scholarly journals Oxygen Plasma Technology-Assisted Preparation of Three-Dimensional Reduced Graphene Oxide/Polypyrrole/Strontium Composite Scaffold for Repair of Bone Defects Caused by Osteoporosis

Molecules ◽  
2021 ◽  
Vol 26 (15) ◽  
pp. 4451
Author(s):  
Xiaoxue Mai ◽  
Zebiao Kang ◽  
Na Wang ◽  
Xiaoli Qin ◽  
Weibo Xie ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Graphene Oxide ◽  
Bone Tissue Engineering ◽  
Reduced Graphene Oxide ◽  
Oxygen Plasma ◽  
Composite Scaffold ◽  
Three Dimensional ◽  
Bone Defects ◽  
Plasma Technology ◽  
Reduced Graphene

Repairs of bone defects caused by osteoporosis have always relied on bone tissue engineering. However, the preparation of composite tissue engineering scaffolds with a three-dimensional (3D) macroporous structure poses huge challenges in achieving osteoconduction and osteoinduction for repairing bone defects caused by osteoporosis. In the current study, a three-dimensional macroporous (150–300 μm) reduced graphene oxide/polypyrrole composite scaffold modified by strontium (Sr) (3D rGO/PPY/Sr) was successfully prepared using the oxygen plasma technology-assisted method, which is simple, safe, and inexpensive. The findings of the MTT assay and AO/EB fluorescence double staining showed that 3D rGO/PPY/Sr has a good biocompatibility and effectively promoted MC3T3-E1 cell proliferation. Furthermore, the ALP assay and alizarin red staining showed that 3D rGO/PPY/Sr increased the expression levels of ALP activity and the formation of calcified nodules. The desirable biocompatibility, osteoconduction, and osteoinduction abilities, assure that the 3D macroporous rGO/PPY/Sr composite scaffold offers promising potential for use in the repair of bone defects caused by osteoporosis in bone tissue engineering.

Room-temperature fabrication of a three-dimensional reduced-graphene oxide/polypyrrole/hydroxyapatite composite scaffold for bone tissue engineering

RSC Advances ◽  
2016 ◽  
Vol 6 (95) ◽  
pp. 92804-92812 ◽  
Author(s):  
Fuxiang Song ◽  
Weibo Jie ◽  
Ting Zhang ◽  
Wen Li ◽  
Yanjiao Jiang ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Graphene Oxide ◽  
Reduced Graphene Oxide ◽  
Bone Healing ◽  
Room Temperature ◽  
Composite Scaffold ◽  
Three Dimensional ◽  
Promising Alternative ◽  
Reduced Graphene ◽  
Hydroxyapatite Composite

The development of tissue engineering (TE) provides a promising alternative strategy for bone healing and regeneration.

Preparation and characterisation of a novel polylactic acid/hydroxyapatite/graphene oxide/aspirin drug-loaded biomimetic composite scaffold

2021 ◽  
Author(s):  
Shuqiong Liu ◽  
Wu Xiaoyan ◽  
Jiapeng Hu ◽  
Zhenzeng Wu ◽  
Yuying Zheng
Keyword(s):  
Tissue Engineering ◽  
Graphene Oxide ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Polylactic Acid ◽  
Composite Scaffold ◽  
Three Dimensional ◽  
Composite Scaffolds ◽  
Biomimetic Scaffolds

Biomimetic scaffolds loaded with drugs can be applied in bone tissue engineering. In this study, a series of three-dimensional polylactic acid/hydroxyapatite/graphene oxide (PLA/HA/GO) drug-loaded biomimetic composite scaffolds with different concentrations...

scholarly journals Reduced graphene oxide: osteogenic potential for bone tissue engineering

2019 ◽  
Vol 13 (7) ◽  
pp. 720-725 ◽  
Author(s):  
Mohammad Hadi Norahan ◽  
Masoud Amroon ◽  
Ramin Ghahremanzadeh ◽  
Navid Rabiee ◽  
Nafiseh Baheiraei
Keyword(s):  
Tissue Engineering ◽  
Graphene Oxide ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Reduced Graphene Oxide ◽  
Osteogenic Potential ◽  
Reduced Graphene

scholarly journals Synthesis and Characterization of Chitosan/Reduced Graphene Oxide Hybrid Composites

Materials ◽  
2019 ◽  
Vol 12 (13) ◽  
pp. 2077 ◽  
Author(s):  
Karolina Kosowska ◽  
Patrycja Domalik-Pyzik ◽  
Małgorzata Krok-Borkowicz ◽  
Jan Chłopek
Keyword(s):  
Tissue Engineering ◽  
Graphene Oxide ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Reduced Graphene Oxide ◽  
Hybrid Composites ◽  
X Ray ◽  
Reduced Graphene ◽  
Wide Range ◽  
Composite Formation

Graphene family materials (GFM) are currently considered to be one of the most interesting nanomaterials with a wide range of application. They can also be used as modifiers of polymer matrices to develop composite materials with favorable properties. In this study, hybrid nanocomposites based on chitosan (CS) and reduced graphene oxide (rGO) were fabricated for potential use in bone tissue engineering. CS/rGO hydrogels were prepared by simultaneous reduction and composite formation in acetic acid or lactic acid and crosslinked with a natural agent—tannic acid (TAc). A broad spectrum of research methods was applied in order to thoroughly characterize both the components and the composite systems, i.e., X-ray Photoelectron Spectroscopy, X-ray Diffractometry, Attenuated Total Reflection Fourier-Transform Infrared Spectroscopy, Scanning Electron Microscopy, ninhydrin assay, mechanical testing, in vitro degradation and bioactivity study, wettability, and, finally, cytocompatibility. The composites formed through the self-assembly of CS chains and exfoliated rGO sheets. Obtained results allowed also to conclude that the type of solvent used impacts the polymer structure and its ability to interact with rGO sheets and the mechanical properties of the composites. Both rGO and TAc acted as crosslinkers of the polymer chains. This study shows that the developed materials demonstrate the potential for use in bone tissue engineering. The next step should be their detailed biological examinations.

scholarly journals Fabrication of Graphene Oxide Aerogel to Repair Neural Tissue

2021 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Khadijeh Zeinali ◽  
Mohammad Taghi Khorasani ◽  
Alimorad Rashidi ◽  
Morteza Daliri Jouparid
Keyword(s):  
Tissue Engineering ◽  
Graphene Oxide ◽  
Reduced Graphene Oxide ◽  
Three Dimensional ◽  
Neural Tissue ◽  
Nerve Tissue ◽  
Neural Tissue Engineering ◽  
Tissue Scaffold ◽  
Reduced Graphene ◽  
Graphene Oxide Aerogel

: The neural tissue engineering has been designed as a subset of tissue engineering for treating congenital malformations and accident injuries, particularly for individuals requiring tissue grafting. Such transplants, usually performed as autografting, can often not meet the requirements of an effective scaffold used in nerve tissue engineering. A novel neural tissue scaffold was introduced here to solve the problem concerning the reduced graphene oxide. The three-dimensional graphene oxide in the neural canal restricts the formation of fibroglandular tissues and facilities neural stem cell proliferation and growth. In these techniques, graphene oxide aerogel was initially made. Then, the freeze-drying process was used to fix the geometry of reduced graphene oxide hydrogels prepared using graphene oxide dispersion and ethylenediamine and gain aerogels. The X-ray diffraction patterns, FTIR and morphological related to samples were examined, followed by conducting in-vitro micropropagation and 4, 6-diamidino-2-phenylindol (DAPI) staining in fibroblast and P19 cultures. The results from immunofluorescence staining demonstrated the neural differentiation of P19 cells. It can be concluded that most cells attached to and differentiated on the scaffold surface and axons can penetrate randomly through them. Finally, the three-dimensional graphene oxide was proposed as an ideal alternative to be used in neural tissue engineering.

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