scholarly journals Synthesis of New Modified with Rhodamine B Peptides for Antiviral Protection of Textile Materials

Molecules ◽  
2021 ◽  
Vol 26 (21) ◽  
pp. 6608
Author(s):  
Petar Todorov ◽  
Stela Georgieva ◽  
Desislava Staneva ◽  
Petia Peneva ◽  
Petar Grozdanov ◽  
...  
Keyword(s):  
Rhodamine B ◽  
Human Adenovirus ◽  
Time Intervals ◽  
Textile Materials ◽  
Solvent Influence ◽  
Closed Ring ◽  
Modified Peptides ◽  
Serotype 5 ◽  
Syncytial Virus

Here we report on the synthesis and characterization of three new N-modified analogues of hemorphin-4 with rhodamine B. Modified with chloroacetyl, chloride cotton fabric has been dyed and color coordinates of the obtained textile materials were determined. Antiviral and virucidal activities of both the peptide-rhodamine B compounds and the dyed textile material were studied. Basic physicochemical properties (acid-base behavior, solvent influence, kinetics) related to the elucidation of structural activity of the new modified peptides based on their steric open/closed ring effect were studied. The obtained results lead to the conclusion that in protic solvent with change in pH of the environment, direct control over the dyeing of textiles can be achieved. Both the new hybrid peptide compounds and the modification of functionalized textile materials with these bioactive hemorphins showed virucidal activity against the human respiratory syncytial virus (HRSV-S2) and human adenovirus serotype 5 (HAdV-5) for different time intervals (30 and 60 min) and the most active compound was Rh-3.

scholarly journals Preliminary Data Related to the Effect of Climacostol Produced by the Freshwater Ciliate Climacostomum virens on Human Adenovirus

Viruses ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 658
Author(s):  
Marco Verani ◽  
Graziano Di Giuseppe ◽  
Ileana Federigi ◽  
Federico Buonanno ◽  
Claudio Ortenzi ◽  
...  
Keyword(s):  
Fungal Pathogens ◽  
Wastewater Treatment Plants ◽  
Human Adenovirus ◽  
Log10 Reduction ◽  
Experimental Conditions ◽  
Viral Pathogens ◽  
Starting Point ◽  
Serotype 5 ◽  
Waterborne Viruses

The new epidemiological scenario has so far focused on the environmental circulation of human viral pathogens. Owing to the side effects of chemical disinfectants, there is an increasing need for knowledge on the use of virucidal compounds, especially those of a natural origin. Climacostol is a molecule produced by a freshwater ciliate and it exhibits activity against bacterial and fungal pathogens. We thus also speculated that there might be an effect on viral viability, which has never been tested. To evaluate such activity, we chose human adenovirus (HAdV), which is representative of waterborne viruses. We conducted experiments using HAdV serotype 5, whose titer was determined by infecting HeLa cell cultures. HAdV5 was shown to be sensitive to climacostol at a concentration of 0.0002 mg/mL, with an approximate 3 Log10 reduction when the initial titer of HAdV5 was approximately 104 and 103 TCID50/mL. These preliminary results could be an important starting point for further research aimed at improving the characterization of climacostol activity under different experimental conditions and against various viruses, including enveloped ones (i.e., the coronavirus). The production of climacostol by a protist living in fresh water also suggests a possible application in the activated sludge of wastewater treatment plants.

Gelatin and Glycerine-Based Bioadhesive Vaginal Hydrogel

2020 ◽  
Vol 17 (4) ◽  
pp. 303-311
Author(s):  
Roberta Cassano ◽  
Federica Curcio ◽  
Delia Mandracchia ◽  
Adriana Trapani ◽  
Sonia Trombino
Keyword(s):  
Differential Scanning Calorimetry ◽  
Inflammatory Process ◽  
Vaginal Mucosa ◽  
Vaginal Infection ◽  
Scanning Calorimetry ◽  
Time Intervals ◽  
Site Specific ◽  
Release Studies ◽  
Hiv Seropositive

Aim: The work’s aim was the preparation and characterization of a hydrogel based on gelatin and glycerine, useful for site-specific release of benzydamine, an anti-inflammatory drug, able to attenuate the inflammatory process typical of the vaginal infection. Objective: The obtained hydrogel has been characterized by Electronic Scanning Microscopy (SEM) and Differential Scanning Calorimetry (DSC). In addition, due to the precursor properties, the hydrogel exhibits a relevant mucoadhesive activity. Methods: The swelling degree was evaluated at two different pHs and at defined time intervals. In particular, phosphate buffers were used at pH 6.6, in order to mimic the typical conditions of infectious diseases at the vaginal level, particularly for HIV-seropositive pregnant women, and pH 4.6, to simulate the physiological environment. Results: The obtained results revealed that the hydrogel swells up well at both pHs. Conclusion: Release studies conducted at both pathological and physiological pHs have shown that benzydamine is released at the level of the vaginal mucosa in a slow and gradual manner. These data support the hypothesis of the hydrogel use for the site-specific release of benzydamine in the vaginal mucosa.

Characterization of imprinting polymeric temperature variation with fluorescent Rhodamine B molecule

2006 ◽  
Vol 83 (4-9) ◽  
pp. 864-868 ◽  
Author(s):  
Fu-Hsiang Ko ◽  
Li-Yu Weng ◽  
Chu-Jung Ko ◽  
Tieh-Chi Chu
Keyword(s):  
Temperature Variation ◽  
Rhodamine B

Characterization of novel respiratory syncytial virus inhibitors identified by high throughput screen

2015 ◽  
Vol 115 ◽  
pp. 71-74 ◽  
Author(s):  
Valerie A. Laganas ◽  
Ewan F. Dunn ◽  
Robert E. McLaughlin ◽  
Choi Lai Tiong-Yip ◽  
Olga Yuzhakov ◽  
...  
Keyword(s):  
Respiratory Syncytial Virus ◽  
High Throughput ◽  
High Throughput Screen ◽  
Syncytial Virus
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