Tissue Engineering Applications

2020 ◽  
Vol 27 (10) ◽  
pp. 1634-1646 ◽  
Author(s):  
Huey-Shan Hung ◽  
Shan-hui Hsu
Keyword(s):  
Tissue Engineering ◽  
Vascular Tissue ◽  
Thrombus Formation ◽  
Vascular Grafts ◽  
Vascular Tissue Engineering ◽  
Great Success ◽  
Natural Polymers ◽  
Vascular Biomaterials

Treatment of cardiovascular disease has achieved great success using artificial implants, particularly synthetic-polymer made grafts. However, thrombus formation and restenosis are the current clinical problems need to be conquered. New biomaterials, modifying the surface of synthetic vascular grafts, have been created to improve long-term patency for the better hemocompatibility. The vascular biomaterials can be fabricated from synthetic or natural polymers for vascular tissue engineering. Stem cells can be seeded by different techniques into tissue-engineered vascular grafts in vitro and implanted in vivo to repair the vascular tissues. To overcome the thrombogenesis and promote the endothelialization effect, vascular biomaterials employing nanotopography are more bio-mimic to the native tissue made and have been engineered by various approaches such as prepared as a simple surface coating on the vascular biomaterials. It has now become an important and interesting field to find novel approaches to better endothelization of vascular biomaterials. In this article, we focus to review the techniques with better potential improving endothelization and summarize for vascular biomaterial application. This review article will enable the development of biomaterials with a high degree of originality, innovative research on novel techniques for surface fabrication for vascular biomaterials application.

Preparation of Electrospun Poly(ε-caprolactone)/Poly(trimethylene carbonate) Blend Scaffold for In Situ Vascular Tissue Engineering

2012 ◽  
Vol 629 ◽  
pp. 60-63
Author(s):  
Tao Jiang ◽  
Guo Quan Zhang ◽  
Hui Li ◽  
Ji Na Xun
Keyword(s):  
Tissue Engineering ◽  
Vascular Graft ◽  
Vascular Tissue ◽  
Electrospinning Process ◽  
Vascular Tissue Engineering ◽  
Trimethylene Carbonate ◽  
Scaffold Materials ◽  
Degradation Time

In the active field of vascular graft research, in situ vascular tissue engineering is a novel concept. This approach aims to use biodegradable synthetic materials. After implantation, the synthetic material progressively degrades and should be replaced by autologous cells. Poly (ε-caprolactone) (PCL) is often used for vascular graft because of its good mechanical strength and its biocompatibility. It is easily processed into micro and nano-fibers by electrospinning to form a porous, cell-friendly scaffold. However, the degradation time of polycaprolactone is too long to match the tissue regeneration time. In this study, poly (ε-caprolactone) /poly (trimethylene carbonate) (PTMC) blend scaffold materials have been prepared for biodegradable vascular graft using an electrospinning process. Because the degradation time of PTMC is shorter than PCL in vivo. The morphological characters of PCL/PTMC blend scaffold materials were investigated by scanning electron microscope (SEM). The molecular components and some physical characteristics of the blend scaffold materials were tested by FT-IR and DSC analysis.

Development of nanofibrous scaffolds for vascular tissue engineering

2013 ◽  
Vol 56 ◽  
pp. 106-113 ◽  
Author(s):  
Jin Zhao ◽  
Hui Qiu ◽  
Deng-long Chen ◽  
Wen-xian Zhang ◽  
Da-chun Zhang ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Vascular Tissue ◽  
Vascular Tissue Engineering ◽  
Nanofibrous Scaffolds

In vitro self-assembly of proepicardial cell aggregates: An embryonic vasculogenic model for vascular tissue engineering

2006 ◽  
Vol 288A (7) ◽  
pp. 700-713 ◽  
Author(s):  
José M. Pérez-Pomares ◽  
V. Mironov ◽  
Juan A. Guadix ◽  
David Macías ◽  
Roger R. Markwald ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Self Assembly ◽  
Vascular Tissue ◽  
Vascular Tissue Engineering ◽  
Cell Aggregates

scholarly journals Vascular Tissue Engineering: Polymers and Methodologies for Small Caliber Vascular Grafts

2021 ◽  
Vol 7 ◽  
Author(s):  
Bruna B. J. Leal ◽  
Naohiro Wakabayashi ◽  
Kyohei Oyama ◽  
Hiroyuki Kamiya ◽  
Daikelly I. Braghirolli ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Vascular Tissue ◽  
Thrombus Formation ◽  
Treatment Options ◽  
Vascular Grafts ◽  
Vascular Tissue Engineering ◽  
Engineering Polymers ◽  
Autologous Grafts

Cardiovascular disease is the most common cause of death in the world. In severe cases, replacement or revascularization using vascular grafts are the treatment options. While several synthetic vascular grafts are clinically used with common approval for medium to large-caliber vessels, autologous vascular grafts are the only options clinically approved for small-caliber revascularizations. Autologous grafts have, however, some limitations in quantity and quality, and cause an invasiveness to patients when harvested. Therefore, the development of small-caliber synthetic vascular grafts (<5 mm) has been urged. Since small-caliber synthetic grafts made from the same materials as middle and large-caliber grafts have poor patency rates due to thrombus formation and intimal hyperplasia within the graft, newly innovative methodologies with vascular tissue engineering such as electrospinning, decellularization, lyophilization, and 3D printing, and novel polymers have been developed. This review article represents topics on the methodologies used in the development of scaffold-based vascular grafts and the polymers used in vitro and in vivo.

Vascular Tissue Engineering Using Polycaprolactone Nanofibrous Scaffolds Fabricated via Electrospinning

2015 ◽  
Vol 7 (3) ◽  
pp. 407-413 ◽  
Author(s):  
Y. A. Elnakady ◽  
Mohammed F. Al Rez ◽  
H. Fouad ◽  
Sarah Abuelreich ◽  
Ahmed M. Albarrag ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Vascular Tissue ◽  
Vascular Tissue Engineering ◽  
Nanofibrous Scaffolds

Use of Polyelectrolyte Films in Vascular Tissue Engineering

2008 ◽  
Author(s):  
H. Kerdjoudj ◽  
V. Moby ◽  
N. Berthelemy ◽  
J. C. Voegel ◽  
P. Menu ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Endothelial Cells ◽  
Vascular Tissue ◽  
Vascular Endothelial Cells ◽  
Medical Science ◽  
Vascular Diseases ◽  
Vascular Tissue Engineering ◽  
High Morbidity ◽  
Layer By Layer

Vascular diseases with their high morbidity and mortality are a major challenge for medical science, engaging the best minds in modern medicine. The development of antithrombogenic surfaces still remains a huge challenge in the vascular tissue engineering field. Various researchers have expanded surface coating procedures allowing endothelial cells (EC) adhesion and retention on vascular substitutes or by incorporating some of the mechanisms employed by vascular endothelial cells i.e. heparin. The short in vivo patency of these grafts is related. Our group study evaluates a new surface modification based on polyelectrolyte building. The layer by layer self assembly and the result in polyelectrolyte multilayer films (PEM) became also in a recent past a challenging, simple and versatile way to engineer surfaces with highly specific properties. Previous studies indicated that the poly(sodium-4 styrene sulfonate)/poly (allylamine hydrochloride) PSS/PAH multilayered films when ended by PAH induce strong adhesion and retention of mature EC which spread and keep their phenotype as well on glass [1,2], on expanded polytetrafluoroethylene ePTFE [3] and on cryopreserved arteries [4,5]. The mechanical properties (compliance), leading to early intimal hyperplasia and graft failure, were lost after artery cryopreservation. We have demonstrated the compliance restoration of PEM treated cryopreserved close to native arteries [5]. The use of an autologous EC source avoids the immunological rejections of the grafts. With an autologous origin, high proliferation capacity and potentialities to proliferate and differentiate into matures EC, the endothelial progenitor cells (EPC) have raised huge interest and offer new opportunities in vascular engineering. Currents protocols for isolation and differentiation of EPC from peripheral blood requires at least 1 month to observe an endothelium-like morphology and about 2 months for confluent EC monolayer. The EPC cultivated on PEM treated glasses showed a monolayer development after only 14 days of culture. The morphological appearance and mature phenotype markers expression and repartition of the monolayer cells are close to mature EC [6]. These main results have led to French patent deposit in June 2007[7].

Electrospun sulfated silk fibroin nanofibrous scaffolds for vascular tissue engineering

Biomaterials ◽  
2011 ◽  
Vol 32 (15) ◽  
pp. 3784-3793 ◽  
Author(s):  
Haifeng Liu ◽  
Xiaoming Li ◽  
Gang Zhou ◽  
Hongbin Fan ◽  
Yubo Fan
Keyword(s):  
Tissue Engineering ◽  
Silk Fibroin ◽  
Vascular Tissue ◽  
Vascular Tissue Engineering ◽  
Nanofibrous Scaffolds
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