Functional peptide-based drug delivery systems

2020 ◽  
Vol 8 (31) ◽  
pp. 6517-6529 ◽  
Author(s):  
Zheng Lian ◽  
Tianjiao Ji
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
The Past ◽  
Functional Peptides ◽  
Functional Peptide ◽  
Smart Drug ◽  
Smart Drug Delivery

Representative strategies for designing smart drug delivery systems by using functional peptides in the past few years are highlighted in this review.

scholarly journals Hydrogel-By-Design: Smart Delivery System for Cancer Immunotherapy

2021 ◽  
Vol 9 ◽  
Author(s):  
Rongwei Cui ◽  
Qiang Wu ◽  
Jing Wang ◽  
Xiaoming Zheng ◽  
Rongying Ou ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Immunotherapy ◽  
Drug Delivery Systems ◽  
Malignant Tumors ◽  
Delivery Systems ◽  
The Past ◽  
Therapeutic Benefits ◽  
Localized Drug Delivery ◽  
Smart Drug ◽  
Smart Drug Delivery

Immunotherapy has emerged as a promising strategy for cancer treatment, in which durable immune responses were generated in patients with malignant tumors. In the past decade, biomaterials have played vital roles as smart drug delivery systems for cancer immunotherapy to achieve both enhanced therapeutic benefits and reduced side effects. Hydrogels as one of the most biocompatible and versatile biomaterials have been widely applied in localized drug delivery systems due to their unique properties, such as loadable, implantable, injectable, degradable and stimulus responsible. Herein, we have briefly summarized the recent advances on hydrogel-by-design delivery systems including the design of hydrogels and their applications for delivering of immunomodulatory molecules (e.g., cytokine, adjuvant, checkpoint inhibitor, antigen), immune cells and environmental regulatory substances in cancer immunotherapy. We have also discussed the challenges and future perspectives of hydrogels in the development of cancer immunotherapy for precision medicine at the end.

scholarly journals Polymer-Based Smart Drug Delivery Systems for Skin Application and Demonstration of Stimuli-Responsiveness

Polymers ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1285
Author(s):  
Louise Van Gheluwe ◽  
Igor Chourpa ◽  
Coline Gaigne ◽  
Emilie Munnier
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Ex Vivo ◽  
Delivery Systems ◽  
Stimuli Responsive ◽  
Stimuli Responsive Polymers ◽  
Smart Drug ◽  
Smart Drug Delivery

Progress in recent years in the field of stimuli-responsive polymers, whose properties change depending on the intensity of a signal, permitted an increase in smart drug delivery systems (SDDS). SDDS have attracted the attention of the scientific community because they can help meet two current challenges of the pharmaceutical industry: targeted drug delivery and personalized medicine. Controlled release of the active ingredient can be achieved through various stimuli, among which are temperature, pH, redox potential or even enzymes. SDDS, hitherto explored mainly in oncology, are now developed in the fields of dermatology and cosmetics. They are mostly hydrogels or nanosystems, and the most-used stimuli are pH and temperature. This review offers an overview of polymer-based SDDS developed to trigger the release of active ingredients intended to treat skin conditions or pathologies. The methods used to attest to stimuli-responsiveness in vitro, ex vivo and in vivo are discussed.

Smart Drug Delivery Systems

Drug Delivery ◽  
2014 ◽  
pp. 265-316
Author(s):  
Eric P. Holowka ◽  
Sujata K. Bhatia
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Smart Drug ◽  
Smart Drug Delivery

scholarly journals Bioceramics: from bone substitutes to nanoparticles for drug delivery

2019 ◽  
Vol 91 (4) ◽  
pp. 687-706 ◽  
Author(s):  
María Vallet-Regí
Keyword(s):  
Drug Delivery ◽  
Biomedical Applications ◽  
Drug Delivery Systems ◽  
Bone Repair ◽  
Research Team ◽  
Research Work ◽  
Bone Substitutes ◽  
Delivery Systems ◽  
Smart Drug ◽  
Smart Drug Delivery

Abstract Since the second half of the 20th century, bioceramics are used for bone repair and regeneration. Inspired by bones and teeth, and aimed at mimicking their structure and composition, several artificial bioceramics were developed for biomedical applications. And nowadays, in the 21st century, with the increasing prominence of nanoscience and nanotechnology, certain bioceramics are being used to build smart drug delivery systems, among other applications. This minireview will mainly describe both tendencies through the research work carried out by the research team of María Vallet-Regí.

Chitosan nanocapsule-mounted cellulose nanofibrils as nanoships for smart drug delivery systems and treatment of avian trichomoniasis

2019 ◽  
Vol 95 ◽  
pp. 290-299 ◽  
Author(s):  
Arash Yunessnia lehi ◽  
Hamidreza Shagholani ◽  
Mohsen Ghorbani ◽  
Ali Nikpay ◽  
Mohammad Soleimani lashkenari ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Cellulose Nanofibrils ◽  
Delivery Systems ◽  
Smart Drug ◽  
Smart Drug Delivery

scholarly journals Stimulus-Responsive Polymeric Nanogels as Smart Drug Delivery Systems

2019 ◽  
Author(s):  
Navid Rabiee ◽  
Sakineh Hajebi ◽  
Mojtaba Bagherzadeh ◽  
Sepideh Ahmadi ◽  
Mohammad Rabiee ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Stimulus Responsive ◽  
Smart Drug ◽  
Smart Drug Delivery
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