scholarly journals Sweet-Tasting Ionic Conjugates of Local Anesthetics and Vasoconstrictors

Molecules ◽  
2021 ◽  
Vol 26 (4) ◽  
pp. 983
Author(s):  
John K. Neubert ◽  
Alexander A. Oliferenko ◽  
Polina V. Oliferenko ◽  
Sergey V. Emets ◽  
David A. Ostrov ◽  
...  
Keyword(s):  
Anion Exchange ◽  
Local Anesthesia ◽  
Local Anesthetics ◽  
Novel Approach ◽  
Ionic Conjugates ◽  
Taste Modulation

Local anesthetics are widely utilized in dentistry, cosmetology, and medicine. Local anesthesia is essential to providing a pain-free experience during dental and local surgeries as well as cosmetic procedures. However, the injection itself may produce discomfort and be a source of aversion. A novel approach toward the taste modulation of local anesthetics is proposed, in which the anesthetics of the “-caine” family serve as cations and are coupled with anionic sweeteners such as saccharinate and acesulfamate. Ionic conjugates of vasoconstrictor epinephrine such as epinephrine saccharinate and epinephrine acesulfamate have also been synthesized. Novel ionic conjugates were developed using anion exchange techniques. Reported compounds are sweet-tasting and are safe to use both topically and as injections.

Local Anesthetics – Substances with Multiple Application in Medicine

2016 ◽  
Vol 4 (1) ◽  
pp. 17
Author(s):  
Rodica Sîrbu ◽  
Emin Cadar ◽  
Cezar Laurențiu Tomescu ◽  
Cristina Luiza Erimia ◽  
Stelian Paris ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Medical Care ◽  
Local Anesthesia ◽  
Short Duration ◽  
Local Anesthetic ◽  
Local Anesthetics ◽  
Nerve Roots ◽  
Nervous Control ◽  
Painful Sensation ◽  
Action Groups

Local anesthetics are substances which, by local action groups on the runners, cause loss of reversible a painful sensation, delimited corresponding to the application. They allow small surgery, short in duration and the endoscopic maneuvers. May be useful in soothe teething pain of short duration and in the locking of the nervous disorders in medical care. Local anesthesia is a process useful for the carrying out of surgery and of endoscopic maneuvers, to soothe teething pain in certain conditions, for depriving the temporary structures peripheral nervous control. Reversible locking of the transmission nociceptive, the set of the vegetative and with a local anesthetic at the level of the innervations peripheral nerve, roots and runners, a trunk nervous, around the components of a ganglion or coolant is cefalorahidian practice anesthesia loco-regional. Local anesthetics summary and semi-summary have multiple applications in dentistry, consulting, surgery and obstetrics, constituting "weapons" very useful in the fight against the pain.

scholarly journals A simple calculation of the maximum dose of the local anesthetic in pediatric dentistry with nomogram in Serbian

2021 ◽  
pp. 22-22
Author(s):  
Rasa Mladenovic
Keyword(s):  
Body Weight ◽  
Local Anesthesia ◽  
Local Anesthetic ◽  
Local Anesthetics ◽  
Maximum Dose ◽  
Simple Calculation ◽  
Pediatric Dentistry ◽  
Special Importance ◽  
Advantages And Disadvantages ◽  
Graphical Tool

Clinicians should identify the risks associated with the use of anesthetics and understand the maximum recommended doses of local anesthetics. Errors in calculating the dose of local anesthetics are common due to the widespread use of these agents. Different methods of calculating the dose of the drug have different advantages and disadvantages, and no method can guarantee a calculation without errors. Nomogram is a simple graphical tool on which one can read the result of arithmetic operations with given numbers. The nomogram for calculating the maximum dose of local anesthetic enables quick cross-checking of the calculation, based on the patient's age or body weight. They are of special importance in the application of local anesthesia in children.

scholarly journals Light-triggered release of conventional local anesthetics from a macromolecular prodrug for on-demand local anesthesia

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Wei Zhang ◽  
Tianjiao Ji ◽  
Yang Li ◽  
Yueqin Zheng ◽  
Manisha Mehta ◽  
...  
Keyword(s):  
Local Anesthesia ◽  
Local Anesthetics ◽  
Triggered Release ◽  
On Demand ◽  
Macromolecular Prodrug

scholarly journals Local Anesthesia Part 2: Technical Considerations

2012 ◽  
Vol 59 (3) ◽  
pp. 127-137 ◽  
Author(s):  
Kenneth L. Reed ◽  
Stanley F. Malamed ◽  
Andrea M. Fonner
Keyword(s):  
Continuing Education ◽  
Local Anesthesia ◽  
Local Anesthetics ◽  
Effective Delivery ◽  
Injection Techniques ◽  
Technical Considerations

An earlier paper by Becker and Reed provided an in-depth review of the pharmacology of local anesthetics. This continuing education article will discuss the importance to the safe and effective delivery of these drugs, including needle gauge, traditional and alternative injection techniques, and methods to make injections more comfortable to patients.

Ionic conjugates of lidocaine and sweeteners as better tasting local anesthetics for dentistry

2015 ◽  
Vol 3 (43) ◽  
pp. 8492-8498 ◽  
Author(s):  
Iryna O. Lebedyeva ◽  
Alexander A. Oliferenko ◽  
Polina V. Oliferenko ◽  
Robert A. Hromas ◽  
John K. Neubert ◽  
...  
Keyword(s):  
Local Anesthetics ◽  
Artificial Sweeteners ◽  
New Type ◽  
Ionic Conjugates

Ionic conjugation of lidocaine with artificial sweeteners creates a new type of taste modulated materials for dentistry.

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