scholarly journals Green Synthesis of Gold Nanoparticles Using Plant Extracts as Beneficial Prospect for Cancer Theranostics

Molecules ◽  
2021 ◽  
Vol 26 (21) ◽  
pp. 6389
Author(s):  
Kaushik Kumar Bharadwaj ◽  
Bijuli Rabha ◽  
Siddhartha Pati ◽  
Tanmay Sarkar ◽  
Bhabesh Kumar Choudhury ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Green Synthesis ◽  
Plant Extracts ◽  
Large Scale ◽  
Cost Effective ◽  
Synthesis Methods ◽  
Characterization Methods ◽  
Cancer Theranostics ◽  
Physical And Chemical

Gold nanoparticles (AuNPs) have been widely explored and are well-known for their medical applications. Chemical and physical synthesis methods are a way to make AuNPs. In any case, the hunt for other more ecologically friendly and cost-effective large-scale technologies, such as environmentally friendly biological processes known as green synthesis, has been gaining interest by worldwide researchers. The international focus on green nanotechnology research has resulted in various nanomaterials being used in environmentally and physiologically acceptable applications. Several advantages over conventional physical and chemical synthesis (simple, one-step approach to synthesize, cost-effectiveness, energy efficiency, and biocompatibility) have drawn scientists’ attention to exploring the green synthesis of AuNPs by exploiting plants’ secondary metabolites. Biogenic approaches, mainly the plant-based synthesis of metal nanoparticles, have been chosen as the ideal strategy due to their environmental and in vivo safety, as well as their ease of synthesis. In this review, we reviewed the use of green synthesized AuNPs in the treatment of cancer by utilizing phytochemicals found in plant extracts. This article reviews plant-based methods for producing AuNPs, characterization methods of synthesized AuNPs, and discusses their physiochemical properties. This study also discusses recent breakthroughs and achievements in using green synthesized AuNPs in cancer treatment and different mechanisms of action, such as reactive oxygen species (ROS), mediated mitochondrial dysfunction and caspase activation, leading to apoptosis, etc., for their anticancer and cytotoxic effects. Understanding the mechanisms underlying AuNPs therapeutic efficacy will aid in developing personalized medicines and treatments for cancer as a potential cancer therapeutic strategy.

scholarly journals Targeted Chemotherapy Delivery via Gold Nanoparticles: A Scoping Review of In Vivo Studies

Crystals ◽  
2021 ◽  
Vol 11 (10) ◽  
pp. 1169
Author(s):  
Ștefan Morărașu ◽  
Ștefan Iacob ◽  
Ionuț Tudorancea ◽  
Sorinel Luncă ◽  
Mihail-Gabriel Dimofte
Keyword(s):  
Gold Nanoparticles ◽  
Cancer Treatment ◽  
Chemical Properties ◽  
In Vivo Studies ◽  
Synthesis Methods ◽  
Experimental Cancer ◽  
Therapy Option ◽  
Physical And Chemical ◽  
System Toxicity

In the field of oncology, a lot of improvements in nanotechnology creates support for better diagnosis and therapeutic opportunities, and due to their physical and chemical properties, gold nanoparticles are highly applicable. We performed a literature review on the studies engaging the usage of gold nanoparticles on murine models with a focus on the type of the carrier, the chemotherapy drug, the target tumoral tissue and outcomes. We identified fifteen studies that fulfilled our search criteria, in which we analyzed the synthesis methods, the most used chemotherapy conjugates of gold nanoparticles in experimental cancer treatment, as well as the improved impact on tumor size and system toxicity. Due to their intrinsic traits, we conclude that chemotherapy conjugates of gold nanoparticles are promising in experimental cancer treatment and may prove to be a safer and improved therapy option than current alternatives.

Eco-Friendly Methods of Gold Nanoparticles Synthesis

2019 ◽  
Vol 9 (3) ◽  
pp. 311-328
Author(s):  
Heba M. Fahmy ◽  
Amena S. El-Feky ◽  
Taiseer M. Abd El-Daim ◽  
Merna M. Abd El-Hameed ◽  
Donia A. Gomaa ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Green Synthesis ◽  
Plant Extracts ◽  
Metallic Nanoparticles ◽  
Synthesis Methods ◽  
Capping Agents ◽  
Synthesis Of Nanoparticles ◽  
Clinical Applicability ◽  
Magnolia Kobus

Background: Owing to the importance of metallic nanoparticles, different researches and studies have been induced to synthesize them in many ways. One of the ways that paid attention last years is the green synthesis methods of nanoparticles or the so-called ''eco-friendly methods''. The most common sources that has been used for green synthesis of nanoparticles are plants, leaves, fungi and microorganisms. The green synthesis methods are widely used because they are inexpensive, usable, and nontoxic. Moreover, plant extracts are rich in reducing and capping agents. Methods: In the present review, green synthesis methods of gold nanoparticles (AuNps) using Chitosan, Klebsiella pneumoniae, Magnolia Kobus, Elettaria cardamomum (Elaichi) aqueous extract and other agents as a reducing/capping agents will be discussed in details. Moreover, we will make a comparison between different green routes of synthesis and the characterization of the obtained nanoparticles from each route. Results: The characterization and applications of the prepared GNPs from different routes are reviewed. Conclusion: The utilization of gold nanoparticles has been advocated because of their high biocomptability, administration in clinical applicability and in diverse aspects of life. It seems that plants are good candidates for nanoparticles production because they are inexpensive, available and renewable sources in addition, it is too simple to prepare extracts from them. Moreover, the great diversity in the types and amounts of reducing agents from plant extracts is responsible for the effortless generation of metallic nanoparticles of various shapes and morphologies.

Facile Synthesis of Gold (Au) Nanoparticles Using Cassia auriculata Flower Extract

2013 ◽  
Vol 678 ◽  
pp. 12-16 ◽  
Author(s):  
J. Dhayananthaprabhu ◽  
R. Lakshmi Narayanan ◽  
K. Thiyagarajan
Keyword(s):  
Gold Nanoparticles ◽  
Green Synthesis ◽  
Large Scale ◽  
Synthesis Method ◽  
Cost Effective ◽  
Scale Production ◽  
Flower Extract ◽  
Cassia Auriculata ◽  
Large Scale Production ◽  
Versatile Tool

The green synthesis is the versatile tool to produce the nano scale materials. The present study deals with the synthesis of gold nanoparticles using the Cassia auriculata flower extract. The complete reduction of gold ions was observed after 45 min of reaction under stirrer condition. The colour changes in reaction mixture (dark red colour) was observed during the reaction period because of the formation of gold nanoparticles in the reaction mixture enables to produce particular colour due to their specific properties (Surface Plasmon Resonance). The formation of gold nanoparticles was confirmed using UV visible spectroscopy, the size of the nanoparticles measured by using particle size analyzer. The morphology of the poly dispersed gold nanoparticles was studied using TEM, This green synthesis method is cost effective; and eco friendly technique to produce large scale production of Nanomaterials

scholarly journals Green Synthesis and Applications of ZnO and TiO2 Nanostructures

Molecules ◽  
2021 ◽  
Vol 26 (8) ◽  
pp. 2236
Author(s):  
Rosana A. Gonçalves ◽  
Rosimara P. Toledo ◽  
Nirav Joshi ◽  
Olivia M. Berengue
Keyword(s):  
Green Synthesis ◽  
Sol Gel ◽  
Cost Effective ◽  
Synthesis Methods ◽  
Green Approach ◽  
Oxide Nanostructures ◽  
Co Precipitation ◽  
Physical And Chemical ◽  
Synthesis Approach ◽  
Tio2 Nanostructures

Over the last two decades, oxide nanostructures have been continuously evaluated and used in many technological applications. The advancement of the controlled synthesis approach to design desired morphology is a fundamental key to the discipline of material science and nanotechnology. These nanostructures can be prepared via different physical and chemical methods; however, a green and ecofriendly synthesis approach is a promising way to produce these nanostructures with desired properties with less risk of hazardous chemicals. In this regard, ZnO and TiO2 nanostructures are prominent candidates for various applications. Moreover, they are more efficient, non-toxic, and cost-effective. This review mainly focuses on the recent state-of-the-art advancements in the green synthesis approach for ZnO and TiO2 nanostructures and their applications. The first section summarizes the green synthesis approach to synthesize ZnO and TiO2 nanostructures via different routes such as solvothermal, hydrothermal, co-precipitation, and sol-gel using biological systems that are based on the principles of green chemistry. The second section demonstrates the application of ZnO and TiO2 nanostructures. The review also discusses the problems and future perspectives of green synthesis methods and the related issues posed and overlooked by the scientific community on the green approach to nanostructure oxides.

Review on Methodologies Used in the Synthesis of Metal Nanoparticles: Significance of Phytosynthesis Using Plant Extract as an Emerging Tool

2020 ◽  
Vol 26 (40) ◽  
pp. 5188-5204
Author(s):  
Uzair Nagra ◽  
Maryam Shabbir ◽  
Muhammad Zaman ◽  
Asif Mahmood ◽  
Kashif Barkat
Keyword(s):  
Green Synthesis ◽  
Metal Nanoparticles ◽  
Plant Extracts ◽  
Biomedical Applications ◽  
Noble Metals ◽  
Cost Effective ◽  
Green Technology ◽  
Critical Parameters ◽  
Nanosized Particles ◽  
Preparation Methods

Nanosized particles, with a size of less than 100 nm, have a wide variety of applications in various fields of nanotechnology and biotechnology, especially in the pharmaceutical industry. Metal nanoparticles [MNPs] have been synthesized by different chemical and physical procedures. Still, the biological approach or green synthesis [phytosynthesis] is considered as a preferred method due to eco-friendliness, nontoxicity, and cost-effective production. Various plants and plant extracts have been used for the green synthesis of MNPs, including biofabrication of noble metals, metal oxides, and bimetallic combinations. Biomolecules and metabolites present in plant extracts cause the reduction of metal ions into nanosized particles by one-step preparation methods. MNPs have remarkable attractiveness in biomedical applications for their use as potential antioxidant, anticancer and antibacterial agents. The present review offers a comprehensive aspect of MNPs production via top-to-bottom and bottom-to-top approach with considerable emphasis on green technology and their possible biomedical applications. The critical parameters governing the MNPs formation by plant-based synthesis are also highlighted in this review.

scholarly journals A simple and efficient automated microvolume radiosynthesis of [18F]Florbetaben

2020 ◽  
Vol 5 (1) ◽  
Author(s):  
Ksenia Lisova ◽  
Jia Wang ◽  
Philip H. Chao ◽  
R. Michael van Dam
Keyword(s):  
Large Scale ◽  
Solid Phase ◽  
Acetonitrile Solution ◽  
Synthesis Methods ◽  
Pet Tracers ◽  
Molar Activity ◽  
Alternative Approaches ◽  
High Yields ◽  
Sufficient Concentration

Abstract Background Current automated radiosynthesizers are generally optimized for producing large batches of PET tracers. Preclinical imaging studies, however, often require only a small portion of a regular batch, which cannot be economically produced on a conventional synthesizer. Alternative approaches are desired to produce small to moderate batches to reduce cost and the amount of reagents and radioisotope needed to produce PET tracers with high molar activity. In this work we describe the first reported microvolume method for production of [18F]Florbetaben for use in imaging of Alzheimer’s disease. Procedures The microscale synthesis of [18F]Florbetaben was adapted from conventional-scale synthesis methods. Aqueous [18F]fluoride was azeotropically dried with K2CO3/K222 (275/383 nmol) complex prior to radiofluorination of the Boc-protected precursor (80 nmol) in 10 μL DMSO at 130 °C for 5 min. The resulting intermediate was deprotected with HCl at 90 °C for 3 min and recovered from the chip in aqueous acetonitrile solution. The crude product was purified via analytical scale HPLC and the collected fraction reformulated via solid-phase extraction using a miniature C18 cartridge. Results Starting with 270 ± 100 MBq (n = 3) of [18F]Fluoride, the method affords formulated product with 49 ± 3% (decay-corrected) yield,> 98% radiochemical purity and a molar activity of 338 ± 55 GBq/μmol. The miniature C18 cartridge enables efficient elution with only 150 μL of ethanol which is diluted to a final volume of 1.0 mL, thus providing a sufficient concentration for in vivo imaging. The whole procedure can be completed in 55 min. Conclusions This work describes an efficient and reliable procedure to produce [18F]Florbetaben in quantities sufficient for large-scale preclinical applications. This method provides very high yields and molar activities compared to reported literature methods. This method can be applied to higher starting activities with special consideration given to automation and radiolysis prevention.

scholarly journals Removal of Heavy Metals from Chithrapuzha River Water by Iron Oxide Nanoparticles Prepared Via Green Synthesis Methods

2020 ◽  
Vol 36 (6) ◽  
pp. 1154-1160
Author(s):  
G. DEEPA ◽  
M. JEYARAJ ◽  
P. N. Magudeswaran
Keyword(s):  
Heavy Metals ◽  
Green Synthesis ◽  
River Water ◽  
Human Life ◽  
Aloe Vera ◽  
Cost Effective ◽  
Water Bodies ◽  
Synthesis Methods ◽  
Healthy Human ◽  
Aquatic Life

On account of industrialization and increasing population, the water bodies get polluted by means of degradable and non-degradable substances. In 21st century, it is necessary to maintain a healthy environment especially water bodies for the survival of not the aquatic animals but also for healthy human life. Recent advances suggest that the issues related to water quality could be resolved by using nanoparticles and nano-filtration membrane methods from the development of nanotechnology. In this research, attempt to remove heavy metals from Chithrapuzha River water at Cochin bar mouth (S1) and Fact barge jetty (S2) using Fe2O3 prepared via green synthesis using Egg albumin and Aloe vera. Our results provoke that, the synthesis of Fe2O3 nanoparticle is cost-effective and eco-friendly and also good in nano-regime. Results of filtration studies showed that Fe2O3 nanoparticles remove heavy metals from Chithrapuzha River water and also increases the DO content which helps the survival of aquatic life.

scholarly journals Metal Oxide Nanoparticles and their Nanocomposite-based Materials as Photocatalysts in the Degradation of Dyes

2021 ◽  
Vol 12 (5) ◽  
pp. 6557-6579
Keyword(s):  
Metal Oxide ◽  
Anthropogenic Activities ◽  
Metal Oxide Nanoparticles ◽  
Chemical Properties ◽  
Cost Effective ◽  
Oxide Nanoparticles ◽  
Synthetic Dyes ◽  
Characterization Methods ◽  
Degradation Of Dyes ◽  
Physical And Chemical

The introduction of inorganic and organic pollutants into water bodies has become a serious issue globally. The waste streams released from the textile, plastic, leather, paper, pharmaceutical, and food industries introduce different natural and synthetic dyes into the aquatic system. Nanomaterials play a significant role in the photocatalytic degradation of dyes present in wastewater. Inorganic metal oxide nanoparticles have many improved physical and chemical properties and attracted much attention in photocatalytic activities. Dyes have been released in our aquatic bodies due to many anthropogenic activities and caused life-threatening problems. Various conventional methods were reported to remove dyes from water and wastewater; the photocatalytic method is one of the efficient and cost-effective. The present review article includes detailed information on photocatalysis, the potential of metal oxide and their composite materials as photocatalysts in the degradation of toxic dyes, and some common synthetic and characterization methods used for metal oxide-based nanoparticles.

scholarly journals Application of biosynthesized metal nanoparticles in electrochemical sensors

2021 ◽  
pp. 77-77
Author(s):  
Totka Dodevska ◽  
Dobrin Hadzhiev ◽  
Ivan Shterev ◽  
Yanna Lazarova
Keyword(s):  
Green Synthesis ◽  
Metal Nanoparticles ◽  
Electrochemical Sensors ◽  
Dynamic Range ◽  
Limit Of Detection ◽  
Cost Effective ◽  
Electrochemical Sensing ◽  
Synthesis Methods ◽  
Range Limit ◽  
Wide Range

Recently, the development of eco-friendly, cost-effective and reliable methods for synthesis of metal nanoparticles has drawn a considerable attention. The so-called green synthesis, using mild reaction conditions and natural resources as plant extracts and microorganisms, has established as a convenient, sustainable, cheap and environmentally safe approach for synthesis of a wide range of nanomaterials. Over the past decade, biosynthesis is regarded as an important tool for reducing the harmful effects of traditional nanoparticle synthesis methods commonly used in laboratories and industry. This review emphasizes the significance of biosynthesized metal nanoparticles in the field of electrochemical sensing. There is increasing evidence that green synthesis of nanoparticles provides a new direction in designing of cost-effective, highly sensitive and selective electrode-catalysts applicable in food, clinical and environmental analysis. The article is based on 157 references and provided a detailed overview on the main approaches for green synthesis of metal nanoparticles and their applications in designing of electrochemical sensor devices. Important operational characteristics including sensitivity, dynamic range, limit of detection, as well as data on stability and reproducibility of sensors have also been covered. Keywords: biosynthesis; green synthesis; nanomaterials; nanotechnology; modified electrodes

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