scholarly journals Synthesis Chalones and Their Isomerization into Flavanones and Azaflavanones

2019 ◽  
Vol 2 (3) ◽  
pp. 70 ◽  
Author(s):  
Djenisa H. A. Rocha ◽  
Patrícia A. A. M. Vaz ◽  
Diana C. G. A. Pinto ◽  
Artur M. S. Silva
Keyword(s):  
Organic Chemistry ◽  
Reaction Time ◽  
Green Chemistry ◽  
Microwave Irradiation ◽  
Aldol Condensation ◽  
Chemistry Laboratory ◽  
Efficient Catalyst ◽  
Theoretical Concepts ◽  
Catalyst Systems ◽  
Organic Chemistry Laboratory

Flavanones [2-aryl-2,3-dihydrochromen-4(1H)ones] and 2-aryl-2,3-dihydroquinolin-4(1H)-ones are valuable precursors in the synthesis of important pharmacological scaffolds, so efficient methodologies towards their synthesis are important in the medicinal chemistry context. Their synthesis also involves theoretical concepts such as aldol condensation, isomerization, and catalysis that make it useful in an undergraduate organic chemistry laboratory. The use of both microwave irradiation as a source of energy to promote reactions and efficient catalysts are considered within green chemistry principles, mostly because the reaction yields are improved and reaction time decreased. In this paper, the efficiency of microwave irradiation use in the synthesis of chalcone derivatives and efficient catalyst systems to promote their isomerization into flavanones and 2-aryl-2,3-dihydroquinolin-4(1H)-ones is demonstrated.

How the Principles of Green Chemistry Changed the Way Organic Chemistry Labs Are Taught at the University of Detroit Mercy

2017 ◽  
Vol 2 (2) ◽  
Author(s):  
Matthew J. Mio
Keyword(s):  
Organic Chemistry ◽  
Green Chemistry ◽  
Learning Outcomes ◽  
Chemistry Laboratory ◽  
Atom Economy ◽  
Laboratory Courses ◽  
Instructional Changes ◽  
Organic Chemistry Laboratory ◽  
The University ◽  
The Way

Abstract Many logistic and instructional changes followed the incorporation of the 12 principles of green chemistry into organic chemistry laboratory courses at the University of Detroit Mercy. Over the last decade, institutional limitations have been turned into green chemical strengths in many areas, including integration of atom economy metrics into learning outcomes, replacing overly toxic equipment and reagents, and modifying matters of reaction scale and type.

Developing and Implementing a Specifications Grading System in an Organic Chemistry Laboratory Course

2020 ◽  
Author(s):  
William J. Howitz ◽  
Kate J. McKnelly ◽  
Renee Link
Keyword(s):  
Organic Chemistry ◽  
Chemistry Laboratory ◽  
Grading System ◽  
Traditional Grading ◽  
Final Grade ◽  
Laboratory Courses ◽  
Lower Division ◽  
Collaborative Learning Environment ◽  
Organic Chemistry Laboratory ◽  
Grade Uncertainty

<p>Large, multi-section laboratory courses are particularly challenging when managing grading with as many as 35 teaching assistants (TAs). Traditional grading systems using point-based rubrics lead to significant variations in how individual TAs grade, which necessitates the use of curving across laboratory sections. Final grade uncertainty perpetuates student anxieties and disincentivizes a collaborative learning environment, so we adopted an alternative grading system, called specifications grading. In this system each student knows exactly what level of proficiency they must demonstrate to earn their desired course grade. Higher grades require demonstrating mastery of skills and content at defined higher levels. Each students’ grade is solely dependent on the work they produce rather than the performance of other students. We piloted specifications grading in the smaller, third quarter course of the lower division organic chemistry laboratory series held during a summer term. Open-ended questions were chosen to gather student and TA perceptions of the new grading system. TAs felt that the new grading system reduced the weekly grading time because it was less ambiguous. Responses from students about the nature of the grading system were mixed. Their perceptions indicate that initial buy-in and multiple reminders about the bigger picture of the grading system will be essential to the success of this grading system on a larger scale.</p>

Microwave Irradiated Acetylation of p-Anisidine: A Step towards Green Chemistry

2008 ◽  
Vol 6 (1) ◽  
Author(s):  
Mousumi Chakraborty ◽  
Vaishali Umrigar ◽  
Parimal A. Parikh
Keyword(s):  
Acetic Acid ◽  
Reaction Time ◽  
Green Chemistry ◽  
Acetic Anhydride ◽  
Microwave Irradiation ◽  
Organic Solvent ◽  
Reaction Times ◽  
Microwave Energy ◽  
Operating Parameters ◽  
Feed Composition

The present study aims at assessing the effect of microwave irradiation against thermal heat on the production of N-acetyl-p-anisidine by acetylation of p-anisidine. The acetylation of p-anisidine under microwave irradiation produces N-acetyl-p-anisidine in shorter reaction times, which offers a benefit to the laboratories as well as industries. It also eliminates the use of excess solvent. Effects of operating parameters such as reaction time, feed composition, and microwave energy and reaction temperature on selectivity to the desired product have been investigated. The results indicate as high as a 98% conversion of N-acetyl-p-anisidine can be achieved within 12-15 minutes using acetic acid. The use of acetic acid as an acetylating agent against conventionally used acetic anhydride eliminates the handling of explosive acetic anhydride and also the energy intensive distillation step for separation of acetic acid. Organic solvent like acetic anhydride are not only hazardous to the environment, they are also expensive and flammable.

Designing and Conducting a Purification Scheme as an Organic Chemistry Laboratory Practical

2008 ◽  
Vol 85 (12) ◽  
pp. 1644 ◽  
Author(s):  
Kate J. Graham ◽  
Brian J. Johnson ◽  
T. Nicholas Jones ◽  
Edward J. McIntee ◽  
Chris P. Schaller
Keyword(s):  
Organic Chemistry ◽  
Chemistry Laboratory ◽  
Purification Scheme ◽  
Organic Chemistry Laboratory
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