scholarly journals ACTH(6–9)PGP Peptide Protects SH-SY5Y Cells from H2O2, tert-Butyl Hydroperoxide, and Cyanide Cytotoxicity via Stimulation of Proliferation and Induction of Prosurvival-Related Genes

Molecules ◽  
2021 ◽  
Vol 26 (7) ◽  
pp. 1878
Author(s):  
Mikhail G. Akimov ◽  
Elena V. Fomina-Ageeva ◽  
Polina V. Dudina ◽  
Ludmila A. Andreeva ◽  
Nikolay F. Myasoyedov ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Adrenocorticotropic Hormone ◽  
Butyl Hydroperoxide ◽  
Tert Butyl ◽  
Cytoprotective Activity ◽  
Tert Butyl Hydroperoxide ◽  
Analog Peptide ◽  
Wide Range ◽  
Related Pathway ◽  
Stimulation Of

Stabilized melanocortin analog peptide ACTH(6–9)PGP (HFRWPGP) possesses a wide range of neuroprotective activities. However, its mechanism of action remains poorly understood. In this paper, we present a study of the proproliferative and cytoprotective activity of the adrenocorticotropic hormone fragment 6–9 (HFRW) linked with the peptide prolyine–glycyl–proline on the SH-SY5Y cells in the model of oxidative stress-related toxicity. The peptide dose-dependently protected cells from H2O2, tert-butyl hydroperoxide, and KCN and demonstrated proproliferative activity. The mechanism of its action was the modulation of proliferation-related NF-κB genes and stimulation of prosurvival NRF2-gene-related pathway, as well as a decrease in apoptosis.

scholarly journals ACTH(6-9)PGP Peptide Protects SH-SY5Y Cells from the H2O2, tert-Butyl Hydroperoxide, and Cyanide Cytotoxicity via Prolif-eration Stimulation and Antioxidant-related Genes Induction

2021 ◽  
Author(s):  
Mikhail G. Akimov ◽  
Elena V. Fomina-Ageeva ◽  
Polina V. Dudina ◽  
Ludmila A. Andreeva ◽  
Nikolay F. Myasoyedov ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Mechanism Of Action ◽  
Adrenocorticotropic Hormone ◽  
Butyl Hydroperoxide ◽  
Tert Butyl ◽  
Cytoprotective Activity ◽  
Tert Butyl Hydroperoxide ◽  
Analog Peptide ◽  
Wide Range

Stabilized melanocortin analog peptide ACTH(6-9)PGP (FRWGPGP) possess a wide range of neuroprotective activities. However, its mechanism of action remains poorly understood. In this paper, we studied the pro-proliferative and cytoprotective activity of the adrenocorticotropic hormone fragment 6-9 (FRWG) linked with the peptide Prolyl-Glycyl-Proline on the SH-SY5Y cells in the model of oxidative stress-related toxicity. The peptide dose-dependently protected cells from H2O2, tert-butyl hydroperoxide, and KCN. The mechanism of its action was the modu-lation of proliferation-related (NF-kB and Nrf-2) and antioxidant-related (HO-1, Nqo1, Gclc) genes and apoptosis decrease.

scholarly journals Protective Effects of Saponin Mixture, Isolated from <i>Astragalus monspessulanus</i> subsp. <i>monspessulanus</i> on Tert-Butyl Hydroperoxide—Induced Oxidative Stress in Isolated Rat Hepatocytes

2015 ◽  
Vol 06 (06) ◽  
pp. 799-803 ◽  
Author(s):  
Magdalena Spasova Kondeva-Burdina ◽  
Viktor Bratkov ◽  
Rumyana Lubomirova Simeonova ◽  
Vessela Bisserova Vitcheva ◽  
Ilina Nikolaeva Krasteva ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Rat Hepatocytes ◽  
Protective Effects ◽  
Isolated Rat Hepatocytes ◽  
Butyl Hydroperoxide ◽  
Tert Butyl ◽  
Tert Butyl Hydroperoxide ◽  
Isolated Rat

scholarly journals Meroterpenoid-Rich Fraction of the Ethanolic Extract from Sargassum serratifolium Suppressed Oxidative Stress Induced by Tert-Butyl Hydroperoxide in HepG2 Cells

Marine Drugs ◽  
2018 ◽  
Vol 16 (10) ◽  
pp. 374 ◽  
Author(s):  
Sujin Lim ◽  
Misung Kwon ◽  
Eun-Ji Joung ◽  
Taisun Shin ◽  
Chul-Woong Oh ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Hepg2 Cells ◽  
Ethanolic Extract ◽  
Glutathione Depletion ◽  
Heme Oxygenase 1 ◽  
Dependent Manner ◽  
Butyl Hydroperoxide ◽  
Tert Butyl ◽  
Tert Butyl Hydroperoxide ◽  
Sargassum Serratifolium

Sargassum species have been reported to be a source of phytochemicals, with a wide range of biological activities. In this study, we evaluated the hepatoprotective effect of a meroterpenoid-rich fraction of the ethanolic extract from Sargassum serratifolium (MES) against tert-butyl hydroperoxide (t-BHP)-treated HepG2 cells. Treatment with MES recovered the cell viability from the t-BHP-induced oxidative damage in a dose-dependent manner. It suppressed the reactive oxygen species production, lipid peroxidation, and glutathione depletion in the t-BHP-treated HepG2 cells. The activity of the antioxidants induced by t-BHP, including superoxide dismutase (SOD) and catalase, was reduced by the MES treatment. Moreover, it increased the nuclear translocation of nuclear factor erythroid 2-related factor 2, leading to the enhanced activity of glutathione S transferase, and the increased production of heme oxygenase-1 and NAD(P)H:quinine oxidoreductase 1 in t-BHP-treated HepG2 cells. These results demonstrate that the antioxidant activity of MES substituted the activity of the SOD and catalase, and induced the production of detoxifying enzymes, indicating that MES might be used as a hepatoprotectant against t-BHP-induced oxidative stress.

Regucalcin counteracts tert-butyl hydroperoxide and cadmium-induced oxidative stress in rat testis

2016 ◽  
Vol 37 (2) ◽  
pp. 159-166 ◽  
Author(s):  
Sara Correia ◽  
Cátia V. Vaz ◽  
Ana M. S. Silva ◽  
José E. Cavaco ◽  
Sílvia Socorro
Keyword(s):  
Oxidative Stress ◽  
Butyl Hydroperoxide ◽  
Rat Testis ◽  
Tert Butyl ◽  
Tert Butyl Hydroperoxide

Oxidative stress in liver of brown bullhead and channel catfish following exposure to tert-butyl hydroperoxide

1999 ◽  
Vol 46 (3-4) ◽  
pp. 231-240 ◽  
Author(s):  
Stephen A Ploch ◽  
Yi-Pin Lee ◽  
Elizabeth MacLean ◽  
Richard T Di Giulio
Keyword(s):  
Oxidative Stress ◽  
Channel Catfish ◽  
Brown Bullhead ◽  
Butyl Hydroperoxide ◽  
Tert Butyl ◽  
Tert Butyl Hydroperoxide

Protective effects of hesperidin against oxidative stress of tert-butyl hydroperoxide in human hepatocytes

2010 ◽  
Vol 48 (10) ◽  
pp. 2980-2987 ◽  
Author(s):  
Mingcang Chen ◽  
Honggang Gu ◽  
Yiyi Ye ◽  
Bing Lin ◽  
Lijuan Sun ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Human Hepatocytes ◽  
Protective Effects ◽  
Butyl Hydroperoxide ◽  
Tert Butyl ◽  
Tert Butyl Hydroperoxide
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