scholarly journals Solid-State NMR Spectroscopy: A Key Tool to Unravel the Supramolecular Structure of Drug Delivery Systems

Molecules ◽  
2021 ◽  
Vol 26 (14) ◽  
pp. 4142
Author(s):  
Marianna Porcino ◽  
Xue Li ◽  
Ruxandra Gref ◽  
Charlotte Martineau-Corcos
Keyword(s):  
Drug Delivery ◽  
Nuclear Magnetic Resonance ◽  
Solid State ◽  
Solid State Nmr ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Atomic Level ◽  
Core Shell ◽  
Comprehensive Understanding ◽  
The Past

In the past decades, nanosized drug delivery systems (DDS) have been extensively developed and studied as a promising way to improve the performance of a drug and reduce its undesirable side effects. DDSs are usually very complex supramolecular assemblies made of a core that contains the active substance(s) and ensures a controlled release, which is surrounded by a corona that stabilizes the particles and ensures the delivery to the targeted cells. To optimize the design of engineered DDSs, it is essential to gain a comprehensive understanding of these core–shell assemblies at the atomic level. In this review, we illustrate how solid-state nuclear magnetic resonance (ssNMR) spectroscopy has become an essential tool in DDS design.

Recent progress in solid-state NMR studies of drugs confined within drug delivery systems

2014 ◽  
Vol 57-58 ◽  
pp. 2-16 ◽  
Author(s):  
Ewa Skorupska ◽  
Agata Jeziorna ◽  
Slawomir Kazmierski ◽  
Marek J. Potrzebowski
Keyword(s):  
Drug Delivery ◽  
Solid State ◽  
Solid State Nmr ◽  
Drug Delivery Systems ◽  
Recent Progress ◽  
Delivery Systems ◽  
Nmr Studies

The application progress of peptides in drug delivery systems in the past decade

2021 ◽  
Vol 66 ◽  
pp. 102880
Author(s):  
Bing Yang ◽  
Tian-tian Wang ◽  
Yu-shun Yang ◽  
Hai-liang Zhu ◽  
Jian-hua Li
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
The Past

scholarly journals Phenylboronic acid-decorated polymeric nanomaterials for advanced bio-application

2019 ◽  
Vol 8 (1) ◽  
pp. 548-561
Author(s):  
Tianyu Lan ◽  
Qianqian Guo
Keyword(s):  
Drug Delivery ◽  
Sialic Acid ◽  
Drug Delivery Systems ◽  
Phenylboronic Acid ◽  
Delivery Systems ◽  
Therapeutic Applications ◽  
The Past ◽  
Recent Advances

Abstract The paradigm of using phenylboronic acid-decorated polymeric nanomaterials for advanced bio-application has been well established over the past decade. Phenylboronic acid and its derivatives are known to form reversible complexes with polyols, including sugar, diol and diphenol. This unique chemistry of phenylboronic acid has given many chances to be exploited for diagnostic and therapeutic applications. This review highlights the recent advances in fabrication of phenylboronic acid-decorated polymeric nanomaterials, especially focus on the interactions with glucose and sialic acid. Applications of these phenylboronic acid-decorated nanomaterials in drug delivery systems and biosensors are discussed.

scholarly journals Manipulating the physical states of confined ibuprofen in SBA-15 based drug delivery systems obtained by solid-state loading: Impact of the loading degree

2020 ◽  
Vol 153 (15) ◽  
pp. 154506
Author(s):  
Benjamin Malfait ◽  
Natália T. Correia ◽  
Carmen Ciotonea ◽  
Jérémy Dhainaut ◽  
Jean-Philippe Dacquin ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Solid State ◽  
Drug Delivery Systems ◽  
Delivery Systems

Functional peptide-based drug delivery systems

2020 ◽  
Vol 8 (31) ◽  
pp. 6517-6529 ◽  
Author(s):  
Zheng Lian ◽  
Tianjiao Ji
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
The Past ◽  
Functional Peptides ◽  
Functional Peptide ◽  
Smart Drug ◽  
Smart Drug Delivery

Representative strategies for designing smart drug delivery systems by using functional peptides in the past few years are highlighted in this review.

scholarly journals Primary biocompatibility tests of poly(lactide-co-glycolide)-(poly-L-orithine/fucoidan) core–shell nanocarriers

2018 ◽  
Vol 5 (7) ◽  
pp. 180320 ◽  
Author(s):  
Duanhua Cai ◽  
Jingqian Fan ◽  
Shibin Wang ◽  
Ruimin Long ◽  
Xia Zhou ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Methylene Chloride ◽  
Drug Carrier ◽  
Delivery Systems ◽  
Core Shell ◽  
Layer By Layer ◽  
Shell Nanoparticles ◽  
Uniform Size ◽  
Covalent Bonds

Layer-by-layer (LbL) self-assembly is the technology used in intermolecular static electricity, hydrogen bonds, covalent bonds and other polymer interactions during film assembling. This technology has been widely studied in the drug carrier field. Given their use in drug delivery systems, the biocompatibility of these potential compounds should be addressed. In this work, the primary biocompatibility of poly(lactide-co-glycolide)-(poly-L-orithine/fucoidan) [PLGA-(PLO/fucoidan)] core–shell nanoparticles (NPs) was investigated. Atomic force microscopy revealed the PLGA-(PLO/Fucoidan) 4 NPs to be spherical, with a uniform size distribution and a smooth surface, and the NPs were stable in physiological saline. The residual amount of methylene chloride was further determined by headspace gas chromatography, in which the organic solvent can be volatilized during preparation. Furthermore, cell viability, acridine orange/ethidium bromide staining, haemolysis and mouse systemic toxicity were all assessed to show that PLGA-(PLO/fucoidan) 4 NPs were biocompatible with cells and mice. Therefore, these NPs are expected to have potential applications in future drug delivery systems.

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