scholarly journals Delta Sleep-Inducing Peptide Recovers Motor Function in SD Rats after Focal Stroke

Molecules ◽  
2021 ◽  
Vol 26 (17) ◽  
pp. 5173
Author(s):  
Elena A. Tukhovskaya ◽  
Alina M. Ismailova ◽  
Elvira R. Shaykhutdinova ◽  
Gulsara A. Slashcheva ◽  
Igor A. Prudchenko ◽  
...  
Keyword(s):  
Motor Performance ◽  
Motor Coordination ◽  
Brain Infarction ◽  
Mutual Effect ◽  
Rotarod Test ◽  
Sd Rats ◽  
Infarction Volume ◽  
Delta Sleep ◽  
The Difference ◽  
Delta Sleep Inducing Peptide

Background and Objectives: Mutual effect of the preliminary and therapeutic intranasal treatment of SD rats with DSIP (8 days) on the outcome of focal stroke, induced with intraluminal middle cerebral occlusion (MCAO), was investigated. Materials and Methods: The groups were the following: MCAO + vehicle, MCAO + DSIP, and SHAM-operated. DSIP or vehicle was applied nasally 60 (±15) minutes prior to the occlusion and for 7 days after reperfusion at dose 120 µg/kg. The battery of behavioral tests was performed on 1, 3, 7, 14, and 21 days after MCAO. Motor coordination and balance and bilateral asymmetry were tested. At the end of the study, animals were euthanized, and their brains were perfused, serial cryoslices were made, and infarction volume in them was calculated. Results: Although brain infarction in DSIP-treated animals was smaller than in vehicle-treated animals, the difference was not significant. However, motor performance in the rotarod test significantly recovered in DSIP-treated animals. Conclusions: Intranasal administration of DSIP in the course of 8 days leads to accelerated recovery of motor functions.

scholarly journals DSIP-Like KND Peptide Reduces Brain Infarction in C57Bl/6 and Reduces Myocardial Infarction in SD Rats When Administered during Reperfusion

Biomedicines ◽  
2021 ◽  
Vol 9 (4) ◽  
pp. 407
Author(s):  
Elena A. Tukhovskaya ◽  
Elvira R. Shaykhutdinova ◽  
Alina M. Ismailova ◽  
Gulsara A. Slashcheva ◽  
Igor A. Prudchenko ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Neuroprotective Effect ◽  
Ischemia Reperfusion ◽  
Brain Infarction ◽  
Cerebral Stroke ◽  
Structural Analogue ◽  
Sd Rats ◽  
Infarction Volume ◽  
Reperfusion Period ◽  
The Brain

A structural analogue of the DSIP, peptide KND, previously showed higher detoxification efficacy upon administration of the cytotoxic drug cisplatin, compared to DSIP. DSIP and KND were investigated using the model of acute myocardial infarction in male SD rats and the model of acute focal stroke in C57Bl/6 mice. A significant decrease in the myocardial infarction area was registered in KND-treated animals relative to saline-treated control animals (19.1 ± 7.3% versus 42.1 ± 9.2%). The brain infarction volume was significantly lower in animals intranasally treated with KND compared to the control saline-treated animals (7.4 ± 3.5% versus 12.2 ± 5.6%). Injection of KND in the first minute of reperfusion in the models of myocardial infarction and cerebral stroke reduced infarction of these organs, indicating a pronounced cardioprotective and neuroprotective effect of KND and potentiality for the treatment of ischemia-reperfusion injuries after transient ischemic attacks on the heart and brain, when administered during the reperfusion period. A preliminary pilot study using the model of myocardial infarction with the administration of DSIP during occlusion, and the model of cerebral stroke with the administration of KND during occlusion, resulted in 100% mortality in animals. Thus, in the case of ischemia-reperfusion injuries of the myocardium and the brain, use of these peptides is only possible during reperfusion.

STUDY OF THE COMBINED INFLUENCE OF SODIUM THIOPENTAL AND DELTA SLEEP-INDUCING PEPTIDE ON ANTIOXIDANT DEFENSE SYSTEM IN RATS

2016 ◽  
pp. 49-52
Author(s):  
A. V. Shvetsov ◽  
E. G. Batotsyrenova ◽  
N. A. Dyuzhikova ◽  
V. A. Kashuro ◽  
N. V. Lapina ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Antioxidant Defense ◽  
Antioxidant Defense System ◽  
Time Interval ◽  
Sodium Thiopental ◽  
Antioxidant Defense Enzymes ◽  
Delta Sleep ◽  
Thiopental Coma ◽  
Glucose 6 Phosphate Dehydrogenase ◽  
Delta Sleep Inducing Peptide

A biochemical investigation was performed into activity of rat antioxidant defense enzymes at different time interval after administration of sodium thiopental and delta-sleep-inducing peptide (DSIP). It was shown that thiopental coma was accompanied by a decreased level of superoxide dismutase ( 6 and 24 h after exposure) and increased level of caspase-3 ( 6 h after exposure) in the rat blood plasma. A pharmacological correction with DSIP induced a decrease of the level of superoxide dismutase ( 6 and 24 h after exposure), glutathione peroxidase and glucose 6-phosphate dehydrogenase (after 6h).

Characterization of Delta-Sleep-Inducing Peptide-Evoked Release of Met-Enkephalin from Brain Synaptosomes in Rats

1991 ◽  
Vol 57 (3) ◽  
pp. 1013-1018 ◽  
Author(s):  
Akihiro Nakamura ◽  
Kenji Sakai ◽  
Yukie Takahashi ◽  
Hirohito Shiomi
Keyword(s):  
Brain Synaptosomes ◽  
Delta Sleep ◽  
Delta Sleep Inducing Peptide

Delta sleep-inducing peptide and glucocorticoid-induced leucine zipper: potential links between circadian mechanisms and obesity?

2009 ◽  
Vol 10 ◽  
pp. 46-51 ◽  
Author(s):  
J. M. Gimble ◽  
A. A. Ptitsyn ◽  
B. C. Goh ◽  
T. Hebert ◽  
G. Yu ◽  
...  
Keyword(s):  
Leucine Zipper ◽  
Delta Sleep ◽  
Delta Sleep Inducing Peptide

P.3.064 Membrane-protective effect of delta-sleep inducing peptide

1997 ◽  
Vol 7 ◽  
pp. S245
Author(s):  
T.I. Bondarenko ◽  
I.A. Goronshinskaya ◽  
I.I. Mikhaleva
Keyword(s):  
Protective Effect ◽  
Delta Sleep ◽  
Delta Sleep Inducing Peptide

Cascade afteraction of delta sleep-inducing peptide in rats

1995 ◽  
Vol 119 (1) ◽  
pp. 1-4 ◽  
Author(s):  
K. V. Sudakov ◽  
J. P. Coghland ◽  
A. V. Kotov ◽  
R. M. Salieva ◽  
Yu. V. Polyntsev ◽  
...  
Keyword(s):  
Delta Sleep ◽  
Delta Sleep Inducing Peptide
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