scholarly journals Hyperthermia evaluation and drug/protein-controlled release using alternating magnetic field stimuli-responsive Mn–Zn ferrite composite particles

RSC Advances ◽  
2020 ◽  
Vol 10 (66) ◽  
pp. 40206-40214
Author(s):  
Wararat Montha ◽  
Weerakanya Maneeprakorn ◽  
I-Ming Tang ◽  
Weeraphat Pon-On
Keyword(s):  
Magnetic Field ◽  
Drug Delivery ◽  
Controlled Release ◽  
Cancer Therapy ◽  
Regenerative Medicine ◽  
Alternating Magnetic Field ◽  
Composite Particles ◽  
Stimuli Responsive ◽  
Zn Ferrite

Drug delivery particles in which the release of biomolecules is triggered by a magnetic simulant have attracted much attention and may have great potential in the fields of cancer therapy and tissue regenerative medicine.

scholarly journals Smart stimuli-responsive nanocarriers for the cancer therapy – nanomedicine

2021 ◽  
Vol 10 (1) ◽  
pp. 933-953
Author(s):  
Baranya Murugan ◽  
Suresh Sagadevan ◽  
Is Fatimah ◽  
Won-Chun Oh ◽  
Mohd Abd Motalib Hossain ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Drug Delivery ◽  
Controlled Release ◽  
Cancer Therapy ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Release Profile ◽  
Acidic Ph ◽  
Stimuli Responsive ◽  
External Stimuli

Abstract Nanomedicine is ongoing current research in the applications of nanotechnology for cancer therapy. Simply from a technology perspective, this field of research has an enormous broadening and success to date. Recently, nanomedicine has also made inroads in the treatment of cancer. Stimuli-responsive nanoparticles are an emerging field of research because its targeting capacity is of great interest in the treatment of cancer. The responsive nanoparticles are efficient in encountering different internal biological stimuli (acidic, pH, redox, and enzyme) and external stimuli (temperature, ultrasounds, magnetic field, and light), which are used as smart nanocarriers for delivery of the chemotherapeutic and imaging agents for cancer therapy. In-depth, the responsive nanocarrier that responds to the biological cues is of pronounced interest due to its capability to provide a controlled release profile at the tumor-specific site. The outlook of this review focuses on the stimuli-responsive nanocarrier drug delivery systems in sequence to address the biological challenges that need to be evaluated to overcome conventional cancer therapy.

Phase-change material filled hollow magnetic nanoparticles for cancer therapy and dual modal bioimaging

Nanoscale ◽  
2015 ◽  
Vol 7 (19) ◽  
pp. 9004-9012 ◽  
Author(s):  
Jinghua Li ◽  
Yan Hu ◽  
Yanhua Hou ◽  
Xinkun Shen ◽  
Gaoqiang Xu ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Drug Delivery ◽  
Magnetic Nanoparticles ◽  
Cancer Therapy ◽  
Phase Change ◽  
Phase Change Material ◽  
Alternating Magnetic Field ◽  
Change Material

An alternating magnetic field triggered nanocarrier for drug delivery is fabricated for dual modal imaging-guided thermo-chemo cancer therapy.

The Smart Dual-Stimuli Responsive Nanoparticles for Controlled AntiTumor Drug Release and Cancer Therapy

2020 ◽  
Vol 20 ◽  
Author(s):  
Feng Wu ◽  
Fei Qiu ◽  
Siew Anthony Wai-Keong ◽  
Yong Diao
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Release ◽  
Targeted Delivery ◽  
Relevant Information ◽  
Therapeutic Effects ◽  
Stimuli Responsive ◽  
Control Effect ◽  
Chemotherapy Drugs ◽  
Excellent Control

Background: In recent years, the emergence of stimuli-responsive nanoparticles makes drug delivery more efficient. As an intelligent and effective targeted delivery platform, it can reduce the side effects generated during drug transportation while enhancing the treatment efficacy. The stimuli-responsive nanoparticles can respond to different stimuli at corresponding times and locations to deliver and release their drugs and associated therapeutic effects. Objective: This review aims to inform researchers on the latest advances in the application of dual-stimuli responsive nanoparticles in precise drug delivery, with special attention to their design, drug release properties, and therapeutic effects. Syntheses of nanoparticles with simultaneous or sequential responses to two or more stimuli (pH-redox, pH-light, redoxlight, temperature-magnetic, pH-redox-temperature, redox-enzyme-light, etc.) and the applications of such responsivity properties for drugs control and release have become a hot topic of recent research. Methods: A database of relevant information for the production of this review was sourced, screened and analyzed from Pubmed, Web of Science, SciFinder by searching for the following keywords: “dual-stimuli responsive”, “controlled release”, “cancer therapy”, “synergistic treatment”. Results: Notably, the nanoparticles with dual-stimuli responsive function have an excellent control effect on drug delivery and release, playing a crucial part in the treatment of tumors. They can improve the encapsulation and delivery efficiency of hydrophobic chemotherapy drugs, combine chemo-photothermal therapies, apply imaging function in the diagnosis of tumors and even conduct multi-drugs delivery to overcome multi-drugs resistance (MDR). Conclusion: With the development of smart dual-stimuli responsive nanoparticles, cancer treatment methods will become more diverse and effective. All the stimuli-responsive nanoparticles functionalities exhibited their characteristics individually within the single nanosystem.

Extremely low frequency alternating magnetic field–triggered and MRI–traced drug delivery by optimized magnetic zeolitic imidazolate framework-90 nanoparticles

Nanoscale ◽  
2016 ◽  
Vol 8 (6) ◽  
pp. 3259-3263 ◽  
Author(s):  
Jie Fang ◽  
Yong Yang ◽  
Wen Xiao ◽  
Bingwen Zheng ◽  
Yun-Bo Lv ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Drug Delivery ◽  
Drug Release ◽  
Low Frequency ◽  
Alternating Magnetic Field ◽  
Zeolitic Imidazolate Framework ◽  
Extremely Low Frequency

An extremely low frequency alternating magnetic field of 20 Hz was proved to be able to remarkably accelerate the drug release from optimized ZIF-90 nanospheres with incorporated Fe3O4 nanoparticles acting as actuator.

Stimuli-Responsive Nano-Drug Delivery Systems for Cancer Therapy

2020 ◽  
pp. 151-162
Author(s):  
Sauraj ◽  
Anuj Kumar ◽  
Bijender Kumar ◽  
Ruchir Priyadarshi ◽  
Chhavi Sharma ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Stimuli Responsive ◽  
Nano Drug Delivery

Stimuli-responsive cancer therapy based on nanoparticles

2014 ◽  
Vol 50 (79) ◽  
pp. 11614-11630 ◽  
Author(s):  
Jing Yu ◽  
Xin Chu ◽  
Yanglong Hou
Keyword(s):  
Magnetic Field ◽  
Cancer Therapy ◽  
Stimuli Responsive ◽  
Ph Reduction ◽  
Stimuli Sensitive

Nanoparticle (NP)-based stimuli-sensitive cancer therapy, including pH-, reduction-sensitive NPs and light-, magnetic field-responsive NPs are reviewed.

Design and self-assembly of albumin nanoclusters as a dynamic-covalent targeting co-delivery and stimuli-responsive controlled release platform

2018 ◽  
Vol 6 (42) ◽  
pp. 6817-6830 ◽  
Author(s):  
Wen Liu ◽  
Jian Dai ◽  
Wei Xue
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Tumor Microenvironment ◽  
Self Assembly ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Stimuli Responsive ◽  
Target Sites

Stimuli-responsive nanomaterial-based drug delivery systems that are able to actively target the tumor microenvironment, enhance intratumoral accumulation and release drugs at target sites are attractive therapeutic platforms at present.

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