scholarly journals Self-Associating Polymers Chitosan and Hyaluronan for Constructing Composite Membranes as Skin-Wound Dressings Carrying Therapeutics

Molecules ◽  
2021 ◽  
Vol 26 (9) ◽  
pp. 2535
Author(s):  
Katarína Valachová ◽  
Ladislav Šoltés
Keyword(s):  
Extracellular Matrix ◽  
Wound Healing ◽  
Composite Membranes ◽  
Skin Wound ◽  
Wound Dressings ◽  
Structural Components ◽  
Skin Wound Healing ◽  
Associating Polymers

Chitosan, industrially acquired by the alkaline N-deacetylation of chitin, belongs to β-N-acetyl-glucosamine polymers. Another β-polymer is hyaluronan. Chitosan, a biodegradable, non-toxic, bacteriostatic, and fungistatic biopolymer, has numerous applications in medicine. Hyaluronan, one of the major structural components of the extracellular matrix in vertebrate tissues, is broadly exploited in medicine as well. This review summarizes that these two biopolymers have a mutual impact on skin wound healing as skin wound dressings and carriers of remedies.

scholarly journals Resveratrol-loaded peptide-hydrogels inhibit scar formation in wound healing through suppressing inflammation

2019 ◽  
Author(s):  
Chen-Chen Zhao ◽  
Lian Zhu ◽  
Zheng Wu ◽  
Rui Yang ◽  
Na Xu ◽  
...  
Keyword(s):  
Wound Healing ◽  
Damage Model ◽  
Skin Wound ◽  
Scar Formation ◽  
Wound Dressings ◽  
Skin Damage ◽  
Skin Wound Healing ◽  
Accelerate Wound Healing ◽  
Peptide Hydrogels

Abstract Scar formation seriously affects the repair of damaged skin especially in adults and the excessive inflammation has been considered as the reason. The self-assembled peptide-hydrogels are ideal biomaterials for skin wound healing due to their similar nanostructure to natural extracellular matrix, hydration environment and serving as drug delivery systems. In our study, resveratrol, a polyphenol compound with anti-inflammatory effect, is loaded into peptide-hydrogel (Fmoc-FFGGRGD) to form a wound dressing (Pep/RES). Resveratrol is slowly released from the hydrogel in situ, and the release amount is controlled by the loading amount. The in vitro cell experiments demonstrate that the Pep/RES has no cytotoxicity and can inhibit the production of pro-inflammatory cytokines of macrophages. The Pep/RES hydrogels are used as wound dressings in rat skin damage model. The results suggest that the Pep/RES dressing can accelerate wound healing rate, exhibit well-organized collagen deposition, reduce inflammation and eventually prevent scar formation. The Pep/RES hydrogels supply a potential product to develop new skin wound dressings for the therapy of skin damage.

scholarly journals Extracellular Matrix-Inspired Growth Factor Delivery Systems for Skin Wound Healing

2015 ◽  
Vol 4 (8) ◽  
pp. 479-489 ◽  
Author(s):  
Priscilla S. Briquez ◽  
Jeffrey A. Hubbell ◽  
Mikaël M. Martino
Keyword(s):  
Extracellular Matrix ◽  
Wound Healing ◽  
Growth Factor ◽  
Delivery Systems ◽  
Skin Wound ◽  
Growth Factor Delivery ◽  
Skin Wound Healing

scholarly journals Toward understanding scarless skin wound healing and pathological scarring

F1000Research ◽  
2019 ◽  
Vol 8 ◽  
pp. 787 ◽  
Author(s):  
Sanna-Maria Karppinen ◽  
Ritva Heljasvaara ◽  
Donald Gullberg ◽  
Kaisa Tasanen ◽  
Taina Pihlajaniemi
Keyword(s):  
Extracellular Matrix ◽  
Wound Healing ◽  
Healing Process ◽  
Cell Types ◽  
Skin Wound ◽  
Skin Wounds ◽  
Medical Problems ◽  
Skin Wound Healing ◽  
Recent Developments ◽  
Acute Wound

The efficient healing of skin wounds is crucial for securing the vital barrier function of the skin, but pathological wound healing and scar formation are major medical problems causing both physiological and psychological challenges for patients. A number of tightly coordinated regenerative responses, including haemostasis, the migration of various cell types into the wound, inflammation, angiogenesis, and the formation of the extracellular matrix, are involved in the healing process. In this article, we summarise the central mechanisms and processes in excessive scarring and acute wound healing, which can lead to the formation of keloids or hypertrophic scars, the two types of fibrotic scars caused by burns or other traumas resulting in significant functional or aesthetic disadvantages. In addition, we discuss recent developments related to the functions of activated fibroblasts, the extracellular matrix and mechanical forces in the wound environment as well as the mechanisms of scarless wound healing. Understanding the different mechanisms of wound healing is pivotal for developing new therapies to prevent the fibrotic scarring of large skin wounds.

scholarly journals Beneficial Effects of Green Tea EGCG on Skin Wound Healing: A Comprehensive Review

Molecules ◽  
2021 ◽  
Vol 26 (20) ◽  
pp. 6123
Author(s):  
Fa-Wei Xu ◽  
Ying-Li Lv ◽  
Yu-Fan Zhong ◽  
Ya-Nan Xue ◽  
Yong Wang ◽  
...  
Keyword(s):  
Wound Healing ◽  
Green Tea ◽  
Clinical Application ◽  
Epigallocatechin Gallate ◽  
Skin Wound ◽  
Wound Dressings ◽  
Skin Wound Healing ◽  
Comprehensive Review ◽  
Beneficial Effects ◽  
Underlying Mechanisms

Epigallocatechin gallate (EGCG) is associated with various health benefits. In this review, we searched current work about the effects of EGCG and its wound dressings on skin for wound healing. Hydrogels, nanoparticles, micro/nanofiber networks and microneedles are the major types of EGCG-containing wound dressings. The beneficial effects of EGCG and its wound dressings at different stages of skin wound healing (hemostasis, inflammation, proliferation and tissue remodeling) were summarized based on the underlying mechanisms of antioxidant, anti-inflammatory, antimicrobial, angiogenesis and antifibrotic properties. This review expatiates on the rationale of using EGCG to promote skin wound healing and prevent scar formation, which provides a future clinical application direction of EGCG.

scholarly journals Impact of Ergothioneine, Hercynine, and Histidine on Oxidative Degradation of Hyaluronan and Wound Healing

Polymers ◽  
2020 ◽  
Vol 13 (1) ◽  
pp. 95
Author(s):  
Katarina Valachova ◽  
Karol Svik ◽  
Csaba Biro ◽  
Maurice N. Collins ◽  
Rastislav Jurcik ◽  
...  
Keyword(s):  
Wound Healing ◽  
Oxidative Degradation ◽  
Composite Membranes ◽  
Skin Wound ◽  
Oh Radicals ◽  
Dependent Manner ◽  
Skin Wound Healing ◽  
Radical Degradation ◽  
Dose Dependent

A high-molecular weight hyaluronan is oxidatively degraded by Cu(II) ions and ascorbate—the so called Weissberger biogenic oxidative system—which is one of the most potent generators of reactive oxygen species, namely •OH radicals. Ergothioneine, hercynine, or histidine were loaded into chitosan/hyaluronan composite membranes to examine their effect on skin wound healing in ischemic rabbits. We also explored the ability of ergothioneine, hercynine, or histidine to inhibit hyaluronan degradation. Rotational viscometry showed that ergothioneine decreased the degree of hyaluronan radical degradation in a dose-dependent manner. While histidine was shown to be potent in scavenging •OH radicals, however, hercynine was ineffective. In vivo results showed that the addition of each investigated agent to chitosan/hyaluronan membranes contributed to a more potent treatment of ischemic skin wounds in rabbits compared to untreated animals and animals treated only with chitosan/hyaluronan membranes.

scholarly journals The Role of Extracellular Matrix in Skin Wound Healing

2021 ◽  
Vol 10 (24) ◽  
pp. 5947
Author(s):  
Nikolai N. Potekaev ◽  
Olga B. Borzykh ◽  
German V. Medvedev ◽  
Denis V. Pushkin ◽  
Marina M. Petrova ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Wound Healing ◽  
Modern Medicine ◽  
Skin Wound ◽  
Economic Losses ◽  
Skin Wound Healing ◽  
Impaired Wound Healing ◽  
Risk Levels ◽  
Fundamental Research ◽  
Chronic Skin

Impaired wound healing is one of the unsolved problems of modern medicine, affecting patients’ quality of life and causing serious economic losses. Impaired wound healing can manifest itself in the form of chronic skin wounds or hypertrophic scars. Research on the biology and physiology of skin wound healing disorders is actively continuing, but, unfortunately, a single understanding has not been developed. The attention of clinicians to the biological and physiological aspects of wound healing in the skin is necessary for the search for new and effective methods of prevention and treatment of its consequences. In addition, it is important to update knowledge about genetic and non-genetic factors predisposing to impaired wound healing in order to identify risk levels and develop personalized strategies for managing such patients. Wound healing is a very complex process involving several overlapping stages and involving many factors. This thematic review focuses on the extracellular matrix of the skin, in particular its role in wound healing. The authors analyzed the results of fundamental research in recent years, finding promising potential for their transition into real clinical practice.

Novel enzymatic crosslinked hydrogels that mimic extracellular matrix for skin wound healing

2018 ◽  
Vol 53 (8) ◽  
pp. 5909-5928 ◽  
Author(s):  
Chenhui Zhu ◽  
Huan Lei ◽  
Daidi Fan ◽  
Zhiguang Duan ◽  
Xian Li ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Wound Healing ◽  
Skin Wound ◽  
Skin Wound Healing

scholarly journals Connexin 43 deficiency accelerates skin wound healing and extracellular matrix remodeling in mice

2015 ◽  
Vol 79 (1) ◽  
pp. 50-56 ◽  
Author(s):  
Bruno Cogliati ◽  
Mathieu Vinken ◽  
Tereza C. Silva ◽  
Cintia M.M. Araújo ◽  
Thiago P.A. Aloia ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Wound Healing ◽  
Connexin 43 ◽  
Skin Wound ◽  
Extracellular Matrix Remodeling ◽  
Matrix Remodeling ◽  
Skin Wound Healing
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