scholarly journals Nutraceuticals: Transformation of Conventional Foods into Health Promoters/Disease Preventers and Safety Considerations

Molecules ◽  
2021 ◽  
Vol 26 (9) ◽  
pp. 2540
Author(s):  
Mudhi AlAli ◽  
Maream Alqubaisy ◽  
Mariam Nasser Aljaafari ◽  
Asma Obaid AlAli ◽  
Laila Baqais ◽  
...  
Keyword(s):  
Future Prospect ◽  
Mechanisms Of Action ◽  
Dietary Fibers ◽  
Collagen Hydrolysate ◽  
Current Trends ◽  
Anti Cancer ◽  
Conventional Foods ◽  
Safety Considerations ◽  
Nutritional Benefits ◽  
Essential Food

Nutraceuticals are essential food constituents that provide nutritional benefits as well as medicinal effects. The benefits of these foods are due to the presence of active compounds such as carotenoids, collagen hydrolysate, and dietary fibers. Nutraceuticals have been found to positively affect cardiovascular and immune system health and have a role in infection and cancer prevention. Nutraceuticals can be categorized into different classes based on their nature and mode of action. In this review, different classifications of nutraceuticals and their potential therapeutic activity, such as anti-cancer, antioxidant, anti-inflammatory and anti-lipid activity in disease will be reviewed. Moreover, the different mechanisms of action of these products, applications, and safety upon consumers including current trends and future prospect of nutraceuticals will be included.

Anticancer Properties of Essential Oils: An Overview

2018 ◽  
Vol 18 (10) ◽  
pp. 957-966 ◽  
Author(s):  
Milene Aparecida Andrade ◽  
Mariana Aparecida Braga ◽  
Pedro Henrique Souza Cesar ◽  
Marcus Vinicius Cardoso Trento ◽  
Mariana Araújo Espósito ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Essential Oils ◽  
Public Health Problem ◽  
Mechanisms Of Action ◽  
Low Molecular Weight ◽  
Anticancer Properties ◽  
Anti Cancer ◽  
Different Types ◽  
Antitumor Properties ◽  
Pharmaceutical Properties

Background: Essential oils are complex mixtures of low molecular weight compounds extracted from plants. Their main constituents are terpenes and phenylpropanoids, which are responsible for their biological and pharmaceutical properties, such as insecticidal, parasiticidal, antimicrobial, antioxidant, anti-inflammatory, analgesic, antinociceptive, anticarcinogenic, and antitumor properties. Cancer is a complex genetic disease considered as a serious public health problem worldwide, accounting for more than 8 million deaths annually. Objective: The activities of prevention and treatment of different types of cancer and the medicinal potential of essential oils are addressed in this review. Conclusion: Several studies have demonstrated anti-carcinogenic and antitumor activity for many essential oils obtained from various plant species. They may be used as a substitution to or in addition to conventional anti-cancer therapy. Although many studies report possible mechanisms of action for essential oils compounds, more studies are necessary in order to apply them safely and appropriately in cancer therapy.

Pyrrole derivatives as potential anti-cancer therapeutics: synthesis, mechanisms of action, safety

2019 ◽  
Vol 28 (5) ◽  
pp. 547-563
Author(s):  
Halyna Kuznietsova ◽  
Natalia Dziubenko ◽  
Iryna Byelinska ◽  
Vasyl Hurmach ◽  
Andriy Bychko ◽  
...  
Keyword(s):  
Cancer Therapeutics ◽  
Mechanisms Of Action ◽  
Pyrrole Derivatives ◽  
Anti Cancer

New application of in silico methods in identifying mechanisms of action and key components of anti-cancer herbal formulation YIV-906 (PHY906)

2019 ◽  
Vol 21 (42) ◽  
pp. 23501-23513 ◽  
Author(s):  
Shuhan Liu ◽  
Xibing He ◽  
Viet Hoang Man ◽  
Beihong Ji ◽  
Junjun Liu ◽  
...  
Keyword(s):  
In Silico ◽  
Mechanisms Of Action ◽  
Herbal Formulation ◽  
Anti Cancer ◽  
In Silico Methods

Human metabolites and herbal chemicals from YIV-906 can act as phosphate mimics and occupy the catalytic centre of DUSP3.

scholarly journals Molecular Mechanisms of the Anti-Cancer Effects of Isothiocyanates from Cruciferous Vegetables in Bladder Cancer

Molecules ◽  
2020 ◽  
Vol 25 (3) ◽  
pp. 575 ◽  
Author(s):  
Tomhiro Mastuo ◽  
Yasuyoshi Miyata ◽  
Tsutomu Yuno ◽  
Yuta Mukae ◽  
Asato Otsubo ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Molecular Mechanisms ◽  
Checkpoint Inhibitors ◽  
Treatment Strategies ◽  
Allyl Isothiocyanate ◽  
Cruciferous Vegetables ◽  
Current Trends ◽  
Carcinogenic Potential ◽  
Anti Cancer ◽  
Future Direction

Bladder cancer (BC) is a representative of urological cancer with a high recurrence and metastasis potential. Currently, cisplatin-based chemotherapy and immune checkpoint inhibitors are used as standard therapy in patients with advanced/metastatic BC. However, these therapies often show severe adverse events, and prolongation of survival is unsatisfactory. Therefore, a treatment strategy using natural compounds is of great interest. In this review, we focused on the anti-cancer effects of isothiocyanates (ITCs) derived from cruciferous vegetables, which are widely cultivated and consumed in many regions worldwide. Specifically, we discuss the anti-cancer effects of four ITC compounds—allyl isothiocyanate, benzyl isothiocyanate, sulforaphane, and phenethyl isothiocyanate—in BC; the molecular mechanisms underlying their anti-cancer effects; current trends and future direction of ITC-based treatment strategies; and the carcinogenic potential of ITCs. We also discuss the advantages and limitations of each ITC in BC treatment, furthering the consideration of ITCs in treatment strategies and for improving the prognosis of patients with BC.

scholarly journals Parthenolide as Cooperating Agent for Anti-Cancer Treatment of Various Malignancies

2020 ◽  
Vol 13 (8) ◽  
pp. 194 ◽  
Author(s):  
Malgorzata Sztiller-Sikorska ◽  
Malgorzata Czyz
Keyword(s):  
Cancer Cells ◽  
Nuclear Factor Kappa B ◽  
Acquired Resistance ◽  
Complementary Therapy ◽  
Mechanisms Of Action ◽  
Nuclear Factor ◽  
Development Of Resistance ◽  
Current State ◽  
Anti Cancer ◽  
Survival Signaling

Primary and acquired resistance of cancer to therapy is often associated with activation of nuclear factor kappa B (NF-κB). Parthenolide (PN) has been shown to inhibit NF-κB signaling and other pro-survival signaling pathways, induce apoptosis and reduce a subpopulation of cancer stem-like cells in several cancers. Multimodal therapies that include PN or its derivatives seem to be promising approaches enhancing sensitivity of cancer cells to therapy and diminishing development of resistance. A number of studies have demonstrated that several drugs with various targets and mechanisms of action can cooperate with PN to eliminate cancer cells or inhibit their proliferation. This review summarizes the current state of knowledge on PN activity and its potential utility as complementary therapy against different cancers.

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