scholarly journals Effects of Sucrose Palmitate on the Physico-Chemical and Mucoadhesive Properties of Buccal Films

Molecules ◽  
2020 ◽  
Vol 25 (22) ◽  
pp. 5248
Author(s):  
András Kelemen ◽  
Bálint Katona ◽  
Szilvia Módra ◽  
Zoltán Aigner ◽  
István Sebe ◽  
...  
Keyword(s):  
Hydroxypropyl Methylcellulose ◽  
Permeation Enhancer ◽  
X Ray ◽  
Positron Annihilation Lifetime ◽  
Physico Chemical ◽  
Different Temperatures ◽  
Measured Contact Angle ◽  
Buccal Films

In our current research, sucrose palmitate (SP) was applied as a possible permeation enhancer for buccal use. This route of administration is a novelty as there is no literature on the use of SP in buccal mucoadhesive films. Films containing SP were prepared at different temperatures, with different concentrations of SP and different lengths of hydroxypropyl methylcellulose (HPMC) chains. The mechanical, structural, and in vitro mucoadhesive properties of films containing SP were investigated. Tensile strength and mucoadhesive force were measured with a device and software developed in our Institute. Positron annihilation lifetime spectroscopy (PALS) and X-ray powder diffractometry (XRPD) were applied for the structure analysis of the films. Mucoadhesive work was calculated in two ways: from the measured contact angle and compared with direct mucoadhesive work, which measured mucoadhesive force, which is direct mucoadhesion work. These results correlate linearly with a correlation coefficient of 0.98. It is also novel because it is a new method for the determination of mucoadhesive work.

Diorganotin difluorobenzoates: synthesis, spectroscopic characterization and in vitro antitumour activity. X-Ray structure determination of bis[di-n-butyl(2,6-difluorobenzoato)tin] oxide

1993 ◽  
Vol 64 (3) ◽  
pp. 279-291 ◽  
Author(s):  
Marcel Gielen ◽  
Monique Biesemans ◽  
Abdelaziz El Khloufi ◽  
Jacqueline Meunier-Piret ◽  
François Kayser ◽  
...  
Keyword(s):  
Tin Oxide ◽  
Structure Determination ◽  
Antitumour Activity ◽  
Spectroscopic Characterization ◽  
X Ray

Confirmation of the new technique for measuring the linear thermal expansion of silicon

1993 ◽  
Vol 8 (1) ◽  
pp. 36-38 ◽  
Author(s):  
Liu Fengchao
Keyword(s):  
Thermal Expansion ◽  
Room Temperature ◽  
Accurate Determination ◽  
Linear Thermal Expansion ◽  
Linear Expansion Coefficient ◽  
X Ray ◽  
High Purity Silicon ◽  
Different Temperatures ◽  
Better Than

This paper further confirms that the direct measurement of diffraction angles at different temperatures by using the X-ray diffractometer is better than measurement of the lattice parameters for the rapid and accurate determination of the linear thermal expansion of silicon. High purity silicon has the linear expansion coefficient, α= (2.45±0.05) × 10−6/°C at room temperature. This value does not change for doped P-type and N-type silicon.

scholarly journals A first-prototype multi-determinant X-ray constrained wavefunction approach: the X-ray constrained extremely localized molecular orbital–valence bond method

2017 ◽  
Vol 73 (4) ◽  
pp. 312-316 ◽  
Author(s):  
Alessandro Genoni
Keyword(s):  
Valence Bond ◽  
Resonance Structure ◽  
X Ray Diffraction ◽  
X Ray ◽  
Localized Molecular Orbitals ◽  
Structure Factors ◽  
Different Temperatures ◽  
Explicit Consideration ◽  
Bond Method

All the current variants of Jayatilaka's X-ray constrained wavefunction (XCW) approach work within the framework of the single-determinant wavefunctionansatz. In this paper, a first-prototype multi-determinant XCW technique is proposed. The strategy assumes that the desired XCW is written as a valence-bond-like expansion in terms of pre-determined single Slater determinants constructed with extremely localized molecular orbitals. The method, which can be particularly suitable to investigate systems with a multi-reference character, has been applied to determine the weights of the resonance structures of naphthalene at different temperatures by exploiting experimental high-resolution X-ray diffraction data. The results obtained have shown that the explicit consideration of experimental structure factors in the determination of the resonance structure weights may lead to results significantly different compared with those resulting only from the simple energy minimization.

scholarly journals UNSUCCESSFUL DELIVERY OF TETRANDRINE FROM COLON-TARGETED DOSAGE FORMS COMPRISING ALGINATE/HYDROXYPROPYL METHYLCELLULOSE AND ALGINATE–CHITOSAN BEADS

2018 ◽  
Vol 10 (1) ◽  
pp. 396
Author(s):  
Raditya Iswandana ◽  
Metah Putri Mutia ◽  
Farahia Khairina Widyaningrum
Keyword(s):  
Hydroxypropyl Methylcellulose ◽  
Dosage Forms ◽  
X Ray Diffraction ◽  
Scanning Calorimetry ◽  
Chitosan Beads ◽  
X Ray ◽  
Moisture Contents ◽  
Ph Conditions ◽  
Upper Gastrointestinal

Objective: The objective of this study was to optimize the formulations of antifibrotic tetrandrine beads using alginate and various concentrations ofhydroxypropyl methylcellulose (HPMC) and chitosan.Methods: Beads were formulated with six (F1–F6) concentrations of polymer and were then characterized using scanning electron microscopy,differential scanning calorimetry, and X-ray diffraction; these beads were used for measurements of moisture contents, swelling, and in vitro drugrelease.Results: Beads with the highest concentrations of HPMC and chitosan produced the highest entrapment efficiencies of 49.83% and 50.71%,respectively. Moreover, drug release under stomach conditions (HCl pH 1.2 medium) was restricted to 75.01%, 61.01%, 51.86%, 74.84%, 66.00%,and 41.63% with increasing HPMC and chitosan concentrations (F1–F6, respectively).Conclusion: Beads of all formulations showed inadequate retention of tetrandrine under pH conditions of the upper gastrointestinal tract and wouldlikely be unsuccessful as colon-targeted dosage forms.

Physico-Chemical Characteristics of TiO2 Derived Nanotube Synthesized by the Hydrothermal Process as a Bioceramic

2014 ◽  
Vol 631 ◽  
pp. 198-201 ◽  
Author(s):  
H. Eslami ◽  
F. Moztarzadeh ◽  
T.S. Jafarzadeh Kashi ◽  
M. Solati-Hashjin ◽  
K. Khoshroo ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
Cellular Response ◽  
Hydrothermal Process ◽  
In Vitro Study ◽  
High Specific Surface Area ◽  
Fesem Image ◽  
Physico Chemical ◽  
Different Temperatures ◽  
Main Factor

Titania (TiO2) nanotube gaining predominance as a bioceramic due to its excellent features such as high specific surface area and exhibiting appropriate cellular response. At present, we showed a conversion from titania nanoparticle to nanotube by hydrothermal treatment with 10M soduim hydroxide and 1M HCl solutions at 150°C over 48h. Then the sample annealed at various temperatures. Results indicate the reaction temperature is a main factor in determining the aspect ratio of the tubes. FESEM image conformed the synthesis of nanotube. In vitro study by using 150 °C-synthesized nanotube calcined at different temperatures are also presented establishing the potential of nanotubes in biomedical applications

Phase analysis of sintered yttria–zirconia ceramics by x-ray diffraction

1986 ◽  
Vol 1 (2) ◽  
pp. 295-299 ◽  
Author(s):  
A. Paterson ◽  
R. Stevens
Keyword(s):  
Tetragonal Phase ◽  
Cubic Phase ◽  
X Ray Diffraction ◽  
Zirconia Ceramics ◽  
X Ray ◽  
Different Temperatures ◽  
Shear Transformation ◽  
Original Amount ◽  
Good Agreement

Determination of the amount of cubic and tetragonal phase in yttria–zirconia using high-angle XRD (x-ray diffraction) has been complicated by problems of resolution and interpretation. The evidence, from electron diffraction studies, for a c→t shear transformation also needs to be taken into account. Two compositions, a 3 and a 5.7 mol % Y2O3−ZrO2, were sintered and thermally treated at different temperatures between 1450°and 1700°C. X-ray diffraction traces revealed the anticipated tetragonal (400) and (004) reflections. The region of the diffraction pattern that was thought to arise from the cubic phase could be best interpreted as a second tetragonal phase t'. The original amount of cubic phase computed from the t' reflections showed good agreement with the phase diagram of Scott. The lattice parameters of the t' phase were determined, and the volume of the tetragonal (t') unit cell was calculated.

scholarly journals Computer Aided Formulation and Characterization of Propranolol Hcl Buccal Tablet Using Polymeric Blend

2017 ◽  
Vol 8 (1) ◽  
pp. 1-13
Author(s):  
Sana Hanif ◽  
Nadeem Irfan ◽  
Zeeshan Danish ◽  
Nisaar Hussain ◽  
Muhammad Ali ◽  
...  
Keyword(s):  
Release Kinetics ◽  
Hydroxypropyl Methylcellulose ◽  
Continuous Release ◽  
Mucoadhesive Polymers ◽  
Propranolol Hcl ◽  
Physico Chemical ◽  
Buccal Tablet ◽  
Intelligence Approach

The current study was aimed to formulate a continuous release mucoadhesive buccal tablet containing propranolol HCl. The type and quantities of polymers as well as method of compression were set in a preliminary study (F1-F13). Direct compression method was employed in the main study (F14-F24) using Carbopol® 934P (CP), ethylcellulose (EC), sodium alginate (SA), hydroxypropyl methylcellulose (HPMC k4M) and carboxymethylcellulose (CMC) as mucoadhesive polymers and were tested for physicochemical tests i.e. swellability, surface pH, mucoadhesive time, mucoadhesive strength, in vitro release etc. Results obtained from the study were optimized using NeuralPower® 3.1, an artificial intelligence approach. Against the desirability of physico-chemical parameters, the software optimized the ingredients as HPMC (150mg), CMC (25mg), CP (20mg) and EC (20mg). Outcome revealed that HPMC primarily contributed to the physicochemical properties of mucoadhesive formulation. To compare prediction, optimized ingredients were formulated (F25) and tested. The swellability index of confirmation formulation (F25) was 102% at 6 h. As predicted, similar release pattern was of F25 was obtained as 26% (0.5h), 34% (1h), 40% (2h), 45% (3h), 50% (4h), 62% (5h), 76% (6h), 85% (7h) and 97% (8h) respectively. For release kinetics, DD solver® suggested the release of the drug to be non-Fickian.

The Morphology of Corrosion Products in FeAl Alloys after Heat-Resistance Tests at Different Temperatures

2015 ◽  
Vol 227 ◽  
pp. 409-412 ◽  
Author(s):  
Agnieszka Fornalczyk ◽  
Janusz Cebulski ◽  
Pasek Dorota
Keyword(s):  
Heat Resistance ◽  
Surface Condition ◽  
Intermetallic Phases ◽  
Passive Layer ◽  
Operating Conditions ◽  
Corrosion Products ◽  
X Ray ◽  
Physico Chemical ◽  
Different Temperatures ◽  
Resistance Tests

The alloys based on intermetallic phases involving Al belong to a new group of heat-resistant materials. Their physico-chemical and mechanical properties allow to apply them in the operating conditions in corrosive environment and elevated temperature. Research conducted for many years has shown that these materials can work at temperature up to 1100°C without degradation of their occurrence in the environment containing oxygen and sulphur. Heat resistance of these materials is provided by forming the Al2O3 passive layer on the surface. This layer is a protective barrier, which hinders the oxygen diffusion into the surface. This paper presents the morphology of passive Al2O3 layer depending on the temperature of its formation. The study allows to define the surface condition for corrosion products carried out using scanning electron microscopy together with EDS X-ray microanalysis.

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