scholarly journals Graphene Oxide-Based Stimuli-Responsive Platforms for Biomedical Applications

Molecules ◽  
2021 ◽  
Vol 26 (9) ◽  
pp. 2797
Author(s):  
Tejal V. Patil ◽  
Dinesh K. Patel ◽  
Sayan Deb Dutta ◽  
Keya Ganguly ◽  
Ki-Taek Lim
Keyword(s):  
Drug Delivery ◽  
Wound Healing ◽  
Graphene Oxide ◽  
Cancer Therapy ◽  
Electric Fields ◽  
High Surface ◽  
High Surface Area ◽  
Stimuli Responsive ◽  
Internal Factors ◽  
Responsive Materials

Graphene is a two-dimensional sp2 hybridized carbon material that has attracted tremendous attention for its stimuli-responsive applications, owing to its high surface area and excellent electrical, optical, thermal, and mechanical properties. The physicochemical properties of graphene can be tuned by surface functionalization. The biomedical field pays special attention to stimuli-responsive materials due to their responsive abilities under different conditions. Stimuli-responsive materials exhibit great potential in changing their behavior upon exposure to external or internal factors, such as pH, light, electric field, magnetic field, and temperature. Graphene-based materials, particularly graphene oxide (GO), have been widely used in stimuli-responsive applications due to their superior biocompatibility compared to other forms of graphene. GO has been commonly utilized in tissue engineering, bioimaging, biosensing, cancer therapy, and drug delivery. GO-based stimuli-responsive platforms for wound healing applications have not yet been fully explored. This review describes the effects of different stimuli-responsive factors, such as pH, light, temperature, and magnetic and electric fields on GO-based materials and their applications. The wound healing applications of GO-based materials is extensively discussed with cancer therapy and drug delivery.

Functionalized Nano-graphene Oxide as Multi-modal Clinic for Effective Drug Delivery

2017 ◽  
Vol 10 (4) ◽  
pp. 3768-3771
Author(s):  
Soumitra Satapathi ◽  
Rutusmita Mishra ◽  
Manisha Chatterjee ◽  
Partha Roy ◽  
Somesh Mohapatra
Keyword(s):  
Drug Delivery ◽  
Graphene Oxide ◽  
Cancer Cell ◽  
High Surface ◽  
High Surface Area ◽  
Cancer Cell Line ◽  
Xrd Analysis ◽  
Graphene Derivatives ◽  
Nano Graphene

Nano-materials based drug delivery modalities to specific organs and tissues has become one of the critical endeavors in pharmaceutical research. Recently, two-dimensional graphene has elicited considerable research interest because of its potential application in drug delivery systems. Here we report, the drug delivery applications of PEGylated nano-graphene oxide (nGO-PEG), complexed with a multiphoton active and anti-cancerous diarylheptanoid drug curcumin. Specifically, graphene-derivatives were used as nanovectors for the delivery of the hydrophobic anticancer drug curcumin due to its high surface area and easy surface functionalization. nGO was synthesized by modified Hummer’s method and confirmed by XRD analysis. The formation of nGO, nGO-PEG and nGO-PEG-Curcumin complex were monitored through UV-vis, IR spectroscopy. MTT assay and AO/EB staining found that nGO-PEG-Curcumin complex afforded highly potent cancer cell killing in vitro with a human breast cancer cell line MCF7.

Role of Gold Nanoparticles in Drug Delivery and Cancer Therapy

2021 ◽  
pp. 124-140
Author(s):  
Mohammad Nadeem Lone ◽  
Irshad Ahmad Wani ◽  
Gulam Nabi Yatoo ◽  
Zubaid U-Khazir ◽  
Javid Ahmad Banday
Keyword(s):  
Drug Delivery ◽  
Gold Nanoparticles ◽  
Cancer Therapy ◽  
High Surface ◽  
High Surface Area ◽  
Volume Ratio ◽  
Drug Carriers ◽  
Photothermal Effect ◽  
Intracellular Release ◽  
High Dispersity

Among various nanoparticles (NPs), gold nanoparticles (GNPs) gained valuable attention in the field of medicine because of some unique properties like small size and high surface area-to-volume ratio, inert nature, stability, high dispersity, non-cytotoxicity, and biocompatibility. These NPs are evolving as promising agents especially in drug carriers, cancer therapy, and constantly being exploring as photothermal agents, contrast agents, and radiosensitisers. Besides, GNPs interact with thiols that provides an effective and selective means of controlled intracellular release. At the present, cancer patients are increasing rapidly at national and international levels. In this chapter, efforts have taken to highlight the importance of GNPs, their critical mediation in drug delivery, as sensors for probing and imaging tumors and anti-angiogenesis. More importantly, this short piece of analysis highlights the photothermal effect of GNPs in therapy and as radiosensitizers. Finally, the current challenges and future perspectives of GNP's in cancer management are also discussed.

Tumor targeting dual stimuli responsive controllable release nanoplatform based on DNA-conjugated reduced graphene oxide for chemo-photothermal synergetic cancer therapy

2018 ◽  
Vol 6 (26) ◽  
pp. 4360-4367 ◽  
Author(s):  
Wenjing Jiang ◽  
Fan Mo ◽  
Yaohui Lin ◽  
Xusheng Wang ◽  
LiangJun Xu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Graphene Oxide ◽  
Cancer Therapy ◽  
Reduced Graphene Oxide ◽  
Tumor Targeting ◽  
Stimuli Responsive ◽  
Release Drug ◽  
Reduced Graphene ◽  
Controllable Release

A tumor targeting dual stimuli responsive controllable release drug delivery nanoplatform was fabricated for chemo-photothermal synergetic cancer therapy based on DNA-conjugated reduced graphene oxide.

The Smart Dual-Stimuli Responsive Nanoparticles for Controlled AntiTumor Drug Release and Cancer Therapy

2020 ◽  
Vol 20 ◽  
Author(s):  
Feng Wu ◽  
Fei Qiu ◽  
Siew Anthony Wai-Keong ◽  
Yong Diao
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Release ◽  
Targeted Delivery ◽  
Relevant Information ◽  
Therapeutic Effects ◽  
Stimuli Responsive ◽  
Control Effect ◽  
Chemotherapy Drugs ◽  
Excellent Control

Background: In recent years, the emergence of stimuli-responsive nanoparticles makes drug delivery more efficient. As an intelligent and effective targeted delivery platform, it can reduce the side effects generated during drug transportation while enhancing the treatment efficacy. The stimuli-responsive nanoparticles can respond to different stimuli at corresponding times and locations to deliver and release their drugs and associated therapeutic effects. Objective: This review aims to inform researchers on the latest advances in the application of dual-stimuli responsive nanoparticles in precise drug delivery, with special attention to their design, drug release properties, and therapeutic effects. Syntheses of nanoparticles with simultaneous or sequential responses to two or more stimuli (pH-redox, pH-light, redoxlight, temperature-magnetic, pH-redox-temperature, redox-enzyme-light, etc.) and the applications of such responsivity properties for drugs control and release have become a hot topic of recent research. Methods: A database of relevant information for the production of this review was sourced, screened and analyzed from Pubmed, Web of Science, SciFinder by searching for the following keywords: “dual-stimuli responsive”, “controlled release”, “cancer therapy”, “synergistic treatment”. Results: Notably, the nanoparticles with dual-stimuli responsive function have an excellent control effect on drug delivery and release, playing a crucial part in the treatment of tumors. They can improve the encapsulation and delivery efficiency of hydrophobic chemotherapy drugs, combine chemo-photothermal therapies, apply imaging function in the diagnosis of tumors and even conduct multi-drugs delivery to overcome multi-drugs resistance (MDR). Conclusion: With the development of smart dual-stimuli responsive nanoparticles, cancer treatment methods will become more diverse and effective. All the stimuli-responsive nanoparticles functionalities exhibited their characteristics individually within the single nanosystem.

Lawsone Derived Zn (II) and Fe (III) Metal Organic Frameworks with pH Dependent Emission for Controlled Drug Delivery

2021 ◽  
Author(s):  
Sirajunnisa P ◽  
Liz Hannah George ◽  
Narayanapillai Manoj ◽  
Prathapan S ◽  
G.S. Sailaja
Keyword(s):  
Drug Delivery ◽  
Porous Structure ◽  
High Surface ◽  
Metal Organic Frameworks ◽  
High Surface Area ◽  
Controlled Drug Delivery ◽  
Sensing Applications ◽  
Porous Carriers ◽  
Metal Organic ◽  
Ph Dependent

Fluorescent biocompatible porous carriers have been investigated as suitable probes for drug delivery and sensing applications owing to their intrinsic fluorescence and high surface area originating from their porous structure...

scholarly journals NIR-responsive MXene nanobelts for wound healing

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Lin Jin ◽  
Xiaoqing Guo ◽  
Di Gao ◽  
Cui Wu ◽  
Bin Hu ◽  
...  
Keyword(s):  
Wound Healing ◽  
Vitamin E ◽  
Surface Area ◽  
Near Infrared ◽  
Coating Layer ◽  
High Surface ◽  
High Surface Area ◽  
High Mass ◽  
Polymeric Coating ◽  
Mass Loading

AbstractEffectively achieving wound healing is a great challenge. Herein, we facilely prepared temperature-responsive MXene nanobelt fibers (T-RMFs) carrying vitamin E with a controllable release ability for wound healing. These T-RMFs were composed of MXene nanosheets spread along polyacrylonitrile and polyvinylpyrrolidone composite nanobelts together with a thermosensitive PAAV- coating layer. The high mass loading and high surface area of the MXene nanosheets endow the T-RMFs with excellent photothermal properties. The temperature could be easily controlled by near-infrared (NIR) irradiation exposure, and then the thermoresponsive polymeric coating layer relaxed the interface to dissolve vitamin E and promote vitamin E release. The T-RMFs demonstrated excellent biocompatibility and wound-healing functions in cellular and animal tests. The facile method, high mass loading, high surface area, excellent wound-healing functions, interesting nanosheet/nanobelt structure, mass production potential, and NIR responsive properties of these T-RMFs indicate the great potential of our nanobelts for wound healing, tissue engineering, and much broader application areas. This facile nanosheet/nanobelt preparation strategy paves a new way for nanomaterial fabrication and applications.

scholarly journals Hyperthermia evaluation and drug/protein-controlled release using alternating magnetic field stimuli-responsive Mn–Zn ferrite composite particles

RSC Advances ◽  
2020 ◽  
Vol 10 (66) ◽  
pp. 40206-40214
Author(s):  
Wararat Montha ◽  
Weerakanya Maneeprakorn ◽  
I-Ming Tang ◽  
Weeraphat Pon-On
Keyword(s):  
Magnetic Field ◽  
Drug Delivery ◽  
Controlled Release ◽  
Cancer Therapy ◽  
Regenerative Medicine ◽  
Alternating Magnetic Field ◽  
Composite Particles ◽  
Stimuli Responsive ◽  
Zn Ferrite

Drug delivery particles in which the release of biomolecules is triggered by a magnetic simulant have attracted much attention and may have great potential in the fields of cancer therapy and tissue regenerative medicine.

scholarly journals Metal-Organic Framework-Based Engineered Materials—Fundamentals and Applications

Molecules ◽  
2020 ◽  
Vol 25 (7) ◽  
pp. 1598 ◽  
Author(s):  
Tahir Rasheed ◽  
Komal Rizwan ◽  
Muhammad Bilal ◽  
Hafiz M. N. Iqbal
Keyword(s):  
Drug Delivery ◽  
Metal Organic Framework ◽  
High Surface ◽  
High Surface Area ◽  
Co2 Reduction ◽  
Biological Species ◽  
Crystalline Materials ◽  
Potential Applications ◽  
Metal Organic ◽  
Catalytic Chemistry

Metal-organic frameworks (MOFs) are a fascinating class of porous crystalline materials constructed by organic ligands and inorganic connectors. Owing to their noteworthy catalytic chemistry, and matching or compatible coordination with numerous materials, MOFs offer potential applications in diverse fields such as catalysis, proton conduction, gas storage, drug delivery, sensing, separation and other related biotechnological and biomedical applications. Moreover, their designable structural topologies, high surface area, ultrahigh porosity, and tunable functionalities all make them excellent materials of interests for nanoscale applications. Herein, an effort has been to summarize the current advancement of MOF-based materials (i.e., pristine MOFs, MOF derivatives, or MOF composites) for electrocatalysis, photocatalysis, and biocatalysis. In the first part, we discussed the electrocatalytic behavior of various MOFs, such as oxidation and reduction candidates for different types of chemical reactions. The second section emphasizes on the photocatalytic performance of various MOFs as potential candidates for light-driven reactions, including photocatalytic degradation of various contaminants, CO2 reduction, and water splitting. Applications of MOFs-based porous materials in the biomedical sector, such as drug delivery, sensing and biosensing, antibacterial agents, and biomimetic systems for various biological species is discussed in the third part. Finally, the concluding points, challenges, and future prospects regarding MOFs or MOF-based materials for catalytic applications are also highlighted.

scholarly journals Attached β-cyclodextrin/γ-(2,3-epoxypropoxy) propyl trimethoxysilane to graphene oxide and its application in copper removal

2017 ◽  
Vol 75 (10) ◽  
pp. 2403-2411 ◽  
Author(s):  
Zongxue Yu ◽  
Qi Chen ◽  
Liang Lv ◽  
Yang Pan ◽  
Guangyong Zeng ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
High Surface ◽  
High Surface Area ◽  
Esterification Reaction ◽  
X Ray Diffraction ◽  
X Ray ◽  
Cavity Structure ◽  
Optimum Ph ◽  
Exchange Adsorption ◽  
Langmuir Isotherm Model

The environmental applications of graphene oxide and β-cyclodextrin (β-CD) have attracted great attention since their first discovery. Novel nanocomposites were successfully prepared by using an esterification reaction between β-cyclodextrin/γ-(2,3-epoxypropoxy) propyl trimethoxysilane grafted graphene oxide (β-CD/GPTMS/GO). The β-CD/GPTMS/GO nanocomposites were used to remove the Cu2+ from aqueous solutions. The characteristics of β-CD/GPTMS/GO were detected by scanning electron microscopy (SEM), Fourier transform infrared, X-ray diffraction (XRD), thermogravimetric analysis (TG) and energy dispersive X-ray (EDX). The dispersibility of graphene oxide was excellent due to the addition of β-CD. The adsorption isotherms data obtained at the optimum pH 7 were fitted by Langmuir isotherm model. The excellent adsorption properties of β-CD/GPTMS/GO for Cu2+ ions could be attributed to the apolar cavity structure of β-CD, the high surface area and abundant functional groups on the surface of GO. The adsorption patterns of β-CD/GPTMS/GO were electrostatic attraction, formation of host-guest inclusion complexes and the ion exchange adsorption. The efficient adsorption of β-CD/GPTMS/GO for Cu2+ ions suggested that these novel nanocomposites may be ideal candidates for removing other cation pollutants from waste water.

Recent trends in carbon nanotubes based prostate cancer therapy: A biomedical hybrid for diagnosis and treatment

2021 ◽  
Vol 18 ◽  
Author(s):  
Raja Murugesan ◽  
Sureshkumar Raman
Keyword(s):  
Prostate Cancer ◽  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Drug Loading ◽  
High Surface ◽  
High Surface Area ◽  
High Capacity ◽  
Chemical Properties ◽  
Diagnosis And Treatment ◽  
High Level

: At present treatment methods for cancer are limited, partially due to the solubility, poor cellular distribution of drug molecules and, the incapability of drugs to annoy the cellular barriers. Carbon nanotubes (CNTs) generally have excellent physio-chemical properties, which include high-level penetration into the cell membrane, high surface area and high capacity of drug loading by in circulating modification with bio-molecules, project them as an appropriate candidate to diagnose and deliver drugs to prostate cancer (PCa). Additionally, the chemically modified CNTs which have excellent 'Biosensing' properties therefore makes it easy for detecting PCa without fluorescent agent and thus targets the particular site of PCa and also, Drug delivery can accomplish a high efficacy, enhanced permeability with less toxic effects. While CNTs have been mainly engaged in cancer treatment, a few studies are focussed on the diagnosis and treatment of PCa. Here, we detailly reviewed the current progress of the CNTs based diagnosis and targeted drug delivery system for managing and curing PCa.

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