scholarly journals Multifunctional Nanocarriers for Lung Drug Delivery

Nanomaterials ◽  
2020 ◽  
Vol 10 (2) ◽  
pp. 183 ◽  
Author(s):  
Jorge F. Pontes ◽  
Ana Grenha
Keyword(s):  
Drug Delivery ◽  
Final Section ◽  
Surface Engineering ◽  
Material Structure ◽  
Chemical Modifications ◽  
Pharmaceutical Ingredients ◽  
Therapeutic Outcomes ◽  
Lung Drug Delivery ◽  
Multifunctional Nanocarriers ◽  
Systemic Application

Nanocarriers have been increasingly proposed for lung drug delivery applications. The strategy of combining the intrinsic and more general advantages of the nanostructures with specificities that improve the therapeutic outcomes of particular clinical situations is frequent. These include the surface engineering of the carriers by means of altering the material structure (i.e., chemical modifications), the addition of specific ligands so that predefined targets are reached, or even the tuning of the carrier properties to respond to specific stimuli. The devised strategies are mainly directed at three distinct areas of lung drug delivery, encompassing the delivery of proteins and protein-based materials, either for local or systemic application, the delivery of antibiotics, and the delivery of anticancer drugs—the latter two comprising local delivery approaches. This review addresses the applications of nanocarriers aimed at lung drug delivery of active biological and pharmaceutical ingredients, focusing with particular interest on nanocarriers that exhibit multifunctional properties. A final section addresses the expectations regarding the future use of nanocarriers in the area.

scholarly journals Antiviral Activity of Carrageenans and Processing Implications

Marine Drugs ◽  
2021 ◽  
Vol 19 (8) ◽  
pp. 437
Author(s):  
Milena Álvarez-Viñas ◽  
Sandra Souto ◽  
Noelia Flórez-Fernández ◽  
Maria Dolores Torres ◽  
Isabel Bandín ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Antiviral Activity ◽  
Drug Delivery Systems ◽  
Biological Properties ◽  
Red Seaweed ◽  
Processing Conditions ◽  
Chemical Modifications ◽  
Viral Attachment ◽  
Extraction Stage ◽  
Composition Structure

Carrageenan and carrageenan oligosaccharides are red seaweed sulfated carbohydrates with well-known antiviral properties, mainly through the blocking of the viral attachment stage. They also exhibit other interesting biological properties and can be used to prepare different drug delivery systems for controlled administration. The most active forms are λ-, ι-, and κ-carrageenans, the degree and sulfation position being determined in their properties. They can be obtained from sustainable worldwide available resources and the influence of manufacturing on composition, structure, and antiviral properties should be considered. This review presents a survey of the antiviral properties of carrageenan in relation to the processing conditions, particularly those assisted by intensification technologies during the extraction stage, and discusses the possibility of further chemical modifications.

scholarly journals Drug Delivery by Ultrasound-Responsive Nanocarriers for Cancer Treatment

Pharmaceutics ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1135
Author(s):  
Kristin Entzian ◽  
Achim Aigner
Keyword(s):  
Drug Delivery ◽  
Biological Effects ◽  
Invasive Technique ◽  
Stimuli Responsive ◽  
Comprehensive Overview ◽  
Drug Concentrations ◽  
Therapeutic Outcomes ◽  
Cost Efficient ◽  
Safety Considerations

Conventional cancer chemotherapies often exhibit insufficient therapeutic outcomes and dose-limiting toxicity. Therefore, there is a need for novel therapeutics and formulations with higher efficacy, improved safety, and more favorable toxicological profiles. This has promoted the development of nanomedicines, including systems for drug delivery, but also for imaging and diagnostics. Nanoparticles loaded with drugs can be designed to overcome several biological barriers to improving efficiency and reducing toxicity. In addition, stimuli-responsive nanocarriers are able to release their payload on demand at the tumor tissue site, preventing premature drug loss. This review focuses on ultrasound-triggered drug delivery by nanocarriers as a versatile, cost-efficient, non-invasive technique for improving tissue specificity and tissue penetration, and for achieving high drug concentrations at their intended site of action. It highlights aspects relevant for ultrasound-mediated drug delivery, including ultrasound parameters and resulting biological effects. Then, concepts in ultrasound-mediated drug delivery are introduced and a comprehensive overview of several types of nanoparticles used for this purpose is given. This includes an in-depth compilation of the literature on the various in vivo ultrasound-responsive drug delivery systems. Finally, toxicological and safety considerations regarding ultrasound-mediated drug delivery with nanocarriers are discussed.

Starch chemical modifications applied to drug delivery systems: From fundamentals to FDA-approved raw materials

2021 ◽  
Vol 184 ◽  
pp. 218-234
Author(s):  
Paulo Vitor França Lemos ◽  
Henrique Rodrigues Marcelino ◽  
Lucas Guimarães Cardoso ◽  
Carolina Oliveira de Souza ◽  
Janice Izabel Druzian
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Raw Materials ◽  
Delivery Systems ◽  
Chemical Modifications

scholarly journals Functionalized poly(lactic-co-glycolic acid) enhances drug delivery and provides chemical moieties for surface engineering while preserving biocompatibility

2009 ◽  
Vol 5 (8) ◽  
pp. 2860-2871 ◽  
Author(s):  
James P. Bertram ◽  
Steven M. Jay ◽  
Sara R. Hynes ◽  
Rebecca Robinson ◽  
Jason M. Criscione ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Glycolic Acid ◽  
Surface Engineering

Versatile surface engineering of porous nanomaterials with bioinspired polyphenol coatings for targeted and controlled drug delivery

Nanoscale ◽  
2016 ◽  
Vol 8 (16) ◽  
pp. 8600-8606 ◽  
Author(s):  
Juan Li ◽  
Shuxian Wu ◽  
Cuichen Wu ◽  
Liping Qiu ◽  
Guizhi Zhu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Surface Engineering ◽  
Controlled Drug Delivery ◽  
Porous Nanomaterials

scholarly journals Selective Modification of Chitosan to Enable the Formation of Chitosan-DNA Condensates by Electron Donator Stabilization

2011 ◽  
Vol 2011 ◽  
pp. 1-11 ◽  
Author(s):  
Karl E. Kador ◽  
Anuradha Subramanian
Keyword(s):  
Drug Delivery ◽  
Gene Delivery ◽  
Transfection Efficiency ◽  
Protonated Form ◽  
Chemical Modifications ◽  
Modified Chitosan

Chitosan, a polyaminosaccharide, has been investigated for its use in the field of drug-delivery and biomaterial applications because of its natural biocompatibility and polycationic properties. Chemical modifications of chitosan have been attempted in an effort to increase the transfection efficiency with respect to gene delivery applications; however, it is unknown how these modifications affect the formation of the condensates. This study attempts to determine the effects of modification of the cationic center of chitosan on the ability to condense DNA. Specifically, electron-donating or -withdrawing groups were used as modifiers of the cationic charge on the chitosan backbone to stabilize the protonated form of chitosan, which is necessary to form condensates and increase the efficiency of the polymer to condense DNA by yielding condensates at a lower nitrogen to phosphorous (N : P) ratio. While an N : P ratio of 7 is needed to condense DNA with unmodified chitosan, phthalate-modified chitosan yielded condensates were obtained at an N : P ratio of 1.0.

Atomic scale surface engineering of micro- to nano-sized pharmaceutical particles for drug delivery applications

Nanoscale ◽  
2017 ◽  
Vol 9 (32) ◽  
pp. 11410-11417 ◽  
Author(s):  
D. Zhang ◽  
M. J. Quayle ◽  
G. Petersson ◽  
J. R. van Ommen ◽  
S. Folestad
Keyword(s):  
Drug Delivery ◽  
Atomic Layer Deposition ◽  
Surface Engineering ◽  
Atomic Layer ◽  
Atomic Scale ◽  
Ambient Conditions ◽  
Surface Layers ◽  
Layer Deposition ◽  
Atomic Surface ◽  
Scale Surface

Few atomic surface layers via atomic layer deposition under near ambient conditions significantly altered dissolution and dispersion of pharmaceutical particles.

scholarly journals New Opportunity to Formulate Intranasal Vaccines and Drug Delivery Systems Based on Chitosan

2020 ◽  
Vol 21 (14) ◽  
pp. 5016
Author(s):  
Roxana Popescu ◽  
Mihaela Violeta Ghica ◽  
Cristina-Elena Dinu-Pîrvu ◽  
Valentina Anuța ◽  
Dumitru Lupuliasa ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Surface Tension ◽  
Zeta Potential ◽  
Conformational Changes ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Active Pharmaceutical Ingredients ◽  
Nasal Drug Delivery ◽  
Pharmaceutical Ingredients ◽  
Permeability Enhancement

In an attempt to develop drug delivery systems that bypass the blood–brain barrier (BBB) and prevent liver and intestinal degradation, it was concluded that nasal medication meets these criteria and can be used for drugs that have these drawbacks. The aim of this review is to present the influence of the properties of chitosan and its derivatives (mucoadhesion, permeability enhancement, surface tension, and zeta potential) on the development of suitable nasal drug delivery systems and on the nasal bioavailability of various active pharmaceutical ingredients. Interactions between chitosan and proteins, lipids, antigens, and other molecules lead to complexes that have their own applications or to changing characteristics of the substances involved in the bond (conformational changes, increased stability or solubility, etc.). Chitosan and its derivatives have their own actions (antibacterial, antifungal, immunostimulant, antioxidant, etc.) and can be used as such or in combination with other molecules from the same class to achieve a synergistic effect. The applicability of the properties is set out in the second part of the paper, where nasal formulations based on chitosan are described (vaccines, hydrogels, nanoparticles, nanostructured lipid carriers (NLC), powders, emulsions, etc.).

scholarly journals Marine Polysaccharides in Pharmaceutical Applications: Fucoidan and Chitosan as Key Players in the Drug Delivery Match Field

Marine Drugs ◽  
2019 ◽  
Vol 17 (12) ◽  
pp. 654 ◽  
Author(s):  
Ana Isabel Barbosa ◽  
Ana Joyce Coutinho ◽  
Sofia A. Costa Lima ◽  
Salette Reis
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Biomedical Applications ◽  
Chemical Structure ◽  
Final Section ◽  
Biological Properties ◽  
Production Methods ◽  
Bioactive Properties ◽  
Wide Range ◽  
Per Se

The use of marine-origin polysaccharides has increased in recent research because they are abundant, cheap, biocompatible, and biodegradable. These features motivate their application in nanotechnology as drug delivery systems; in tissue engineering, cancer therapy, or wound dressing; in biosensors; and even water treatment. Given the physicochemical and bioactive properties of fucoidan and chitosan, a wide range of nanostructures has been developed with these polysaccharides per se and in combination. This review provides an outline of these marine polysaccharides, including their sources, chemical structure, biological properties, and nanomedicine applications; their combination as nanoparticles with descriptions of the most commonly used production methods; and their physicochemical and biological properties applied to the design of nanoparticles to deliver several classes of compounds. A final section gives a brief overview of some biomedical applications of fucoidan and chitosan for tissue engineering and wound healing.

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