scholarly journals Synthesis, Spectral Characterization and Biological Activities of Co(II) and Ni(II) Mixed Ligand Complexes

Molecules ◽  
2021 ◽  
Vol 26 (4) ◽  
pp. 823
Author(s):  
P. Manimaran ◽  
S. Balasubramaniyan ◽  
Mohammad Azam ◽  
D. Rajadurai ◽  
Saud I. Al-Resayes ◽  
...  
Keyword(s):  
Metal Complexes ◽  
Pathogenic Bacteria ◽  
High Efficiency ◽  
Biological Activities ◽  
Visible Spectrum ◽  
Fungal Species ◽  
Molar Conductance ◽  
Molar Ratio ◽  
Cell Parameters

2,4-Dinitrophynylhydrazine and two thiocyanate ions in a (M:L1:L2) 1:2:2 molar ratio was synthesized in the complexes of Co(II) and Ni(II). The prepared compounds were identified through a C.H.N.S. analysis, conductivity measurements, powder X-ray diffraction (PXRD), the infrared spectrum, and a UV-visible spectrum analysis, in addition to the magnetic properties being measured. The measurements of the molar conductance implieda nonelectrolytic nature of compounds Co(II) and Ni(II). The magnetic susceptibility, as well as electronic spectra, represented all the metal complexesthroughoctahedral geometry, respectively. The PXRD patterns suggested that all the complexes were an orthorhombic system with unit cell parameters. The in-vitro biological activity of the ligand and the metal complexes were screened against the Gram-positive and negative pathogenic bacteria Staphylococcus aureus, Bacillus subtilis, Pseudomonas, aeruginosa and Escherichia coli, as well as the fungal species of Aspergillusniger and Candida albicans.Thus, the metal complexes showeda high efficiency of antimicrobial activity compared with the ligand. Furthermore, applications of the ligand, as well as the metal complexes, were tested for in-vitro antioxidant potential in aDPPH assay. The results showed that the activity of the metal complexes with the in-vitro antioxidant was more active than that of 2,4-dinitrophenylhydrazine(DNPH).

scholarly journals Biological Study of Transition Metal Complexes with Adenine Ligand

Proceedings ◽  
2019 ◽  
Vol 41 (1) ◽  
pp. 77 ◽  
Author(s):  
Hamad M. I. Hasan ◽  
Aaza I. Yahiya ◽  
Safaa S. Hassan ◽  
Mabrouk M. Salama
Keyword(s):  
Metal Complexes ◽  
Molar Conductance ◽  
Molar Ratio ◽  
Biological Study ◽  
Ratio Method ◽  
Spectroscopic Techniques ◽  
Stoichiometric Ratio ◽  
Metal Contents ◽  
Molar Ratio Method

Adenine complexes were prepared with some of the first series transition metals in a stoichiometric ratio of 1: 2 (Mn+: L), where Mn+ = Mn2+, Fe3+, Co2+, Ni2+, Cu2+, Zn2+, and Cd2+ ions. The Complexes were characterized by the physicochemical and spectroscopic techniques as electric conductivity, metal contents, IR, UV–Visible, and molar conductance techniques. The stoichiometric ratios of the synthesized complexes were confirmed by using molar ratio method. The dissociation constant of adenine ligand was determined spectrophotometrically. Solvent effect on the electronic spectra of the adenine ligand was examined using solvents with different polarities. The biological activity of adenine ligand and its metal complexes were tested in vitro against some selected species of fungi and bacteria. The results showed a satisfactory spectrum against the tested organisms.

scholarly journals Physico-chemical and biological studies of Cu(II), Co(II) and Ni(II) complexes of an N4 coordinating ligand derived from diacetylbisethylenediamine and benzoic acid

2012 ◽  
Vol 77 (5) ◽  
pp. 627-637 ◽  
Author(s):  
Pal Singh ◽  
Nanda Srivastava
Keyword(s):  
Benzoic Acid ◽  
Metal Complexes ◽  
Magnetic Moment ◽  
Biological Activities ◽  
Molar Conductance ◽  
Planar Geometry ◽  
Cyclic Voltammetric Study ◽  
Biological Studies ◽  
Antibacterial And Antifungal

Mononuclear metal complexes of the type [ML1]Cl2 (where, M = = Cu(II), Co(II) or Ni(II) and L1 = ligand) were synthesized by the reaction of a new N4 coordinating ligand, derived from diacetylbisethylenediamine with benzoic acid, and the corresponding hydrated metal chloride salts. The metal complexes were characterized by elemental analysis, melting point determination, molar conductance and magnetic moment measurements, IR, UV-Vis, 1H- and 13C-NMR, and ESR spectroscopy. The ligand and all the metal complexes were stable in the solid state at room temperature. From the analytical and spectroscopic investigations, the stoichiometry of the complexes was found to be 1:1 (metal:ligand). Based on the electronic spectra and magnetic moment data, the metal complexes had a square planar geometry. The molar conductance values show the 1:2 electrolytic nature of the metal complexes. A cyclic voltammetric study of the Cu(II) metal complex has also performed, which showed one electron quasi-reversible reduction around -0.92 to -1.10 V. In vitro biological activities of the ligand and metal complexes was checked against two bacteria Bacillus subtilis and Escherichia coli and two fungi Aspirgillus niger and A. flavus which showed the antibacterial and antifungal properties of the ligand and its metal complexes.

scholarly journals Transition Metal Complexes of Mixed Bioligands: Synthesis, Characterization, DFT Modeling, and Applications

2019 ◽  
Vol 2019 ◽  
pp. 1-18 ◽  
Author(s):  
Mohamed S. A. Abdel-Mottaleb ◽  
Eman H. Ismail
Keyword(s):  
Transition Metal ◽  
Metal Complexes ◽  
Corrosion Inhibition ◽  
Transition Metal Complexes ◽  
Pathogenic Bacteria ◽  
Chemical Potential ◽  
Biological Activities ◽  
Aluminum Surface ◽  
Bacteria And Fungi

Divalent transition metal complexes [MGlu-Arg (H2O)]H2O and [MGlu-Arg (H2O)]H2O, where M = Co, Ni, Cu, and Zn, Glu = glutamic acid, and Arg = L-arginine, are prepared and characterized using different techniques. DFT and TD-DFT modelling validated and interpreted some experimental results. Weight loss technique reveals efficient corrosion inhibition action of these complexes towards aluminum metal at different temperatures. Our results point to corrosion inhibition through chemical adsorption on the aluminum surface. Additionally, a facile calcination of Co and Cu complexes at 550°C yields nanosized oxides of Co3O4, CoO, and CuO crystalline phases. The complexes show remarkable biological activities towards pathogenic bacteria and fungi. Moreover, in vitro anticancer activity evaluation of these complexes is achieved against hepatocellular carcinoma (HepG-2). The results are correlated with molecular descriptors such as chemical potential and hardness obtained from the frontier orbitals.

scholarly journals Synthesis, Thermal Characterization and in vitro Antibacterial Assessment of Co(II) and Cd(II) Complexes of Schiff Base Derived from Amoxicillin and Thiophene-2-carbaldehyde

2019 ◽  
Vol 31 (4) ◽  
pp. 951-959 ◽  
Author(s):  
N.K. Chaudhary ◽  
B. Guragain
Keyword(s):  
Metal Complexes ◽  
Biological Activities ◽  
Geometry Optimization ◽  
Thermal Characterization ◽  
Molar Conductance ◽  
Sem Analysis ◽  
Biological Data ◽  
Spectral Studies ◽  
Tetrahedral Geometry

A novel AMXTC2 ligand was prepared by simultaneous stirring and refluxing of an equimolar mixture of amoxicillin and thiophene-2-carbaldehyde in methanol and was further used to synthesize metal complexes by metalation with cobalt and cadmium salts, taking ligand metal ratio 2:1. They were characterized by elemental microanalysis, FT-IR, mass, UV-visible, 1H NMR, thermal analysis, magnetic moment and molar conductance measurements. The coordination sites in the ligand were verified by their comparative and extensive spectral studies. The detailed exploration of the data suggested octahedral geometry for Co-AMXTC2 and tetrahedral geometry for Cd-AMXTC2 complexes. The thermodynamic and kinetic parameters such as E*, ΔH*, ΔS* and ΔG* of various decomposition steps were calculated from TGA curves using the Coats-Redfern method. The molar conductivity data suggested non-electrolytic nature of the complexes. SEM analysis was done to observe their surface morphology. The geometry optimization of the proposed molecular structure of the complexes was achieved by running MM2 calculation in Gaussian supported Cs-ChemOffice Ultra-11 program software. The biological activities had been evaluated in vitro against E. coli, K. pneumonia, P. vulgaris and S. aureus pathogens in order to assess their antibacterial potency. The biological data revealed better growth inhibitory action of the ligand and metal complexes with bacterial pathogens.

scholarly journals Spectral, NLO, Fluorescence, and Biological Activity of Knoevenagel Condensate of β-Diketone Ligands and Their Metal(II) Complexes

2011 ◽  
Vol 2011 ◽  
pp. 1-8
Author(s):  
S. Sumathi ◽  
C. Anitha ◽  
P. Tharmaraj ◽  
C. D. Sheela
Keyword(s):  
Metal Complexes ◽  
Second Harmonic ◽  
Biological Activities ◽  
Analytical Data ◽  
Structural Features ◽  
Considerable Effect ◽  
Molar Conductance ◽  
Spectral Studies ◽  
Planar Geometry

Transition metal complexes of various acetylacetone-based ligands of the type ML (where M=  Cu(II), Ni(II), Co(II); L=  3-(aryl)-pentane-2,4-dione) have been synthesized. The structural features have been derived from their elemental analysis, magnetic susceptibility, molar conductance, IR, UV-Vis, H1NMR, mass and ESR spectral studies. Conductivity measurements reveal that all the complexes are nonelectrolytic in nature. Spectroscopic and other analytical data of the complexes suggest square planar geometry for copper(II), cobalt(II), and nickel(II) complexes of 3-(3-phenylallylidene)pentane-2,4-dione and octahedral geometry for other metal(II) complexes. The redox behaviors of the copper(II) complexes have been studied by cyclic voltammetry. The free ligands and their metal complexes have been screened for their in vitro biological activities against bacteria and fungus. The metal(II) complexes are found to possess increased activities compared to those of the free ligands. All synthesized compounds may serve as potential photoactive materials as indicated from their characteristic fluorescence properties. The second harmonic generation (SHG) efficiency of the ligands was found to have considerable effect compared to that of urea and KDP.

scholarly journals Synthesis, Spectroscopic Characterization, and In Vitro Antimicrobial Studies of Pyridine-2-Carboxylic Acid N′-(4-Chloro-Benzoyl)-Hydrazide and Its Co(II), Ni(II), and Cu(II) Complexes

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Jagvir Singh ◽  
Prashant Singh
Keyword(s):  
Metal Complexes ◽  
Acid Hydrazide ◽  
Spectroscopic Characterization ◽  
Fungal Species ◽  
Molar Conductance ◽  
Antimicrobial Studies ◽  
Spectral Bands ◽  
Elemental Analyses ◽  
Solid Complexes

N-substituted pyridine hydrazide (pyridine-2-carbonyl chloride and 4-chloro-benzoic acid hydrazide) undergoes hydrazide formation of the iminic carbon nitrogen double bond through its reaction with cobalt(II), nickel(II), and copper(II) metal salts in ethanol which are reported and characterized based on elemental analyses, IR, solid reflectance, magnetic moment, molar conductance, and thermal analysis (TG). From the elemental analyses data, 1 : 2 metal complexes are formed having the general formulae [MCl2(HL)2] ·yH2O (where M = Co(II), Ni(II), and Cu(II),y= 1–3). The important infrared (IR) spectral bands corresponding to the active groups in the ligand and the solid complexes under investigation were studied. IR spectra show that ligand is coordinated to the metal ions in a neutral bidentate manner with ON donor sites. The solid complexes have been synthesized and studied by thermogravimetric analysis. All the metal chelates are found to be nonelectrolytes. From the magnetic and solid reflectance spectra, the complexes (cobalt(II), nickel(II), and copper(II)) have octahedral and square planner geometry, respectively. The antibacterial and antifungal activity’s data show that the metal complexes have a promising biological activity comparable with the parent ligand against bacterial and fungal species.

scholarly journals Biological and Spectral Studies of Newly Synthesized Triazole Schiff Bases and Their Si(IV), Sn(IV) Complexes

2011 ◽  
Vol 2011 ◽  
pp. 1-10 ◽  
Author(s):  
Kiran Singh ◽  
Parvesh Puri ◽  
Yogender Kumar ◽  
Chetan Sharma ◽  
Kamal Rai Aneja
Keyword(s):  
Nmr Spectroscopy ◽  
Metal Complexes ◽  
Schiff Bases ◽  
Molar Conductance ◽  
Molar Ratio ◽  
Spectral Studies ◽  
Trigonal Bipyramidal ◽  
Elemental Analyses ◽  
Bacteria And Fungi

The Schiff bases HL1-3have been prepared by the reaction of 5-bromothiophene-2-carboxaldehyde with 4-amino-5-mercapto-3-methyl/propyl/isopropyl-s-triazole, respectively. Organosilicon(IV) and organotin(IV) complexes of formulae (CH3)2MCl(L1-3), (CH3)2M(L1-3)2were synthesized from the reaction of (CH3)2MCl2and the Schiff bases in 1 : 1 and 1 : 2 molar ratio, where and Sn. The synthesized Schiff bases and their metal complexes have been characterized with the aid of various physicochemical techniques like elemental analyses, molar conductance, UV, IR,1H,13C,29Si, and119Sn NMR spectroscopy. Based on these studies, the trigonal bipyramidal and octahedral geometries have been proposed for these complexes. The ligands and their metal complexes have been screenedin vitroagainst some bacteria and fungi.

Synthesis, Characterization and Biological Studies of Some Transition Metal Complexes with Pyrazine Schiff Base Hydra zone Ligand

2020 ◽  
Vol 15 (2) ◽  
pp. 61-72
Keyword(s):  
Metal Complexes ◽  
Metal Ion ◽  
Metal Salt ◽  
Free Ligand ◽  
Spectroscopic Studies ◽  
Fungal Species ◽  
Molar Conductance ◽  
Central Metal ◽  
Biological Studies

New pyrazine carbohydra zone ligand N'-(1-(5-chloro-2-hydroxyphenyl) ethylidene) pyrazine-2-carbohydrazide (H2L), prepared by the condensation of equimolar amounts of pyrazine-2-carbohydrazide with 2-hydroxy-5-chloroacetophenone in methanol, reacts with suitable metal salt precursors to give complexes of two general formulae: [M(HL)(Cl)(H2O)2] {M = Mn(II), Co(II), Ni(II) and Cu(II)} and [M(L)(H2O)] {M = Zn(II) and Cd(II)}. Structure of ligand was confirmed by elemental analysis, IR, 1H and 13C NMR and mass spectroscopy, while synthesized complexes were additionally characterized by magnetic susceptibility measurements, molar conductivity measurements, XRD, ESR (for Cu(II)), SEM and thermogravimetric analysis. Spectroscopic studies confirmed a tridentate ONO donor behavior of the ligand towards the central metal ion. The molar conductance (12–17 W–1 cm2 mol–1) measurements in DMSO indicated non-electrolytic nature. Thermal behavior of the complexes suggests their extended stability and the thermal decomposition generally proceeds via partial loss of the organic moiety and ends with the formation of respective metal oxide as a final product. Various kinetic and thermodynamic parameters were evaluated using the Coats-Redfern method. The solid-state electrical conductivity of the complexes measured in the temperature range 303-463 K suggested their semiconducting behavior. The ligand and its metal complexes were screened in vitro for their antibacterial activity against the Gram-positive bacteria S. aureus and B. subtilis, the Gram-negative bacteria E. coli and S. typhi and the fungi C. albicans and A. niger. The obtained results indicated improved activity of the complexes compared to the free ligand against all studied bacterial and fungal species.

Combinatorial Synthesis of Novel 1-Sulfonyloxy/acyloxyeugenol Derivatives as Fungicidal Agents

2021 ◽  
Vol 24 ◽  
Author(s):  
Genqiang Chen ◽  
Lina Zhu ◽  
Jiaxuan He ◽  
Song Zhang ◽  
Yuanhao Li ◽  
...  
Keyword(s):  
Fungicidal Activity ◽  
High Efficiency ◽  
Biological Activities ◽  
Phytophthora Capsici ◽  
Effective Control ◽  
Syzygium Aromaticum ◽  
Wide Range ◽  
Structural Skeleton ◽  
Acyloxy Group

Background: Developing the high-efficiency and low-risk small-molecule green-fungicide is the key to effective control of the plant pathogenic oomycetes. Essential oils play a very important role in novel fungicide discovery for their unique sources and potential target sites. Eugenol, a kind of plant essential oil, was mainly isolated from the unopened and dried flower buds of Syzygium aromaticum of the Myrtaceae family. Due to its unique structural skeleton, eugenol and its derivatives have exhibited a wide range of biological activities. However, study on the synthesis of novel 1-sulfonyloxy/acyloxyeugenol derivatives as fungicidal agents against Phytophthora capsici has not yet been reported. Methods: Twenty-six novel 1-sulfonyloxy/acyloxyeugenol derivatives (3a-p and 5a-j) were prepared and their structures were well characterized by 1H NMR, HRMS, and m.p.. Their fungicidal activity was evaluated against P. capsici by using the mycelial growth rate method. Results: To find novel natural-product-based fungicidal agents to control the plant pathogenic oomycetes, we herein designed and synthesized two series of novel 1-sulfonyloxy/acyloxyeugenol derivatives (3a-p and 5a-j) as fungicidal agents against P. capsici Leonian, in vitro. Results of fungicidal activity revealed that, among all compounds, especially compounds 3a, 3f, and 3n displayed the most potent anti-oomycete activity against P. capsici with EC50 values of 79.05, 75.05, and 70.80, respectively. Conclusion: The results revealed that the anti-oomycete activity of eugenol with the sulfonyloxy group was higher than that with the acyloxy group. It is suggested that the fungicidal activity of eugenol can be improved by introducing the sulfonyloxy group. This will pave the way for further design, structural modification, and to develop eugenol derivatives as fungicidal agents.

scholarly journals Distribution of Zinc in Mycelial Cells and Antioxidant and Anti-Inflammatory Activities of Mycelia Zinc Polysaccharides from Thelephora ganbajun TG-01

2020 ◽  
Vol 2020 ◽  
pp. 1-17
Author(s):  
Lan Zheng ◽  
Yaohong Ma ◽  
Yunjuan Zhang ◽  
Qingjun Meng ◽  
Junhui Yang ◽  
...  
Keyword(s):  
Biological Activities ◽  
Zinc Content ◽  
Helical Conformation ◽  
Molar Ratio ◽  
Oxygen Species ◽  
Zinc Supplement ◽  
Chronic Oxidative Stress ◽  
Main Fraction ◽  
Anti Inflammatory

This study demonstrates that Thelephora ganbajun had a strong ability to absorb zinc, and zinc can be compartmentally stored in the small vesicles and mainly accumulated in the form of zinc-enriched polysaccharides (zinc content was 25.0±1.27 mg/g). Mycelia zinc polysaccharides (MZPS) and its fractions were isolated. The main fraction (MZPS-2) with the highest antioxidant activity in vitro was composed of mannose : galacturonic acid : glucose : galactose in a molar ratio of 61.19 : 1 : 39.67 : 48.67, with a weight-averaged molecular weight of 5.118×105 Da. MZPS-2 had both α-pyranose and β-pyranose configuration and had a triple helical conformation. By establishing zebrafish models, we found that MZPS-2 can significantly scavenge free radicals, reduce the generation of reactive oxygen species caused by inflammation, and inhibit the recruitment of neutrophils toward the injury site. Therefore, MZPS-2 exhibited antioxidant and anti-inflammatory effects and can be used as a zinc supplement with specific biological activities to alleviate zinc deficiency complications, such as chronic oxidative stress or inflammation.

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