scholarly journals Biosensors-on-Chip: An Up-to-Date Review

Molecules ◽  
2020 ◽  
Vol 25 (24) ◽  
pp. 6013
Author(s):  
Cristina Chircov ◽  
Alexandra Cătălina Bîrcă ◽  
Alexandru Mihai Grumezescu ◽  
Ecaterina Andronescu
Keyword(s):  
Neurodegenerative Disorders ◽  
System Development ◽  
Point Of Care ◽  
Quantitative Information ◽  
Recent Application ◽  
Physical Chemical ◽  
Target Analytes ◽  
Diagnosis Of Cancer ◽  
Diagnostic Applications ◽  
On Chip

Generally, biosensors are designed to translate physical, chemical, or biological events into measurable signals, thus offering qualitative and/or quantitative information regarding the target analytes. While the biosensor field has received considerable scientific interest, integrating this technology with microfluidics could further bring significant improvements in terms of sensitivity and specificity, resolution, automation, throughput, reproducibility, reliability, and accuracy. In this manner, biosensors-on-chip (BoC) could represent the bridging gap between diagnostics in central laboratories and diagnostics at the patient bedside, bringing substantial advancements in point-of-care (PoC) diagnostic applications. In this context, the aim of this manuscript is to provide an up-to-date overview of BoC system development and their most recent application towards the diagnosis of cancer, infectious diseases, and neurodegenerative disorders.

scholarly journals On-Chip PCR Based Plasmonic Microfluidic Platform: Ultrafast Point-of-Care Diagnostics of SARS-CoV-2

2021 ◽  
Vol 3 (1) ◽  
pp. 5-11
Author(s):  
Megha Agrawal ◽  
Keyword(s):  
Small Volume ◽  
Point Of Care ◽  
Rapid Screening ◽  
Viral Diseases ◽  
Chain Reaction ◽  
Point Of Care Diagnostics ◽  
Screening And Identification ◽  
Polymerase Chain ◽  
Diagnostic Applications ◽  
On Chip

It is critically important to have rapid screening and identification of contagious viral diseases such as the current COVID-19 pandemic that is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Rapid and accurate diagnostic is essential for preventing worldwide spread of virus and ensuring in-time care for patients during the fast spread of pandemic diseases. Nanobiotechnology enabled tools have allowed to develop advanced polymerase chain reaction (PCR) based diagnostics of contagious viral diseases. To this end, microfluidic on-chip PCR platforms have shown huge promise for highly efficient, rapid and small-volume bioassay for point-of-care (POC) diagnostic applications in mitigating the challenges of SARS-CoV-2. Here, we discuss latest advances in ultrafast, real-time, and on-chip nanoplasmonic PCR for rapid and quantitative molecular diagnostics at POC level.

Disposable Smart Plastic Biochips For Clinical Diagnostics

2002 ◽  
Vol 729 ◽  
Author(s):  
Chong H. Ahn ◽  
Jin-Woo Choi ◽  
Sanghyo Kim ◽  
Young-Soo Sohn ◽  
Aniruddha Puntambekar ◽  
...  
Keyword(s):  
Passive Control ◽  
Point Of Care ◽  
Low Cost ◽  
Microfluidic System ◽  
Clinical Diagnostics ◽  
Plastic Substrate ◽  
Driving Mechanisms ◽  
Care Health ◽  
Diagnostic Applications ◽  
On Chip

AbstractThis paper presents an overview of the development of novel disposable smart plastic fluidic biochips for clinical diagnostic applications. The biochip is manufactured using a low-cost, rapid turn around injection molding/embossing process on a plastic substrate. The plastic fluidic biochip uses a novel sPROMs (structurally programmable microfluidic system) approach to achieve passive control of fluidic sequencing [1-2]. The plastic biochip also uses an on-chip pressurized air source for fluidic movement thus eliminating the need for active driving mechanisms and allowing for a truly disposable approach. Furthermore, electrochemical biosensors are also integrated on-chip to analyze various metabolically significant parameters such as PO2(partial pressure of oxygen), Glucose, Lactate,and pH. The fluidic biochip is being developed for point-of-care health monitoring applications where parameters such as small size, simplicity of operation, disposability, reduced cross-contamination are vital. The issues mentioned above are successfully addressed using the approach of this work and are discussed in this paper.

Trends in Diagnosis for Active Tuberculosis Using Nanomaterials

2019 ◽  
Vol 26 (11) ◽  
pp. 1946-1959 ◽  
Author(s):  
Le Minh Tu Phan ◽  
Lemma Teshome Tufa ◽  
Hwa-Jung Kim ◽  
Jaebeom Lee ◽  
Tae Jung Park
Keyword(s):  
Sensitivity And Specificity ◽  
High Efficiency ◽  
Point Of Care ◽  
High Sensitivity ◽  
Signs And Symptoms ◽  
Diagnostic Methods ◽  
Advantages And Disadvantages ◽  
Treatment And Prevention ◽  
Clinical Tools ◽  
Diagnostic Applications

Background:Tuberculosis (TB), one of the leading causes of death worldwide, is difficult to diagnose based only on signs and symptoms. Methods for TB detection are continuously being researched to design novel effective clinical tools for the diagnosis of TB.Objective:This article reviews the methods to diagnose TB at the latent and active stages and to recognize prospective TB diagnostic methods based on nanomaterials.Methods:The current methods for TB diagnosis were reviewed by evaluating their advantages and disadvantages. Furthermore, the trends in TB detection using nanomaterials were discussed regarding their performance capacity for clinical diagnostic applications.Results:Current methods such as microscopy, culture, and tuberculin skin test are still being employed to diagnose TB, however, a highly sensitive point of care tool without false results is still needed. The utilization of nanomaterials to detect the specific TB biomarkers with high sensitivity and specificity can provide a possible strategy to rapidly diagnose TB. Although it is challenging for nanodiagnostic platforms to be assessed in clinical trials, active TB diagnosis using nanomaterials is highly expected to achieve clinical significance for regular application. In addition, aspects and future directions in developing the high-efficiency tools to diagnose active TB using advanced nanomaterials are expounded.Conclusion:This review suggests that nanomaterials have high potential as rapid, costeffective tools to enhance the diagnostic sensitivity and specificity for the accurate diagnosis, treatment, and prevention of TB. Hence, portable nanobiosensors can be alternative effective tests to be exploited globally after clinical trial execution.

scholarly journals On-Chip Liquid Biopsy: Progress in Isolation of Exosomes for Early Diagnosis of Cancer

2017 ◽  
Vol 112 (3) ◽  
pp. 461a ◽  
Author(s):  
Sung Cheol Kim ◽  
Navneet Dogra ◽  
Benjamin H. Wunsch ◽  
Joshua T. Smith ◽  
Stacey M. Gifford ◽  
...  
Keyword(s):  
Early Diagnosis ◽  
Liquid Biopsy ◽  
Early Diagnosis Of Cancer ◽  
Diagnosis Of Cancer ◽  
On Chip

The MOBEL Project

2011 ◽  
pp. 1171-1190
Author(s):  
Inger Dybdahl Sorby ◽  
Line Melby ◽  
Yngve Dahl ◽  
Gry Seland
Keyword(s):  
Communication Systems ◽  
Information Needs ◽  
System Development ◽  
Point Of Care ◽  
User Involvement ◽  
Clinical Information ◽  
Problem Area ◽  
Patient Centered ◽  
Mobile Information ◽  
Information And Communication

This chapter presents results and experiences from the MOBEL (MOBile ELectronic patient record) project at the Norwegian University of Science and Technology (NTNU) in Trondheim, Norway. MOBEL was a multidisciplinary research project established in 2000. The problem area of the project was communication and information needs in hospital wards, and the aim of the project was to develop and explore methods and prototypes for point of care clinical information systems (PoCCS) that support clinicians in their patient-centered activities. The chapter summarizes four sub studies performed during the project. Each study presents different approaches to user-centered design of PoCCS. Findings from these studies confirm the need for mobile information and communication technology (ICT) in hospitals. Furthermore, the studies demonstrate how more user involvement and complementary approaches to traditional requirements engineering (RE) and system development methods can be useful when developing mobile information and communication systems for clinicians.

The MOBEL Project

2010 ◽  
pp. 52-73
Author(s):  
Inger Dybdahl Sorby ◽  
Line Melby ◽  
Yngve Dahl ◽  
Gry Seland
Keyword(s):  
Communication Systems ◽  
Information Needs ◽  
System Development ◽  
Point Of Care ◽  
User Involvement ◽  
Clinical Information ◽  
Problem Area ◽  
Patient Centered ◽  
Mobile Information ◽  
Information And Communication

This chapter presents results and experiences from the MOBEL (MOBile ELectronic patient record) project at the Norwegian University of Science and Technology (NTNU) in Trondheim, Norway. MOBEL was a multidisciplinary research project established in 2000. The problem area of the project was communication and information needs in hospital wards, and the aim of the project was to develop and explore methods and prototypes for point of care clinical information systems (PoCCS) that support clinicians in their patient-centered activities. The chapter summarizes four sub studies performed during the project. Each study presents different approaches to user-centered design of PoCCS. Findings from these studies confirm the need for mobile information and communication technology (ICT) in hospitals. Furthermore, the studies demonstrate how more user involvement and complementary approaches to traditional requirements engineering (RE) and system development methods can be useful when developing mobile information and communication systems for clinicians.

Point-of-Care Systems for Rapid DNA Quantification in Oncology

2008 ◽  
Vol 94 (2) ◽  
pp. 216-225 ◽  
Author(s):  
Marco Bianchessi ◽  
Sarah Burgarella ◽  
Marco Cereda
Keyword(s):  
Point Of Care ◽  
Low Cost ◽  
Semiconductor Industry ◽  
Point Of Care Testing ◽  
Lab On Chip ◽  
Diagnostic Assays ◽  
Care Systems ◽  
Point Of Care Systems ◽  
The Common ◽  
On Chip

The development of new powerful applications and the improvement in fabrication techniques are promising an explosive growth in lab-on-chip use in the upcoming future. As the demand reaches significant levels, the semiconductor industry may enter in the field, bringing its capability to produce complex devices in large volumes, high quality and low cost. The lab-on-chip concept, when applied to medicine, leads to the point-of-care concept, where simple, compact and cheap instruments allow diagnostic assays to be performed quickly by untrained personnel directly at the patient's side. In this paper, some practical and economical considerations are made to support the advantages of point-of-care testing. A series of promising technologies developed by STMicroelectronics on lab-on-chips is also presented, mature enough to enter in the common medical practice. The possible use of these techniques for cancer research, diagnosis and treatment are illustrated together with the benefits offered by their implementation in point-of-care testing.

scholarly journals Nanomaterial-based devices for point-of-care diagnostic applications

2018 ◽  
Vol 47 (13) ◽  
pp. 4697-4709 ◽  
Author(s):  
Daniel Quesada-González ◽  
Arben Merkoçi
Keyword(s):  
Point Of Care ◽  
Diagnostic Applications

In this review, we have discussed the capabilities of nanomaterials for point-of-care (PoC) diagnostics and explained how these materials can help to strengthen, miniaturize and improve the quality of diagnostic devices.

Sign in / Sign up

Export Citation Format

Share Document